This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternativ... See more...

Aliases for RAB11FIP1 Gene

Aliases for RAB11FIP1 Gene

  • RAB11 Family Interacting Protein 1 2 3 5
  • RAB11 Family Interacting Protein 1 (Class I) 2 3
  • Rab11 Family-Interacting Protein 1 3 4
  • Rab11-FIP1 3 4
  • RCP 3 4
  • Rab-Interacting Recycling Protein 3
  • RAB11 Coupling Protein 3
  • Rab Effector Protein 3
  • Rab-Coupling Protein 4
  • EC 3.2.1.28 52
  • EC 6.1.1.7 52
  • NOEL1A 3

External Ids for RAB11FIP1 Gene

Previous GeneCards Identifiers for RAB11FIP1 Gene

  • GC08M037835
  • GC08M037716
  • GC08M036250

Summaries for RAB11FIP1 Gene

Entrez Gene Summary for RAB11FIP1 Gene

  • This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

GeneCards Summary for RAB11FIP1 Gene

RAB11FIP1 (RAB11 Family Interacting Protein 1) is a Protein Coding gene. Diseases associated with RAB11FIP1 include Griscelli Syndrome. Among its related pathways are Endocytosis and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RAB11FIP5.

UniProtKB/Swiss-Prot Summary for RAB11FIP1 Gene

  • A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Gene Wiki entry for RAB11FIP1 Gene

Additional gene information for RAB11FIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB11FIP1 Gene

Genomics for RAB11FIP1 Gene

GeneHancer (GH) Regulatory Elements for RAB11FIP1 Gene

Promoters and enhancers for RAB11FIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB11FIP1

Top Transcription factor binding sites by QIAGEN in the RAB11FIP1 gene promoter:
  • AP-4
  • Bach1
  • Egr-1
  • FOXI1
  • HFH-3
  • Ik-1
  • NF-1
  • NF-1/L
  • TBP
  • XBP-1

Genomic Locations for RAB11FIP1 Gene

Genomic Locations for RAB11FIP1 Gene
chr8:37,858,618-37,899,497
(GRCh38/hg38)
Size:
40,880 bases
Orientation:
Minus strand
chr8:37,716,136-37,757,015
(GRCh37/hg19)
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for RAB11FIP1 Gene

Genes around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP1 Gene

Proteins for RAB11FIP1 Gene

  • Protein details for RAB11FIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WKZ4-RFIP1_HUMAN
    Recommended name:
    Rab11 family-interacting protein 1
    Protein Accession:
    Q6WKZ4
    Secondary Accessions:
    • J3KNP0
    • Q307T1
    • Q6AZK4
    • Q6WKZ2
    • Q6WKZ6
    • Q86YV4
    • Q8TDL1
    • Q9H642

    Protein attributes for RAB11FIP1 Gene

    Size:
    1283 amino acids
    Molecular mass:
    137167 Da
    Quaternary structure:
    • Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.

    Three dimensional structures from OCA and Proteopedia for RAB11FIP1 Gene

    Alternative splice isoforms for RAB11FIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP1 Gene

Selected DME Specific Peptides for RAB11FIP1 Gene

Q6WKZ4:
  • VNFTLPK
  • QAGSLVE

Post-translational modifications for RAB11FIP1 Gene

  • Ubiquitination at Lys1212
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11FIP1 Gene

Domains & Families for RAB11FIP1 Gene

Gene Families for RAB11FIP1 Gene

Protein Domains for RAB11FIP1 Gene

Blocks:
  • C2 domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB11FIP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75044, highly similar to Homo sapiens Rab coupling protein (RCP), mRNA (Q307T1_HUMAN)
  • RAB11 family interacting protein 1 (Class I), isoform CRA_b (Q67C35_HUMAN)
  • Rab-coupling protein (RFIP1_HUMAN)
genes like me logo Genes that share domains with RAB11FIP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Function for RAB11FIP1 Gene

Molecular function for RAB11FIP1 Gene

UniProtKB/Swiss-Prot Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Enzyme Numbers (IUBMB) for RAB11FIP1 Gene

Phenotypes From GWAS Catalog for RAB11FIP1 Gene

Gene Ontology (GO) - Molecular Function for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IBA 21873635
genes like me logo Genes that share ontologies with RAB11FIP1: view
genes like me logo Genes that share phenotypes with RAB11FIP1: view

Animal Model Products

CRISPR Products

miRNA for RAB11FIP1 Gene

miRTarBase miRNAs that target RAB11FIP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP1 Gene

Localization for RAB11FIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).
[Isoform 2]: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP1 gene
Compartment Confidence
cytosol 5
endosome 4
plasma membrane 2
cytoskeleton 2
golgi apparatus 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0030670 phagocytic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA,IBA --
genes like me logo Genes that share ontologies with RAB11FIP1: view

Pathways & Interactions for RAB11FIP1 Gene

PathCards logo

SuperPathways for RAB11FIP1 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
2 Endocytosis
3 wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.32
genes like me logo Genes that share pathways with RAB11FIP1: view

Pathways by source for RAB11FIP1 Gene

1 KEGG pathway for RAB11FIP1 Gene
1 GeneGo (Thomson Reuters) pathway for RAB11FIP1 Gene
  • Transport Clathrin-coated vesicle cycle
1 Cell Signaling Technology pathway for RAB11FIP1 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0045055 regulated exocytosis IBA 21873635
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
genes like me logo Genes that share ontologies with RAB11FIP1: view

No data available for SIGNOR curated interactions for RAB11FIP1 Gene

Drugs & Compounds for RAB11FIP1 Gene

No Compound Related Data Available

Transcripts for RAB11FIP1 Gene

mRNA/cDNA for RAB11FIP1 Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for RAB11FIP1 Gene

GeneLoc Exon Structure for
RAB11FIP1

Expression for RAB11FIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB11FIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP1 Gene

This gene is overexpressed in Whole Blood (x6.2), Esophagus - Mucosa (x4.6), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for RAB11FIP1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Cervix (10.4), and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB11FIP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB11FIP1

SOURCE GeneReport for Unigene cluster for RAB11FIP1 Gene:

Hs.191179

mRNA Expression by UniProt/SwissProt for RAB11FIP1 Gene:

Q6WKZ4-RFIP1_HUMAN
Tissue specificity: Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.

Evidence on tissue expression from TISSUES for RAB11FIP1 Gene

  • Intestine(4.5)
  • Lung(4.5)
  • Stomach(4.3)
  • Spleen(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAB11FIP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP1 Gene

Orthologs for RAB11FIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP1 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP1 30
  • 80.18 (n)
GOT1L1 31
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip1 30
  • 75.79 (n)
mouse
(Mus musculus)
Mammalia Rab11fip1 17 31 30
  • 75.09 (n)
cow
(Bos Taurus)
Mammalia RAB11FIP1 31 30
  • 73.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP1 31
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP1 31
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP1 31
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP1 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip1 30
  • 59.94 (n)
zebrafish
(Danio rerio)
Actinopterygii rab11fip1b 31
  • 23 (a)
ManyToMany
rab11fip1a 31
  • 13 (a)
ManyToMany
Dr.27096 30
fruit fly
(Drosophila melanogaster)
Insecta Rip11 31
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 31
  • 20 (a)
OneToMany
Species where no ortholog for RAB11FIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP1 Gene

ENSEMBL:
Gene Tree for RAB11FIP1 (if available)
TreeFam:
Gene Tree for RAB11FIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB11FIP1: view image

Paralogs for RAB11FIP1 Gene

Paralogs for RAB11FIP1 Gene

(4) SIMAP similar genes for RAB11FIP1 Gene using alignment to 3 proteins:

  • RFIP1_HUMAN
  • E7EX40_HUMAN
  • Q67C35_HUMAN

Pseudogenes.org Pseudogenes for RAB11FIP1 Gene

genes like me logo Genes that share paralogs with RAB11FIP1: view

Variants for RAB11FIP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB11FIP1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
719718 Benign: not provided 37,872,258(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
776319 Benign: not provided 37,874,548(-) G/A MISSENSE_VARIANT
776320 Benign: not provided 37,899,277(-) G/C SYNONYMOUS_VARIANT
782113 Benign: not provided 37,872,228(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
785247 Benign: not provided 37,899,310(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RAB11FIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV insertion 20534489
nsv528598 CNV loss 19592680

Variation tolerance for RAB11FIP1 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB11FIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Disorders for RAB11FIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB11FIP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
griscelli syndrome
  • ch��diak-higashi-like syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAB11FIP1

genes like me logo Genes that share disorders with RAB11FIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11FIP1 Gene

Publications for RAB11FIP1 Gene

  1. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PMID: 11786538) Lindsay AJ … McCaffrey MW (The Journal of biological chemistry 2002) 2 3 4 23 54
  2. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. (PMID: 16920206) Jin M … Goldenring JR (Biochimica et biophysica acta 2006) 3 4 23 54
  3. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PMID: 15280022) Lindsay AJ … McCaffrey MW (FEBS letters 2004) 3 4 23 54
  4. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. (PMID: 15355514) Damiani MT … Colombo MI (Traffic (Copenhagen, Denmark) 2004) 3 4 23 54
  5. The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden AA … Prekeris R (Molecular biology of the cell 2004) 3 4 23 54

Products for RAB11FIP1 Gene

Sources for RAB11FIP1 Gene