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The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Autosomal Dominant Non-Syndromic Intellectual Disability and Charcot-Marie-Tooth Disease, Type 4C. Among its related pathways are Organelle biogenesis and maintenance and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is RAB11B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IDA | 15837192 |
GO:0005515 | protein binding | IPI | 12470645 |
GO:0005525 | GTP binding | IEA | -- |
GO:0008017 | microtubule binding | IDA | 24561039 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | spindle pole | IDA | 24561039 |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IBA | 21873635 |
GO:0005771 | multivesicular body | IDA | 15634213 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Aquaporin-mediated transport | ||
2 | Cargo trafficking to the periciliary membrane | ||
3 | Organelle biogenesis and maintenance |
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4 | Vesicle-mediated transport | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003091 | renal water homeostasis | TAS | -- |
GO:0006886 | intracellular protein transport | IBA | -- |
GO:0006887 | exocytosis | IBA | 21873635 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007080 | mitotic metaphase plate congression | IMP | 24561039 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: | |||||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | RAB11A 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | RAB11A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RAB11A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rab11a 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RAB11A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rab11a 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RAB11A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RAB11A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAB11A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab11a 30 |
|
||
Str.6874 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | rab11a 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004559 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rab11 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | rab-11.2 31 |
|
ManyToMany | |
rab-11.1 30 31 32 |
|
ManyToMany | |||
F11A5.3 32 |
|
|
|||
C33D12.6 32 |
|
|
|||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00671g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YPT31 30 31 33 |
|
ManyToMany | |
YPT32 31 |
|
ManyToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER434C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RABA1f 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.15815 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0564400 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ypt3 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01523 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3887 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant non-syndromic intellectual disability |
|
|
charcot-marie-tooth disease, type 4c |
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diarrhea 2, with microvillus atrophy |
|
|
barrett esophagus |
|
|
congenital diarrhea |
|
|