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Aliases for QRSL1 Gene

Aliases for QRSL1 Gene

  • Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1 2 3 5
  • Glutamyl-TRNA(Gln) Amidotransferase, Subunit A 2 3
  • Glutaminyl-TRNA Synthase-Like Protein 1 3 4
  • Glu-AdT Subunit A 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit A, Mitochondrial 3
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog 3
  • EC 6.3.5.7 4
  • GatA 3

External Ids for QRSL1 Gene

Previous GeneCards Identifiers for QRSL1 Gene

  • GC06P107077
  • GC06P107123
  • GC06P107185
  • GC06P104524

Summaries for QRSL1 Gene

GeneCards Summary for QRSL1 Gene

QRSL1 (Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1) is a Protein Coding gene. Diseases associated with QRSL1 include Lymphogranuloma Venereum and Intestinal Volvulus. Among its related pathways are tRNA Aminoacylation and Metabolism. Gene Ontology (GO) annotations related to this gene include carbon-nitrogen ligase activity, with glutamine as amido-N-donor and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.

UniProtKB/Swiss-Prot for QRSL1 Gene

  • Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Additional gene information for QRSL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRSL1 Gene

Genomics for QRSL1 Gene

GeneHancer (GH) Regulatory Elements for QRSL1 Gene

Promoters and enhancers for QRSL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J106628 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 722.3 0.0 -3 2.9 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 FOS QRSL1 RTN4IP1 CRYBG1 RNU6-527P
GH06J106666 Enhancer 0.8 ENCODE dbSUPER 43.8 +37.7 37676 1.4 JUNB MAFG EBF1 MEF2B BATF MAFF ZNF316 POLR2A IKZF1 ETV6 QRSL1 GC06P106672 RPL21P65
GH06J106590 Enhancer 0.7 Ensembl ENCODE dbSUPER 42.9 -37.9 -37933 1.8 JUND QRSL1 RTN4IP1 MIR587 LINC02532 GC06P106588 GC06P106608
GH06J106574 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 19.8 -54.6 -54570 1.3 SOX13 JUN FEZF1 FOSL1 CTBP1 GATA3 FOSL2 FOS EZH2 SOX5 QRSL1 RTN4IP1 PRDM1 GC06P106588 GC06P106541
GH06J106636 Enhancer 1.1 Ensembl ENCODE dbSUPER 21.3 +8.2 8181 2.6 MEIS2 PKNOX1 BMI1 BATF IRF4 IKZF2 RUNX3 CREM SRF L3MBTL2 QRSL1 RNU6-527P LINC02532 MIR587 RPL21P65 RTN4IP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around QRSL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QRSL1 gene promoter:
  • Nkx2-5
  • deltaCREB
  • CREB
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • GATA-3

Genomic Locations for QRSL1 Gene

Genomic Locations for QRSL1 Gene
chr6:106,629,566-106,668,417
(GRCh38/hg38)
Size:
38,852 bases
Orientation:
Plus strand
chr6:107,077,441-107,116,292
(GRCh37/hg19)
Size:
38,852 bases
Orientation:
Plus strand

Genomic View for QRSL1 Gene

Genes around QRSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRSL1 Gene

Proteins for QRSL1 Gene

  • Protein details for QRSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R6-GATA_HUMAN
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Protein Accession:
    Q9H0R6
    Secondary Accessions:
    • Q5VWJ4
    • Q9HA60
    • Q9NV19

    Protein attributes for QRSL1 Gene

    Size:
    528 amino acids
    Molecular mass:
    57460 Da
    Quaternary structure:
    • Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
    SequenceCaution:
    • Sequence=CAH72094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for QRSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QRSL1 Gene

Post-translational modifications for QRSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QRSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for QRSL1 Gene

Domains & Families for QRSL1 Gene

Gene Families for QRSL1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for QRSL1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QRSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0R6

UniProtKB/Swiss-Prot:

GATA_HUMAN :
  • Belongs to the amidase family. GatA subfamily.
Family:
  • Belongs to the amidase family. GatA subfamily.
genes like me logo Genes that share domains with QRSL1: view

Function for QRSL1 Gene

Molecular function for QRSL1 Gene

UniProtKB/Swiss-Prot Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.

Enzyme Numbers (IUBMB) for QRSL1 Gene

Phenotypes From GWAS Catalog for QRSL1 Gene

Gene Ontology (GO) - Molecular Function for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004040 amidase activity IEA --
GO:0005515 protein binding IPI 19805282
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view
genes like me logo Genes that share phenotypes with QRSL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QRSL1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QRSL1 Gene

Localization for QRSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRSL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRSL1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 19805282
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

Pathways & Interactions for QRSL1 Gene

genes like me logo Genes that share pathways with QRSL1: view

Pathways by source for QRSL1 Gene

2 KEGG pathways for QRSL1 Gene

Gene Ontology (GO) - Biological Process for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0031647 regulation of protein stability IEA --
GO:0032543 mitochondrial translation IMP,IEA 19805282
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

No data available for SIGNOR curated interactions for QRSL1 Gene

Drugs & Compounds for QRSL1 Gene

(4) Drugs for QRSL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Glutamic Acid Approved Nutra Full agonist, Agonist 251
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for QRSL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with QRSL1: view

Transcripts for QRSL1 Gene

mRNA/cDNA for QRSL1 Gene

Unigene Clusters for QRSL1 Gene

Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for QRSL1 Gene

GeneLoc Exon Structure for
QRSL1
ECgene alternative splicing isoforms for
QRSL1

Expression for QRSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QRSL1 Gene

Protein differential expression in normal tissues from HIPED for QRSL1 Gene

This gene is overexpressed in Heart (39.9), Plasma (13.3), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QRSL1 Gene



Protein tissue co-expression partners for QRSL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of QRSL1 Gene:

QRSL1

SOURCE GeneReport for Unigene cluster for QRSL1 Gene:

Hs.406917

Evidence on tissue expression from TISSUES for QRSL1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with QRSL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRSL1 Gene

Orthologs for QRSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QRSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QRSL1 34 33
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia QRSL1 34 33
  • 91.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia QRSL1 34 33
  • 89.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Qrsl1 16 34 33
  • 84.99 (n)
rat
(Rattus norvegicus)
Mammalia Qrsl1 33
  • 83.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia QRSL1 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QRSL1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves QRSL1 34 33
  • 75.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QRSL1 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qrsl1 33
  • 70.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia qrsl1-prov 33
zebrafish
(Danio rerio)
Actinopterygii qrsl1 34 33
  • 65.76 (n)
OneToOne
Dr.12246 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004057 33
  • 55.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta gatA 34 33
  • 54.5 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y41D4A.6 34 33
  • 54.08 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09845g 33
  • 46.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HER2 36 34 33
  • 45.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR140C 33
  • 44.62 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G25660 33
  • 48.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.03 33
  • 45.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00660 33
  • 45.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToOne
Cin.13009 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13009 33
Species where no ortholog for QRSL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QRSL1 Gene

ENSEMBL:
Gene Tree for QRSL1 (if available)
TreeFam:
Gene Tree for QRSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for QRSL1: view image

Paralogs for QRSL1 Gene

Pseudogenes.org Pseudogenes for QRSL1 Gene

genes like me logo Genes that share paralogs with QRSL1: view

No data available for Paralogs for QRSL1 Gene

Variants for QRSL1 Gene

Sequence variations from dbSNP and Humsavar for QRSL1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000110281 -- 106,645,234(+) C/G intron_variant
rs1000327489 -- 106,632,391(+) T/A intron_variant
rs1000415521 -- 106,637,416(+) A/G intron_variant
rs1000474045 -- 106,657,460(+) C/G/T intron_variant
rs1000527613 -- 106,657,129(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QRSL1 Gene

Variant ID Type Subtype PubMed ID
nsv970157 CNV duplication 23825009
nsv516902 CNV loss 19592680
nsv1142470 CNV tandem duplication 24896259
nsv1124109 CNV deletion 24896259
nsv1114860 CNV deletion 24896259
esv3610281 CNV loss 21293372

Variation tolerance for QRSL1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRSL1 Gene

Human Gene Mutation Database (HGMD)
QRSL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QRSL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRSL1 Gene

Disorders for QRSL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for QRSL1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lymphogranuloma venereum
  • climatic or tropical bubo
intestinal volvulus
  • twist of intestine, bowel, or colon
mitochondrial disorders
  • mitochondrial encephalomyopathies
- elite association - COSMIC cancer census association via MalaCards
Search QRSL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GATA_HUMAN
  • Note=Defects in QRSL1 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies. {ECO:0000269 PubMed:26741492}.

Additional Disease Information for QRSL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with QRSL1: view

No data available for Genatlas for QRSL1 Gene

Publications for QRSL1 Gene

  1. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A … Suzuki T (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for QRSL1 Gene

Sources for QRSL1 Gene

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