Aliases for RAB11A Gene
External Ids for RAB11A Gene
Previous GeneCards Identifiers for RAB11A Gene
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for RAB11A Gene
RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Autosomal Dominant Non-Syndromic Intellectual Disability and Charcot-Marie-Tooth Disease, Type 4C. Among its related pathways are Remodeling of Adherens Junctions and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is RAB11B.
UniProtKB/Swiss-Prot Summary for RAB11A Gene
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.