Free for academic non-profit institutions. Other users need a Commercial license

Aliases for QSOX1 Gene

Aliases for QSOX1 Gene

  • Quiescin Sulfhydryl Oxidase 1 2 3 5
  • Quiescin Q6 Sulfhydryl Oxidase 1 2 3
  • Thiol Oxidase 1 2 3
  • Quiescin Q6 2 4
  • EC 4 56
  • QSCN6 3 4
  • Testis Tissue Sperm-Binding Protein Li 62n 3
  • Sulfhydryl Oxidase 1 3
  • HQSOX 4
  • Q6 3

External Ids for QSOX1 Gene

Previous HGNC Symbols for QSOX1 Gene

  • QSCN6

Previous GeneCards Identifiers for QSOX1 Gene

  • GC01P178391
  • GC01P180123
  • GC01P151355

Summaries for QSOX1 Gene

Entrez Gene Summary for QSOX1 Gene

  • This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for QSOX1 Gene

QSOX1 (Quiescin Sulfhydryl Oxidase 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.

UniProtKB/Swiss-Prot for QSOX1 Gene

  • Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.

Gene Wiki entry for QSOX1 Gene

Additional gene information for QSOX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSOX1 Gene

Genomics for QSOX1 Gene

GeneHancer (GH) Regulatory Elements for QSOX1 Gene

Promoters and enhancers for QSOX1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I180150 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 599.8 +0.0 14 8.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 QSOX1 LOC105371636 ACBD6 ENSG00000261831 AXDND1 ENSG00000260360 TOR1AIP1 CEP350 PIR57354 GC01M180833
GH01I180165 Enhancer 1.3 Ensembl ENCODE dbSUPER 43.8 +13.5 13476 6 HDGF PKNOX1 NEUROD1 SIN3A ZBTB7B BRCA1 ZNF48 GLIS2 ZNF207 ZNF143 PIR57354 QSOX1 GC01M180833
GH01I180116 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -37.3 -37253 2.1 FOXA2 MLX ARNT ARID4B FOS SP5 MXD4 KAT8 MIER3 SMARCA4 QSOX1 ACBD6 TOR1AIP1 TOR1AIP2 ENSG00000261831 ENSG00000261817 RPS24P5
GH01I180180 Enhancer 0.6 dbSUPER 26.8 +27.9 27910 4.1 CTCF PKNOX1 ATF1 MAFG DPF2 ZIC2 ZNF316 CREM EMSY MAFK QSOX1 LHX4 TOR1AIP1 TOR1AIP2 PIR48513 GC01P180178 FLJ23867
GH01I179951 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.1 -200.4 -200437 5.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC CEP350 ENSG00000260360 LOC101928933 PIR45618 LHX4 QSOX1 ENSG00000261831
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around QSOX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QSOX1 gene promoter:

Genomic Locations for QSOX1 Gene

Genomic Locations for QSOX1 Gene
49,198 bases
Plus strand

Genomic View for QSOX1 Gene

Genes around QSOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QSOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QSOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QSOX1 Gene

Proteins for QSOX1 Gene

  • Protein details for QSOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfhydryl oxidase 1
    Protein Accession:
    Secondary Accessions:
    • Q59G29
    • Q5T2X0
    • Q8TDL6
    • Q8WVP4

    Protein attributes for QSOX1 Gene

    747 amino acids
    Molecular mass:
    82578 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.
    • Quiescin Q6 means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts.
    • Sequence=BAD92517.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for QSOX1 Gene

    Alternative splice isoforms for QSOX1 Gene


neXtProt entry for QSOX1 Gene

Selected DME Specific Peptides for QSOX1 Gene


Post-translational modifications for QSOX1 Gene

  • Glycosylation at isoforms=2130, isoforms=2243, Thr276, Thr277, isoforms=2281, isoforms=2282, isoforms=2289, Ser493, Ser549, isoforms=2575, Ser576, Ser588, isoforms=590, isoforms=592, Thr593, isoforms=604, Ser643, and isoforms=647
  • Modification sites at PhosphoSitePlus

Other Protein References for QSOX1 Gene

Domains & Families for QSOX1 Gene

Gene Families for QSOX1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for QSOX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
  • Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
genes like me logo Genes that share domains with QSOX1: view

Function for QSOX1 Gene

Molecular function for QSOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 RC(R)SH + O(2) = RC(R)S-S(R)CR + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
UniProtKB/Swiss-Prot Induction:
Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.

Enzyme Numbers (IUBMB) for QSOX1 Gene

Phenotypes From GWAS Catalog for QSOX1 Gene

Gene Ontology (GO) - Molecular Function for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IDA 17331072
GO:0016491 oxidoreductase activity IEA --
GO:0016971 flavin-linked sulfhydryl oxidase activity IDA 17331072
GO:0016972 thiol oxidase activity IEA --
genes like me logo Genes that share ontologies with QSOX1: view
genes like me logo Genes that share phenotypes with QSOX1: view

Animal Model Products

miRNA for QSOX1 Gene

miRTarBase miRNAs that target QSOX1

Clone Products

  • Addgene plasmids for QSOX1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSOX1 Gene

Localization for QSOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QSOX1 Gene

Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QSOX1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 10708601
GO:0005623 cell IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA,IEA --
genes like me logo Genes that share ontologies with QSOX1: view

Pathways & Interactions for QSOX1 Gene

genes like me logo Genes that share pathways with QSOX1: view

Gene Ontology (GO) - Biological Process for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0016242 negative regulation of macroautophagy IMP 24475161
GO:0043312 neutrophil degranulation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with QSOX1: view

No data available for SIGNOR curated interactions for QSOX1 Gene

Drugs & Compounds for QSOX1 Gene

(4) Drugs for QSOX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with QSOX1: view

Transcripts for QSOX1 Gene

Unigene Clusters for QSOX1 Gene

Quiescin Q6 sulfhydryl oxidase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for QSOX1

Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - -
SP5: - -
SP6: - - -
SP7: -
SP9: -

Relevant External Links for QSOX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QSOX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QSOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for QSOX1 Gene

This gene is overexpressed in Amniocyte (19.2), Milk (10.4), and Serum (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QSOX1 Gene

Protein tissue co-expression partners for QSOX1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QSOX1 Gene:


SOURCE GeneReport for Unigene cluster for QSOX1 Gene:


mRNA Expression by UniProt/SwissProt for QSOX1 Gene:

Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.

Evidence on tissue expression from TISSUES for QSOX1 Gene

  • Lung(5)
  • Nervous system(4.8)
  • Kidney(4.7)
  • Bone marrow(4.3)
  • Stomach(3.8)
  • Intestine(3.3)
  • Skin(3)
  • Pancreas(2.3)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with QSOX1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for QSOX1 Gene

Orthologs for QSOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for QSOX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QSOX1 33 34
  • 99.28 (n)
(Bos Taurus)
Mammalia QSOX1 33 34
  • 85.38 (n)
(Rattus norvegicus)
Mammalia Qsox1 33
  • 79.18 (n)
(Mus musculus)
Mammalia Qsox1 33 16 34
  • 78.59 (n)
(Canis familiaris)
Mammalia QSOX1 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia QSOX1 34
  • 54 (a)
(Monodelphis domestica)
Mammalia QSOX1 34
  • 53 (a)
(Gallus gallus)
Aves QSOX1 33 34
  • 62.31 (n)
(Anolis carolinensis)
Reptilia QSOX1 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia qsox1 33
  • 51.78 (n)
(Danio rerio)
Actinopterygii qsox1 33 34
  • 53.4 (n)
sbcb840 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007491 33
  • 47.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4670 33 34
  • 46.57 (n)
CG17843 34
  • 29 (a)
CG31413 34
  • 25 (a)
CG6690 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea T10H10.2 33 34
  • 43.01 (n)
F35G2.1 34
  • 22 (a)
F47B7.2 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for QSOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QSOX1 Gene

Gene Tree for QSOX1 (if available)
Gene Tree for QSOX1 (if available)

Paralogs for QSOX1 Gene

Paralogs for QSOX1 Gene

(4) SIMAP similar genes for QSOX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QSOX1: view

Variants for QSOX1 Gene

Sequence variations from dbSNP and Humsavar for QSOX1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000011175 -- 180,165,960(+) C/T intron_variant
rs1000093223 -- 180,180,030(+) C/T intron_variant
rs1000099301 -- 180,198,140(+) C/T downstream_transcript_variant
rs1000125978 -- 180,158,962(+) A/C intron_variant
rs1000170006 -- 180,196,725(+) G/A/T coding_sequence_variant, intron_variant, missense_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for QSOX1 Gene

Variant ID Type Subtype PubMed ID
dgv474n100 CNV gain 25217958
dgv475n100 CNV gain 25217958
dgv476n100 CNV gain 25217958
nsv1001565 CNV loss 25217958
nsv1119737 CNV deletion 24896259
nsv466239 CNV gain 19166990
nsv472946 CNV novel sequence insertion 20440878
nsv522045 CNV loss 19592680
nsv528041 CNV loss 19592680
nsv548345 CNV gain 21841781
nsv832004 CNV gain 17160897
nsv952285 CNV deletion 24416366

Variation tolerance for QSOX1 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QSOX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSOX1 Gene

Disorders for QSOX1 Gene

Additional Disease Information for QSOX1

No disorders were found for QSOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QSOX1 Gene

Publications for QSOX1 Gene

  1. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PMID: 9878249) Coppock DL … Gilleran S (Genomics 1998) 2 3 4 22 58
  2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PMID: 12176051) Thorpe C … Coppock DL (Archives of biochemistry and biophysics 2002) 2 3 4 58
  3. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PMID: 10708601) Coppock D … Cina-Poppe DA (Biochemical and biophysical research communications 2000) 3 4 22 58
  4. Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PMID: 10542195) Hoober KL … Thorpe C (The Journal of biological chemistry 1999) 3 4 22 58
  5. Preferential gene expression in quiescent human lung fibroblasts. (PMID: 8396966) Coppock DL … Gilleran S (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993) 2 3 22 58

Products for QSOX1 Gene

  • Addgene plasmids for QSOX1

Sources for QSOX1 Gene

Loading form....