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This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this ge... See more...
Aliases for QSOX1 Gene
Aliases for QSOX1 Gene
External Ids for QSOX1 Gene
- HGNC: 9756
- Entrez Gene: 5768
- Ensembl: ENSG00000116260
- OMIM: 603120
- UniProtKB: O00391
Previous HGNC Symbols for QSOX1 Gene
- QSCN6
Previous GeneCards Identifiers for QSOX1 Gene
- GC01P178391
- GC01P180123
- GC01P151355
Summaries for QSOX1 Gene
-
This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for QSOX1 Gene
QSOX1 (Quiescin Sulfhydryl Oxidase 1) is a Protein Coding gene. Diseases associated with QSOX1 include Breast Cancer. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.
UniProtKB/Swiss-Prot Summary for QSOX1 Gene
-
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
Additional gene information for QSOX1 Gene
- HGNC(9756)
- Entrez Gene(5768)
- Ensembl(ENSG00000116260)
- OMIM(603120)
- UniProtKB(O00391)
- Open Targets Platform(ENSG00000116260)
- Monarch Initiative
- Search for QSOX1 at DataMed
- Search for QSOX1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for QSOX1 Gene
Genomics for QSOX1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for QSOX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around QSOX1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for QSOX1
- Top Transcription factor binding sites by QIAGEN in the QSOX1 gene promoter:
-
- AML1a
- Cart-1
- IRF-1
- IRF-2
- Pax-4a
- POU2F1
- POU2F1a
- Spz1
Genomic Locations for QSOX1 Gene
Genomic Locations for QSOX1 Gene
- chr1:180,154,833-180,204,030
- (GRCh38/hg38)
- Size:
- 49,198 bases
- Orientation:
- Plus strand
- chr1:180,123,968-180,173,165
- (GRCh37/hg19)
- Size:
- 49,198 bases
- Orientation:
- Plus strand
Genomic View for QSOX1 Gene
Genes around QSOX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.2 by HGNC
- 1q25.2 by Entrez Gene
- 1q25.2 by Ensembl
QSOX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for QSOX1 Gene
Proteins for QSOX1 Gene
-
Protein details for QSOX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00391-QSOX1_HUMAN
- Recommended name:
- Sulfhydryl oxidase 1
- Protein Accession:
- O00391
- Q59G29
- Q5T2X0
- Q8TDL6
- Q8WVP4
Protein attributes for QSOX1 Gene
- Size:
- 747 amino acids
- Molecular mass:
- 82578 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=BAD92517.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts.
Three dimensional structures from OCA and Proteopedia for QSOX1 Gene
Protein Expression for QSOX1 Gene
Selected DME Specific Peptides for QSOX1 Gene
- O00391:
-
- EDPQFPK
- SWCGHCI
- LFHFLTVQA
- FPKVQWP
- HFRGFPCSLW
- ADRSKIYMADLESALHYILR
Post-translational modifications for QSOX1 Gene
- N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).
-
Glycosylation at Asn130, Asn243, Thr276, Thr277, Thr281, Thr282, Thr289, Ser493, Ser549, Asn575, Ser576, Thr577, Ser588, Thr590, Asn591, Thr592, Thr593, Ser604, Ser643, Thr647, and Ser655
- NX_O00391 (NX_O00391-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- QSOX1_HUMAN (1774)
Other Protein References for QSOX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ QSOX1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for QSOX1
- Novus Biologicals Antibodies for QSOX1
-
Abcam antibodies for QSOX1
- Invitrogen Antibodies for QSOX1 (AFLGC-Qsox1)
-
Boster Bio Antibodies for QSOX1
-
Custom Antibody ServicesProSci Antibodies for QSOX1
Protein Products
-
OriGene Purified Proteins for QSOX1
- Search Origene for MassSpec and Protein Over-expression Lysates for QSOX1
- Origene Custom Protein Services for QSOX1
-
Abcam proteins for QSOX1
Assay Products
Domains & Families for QSOX1 Gene
Gene Families for QSOX1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for QSOX1 Gene
- InterPro:
- Blocks:
-
- Thioredoxin type domain
- Erv1/Alr
- ProtoNet:
Suggested Antigen Peptide Sequences for QSOX1 Gene
- GenScript: Design optimal peptide antigens:
-
- Bone-derived growth factor (Q13876_HUMAN)
- Quiescin Q6 sulfhydryl oxidase 1 (Q5T2X6_HUMAN)
- Quiescin Q6 (QSOX1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00391- Family:
-
- Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Function for QSOX1 Gene
Molecular function for QSOX1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2; Evidence={ECO:0000269|PubMed:18393449, ECO:0000269|PubMed:22801504, ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:23867277, ECO:0000269|PubMed:26819240, ECO:0000269|PubMed:29757379, ECO:0000269|PubMed:30367560};.
- UniProtKB/Swiss-Prot Induction:
- Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.
Enzyme Numbers (IUBMB) for QSOX1 Gene
Phenotypes From GWAS Catalog for QSOX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | IBA,IDA | 17331072 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IBA,IDA | 17331072 |
| GO:0016972 | thiol oxidase activity | IEA | -- |
| GO:0071949 | FAD binding | IDA | 20211621 |
Phenotypes for QSOX1 Gene
- MGI mutant phenotypes for QSOX1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for QSOX1:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Decreased Salmonella enterica Typhimurium invasion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Increased hepcidin::fluc mRNA expression
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased caspase activity
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for QSOX1 - Select products 50% OFF >
- * QSOX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for QSOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for QSOX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for QSOX1
miRNA for QSOX1 Gene
- miRTarBase miRNAs that target QSOX1
-
- hsa-miR-124-3p (MIRT022900)
- hsa-let-7e-5p (MIRT051544)
- hsa-miR-5096 (MIRT521504)
- hsa-miR-6803-5p (MIRT521505)
- hsa-miR-6751-5p (MIRT521506)
- hsa-miR-3187-3p (MIRT521507)
- hsa-miR-4435 (MIRT521508)
- hsa-miR-588 (MIRT521509)
- hsa-miR-4701-5p (MIRT521510)
- hsa-miR-548s (MIRT521511)
- hsa-miR-197-3p (MIRT521512)
- hsa-miR-6832-5p (MIRT521513)
- hsa-miR-193b-5p (MIRT521514)
- hsa-miR-7110-5p (MIRT521515)
- hsa-miR-6842-5p (MIRT521516)
- hsa-miR-6752-5p (MIRT521517)
- hsa-miR-6835-5p (MIRT521518)
- hsa-miR-3926 (MIRT521519)
- hsa-miR-1273f (MIRT521520)
- hsa-miR-4716-5p (MIRT521521)
- hsa-miR-4781-3p (MIRT521522)
- hsa-miR-320e (MIRT521523)
- hsa-miR-6807-5p (MIRT521524)
- hsa-miR-6778-3p (MIRT521525)
- hsa-miR-150-5p (MIRT521526)
- hsa-miR-7107-5p (MIRT521527)
- hsa-miR-1234-3p (MIRT521528)
- hsa-miR-186-3p (MIRT521529)
- hsa-miR-520h (MIRT521530)
- hsa-miR-520g-3p (MIRT521531)
- hsa-miR-3159 (MIRT521532)
- hsa-miR-520e (MIRT521533)
- hsa-miR-520d-3p (MIRT521534)
- hsa-miR-520c-3p (MIRT521535)
- hsa-miR-520b (MIRT521536)
- hsa-miR-520a-3p (MIRT521537)
- hsa-miR-373-3p (MIRT521538)
- hsa-miR-372-3p (MIRT521539)
- hsa-miR-302e (MIRT521540)
- hsa-miR-302d-3p (MIRT521541)
- hsa-miR-302c-3p (MIRT521542)
- hsa-miR-302b-3p (MIRT521543)
- hsa-miR-302a-3p (MIRT521544)
- hsa-miR-93-5p (MIRT521545)
- hsa-miR-526b-3p (MIRT521546)
- hsa-miR-519d-3p (MIRT521547)
- hsa-miR-20b-5p (MIRT521548)
- hsa-miR-20a-5p (MIRT521549)
- hsa-miR-17-5p (MIRT521550)
- hsa-miR-106b-5p (MIRT521551)
- hsa-miR-106a-5p (MIRT521552)
- hsa-miR-6783-3p (MIRT722478)
- hsa-miR-1343-3p (MIRT722479)
- hsa-miR-3156-3p (MIRT722480)
- hsa-miR-711 (MIRT722481)
- hsa-miR-6859-3p (MIRT722482)
- hsa-miR-532-3p (MIRT722483)
- hsa-miR-4301 (MIRT722484)
- hsa-miR-3150b-3p (MIRT740326)
- hsa-miR-3174 (MIRT740634)
- hsa-miR-4323 (MIRT744051)
- hsa-miR-4530 (MIRT745970)
- hsa-miR-4689 (MIRT747039)
- hsa-miR-4784 (MIRT748843)
- hsa-miR-646 (MIRT752757)
- hsa-miR-6858-5p (MIRT757797)
- hsa-miR-921 (MIRT760490)
- hsa-miR-106a-3p (MIRT761111)
- hsa-miR-122-5p (MIRT761350)
- hsa-miR-1286 (MIRT762240)
- hsa-miR-130a-3p (MIRT762488)
- hsa-miR-130b-3p (MIRT762506)
- hsa-miR-1825 (MIRT763001)
- hsa-miR-1827 (MIRT763095)
- hsa-miR-199a-5p (MIRT763630)
- hsa-miR-199b-5p (MIRT763641)
- hsa-miR-2467-5p (MIRT764157)
- hsa-miR-301a-3p (MIRT764413)
- hsa-miR-301b-3p (MIRT764431)
- hsa-miR-3135b (MIRT764947)
- hsa-miR-3188 (MIRT765337)
- hsa-miR-3652 (MIRT766308)
- hsa-miR-3666 (MIRT766551)
- hsa-miR-3671 (MIRT766576)
- hsa-miR-3925-3p (MIRT767681)
- hsa-miR-3975 (MIRT767905)
- hsa-miR-4295 (MIRT768465)
- hsa-miR-4430 (MIRT768943)
- hsa-miR-4499 (MIRT769766)
- hsa-miR-454-3p (MIRT770247)
- hsa-miR-4634 (MIRT770505)
- hsa-miR-4649-3p (MIRT770658)
- hsa-miR-4695-3p (MIRT771150)
- hsa-miR-4722-5p (MIRT771577)
- hsa-miR-4768-3p (MIRT772121)
- hsa-miR-485-5p (MIRT772636)
- hsa-miR-504-3p (MIRT773070)
- hsa-miR-580-3p (MIRT775307)
- hsa-miR-607 (MIRT775463)
- hsa-miR-652-3p (MIRT777274)
- hsa-miR-6736-3p (MIRT778044)
- hsa-miR-6787-3p (MIRT779202)
- hsa-miR-6808-5p (MIRT779696)
- hsa-miR-6857-3p (MIRT780505)
- hsa-miR-6884-5p (MIRT781024)
- hsa-miR-6893-5p (MIRT781229)
- hsa-miR-8083 (MIRT782412)
- hsa-miR-873-3p (MIRT782468)
- hsa-miR-940 (MIRT782923)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for QSOX1
- Browse OriGene Inhibitory RNA Products For QSOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QSOX1
Clone Products
- Applied Biological Materials (abm): Clones for QSOX1 - Select products 50% OFF >
- * QSOX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210448
- MG217688
- MR210448
- MR210448L3
- MR210448L4
- MR217688
- MR217688L3
- MR217688L4
- RC204373
- RC204373L1
- RC204373L2
- RC204373L3
- RC204373L4
- RC215121
- RC215121L1
- RC215121L2
- RC215121L3
- RC215121L4
- RG204373
- RG215121
- RR200253
- RR200253L3
- RR200253L4
- RR200254
- RR200254L3
- RR200254L4
- MR210448L3V
- MR210448L4V
- MR217688L3V
- MR217688L4V
- RC204373L1V
- RC204373L2V
- RC204373L3V
- RC204373L4V
- RC215121L1V
- RC215121L2V
- RC215121L3V
- RC215121L4V
- RR200253L3V
- RR200253L4V
- RR200254L3V
- RR200254L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for QSOX1
- Addgene plasmids for QSOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for QSOX1
Cell Line Products
-
Horizon Cell Lines for QSOX1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSOX1 Gene
Localization for QSOX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for QSOX1 Gene
- [Isoform 1]: Golgi apparatus membrane. Single-pass membrane protein. Secreted. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000305 PubMed:29757379}.
- [Isoform 2]: Secreted. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. {ECO:0000269 PubMed:10708601}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Golgi apparatus (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA,IDA | 29757379 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 10708601 |
| GO:0005623 | cell | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for QSOX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Innate Immune System |
.61
|
|
Pathways by source for QSOX1 Gene
7 Reactome pathways for QSOX1 Gene
Interacting Proteins for QSOX1 Gene
GPS-Prot Interaction Network for QSOX1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006457 | protein folding | IBA | 21873635 |
| GO:0016242 | negative regulation of macroautophagy | IMP | 24475161 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for QSOX1 Gene
Transcripts for QSOX1 Gene
mRNA/cDNA for QSOX1 Gene
- 2 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367600 2519 nts (view in UCSC)
- ENST00000367602 9276 nts (view in UCSC)
- ENST00000392029 1075 nts (view in UCSC)
- ENST00000443059 893 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for QSOX1 - Select products 50% OFF >
- * QSOX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for QSOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for QSOX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for QSOX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for QSOX1
- Browse OriGene Inhibitory RNA Products For QSOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QSOX1
Clone Products
- Applied Biological Materials (abm): Clones for QSOX1 - Select products 50% OFF >
- * QSOX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210448
- MG217688
- MR210448
- MR210448L3
- MR210448L4
- MR217688
- MR217688L3
- MR217688L4
- RC204373
- RC204373L1
- RC204373L2
- RC204373L3
- RC204373L4
- RC215121
- RC215121L1
- RC215121L2
- RC215121L3
- RC215121L4
- RG204373
- RG215121
- RR200253
- RR200253L3
- RR200253L4
- RR200254
- RR200254L3
- RR200254L4
- MR210448L3V
- MR210448L4V
- MR217688L3V
- MR217688L4V
- RC204373L1V
- RC204373L2V
- RC204373L3V
- RC204373L4V
- RC215121L1V
- RC215121L2V
- RC215121L3V
- RC215121L4V
- RR200253L3V
- RR200253L4V
- RR200254L3V
- RR200254L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for QSOX1
- Addgene plasmids for QSOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for QSOX1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Relevant External Links for QSOX1 Gene
- GeneLoc Exon Structure for
- QSOX1
Expression for QSOX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Amniocyte (19.2), Milk (10.4), and Serum (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QSOX1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for QSOX1
SOURCE GeneReport for Unigene cluster for QSOX1 Gene:
Hs.744925mRNA Expression by UniProt/SwissProt for QSOX1 Gene:
O00391-QSOX1_HUMAN
Tissue specificity:
Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
Evidence on tissue expression from TISSUES for QSOX1 Gene
- Lung(5)
- Nervous system(4.9)
- Kidney(4.8)
- Bone marrow(4.4)
- Stomach(3.8)
- Intestine(3.5)
- Skin(3.5)
- Pancreas(2.7)
- Heart(2.4)
- Muscle(2.3)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for QSOX1
-
OriGene qPCR primer pairs and template standards for QSOX1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for QSOX1 Gene
Orthologs for QSOX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | QSOX1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | QSOX1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Qsox1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Qsox1 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | QSOX1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | QSOX1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | QSOX1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | QSOX1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | QSOX1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | qsox1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | qsox1 30 31 |
|
OneToOne | |
| sbcb840 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007491 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG4670 30 31 |
|
ManyToMany | |
| CG17843 31 |
|
ManyToMany | |||
| CG31413 31 |
|
ManyToMany | |||
| CG6690 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | T10H10.2 30 31 |
|
ManyToMany | |
| F47B7.2 31 |
|
ManyToMany | |||
| F35G2.1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for QSOX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for QSOX1 Gene
- ENSEMBL:
- Gene Tree for QSOX1 (if available)
- TreeFam:
- Gene Tree for QSOX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for QSOX1: view image
Paralogs for QSOX1 Gene
Variants for QSOX1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for QSOX1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709336 | Benign: not provided | 180,196,252(+) | C/T | INTRON_VARIANT | |
| 720745 | Benign: not provided | 180,196,812(+) | C/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 746984 | Likely Benign: not provided | 180,190,513(+) | G/A | SYNONYMOUS_VARIANT | |
| 747248 | Likely Benign: not provided | 180,178,787(+) | C/T | INTRON_VARIANT | |
| 773117 | Benign: not provided | 180,186,188(+) | C/A | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv474n100 | CNV | gain | 25217958 |
| dgv475n100 | CNV | gain | 25217958 |
| dgv476n100 | CNV | gain | 25217958 |
| nsv1001565 | CNV | loss | 25217958 |
| nsv1119737 | CNV | deletion | 24896259 |
| nsv466239 | CNV | gain | 19166990 |
| nsv472946 | CNV | novel sequence insertion | 20440878 |
| nsv522045 | CNV | loss | 19592680 |
| nsv528041 | CNV | loss | 19592680 |
| nsv548345 | CNV | gain | 21841781 |
| nsv832004 | CNV | gain | 17160897 |
| nsv952285 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.57;
77.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for QSOX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- QSOX1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSOX1 Gene
Disorders for QSOX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
Search QSOX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for QSOX1
No data available for UniProtKB/Swiss-Prot and Genatlas for QSOX1 Gene
Publications for QSOX1 Gene
- The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PMID: 9878249) Coppock DL … Gilleran S (Genomics 1998) 2 3 4 23
- Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PMID: 12176051) Thorpe C … Coppock DL (Archives of biochemistry and biophysics 2002) 2 3 4
- Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PMID: 10708601) Coppock D … Cina-Poppe DA (Biochemical and biophysical research communications 2000) 3 4 23
- Preferential gene expression in quiescent human lung fibroblasts. (PMID: 8396966) Coppock DL … Gilleran S (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993) 2 3 23
- cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures. (PMID: 30367560) Javitt G … Fass D (Protein science : a publication of the Protein Society 2019) 3 4
ExternalLinks
Products for QSOX1 Gene
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Sources for QSOX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (30) HomoloGene
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- (36) Pseudogene
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