RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009] See more...

Aliases for RAB10 Gene

Aliases for RAB10 Gene

  • RAB10, Member RAS Oncogene Family 2 3 5
  • Ras-Related GTP-Binding Protein 2 3
  • Ras-Related Protein Rab-10 3 4
  • GTP-Binding Protein RAB10 3

External Ids for RAB10 Gene

Previous GeneCards Identifiers for RAB10 Gene

  • GC02P026178
  • GC02P026349
  • GC02P026231
  • GC02P026168
  • GC02P026256
  • GC02P025993

Summaries for RAB10 Gene

Entrez Gene Summary for RAB10 Gene

  • RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB10 Gene

RAB10 (RAB10, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB10 include Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia and Parkinson Disease, Late-Onset. Among its related pathways are Vesicle-mediated transport and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB8A.

UniProtKB/Swiss-Prot Summary for RAB10 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148).

Gene Wiki entry for RAB10 Gene

Additional gene information for RAB10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB10 Gene

Genomics for RAB10 Gene

GeneHancer (GH) Regulatory Elements for RAB10 Gene

Promoters and enhancers for RAB10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB10 gene promoter:
  • AP-2gamma
  • E47
  • Egr-2
  • FOXO4
  • Hand1
  • HNF-3beta
  • IRF-1
  • Olf-1
  • p300
  • Pax-5

Genomic Locations for RAB10 Gene

Genomic Locations for RAB10 Gene
chr2:26,033,860-26,137,454
(GRCh38/hg38)
Size:
103,595 bases
Orientation:
Plus strand
chr2:26,256,729-26,360,323
(GRCh37/hg19)
Size:
103,595 bases
Orientation:
Plus strand

Genomic View for RAB10 Gene

Genes around RAB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB10 Gene

Proteins for RAB10 Gene

  • Protein details for RAB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61026-RAB10_HUMAN
    Recommended name:
    Ras-related protein Rab-10
    Protein Accession:
    P61026
    Secondary Accessions:
    • D6W538
    • O88386
    • Q6IA52
    • Q9D7X6
    • Q9H0T3

    Protein attributes for RAB10 Gene

    Size:
    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    • Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Interacts with GDI1 and with GDI2; negatively regulates RAB10 association with membranes and activation (PubMed:19570034, PubMed:26824392, PubMed:29125462). Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity). Interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 and EHBP1L1; at least in case of MICAL1 two molecules of RAB10 can bind to one molecule of MICAL1 (PubMed:27552051). Interacts with TBC1D13 (By similarity). Interacts with SEC16A (By similarity). Interacts with CHM and CHML (PubMed:29125462). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-73 (PubMed:26824392). Interacts (when phosphorylated on Thr-73) with RILPL1 and RILPL2 (PubMed:30398148, PubMed:29125462).

    Three dimensional structures from OCA and Proteopedia for RAB10 Gene

neXtProt entry for RAB10 Gene

Post-translational modifications for RAB10 Gene

  • Phosphorylation of Thr-73 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB10 Gene

Domains & Families for RAB10 Gene

Gene Families for RAB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB10 Gene

GenScript: Design optimal peptide antigens:
  • GTP-binding protein RAB10 (Q9UL28_HUMAN)
  • Ras-related protein Rab-10 (RAB10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61026

UniProtKB/Swiss-Prot:

RAB10_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB10: view

Function for RAB10 Gene

Molecular function for RAB10 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148).
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by the DENND4C guanine exchange factor (GEF).

Phenotypes From GWAS Catalog for RAB10 Gene

Gene Ontology (GO) - Molecular Function for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 20937701
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB10: view
genes like me logo Genes that share phenotypes with RAB10: view

Animal Models for RAB10 Gene

MGI Knock Outs for RAB10:

Animal Model Products

CRISPR Products

miRNA for RAB10 Gene

miRTarBase miRNAs that target RAB10

Clone Products

  • Addgene plasmids for RAB10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB10 Gene

Localization for RAB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB10 Gene

Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasm, cytoskeleton, cilium basal body. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region. Note=Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). {ECO:0000250 UniProtKB:P24409, ECO:0000269 PubMed:20576682, ECO:0000269 PubMed:22908308, ECO:0000269 PubMed:23263280, ECO:0000269 PubMed:30398148}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB10 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
plasma membrane 4
cytosol 4
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000145 colocalizes_with exocyst ISS --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA,IDA 20576682
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RAB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB10 Gene

Pathways & Interactions for RAB10 Gene

genes like me logo Genes that share pathways with RAB10: view

Pathways by source for RAB10 Gene

1 Qiagen pathway for RAB10 Gene
  • Epithelial Tight Junctions
1 Cell Signaling Technology pathway for RAB10 Gene

Gene Ontology (GO) - Biological Process for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006893 Golgi to plasma membrane transport ISS --
GO:0006904 vesicle docking involved in exocytosis IBA 21873635
GO:0007409 axonogenesis ISS --
GO:0009306 protein secretion IBA 21873635
genes like me logo Genes that share ontologies with RAB10: view

No data available for SIGNOR curated interactions for RAB10 Gene

Drugs & Compounds for RAB10 Gene

No Compound Related Data Available

Transcripts for RAB10 Gene

mRNA/cDNA for RAB10 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for RAB10

Alternative Splicing Database (ASD) splice patterns (SP) for RAB10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for RAB10 Gene

GeneLoc Exon Structure for
RAB10
ECgene alternative splicing isoforms for
RAB10

Expression for RAB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB10 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB10 Gene



Protein tissue co-expression partners for RAB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB10 Gene:

RAB10

SOURCE GeneReport for Unigene cluster for RAB10 Gene:

Hs.467960

mRNA Expression by UniProt/SwissProt for RAB10 Gene:

P61026-RAB10_HUMAN
Tissue specificity: Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255).

Evidence on tissue expression from TISSUES for RAB10 Gene

  • Nervous system(5)
  • Intestine(2.7)
  • Lung(2.7)
  • Muscle(2.5)
  • Skin(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RAB10: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB10 Gene

Orthologs for RAB10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB10 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RAB10 33
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB10 33 32
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB10 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB10 33 32
  • 97.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB10 33 32
  • 96.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rab10 17 33 32
  • 95.33 (n)
rat
(Rattus norvegicus)
Mammalia Rab10 32
  • 95.33 (n)
chicken
(Gallus gallus)
Aves RAB10 33 32
  • 89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB10 33
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68629 32
zebrafish
(Danio rerio)
Actinopterygii rab10 33 32
  • 84.33 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab8 34
  • 78 (a)
Rab10 33 34 32
  • 69.68 (n)
OneToOne
CG2885 34
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000671 32
  • 70.69 (n)
worm
(Caenorhabditis elegans)
Secernentea rab-10 33 32
  • 69.9 (n)
OneToOne
rab-8 34
  • 69 (a)
4R79.2 34
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RABE1e 32
  • 61.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 71 (a)
OneToOne
Cin.3286 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3286 32
Species where no ortholog for RAB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB10 Gene

ENSEMBL:
Gene Tree for RAB10 (if available)
TreeFam:
Gene Tree for RAB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB10: view image

Paralogs for RAB10 Gene

genes like me logo Genes that share paralogs with RAB10: view

Variants for RAB10 Gene

Sequence variations from dbSNP and Humsavar for RAB10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000005272 -- 26,113,298(+) C/T intron_variant
rs1000016526 -- 26,123,412(+) G/A intron_variant
rs1000040742 -- 26,137,038(+) TTT/T 3_prime_UTR_variant
rs1000071272 -- 26,083,274(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000103056 -- 26,113,543(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB10 Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV loss 17666407
esv3590106 CNV loss 21293372
esv3590107 CNV loss 21293372
esv3590108 CNV loss 21293372
esv3590109 CNV loss 21293372
nsv475540 CNV novel sequence insertion 20440878
nsv508717 CNV deletion 20534489
nsv963216 CNV duplication 23825009

Variation tolerance for RAB10 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB10 Gene

Human Gene Mutation Database (HGMD)
RAB10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB10 Gene

Disorders for RAB10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAB10 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
inclusion body myopathy with paget disease of bone and frontotemporal dementia
  • pagetoid amyotrophic lateral sclerosis
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search RAB10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB10 Gene

Publications for RAB10 Gene

  1. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. (PMID: 29127255) Fan Y … Sammler EM (The Biochemical journal 2018) 3 4 56
  2. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. (PMID: 26824392) Steger M … Mann M (eLife 2016) 3 4 56
  3. Rab10 GTPase regulates ER dynamics and morphology. (PMID: 23263280) English AR … Voeltz GK (Nature cell biology 2013) 3 4 56
  4. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. (PMID: 22908308) Chen Y … Lippincott-Schwartz J (The Journal of cell biology 2012) 3 4 56
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56

Products for RAB10 Gene

Sources for RAB10 Gene