Aliases for QSOX1 Gene
External Ids for QSOX1 Gene
Previous HGNC Symbols for QSOX1 Gene
Previous GeneCards Identifiers for QSOX1 Gene
This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for QSOX1 Gene
QSOX1 (Quiescin Sulfhydryl Oxidase 1) is a Protein Coding gene. Diseases associated with QSOX1 include Breast Cancer. Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.
UniProtKB/Swiss-Prot Summary for QSOX1 Gene
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).