Aliases for RAB12 Gene
GeneCards Summary for RAB12 Gene
RAB12 (RAB12, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB12 include Parkinson Disease, Late-Onset. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB3C.
UniProtKB/Swiss-Prot Summary for RAB12 Gene
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).