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The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] See more...
Aliases for RAB11A Gene
Aliases for RAB11A Gene
External Ids for RAB11A Gene
- HGNC: 9760
- NCBI Entrez Gene: 8766
- Ensembl: ENSG00000103769
- OMIM®: 605570
- UniProtKB/Swiss-Prot: P62491
Previous GeneCards Identifiers for RAB11A Gene
- GC15P061897
- GC15P059260
- GC15P063740
- GC15P063877
- GC15P063948
- GC15P066161
- GC15P042986
- GC15P066018
- GC15P065784
- GC15P066280
- GC15P069500
- GC15P069608
- GC15P069658
- GC15P071832
- GC15P066274
- GC15P066340
- GC15P066869
- GC15P067397
- GC15P067919
- GC15P068411
- GC15P068917
- GC15P069390
- GC15P072880
- GC15P073961
Summaries for RAB11A Gene
-
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for RAB11A Gene
RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Autosomal Dominant Non-Syndromic Intellectual Disability and Charcot-Marie-Tooth Disease, Type 4C. Among its related pathways are Remodeling of Adherens Junctions and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is RAB11B.
UniProtKB/Swiss-Prot Summary for RAB11A Gene
-
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
Additional gene information for RAB11A Gene
- HGNC (9760)
- NCBI Entrez Gene (8766)
- Ensembl (ENSG00000103769)
- OMIM® (605570)
- UniProtKB/Swiss-Prot (P62491)
- Open Targets Platform(ENSG00000103769)
- Alliance of Genome Resources
- Search for RAB11A at DataMed
- Search for RAB11A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB11A Gene
Genomics for RAB11A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAB11A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAB11A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB11A
- Top Transcription factor binding sites by QIAGEN in the RAB11A gene promoter:
-
- C/EBPalpha
- En-1
- GATA-1
- Lmo2
- NRF-2
- Roaz
- S8
- Sox5
- SRF
- SRF (504 AA)
Genomic Locations for RAB11A Gene
Latest Assembly
- chr15:65,726,054-65,891,989
- (GRCh38/hg38)
- Size:
- 165,936 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:66,161,829-66,184,327
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 22,499 bases
- Orientation:
- Plus strand
Genomic View for RAB11A Gene
Genes around RAB11A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by HGNC
- 15q22.31 by Entrez Gene
- 15q22.31 by Ensembl
RAB11A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAB11A Gene
Proteins for RAB11A Gene
-
Protein details for RAB11A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62491-RB11A_HUMAN
- Recommended name:
- Ras-related protein Rab-11A
- Protein Accession:
- P62491
- B2R4B6
- B4DT13
- P24410
- Q5TZN9
- Q9JLX1
Protein attributes for RAB11A Gene
- Size:
- 216 amino acids
- Molecular mass:
- 24394 Da
- Quaternary structure:
-
- Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27 (PubMed:21976701, PubMed:17082457). Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309, PubMed:30217979). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (PubMed:28384198).
Three dimensional structures from OCA and Proteopedia for RAB11A Gene
Protein Expression for RAB11A Gene
Post-translational modifications for RAB11A Gene
Other Protein References for RAB11A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ RAB11A Antibody
- LifeSpan BioSciences RAB11A Monoclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for RAB11A
- Novus Biologicals Antibodies for RAB11A
-
Abcam antibodies for RAB11A
- Invitrogen Antibodies for RAB11A (AFLGC-RAB11A)
-
Custom Antibody ServicesProSci Antibodies for RAB11A
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAB11A
Protein products for research
-
OriGene Purified Proteins for RAB11A
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB11A
- Origene Custom Protein Services for RAB11A
- ProSpec Recombinant Proteins for RAB11A
-
Abcam proteins for RAB11A
Assay products for research
No data available for DME Specific Peptides for RAB11A Gene
Domains & Families for RAB11A Gene
Gene Families for RAB11A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAB11A Gene
- InterPro:
- Blocks:
-
- GTP-binding nuclear protein Ran
- Ras small GTPase, Ras type
- Ras small GTPase, Rho type
Suggested Antigen Peptide Sequences for RAB11A Gene
- GenScript: Design optimal peptide antigens:
-
- YL8 (RB11A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62491- Family:
-
- Belongs to the small GTPase superfamily. Rab family.
Function for RAB11A Gene
Molecular function for RAB11A Gene
- UniProtKB/Swiss-Prot Function:
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
- GENATLAS Biochemistry:
- RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and large,putatively involved in secretory pathway
Phenotypes From GWAS Catalog for RAB11A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA,IDA | 15837192 |
| GO:0005515 | protein binding | IPI | 12470645 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0008017 | microtubule binding | IDA | 24561039 |
Phenotypes for RAB11A Gene
- MGI mutant phenotypes for RAB11A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RAB11A:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased shRNA abundance (Z-score < -2)
- Increased homologous recombination repair frequency
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased peripheral FA formation, increased cell spreading
- Increased cell number in S
Animal Models for RAB11A Gene
- MGI Knock Outs for RAB11A:
-
- Rab11a Rab11a<tm1b(KOMP)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RAB11A - Starting at $85 >
- * RAB11A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RAB11A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB11A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB11A
miRNA for RAB11A Gene
- miRTarBase miRNAs that target RAB11A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB11A
- Browse OriGene Inhibitory RNA Products For RAB11A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11A
Clone products for research
- Applied Biological Materials (abm): Clones for RAB11A - Starting at $45 >
- * RAB11A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RAB11A
- Addgene plasmids for RAB11A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB11A
Cell Lines for research
-
Horizon Cell Lines for RAB11A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAB11A Gene
Localization for RAB11A Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAB11A Gene
- Cell membrane. Lipid-anchor. Recycling endosome membrane. Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:11994279, ECO:0000269 PubMed:15601896, ECO:0000269 PubMed:20890297, ECO:0000269 PubMed:21255211}.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| lysosome | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
- Centriolar satellite (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IDA | 24561039 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IBA | 21873635 |
| GO:0005771 | multivesicular body | IDA | 15634213 |
| GO:0005794 | Golgi apparatus | HDA | 16791210 |
Pathways & Interactions for RAB11A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Aquaporin-mediated transport | ||
| 2 | Cargo trafficking to the periciliary membrane | ||
| 3 | Organelle biogenesis and maintenance |
.56
|
|
| 4 | Vesicle-mediated transport | ||
| 5 | Metabolism of proteins | ||
Pathways by source for RAB11A Gene
1 Sino Biological pathway for RAB11A Gene
3 BioSystems pathways for RAB11A Gene
15 Reactome pathways for RAB11A Gene
5 KEGG pathways for RAB11A Gene
4 GeneGo (Thomson Reuters) pathways for RAB11A Gene
- Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
- Transport Clathrin-coated vesicle cycle
- wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
- wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
2 Qiagen pathways for RAB11A Gene
- Epithelial Tight Junctions
- Remodeling of Adherens Junctions
1 Cell Signaling Technology pathway for RAB11A Gene
Interacting Proteins for RAB11A Gene
Selected Interacting proteins:
P62491-RB11A_HUMAN
ENSP00000261890
for RAB11A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RAB11A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006887 | exocytosis | IBA | 21873635 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007080 | mitotic metaphase plate congression | IMP | 24561039 |
| GO:0010634 | positive regulation of epithelial cell migration | IMP | 22613965 |
Transcripts for RAB11A Gene
mRNA/cDNA for RAB11A Gene
- 2 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261890 4895 nts (view in UCSC)
- ENST00000563580 553 nts (view in UCSC)
- ENST00000564910 978 nts (view in UCSC)
- ENST00000565075 711 nts (view in UCSC)
- ENST00000566233 588 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RAB11A - Starting at $85 >
- * RAB11A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RAB11A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB11A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB11A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB11A
- Browse OriGene Inhibitory RNA Products For RAB11A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB11A
Clone products for research
- Applied Biological Materials (abm): Clones for RAB11A - Starting at $45 >
- * RAB11A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RAB11A
- Addgene plasmids for RAB11A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB11A
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | |||||||||||||||
| SP3: | - | - |
Relevant External Links for RAB11A Gene
- GeneLoc Exon Structure for
- RAB11A
Expression for RAB11A Gene
This gene is overexpressed in Adipocyte (22.6), Monocytes (10.2), Bone (7.4), and Tlymphocyte (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAB11A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB11A
SOURCE GeneReport for Unigene cluster for RAB11A Gene:
Hs.321541Evidence on tissue expression from TISSUES for RAB11A Gene
- Nervous system(5)
- Blood(4.6)
- Skin(4.1)
- Pancreas(3.8)
- Kidney(3.7)
- Intestine(3.5)
- Lung(3.4)
- Eye(3.3)
- Heart(3.1)
- Adrenal gland(3.1)
- Muscle(3.1)
- Spleen(3)
- Stomach(2.9)
- Lymph node(2.9)
- Liver(2.9)
- Thyroid gland(2.9)
- Bone marrow(2.6)
- Gall bladder(2.5)
Primer products for research
-
OriGene qPCR primer pairs for RAB11A
-
OriGene qPCR primer pairs and template standards for RAB11A
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11A Gene
Orthologs for RAB11A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | RAB11A 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | RAB11A 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAB11A 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rab11a 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAB11A 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rab11a 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAB11A 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RAB11A 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAB11A 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab11a 29 |
|
||
| Str.6874 29 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | rab11a 29 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004559 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rab11 29 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rab-11.2 30 |
|
ManyToMany | |
| rab-11.1 29 30 31 |
|
ManyToMany | |||
| F11A5.3 31 |
|
|
|||
| C33D12.6 31 |
|
|
|||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00671g 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YPT31 29 30 32 |
|
ManyToMany | |
| YPT32 30 |
|
ManyToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER434C 29 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RABA1f 29 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.15815 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0564400 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ypt3 29 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01523 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3887 29 |
|
- Species where no ortholog for RAB11A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAB11A Gene
- ENSEMBL:
- Gene Tree for RAB11A (if available)
- TreeFam:
- Gene Tree for RAB11A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAB11A: view image
- Alliance of Genome Resources:
- Additional Orthologs for RAB11A
Paralogs for RAB11A Gene
Paralogs for RAB11A Gene
- RAB11B 5
- RAB25 5
- RAB2B 5
- RAB2A 5
- RAB14 5
- RAB1A 5
- RAB1B 5
- RAB4B 5
- RAB4B-EGLN2 5
- RAB4A 5
- RAB8A 5
- RAB8B 5
- RAB39B 5
- RASEF 5
- RAB15 5
- RAB43 5
- RAB35 5
- RAB26 5
- RAB10 5
- RAB5B 5
- RAB5C 5
- RAB19 5
- RAB39A 5
- ENSG00000285641 5
- RAB13 5
- RAB40C 5
- RAB12 5
- RAB5A 5
- RAB3D 5
- RAB30 5
- RAB40B 5
- RAB18 5
- RAB3C 5
- RAB40AL 5
- RAB40A 5
- RAB33A 5
- RAB27A 5
- RAB3B 5
- RAB9A 5
- RAB27B 5
- RAB9B 5
- RAB3A 5
- ENSG00000267261 5
- RAB33B 5
- RAB42 5
- RAB37 5
- RABL2A 5
- RAB17 5
- RAB36 5
- RAB31 5
- RAB28 5
- RABL2B 5
- RAB22A 5
- RAB21 5
- RAB44 5
- RAB23 5
- RAB6A 5
- RAB32 5
- RAB6B 5
- RAB38 5
- RAB7A 5
- RAB29 5
- RAB20 5
- RAB6D 5
- RAB24 5
- DNAJC27 5
- RAB41 5
- RAB6C 5
- IFT27 5
- RAB34 5
- RAB7B 5
(102) SIMAP similar genes for RAB11A Gene using alignment to 6 proteins:
- RB11A_HUMAN
- B4DQU5_HUMAN
- H3BMH2_HUMAN
- H3BN38_HUMAN
- H3BSC1_HUMAN
- J3KQP6_HUMAN
- RAB11B
- RAB25
- RAB19
- RAB43
- DKFZp686J06205
- RAB13
- RAB30
- rab1b
- RAB8B
- RAB3A
- RAB5C
- RAB5B
- DKFZp686J07132
- RAB7A
- RAB38
- RAB15
- RAB8A
- RAB2B
- RAB3B
- RAB5A
- RAB37
- DKFZp313C1541
- RAB6A'
- RAB39B
- RAB14
- RAB3C
- RAB1C
- RAB2A
- RAB10
- RAB3D
- RAB4B
- RAB36
- RAB6A
- RAB22A
- RAB4A
- RABL2B
- RAB6B
- RABL2A
- RAB17
- TC4
- RANP1
- RAB9B
- RAB23
- RAB31
- RAB26
- RAB39A
- RAB44
- RAB21
- RAB41
- RAB34
- RAB33A
- RAB27B
- RAB18
- RAB6C
- RAB35
- RAB7L1
- RAB27A
- RAB33B
- RAB12
- RAB40B
- RAB32
- RAN
- RAB40AL
- RAB40A
- RAB9A
- RALB
- RAB1B
- RAB24
- LOC51277
- RAB40C
- RAP1B
- RAB1A
- IFT27
- RHEB
- RAB7B
- RHOH
- RAB28
- RALA
- RAP2C
- RAP1A
- RAB42
- KRAS
- HRAS
- MRAS
- RAP2A
- RAP2B
- RAC2
- RASEF
- c-bas/has
- RHOF
- RHEBL1
- NRAS
- RIT1
- RHOD
- RHOB
- CDC42
- ARHH
- RHOA
- RERG
- RHOC
- RRAS2
- ARHE
Pseudogenes.org Pseudogenes for RAB11A Gene
Variants for RAB11A Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.05;
1.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAB11A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB11A Gene
Disorders for RAB11A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal dominant non-syndromic intellectual disability |
|
|
| charcot-marie-tooth disease, type 4c |
|
|
| diarrhea 2, with microvillus atrophy |
|
|
| congenital diarrhea |
|
|
| diarrhea 8, secretory sodium, congenital |
|
|
Search RAB11A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAB11A
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11A Gene
Publications for RAB11A Gene
- Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. (PMID: 19542231) Chu BB … Song BL (The Journal of biological chemistry 2009) 3 4 22
- Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. (PMID: 17462998) Swiatecka-Urban A … Stanton BA (The Journal of biological chemistry 2007) 3 4 22
- Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T … Wakatsuki S (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22
- Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein. (PMID: 15837192) Pasqualato S … Cherfils J (Structure (London, England : 1993) 2005) 3 4 22
- The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden AA … Prekeris R (Molecular biology of the cell 2004) 3 4 22
ExternalLinks
Products for RAB11A Gene
- Custom Antibody ServicesOriGene Antibodies for RAB11A
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Sources for RAB11A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
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- (22) Novoseek
- (23) PharmGKB
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- (25) HMDB
- (26) ASD
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
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- (35) Pseudogene
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- (38) GenAtlas
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- (42) HuGE
- (43) Atlas
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- (49) miRBase
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- (51) OriGene
- (52) PubMed
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- (54) Tocris
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- (56) Novus Biologicals
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- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
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- (102) diseasecard
- (103) NIH Rare Diseases
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- (107) Disease Ontology
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- (109) MeSH
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- (111) CDC
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- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
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- (137) DataMed
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- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
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- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
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- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources