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This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
QTRT1 (Queuine TRNA-Ribosyltransferase Catalytic Subunit 1) is a Protein Coding gene. Diseases associated with QTRT1 include Atypical Autism and Benign Epilepsy With Centrotemporal Spikes. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRT2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008479 | queuine tRNA-ribosyltransferase activity | TAS | 11255023 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0016763 | transferase activity, transferring pentosyl groups | IEA | -- |
GO:0042803 | protein homodimerization activity | IDA | 20354154 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | tRNA processing |
.55
|
|
2 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006400 | tRNA modification | IEA,TAS | 11255023 |
GO:0008033 | tRNA processing | IEA | -- |
GO:0101030 | tRNA-guanine transglycosylation | NAS | 11255023 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
7-Aminomethyl-7-carbaguanine |
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This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | QTRT1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | QTRT1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | QTRT1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Qtrt1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Qtrt1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | QTRT1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | QTRT1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | QTRT1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | qtrt1 30 |
|
||
MGC76136 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7586 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | qtrt1 30 31 |
|
OneToOne | |
zgc66378 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003622 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tgt 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | tgt-1 30 31 |
|
OneToOne | |
Rice (Oryza sativa) |
Liliopsida | Os09g0469900 30 |
|
||
Os.32882 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5170 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07015 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1687.19c 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.603 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1061882 | CNV | gain | 25217958 |
nsv1160584 | CNV | deletion | 26073780 |
nsv1160585 | CNV | deletion | 26073780 |
nsv833745 | CNV | loss | 17160897 |
nsv833746 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
atypical autism |
|
|
benign epilepsy with centrotemporal spikes |
|
|