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Aliases for RAB11FIP1 Gene

Aliases for RAB11FIP1 Gene

  • RAB11 Family Interacting Protein 1 2 3 5
  • RAB11 Family Interacting Protein 1 (Class I) 2 3
  • Rab11-FIP1 3 4
  • RCP 3 4
  • Rab11 Family-Interacting Protein 1 3
  • Rab-Interacting Recycling Protein 3
  • RAB11 Coupling Protein 3
  • Rab Effector Protein 3
  • Rab-Coupling Protein 4
  • NOEL1A 3

External Ids for RAB11FIP1 Gene

Previous GeneCards Identifiers for RAB11FIP1 Gene

  • GC08M037716
  • GC08M036250

Summaries for RAB11FIP1 Gene

Entrez Gene Summary for RAB11FIP1 Gene

  • This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

GeneCards Summary for RAB11FIP1 Gene

RAB11FIP1 (RAB11 Family Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Endocytosis. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RAB11FIP5.

UniProtKB/Swiss-Prot for RAB11FIP1 Gene

  • A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Gene Wiki entry for RAB11FIP1 Gene

Additional gene information for RAB11FIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP1 Gene

Genomics for RAB11FIP1 Gene

GeneHancer (GH) Regulatory Elements for RAB11FIP1 Gene

Promoters and enhancers for RAB11FIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J037889 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.4 +1.6 1590 17.5 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 SP3 ZC3H11A RAB11FIP1 ADGRA2 NSD3 ENSG00000255201 ERLIN2 DDHD2 FGFR1 LOC728024 LETM2 ASH2L
GH08J037966 Promoter 0.7 EPDnew 650.2 -67.0 -67023 0.1 BACH1 ZFP91 EZH2 ADRB3 RAB11FIP1 GOT1L1
GH08J037796 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +98.7 98718 9.3 PKNOX1 ATF1 ARNT ZNF133 SIN3A ZNF2 YY1 ZNF213 ZNF143 ATF7 ADGRA2 GOT1L1 RAB11FIP1 PLPBP GC08M037706 GC08P037815
GH08J037879 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +15.8 15814 8.6 HDGF PKNOX1 SMAD1 ZNF2 IRF4 ZNF207 ZNF143 FOS JUNB ZNF592 RAB11FIP1 NSD3 BAG4 ENSG00000280064
GH08J037761 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +136.6 136610 2.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF143 PLPBP DDHD2 ERLIN2 ADGRA2 ASH2L ENSG00000255201 BRF2 LOC728024 LOC102723701 RAB11FIP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB11FIP1 gene promoter:
  • TBP
  • HFH-3
  • FOXI1
  • XBP-1
  • Egr-1
  • Bach1
  • NF-1
  • NF-1/L
  • Ik-1
  • AP-4

Genomic Locations for RAB11FIP1 Gene

Genomic Locations for RAB11FIP1 Gene
chr8:37,858,618-37,899,497
(GRCh38/hg38)
Size:
40,880 bases
Orientation:
Minus strand
chr8:37,716,136-37,757,015
(GRCh37/hg19)
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for RAB11FIP1 Gene

Genes around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP1 Gene

Proteins for RAB11FIP1 Gene

  • Protein details for RAB11FIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WKZ4-RFIP1_HUMAN
    Recommended name:
    Rab11 family-interacting protein 1
    Protein Accession:
    Q6WKZ4
    Secondary Accessions:
    • J3KNP0
    • Q307T1
    • Q6AZK4
    • Q6WKZ2
    • Q6WKZ6
    • Q86YV4
    • Q8TDL1
    • Q9H642

    Protein attributes for RAB11FIP1 Gene

    Size:
    1283 amino acids
    Molecular mass:
    137167 Da
    Quaternary structure:
    • Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.

    Three dimensional structures from OCA and Proteopedia for RAB11FIP1 Gene

    Alternative splice isoforms for RAB11FIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP1 Gene

Post-translational modifications for RAB11FIP1 Gene

  • Ubiquitination at Lys541
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11FIP1 Gene

No data available for DME Specific Peptides for RAB11FIP1 Gene

Domains & Families for RAB11FIP1 Gene

Gene Families for RAB11FIP1 Gene

Protein Domains for RAB11FIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAB11FIP1: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Function for RAB11FIP1 Gene

Molecular function for RAB11FIP1 Gene

UniProtKB/Swiss-Prot Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Phenotypes From GWAS Catalog for RAB11FIP1 Gene

Gene Ontology (GO) - Molecular Function for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RAB11FIP1: view
genes like me logo Genes that share phenotypes with RAB11FIP1: view

Animal Model Products

CRISPR Products

miRNA for RAB11FIP1 Gene

miRTarBase miRNAs that target RAB11FIP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP1 Gene

Localization for RAB11FIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).
Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP1 gene
Compartment Confidence
cytosol 5
endosome 4
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with RAB11FIP1: view

Pathways & Interactions for RAB11FIP1 Gene

genes like me logo Genes that share pathways with RAB11FIP1: view

Pathways by source for RAB11FIP1 Gene

1 KEGG pathway for RAB11FIP1 Gene
1 GeneGo (Thomson Reuters) pathway for RAB11FIP1 Gene
1 Cell Signaling Technology pathway for RAB11FIP1 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0045055 regulated exocytosis IBA --
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
genes like me logo Genes that share ontologies with RAB11FIP1: view

No data available for SIGNOR curated interactions for RAB11FIP1 Gene

Drugs & Compounds for RAB11FIP1 Gene

No Compound Related Data Available

Transcripts for RAB11FIP1 Gene

mRNA/cDNA for RAB11FIP1 Gene

Unigene Clusters for RAB11FIP1 Gene

RAB11 family interacting protein 1 (class I):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11FIP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for RAB11FIP1 Gene

GeneLoc Exon Structure for
RAB11FIP1
ECgene alternative splicing isoforms for
RAB11FIP1

Expression for RAB11FIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11FIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP1 Gene

This gene is overexpressed in Whole Blood (x6.2), Esophagus - Mucosa (x4.6), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for RAB11FIP1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Cervix (10.4), and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB11FIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB11FIP1 Gene:

RAB11FIP1

SOURCE GeneReport for Unigene cluster for RAB11FIP1 Gene:

Hs.191179

mRNA Expression by UniProt/SwissProt for RAB11FIP1 Gene:

Q6WKZ4-RFIP1_HUMAN
Tissue specificity: Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.

Evidence on tissue expression from TISSUES for RAB11FIP1 Gene

  • Intestine(4.5)
  • Lung(4.5)
  • Stomach(4.3)
  • Spleen(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAB11FIP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP1 Gene

Orthologs for RAB11FIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP1 34 33
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP1 33
  • 80.18 (n)
GOT1L1 34
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip1 33
  • 75.79 (n)
mouse
(Mus musculus)
Mammalia Rab11fip1 16 34 33
  • 75.09 (n)
cow
(Bos Taurus)
Mammalia RAB11FIP1 34 33
  • 73.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP1 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP1 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP1 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP1 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip1 33
  • 59.94 (n)
zebrafish
(Danio rerio)
Actinopterygii rab11fip1b 34
  • 23 (a)
ManyToMany
rab11fip1a 34
  • 13 (a)
ManyToMany
Dr.27096 33
fruit fly
(Drosophila melanogaster)
Insecta Rip11 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 34
  • 20 (a)
OneToMany
Species where no ortholog for RAB11FIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP1 Gene

ENSEMBL:
Gene Tree for RAB11FIP1 (if available)
TreeFam:
Gene Tree for RAB11FIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB11FIP1: view image

Paralogs for RAB11FIP1 Gene

Paralogs for RAB11FIP1 Gene

(4) SIMAP similar genes for RAB11FIP1 Gene using alignment to 3 proteins:

  • RFIP1_HUMAN
  • E7EX40_HUMAN
  • Q67C35_HUMAN

Pseudogenes.org Pseudogenes for RAB11FIP1 Gene

genes like me logo Genes that share paralogs with RAB11FIP1: view

Variants for RAB11FIP1 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000112202 -- 37,878,097(-) G/A/C intron_variant
rs1000196590 -- 37,898,883(-) G/A intron_variant
rs1000295767 -- 37,877,904(-) G/A intron_variant
rs1000472151 -- 37,861,422(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000572142 -- 37,861,156(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV insertion 20534489
nsv528598 CNV loss 19592680

Variation tolerance for RAB11FIP1 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB11FIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Disorders for RAB11FIP1 Gene

Additional Disease Information for RAB11FIP1

No disorders were found for RAB11FIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP1 Gene

Publications for RAB11FIP1 Gene

  1. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PMID: 11786538) Lindsay AJ … McCaffrey MW (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. (PMID: 16920206) Jin M … Goldenring JR (Biochimica et biophysica acta 2006) 3 4 22 58
  3. The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden AA … Prekeris R (Molecular biology of the cell 2004) 3 4 22 58
  4. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PMID: 15280022) Lindsay AJ … McCaffrey MW (FEBS letters 2004) 3 4 22 58
  5. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. (PMID: 15355514) Damiani MT … Colombo MI (Traffic (Copenhagen, Denmark) 2004) 3 4 22 58

Products for RAB11FIP1 Gene

Sources for RAB11FIP1 Gene

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