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Aliases for RAB11FIP2 Gene

Aliases for RAB11FIP2 Gene

  • RAB11 Family Interacting Protein 2 2 3 5
  • RAB11 Family Interacting Protein 2 (Class I) 2 3
  • Rab11-FIP2 3 4
  • NRip11 3 4
  • Rab11 Family-Interacting Protein 2 3
  • RAB11-FIP2 Long Isoform 3
  • KIAA0941 4

External Ids for RAB11FIP2 Gene

Previous GeneCards Identifiers for RAB11FIP2 Gene

  • GC10M119754
  • GC10M113392

Summaries for RAB11FIP2 Gene

GeneCards Summary for RAB11FIP2 Gene

RAB11FIP2 (RAB11 Family Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is RAB11FIP1.

UniProtKB/Swiss-Prot for RAB11FIP2 Gene

  • A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Gene Wiki entry for RAB11FIP2 Gene

Additional gene information for RAB11FIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP2 Gene

Genomics for RAB11FIP2 Gene

GeneHancer (GH) Regulatory Elements for RAB11FIP2 Gene

Promoters and enhancers for RAB11FIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J118045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 384 2.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF213 ZNF143 CASC2 RAB11FIP2 RPL17P36 ENSG00000231104
GH10J117174 Enhancer 1.1 Ensembl ENCODE 10.5 +871.4 871427 1.7 ZFP64 SIN3A IRF4 ZNF213 ZNF207 ZNF143 ATF7 RXRA REST MIER2 VAX1 KCNK18 RPL12P26 MIR3663HG RAB11FIP2 LOC105378500 SLC18A2 GC10M117197
GH10J117966 Enhancer 0.8 VISTA 11 +79.9 79908 1.4 OSR2 PKNOX1 PRDM6 ZNF366 ZNF239 FEZF1 ATF2 SP7 ENSG00000231104 RAB11FIP2 LOC105378504
GH10J117979 Enhancer 0.4 ENCODE 11.3 +66.5 66518 1.2 JUND NFE2 FOS ENSG00000231104 RAB11FIP2 LOC105378504
GH10J117928 Enhancer 0.4 UCNEbase 10.5 +118.4 118417 0.2 ENSG00000231104 RAB11FIP2 LOC105378504 ENSG00000263041
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB11FIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB11FIP2 gene promoter:
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • AP-2alphaA
  • Hand1
  • USF-1
  • USF1
  • GATA-1
  • POU3F2

Genomic Locations for RAB11FIP2 Gene

Genomic Locations for RAB11FIP2 Gene
chr10:118,004,916-118,046,877
(GRCh38/hg38)
Size:
41,962 bases
Orientation:
Minus strand
chr10:119,764,427-119,806,114
(GRCh37/hg19)
Size:
41,688 bases
Orientation:
Minus strand

Genomic View for RAB11FIP2 Gene

Genes around RAB11FIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP2 Gene

Proteins for RAB11FIP2 Gene

  • Protein details for RAB11FIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L804-RFIP2_HUMAN
    Recommended name:
    Rab11 family-interacting protein 2
    Protein Accession:
    Q7L804
    Secondary Accessions:
    • A6NEI4
    • Q3I768
    • Q9Y2F0

    Protein attributes for RAB11FIP2 Gene

    Size:
    512 amino acids
    Molecular mass:
    58279 Da
    Quaternary structure:
    • Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3.
    SequenceCaution:
    • Sequence=BAA76785.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB11FIP2 Gene

    Alternative splice isoforms for RAB11FIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP2 Gene

Post-translational modifications for RAB11FIP2 Gene

  • Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB11FIP2 Gene

No data available for DME Specific Peptides for RAB11FIP2 Gene

Domains & Families for RAB11FIP2 Gene

Gene Families for RAB11FIP2 Gene

Protein Domains for RAB11FIP2 Gene

Suggested Antigen Peptide Sequences for RAB11FIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAB11FIP2: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP2 Gene

Function for RAB11FIP2 Gene

Molecular function for RAB11FIP2 Gene

UniProtKB/Swiss-Prot Function:
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Phenotypes From GWAS Catalog for RAB11FIP2 Gene

Gene Ontology (GO) - Molecular Function for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12470645
GO:0017137 Rab GTPase binding IBA --
GO:0019901 protein kinase binding IPI 16775013
GO:0042802 identical protein binding IPI 16905101
GO:0042803 protein homodimerization activity IPI 16905101
genes like me logo Genes that share ontologies with RAB11FIP2: view
genes like me logo Genes that share phenotypes with RAB11FIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP2 Gene

Localization for RAB11FIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP2 Gene

Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endosome 5
cytosol 3
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IDA,IEA 16905101
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane TAS --
genes like me logo Genes that share ontologies with RAB11FIP2: view

Pathways & Interactions for RAB11FIP2 Gene

genes like me logo Genes that share pathways with RAB11FIP2: view

SIGNOR curated interactions for RAB11FIP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0015031 protein transport IEA --
GO:0030010 establishment of cell polarity IMP 16775013
GO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS,IEA --
GO:0045055 regulated exocytosis ISS,IEA --
genes like me logo Genes that share ontologies with RAB11FIP2: view

Drugs & Compounds for RAB11FIP2 Gene

(1) Drugs for RAB11FIP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for RAB11FIP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with RAB11FIP2: view

Transcripts for RAB11FIP2 Gene

mRNA/cDNA for RAB11FIP2 Gene

Unigene Clusters for RAB11FIP2 Gene

RAB11 family interacting protein 2 (class I):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP2

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP2 Gene

No ASD Table

Relevant External Links for RAB11FIP2 Gene

GeneLoc Exon Structure for
RAB11FIP2
ECgene alternative splicing isoforms for
RAB11FIP2

Expression for RAB11FIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11FIP2 Gene

Protein differential expression in normal tissues from HIPED for RAB11FIP2 Gene

This gene is overexpressed in Liver (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB11FIP2 Gene



Protein tissue co-expression partners for RAB11FIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB11FIP2 Gene:

RAB11FIP2

SOURCE GeneReport for Unigene cluster for RAB11FIP2 Gene:

Hs.173656

Evidence on tissue expression from TISSUES for RAB11FIP2 Gene

  • Nervous system(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RAB11FIP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP2 Gene

Orthologs for RAB11FIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP2 34 33
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP2 34 33
  • 93.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP2 34 33
  • 91.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip2 33
  • 89.71 (n)
mouse
(Mus musculus)
Mammalia Rab11fip2 16 34 33
  • 89.53 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP2 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP2 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP2 34 33
  • 80.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip2 33
  • 61.17 (n)
Str.16364 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33937 33
zebrafish
(Danio rerio)
Actinopterygii LOC100334729 33
  • 60.55 (n)
BX842696.1 34
  • 56 (a)
OneToOne
Dr.16541 33
fruit fly
(Drosophila melanogaster)
Insecta Rip11 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 34
  • 22 (a)
OneToMany
Species where no ortholog for RAB11FIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP2 Gene

ENSEMBL:
Gene Tree for RAB11FIP2 (if available)
TreeFam:
Gene Tree for RAB11FIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB11FIP2: view image

Paralogs for RAB11FIP2 Gene

Paralogs for RAB11FIP2 Gene

(2) SIMAP similar genes for RAB11FIP2 Gene using alignment to 2 proteins:

  • RFIP2_HUMAN
  • Q3I768_HUMAN
genes like me logo Genes that share paralogs with RAB11FIP2: view

Variants for RAB11FIP2 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000058048 -- 118,004,994(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000076233 -- 118,005,303(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000087634 -- 118,047,804(-) C/A upstream_transcript_variant
rs1000148151 -- 118,031,614(-) T/C intron_variant
rs1000187129 -- 118,041,221(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP2 Gene

Variant ID Type Subtype PubMed ID
nsv1047815 CNV gain 25217958
nsv516870 CNV loss 19592680
nsv528184 CNV loss 19592680
nsv7566 CNV deletion 18451855
nsv7567 CNV insertion 18451855
nsv825580 CNV gain 20364138
nsv832005 CNV gain 17160897
nsv951858 CNV duplication 24416366

Variation tolerance for RAB11FIP2 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB11FIP2 Gene

Human Gene Mutation Database (HGMD)
RAB11FIP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP2 Gene

Disorders for RAB11FIP2 Gene

Additional Disease Information for RAB11FIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB11FIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP2 Gene

Publications for RAB11FIP2 Gene

  1. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. (PMID: 19542231) Chu BB … Song BL (The Journal of biological chemistry 2009) 3 4 22 58
  2. Crystal structure of rab11 in complex with rab11 family interacting protein 2. (PMID: 16905101) Jagoe WN … Khan AR (Structure (London, England : 1993) 2006) 3 4 22 58
  3. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. (PMID: 15304524) Lindsay AJ … McCaffrey MW (Journal of cell science 2004) 3 4 22 58
  4. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. (PMID: 11994279) Lindsay AJ … McCaffrey MW (The Journal of biological chemistry 2002) 2 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58

Products for RAB11FIP2 Gene

Sources for RAB11FIP2 Gene

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