Aliases for QSOX2 Gene
External Ids for QSOX2 Gene
Previous HGNC Symbols for QSOX2 Gene
Previous GeneCards Identifiers for QSOX2 Gene
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
GeneCards Summary for QSOX2 Gene
QSOX2 (Quiescin Sulfhydryl Oxidase 2) is a Protein Coding gene. Diseases associated with QSOX2 include Neuroblastoma and Deafness, Autosomal Recessive 79. Gene Ontology (GO) annotations related to this gene include thiol oxidase activity. An important paralog of this gene is QSOX1.
UniProtKB/Swiss-Prot for QSOX2 Gene
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.