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Aliases for RAB10 Gene

Aliases for RAB10 Gene

  • RAB10, Member RAS Oncogene Family 2 3 5
  • Ras-Related GTP-Binding Protein 2 3
  • Ras-Related Protein Rab-10 3
  • GTP-Binding Protein RAB10 3

External Ids for RAB10 Gene

Previous GeneCards Identifiers for RAB10 Gene

  • GC02P026178
  • GC02P026349
  • GC02P026231
  • GC02P026168
  • GC02P026256
  • GC02P025993

Summaries for RAB10 Gene

Entrez Gene Summary for RAB10 Gene

  • RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB10 Gene

RAB10 (RAB10, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB8A.

UniProtKB/Swiss-Prot for RAB10 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.

Gene Wiki entry for RAB10 Gene

Additional gene information for RAB10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB10 Gene

Genomics for RAB10 Gene

GeneHancer (GH) Regulatory Elements for RAB10 Gene

Promoters and enhancers for RAB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026032 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.2 +0.6 627 4.4 MLX DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 GLIS1 RCOR2 RAB10 SLC35F6 GAREM2 GC02P026043
GH02J025997 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.5 -35.7 -35659 1.6 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 SLC30A9 FOS DEK RAB10 RNU6-942P DNMT3A GAREM2 GC02P025994 TRMT112P6 GC02M025991
GH02J026007 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 27 -24.9 -24859 2.8 PKNOX1 NFIB SIN3A DNMT3B TCF12 EGR1 RCOR1 FOS CEBPB SP1 RAB10 RNU6-942P KIF3C GAREM2 GC02P025994 TRMT112P6 GC02M025991
GH02J026066 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +35.0 34956 3.8 HDGF PKNOX1 ATF1 ARNT IRF4 BRCA1 NCOA2 TCF12 ZNF766 E2F8 RAB10 RNU6-942P KIF3C GAREM2 HADHB GC02P026059 LOC105374333 RPS2P15
GH02J026011 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -21.3 -21304 3 PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 YY1 FOS RAB10 RNU6-942P KIF3C SLC35F6 GAREM2 TRMT112P6 GC02M025991 GC02P025994
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB10 gene promoter:
  • Pax-5
  • AP-2gamma
  • Olf-1
  • HNF-3beta
  • IRF-1
  • Hand1
  • E47
  • FOXO4
  • Egr-2
  • p300

Genomic Locations for RAB10 Gene

Genomic Locations for RAB10 Gene
chr2:26,033,860-26,137,454
(GRCh38/hg38)
Size:
103,595 bases
Orientation:
Plus strand
chr2:26,256,729-26,360,323
(GRCh37/hg19)
Size:
103,595 bases
Orientation:
Plus strand

Genomic View for RAB10 Gene

Genes around RAB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB10 Gene

Proteins for RAB10 Gene

  • Protein details for RAB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61026-RAB10_HUMAN
    Recommended name:
    Ras-related protein Rab-10
    Protein Accession:
    P61026
    Secondary Accessions:
    • D6W538
    • O88386
    • Q6IA52
    • Q9D7X6
    • Q9H0T3

    Protein attributes for RAB10 Gene

    Size:
    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    • Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Interacts with GDI1 and maybe with GDI2; negatively regulates RAB10 association with membranes and activation (PubMed:19570034). Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity). Interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 and EHBP1L1; at least in case of MICAL1 two molecules of RAB10 can bind to one molecule of MICAL1 (PubMed:27552051). Interacts with TBC1D13 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB10 Gene

neXtProt entry for RAB10 Gene

Post-translational modifications for RAB10 Gene

  • Ubiquitination at posLast=102102
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB10 Gene

Domains & Families for RAB10 Gene

Gene Families for RAB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB10 Gene

Graphical View of Domain Structure for InterPro Entry

P61026

UniProtKB/Swiss-Prot:

RAB10_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB10: view

Function for RAB10 Gene

Molecular function for RAB10 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by the DENND4C guanine exchange factor (GEF).

Phenotypes From GWAS Catalog for RAB10 Gene

Gene Ontology (GO) - Molecular Function for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 17353931
GO:0005525 GTP binding IDA 20937701
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB10: view
genes like me logo Genes that share phenotypes with RAB10: view

Animal Model Products

miRNA for RAB10 Gene

miRTarBase miRNAs that target RAB10

Clone Products

  • Addgene plasmids for RAB10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB10 Gene

Localization for RAB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB10 Gene

Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cell projection, cilium. Endoplasmic reticulum membrane. Note=Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium (PubMed:20576682). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). {ECO:0000250 UniProtKB:P24409, ECO:0000269 PubMed:20576682, ECO:0000269 PubMed:22908308, ECO:0000269 PubMed:23263280}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
endosome 5
mitochondrion 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000145 colocalizes_with exocyst ISS --
GO:0005768 endosome IEA,IDA 20576682
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA,IEA 23263280
genes like me logo Genes that share ontologies with RAB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB10 Gene

Pathways & Interactions for RAB10 Gene

genes like me logo Genes that share pathways with RAB10: view

Pathways by source for RAB10 Gene

1 Qiagen pathway for RAB10 Gene
1 Cell Signaling Technology pathway for RAB10 Gene

Gene Ontology (GO) - Biological Process for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006893 Golgi to plasma membrane transport ISS --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0007409 axonogenesis ISS --
GO:0009306 protein secretion IBA --
genes like me logo Genes that share ontologies with RAB10: view

No data available for SIGNOR curated interactions for RAB10 Gene

Drugs & Compounds for RAB10 Gene

No Compound Related Data Available

Transcripts for RAB10 Gene

mRNA/cDNA for RAB10 Gene

Unigene Clusters for RAB10 Gene

RAB10, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB10

Alternative Splicing Database (ASD) splice patterns (SP) for RAB10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for RAB10 Gene

GeneLoc Exon Structure for
RAB10
ECgene alternative splicing isoforms for
RAB10

Expression for RAB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB10 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB10 Gene



Protein tissue co-expression partners for RAB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB10 Gene:

RAB10

SOURCE GeneReport for Unigene cluster for RAB10 Gene:

Hs.467960

Evidence on tissue expression from TISSUES for RAB10 Gene

  • Nervous system(5)
  • Intestine(2.7)
  • Lung(2.7)
  • Muscle(2.5)
  • Skin(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RAB10: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB10 Gene

Orthologs for RAB10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB10 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RAB10 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB10 34 33
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB10 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB10 34 33
  • 97.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB10 34 33
  • 96.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rab10 16 34 33
  • 95.33 (n)
rat
(Rattus norvegicus)
Mammalia Rab10 33
  • 95.33 (n)
chicken
(Gallus gallus)
Aves RAB10 34 33
  • 89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB10 34
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68629 33
zebrafish
(Danio rerio)
Actinopterygii rab10 34 33
  • 84.33 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab8 35
  • 78 (a)
Rab10 34 35 33
  • 69.68 (n)
OneToOne
CG2885 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000671 33
  • 70.69 (n)
worm
(Caenorhabditis elegans)
Secernentea rab-10 34 33
  • 69.9 (n)
OneToOne
rab-8 35
  • 69 (a)
4R79.2 35
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RABE1e 33
  • 61.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 71 (a)
OneToOne
Cin.3286 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3286 33
Species where no ortholog for RAB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB10 Gene

ENSEMBL:
Gene Tree for RAB10 (if available)
TreeFam:
Gene Tree for RAB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB10: view image

Paralogs for RAB10 Gene

genes like me logo Genes that share paralogs with RAB10: view

Variants for RAB10 Gene

Sequence variations from dbSNP and Humsavar for RAB10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000005272 -- 26,113,298(+) C/T intron_variant
rs1000016526 -- 26,123,412(+) G/A intron_variant
rs1000040742 -- 26,137,038(+) TTT/T 3_prime_UTR_variant
rs1000071272 -- 26,083,274(+) C/T intron_variant
rs1000103056 -- 26,113,543(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB10 Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV loss 17666407
esv3590106 CNV loss 21293372
esv3590107 CNV loss 21293372
esv3590108 CNV loss 21293372
esv3590109 CNV loss 21293372
nsv475540 CNV novel sequence insertion 20440878
nsv508717 CNV deletion 20534489
nsv963216 CNV duplication 23825009

Variation tolerance for RAB10 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB10 Gene

Human Gene Mutation Database (HGMD)
RAB10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB10 Gene

Disorders for RAB10 Gene

Additional Disease Information for RAB10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB10 Gene

Publications for RAB10 Gene

  1. Rab10 GTPase regulates ER dynamics and morphology. (PMID: 23263280) English AR … Voeltz GK (Nature cell biology 2013) 3 4 58
  2. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. (PMID: 22908308) Chen Y … Lippincott-Schwartz J (The Journal of cell biology 2012) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 58
  5. Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. (PMID: 20576682) Babbey CM … Dunn KW (American journal of physiology. Renal physiology 2010) 3 4 58

Products for RAB10 Gene

Sources for RAB10 Gene

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