Aliases for RAB11FIP4 Gene
External Ids for RAB11FIP4 Gene
Previous GeneCards Identifiers for RAB11FIP4 Gene
The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
GeneCards Summary for RAB11FIP4 Gene
RAB11FIP4 (RAB11 Family Interacting Protein 4) is a Protein Coding gene. Diseases associated with RAB11FIP4 include Chromosome 17Q11.2 Deletion Syndrome and Hepatocellular Carcinoma. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is RAB11FIP3.
UniProtKB/Swiss-Prot Summary for RAB11FIP4 Gene
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.