Aliases for QRSL1 Gene
Aliases for QRSL1 Gene
- Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1 2 3 5
- Glutamyl-TRNA(Gln) Amidotransferase, Subunit A 2 3
- Glutaminyl-TRNA Synthase-Like Protein 1 3 4
- Glu-AdT Subunit A 3 4
- Glutamyl-TRNA(Gln) Amidotransferase Subunit A, Mitochondrial 3
- Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog 3
- EC 6.3.5.7 4
- GatA 3
External Ids for QRSL1 Gene
- HGNC: 21020
- Entrez Gene: 55278
- Ensembl: ENSG00000130348
- OMIM: 617209
- UniProtKB: Q9H0R6
Previous GeneCards Identifiers for QRSL1 Gene
- GC06P107077
- GC06P107123
- GC06P107185
- GC06P104524
Summaries for QRSL1 Gene
GeneCards Summary for QRSL1 Gene
QRSL1 (Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1) is a Protein Coding gene. Diseases associated with QRSL1 include Lymphogranuloma Venereum and Intestinal Volvulus. Among its related pathways are tRNA Aminoacylation and Metabolism. Gene Ontology (GO) annotations related to this gene include carbon-nitrogen ligase activity, with glutamine as amido-N-donor and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.
UniProtKB/Swiss-Prot for QRSL1 Gene
-
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRSL1 Gene
Genomics for QRSL1 Gene
GeneHancer (GH) Regulatory Elements for QRSL1 Gene
Promoters and enhancers for QRSL1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J106628 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 722.3 | 0.0 | -3 | 2.9 | PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 FOS | QRSL1 RTN4IP1 CRYBG1 RNU6-527P | |
| GH06J106666 | Enhancer | 0.8 | ENCODE dbSUPER | 43.8 | +37.7 | 37676 | 1.4 | JUNB MAFG EBF1 MEF2B BATF MAFF ZNF316 POLR2A IKZF1 ETV6 | QRSL1 GC06P106672 RPL21P65 | |
| GH06J106590 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 42.9 | -37.9 | -37933 | 1.8 | JUND | QRSL1 RTN4IP1 MIR587 LINC02532 GC06P106588 GC06P106608 | |
| GH06J106574 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 19.8 | -54.6 | -54570 | 1.3 | SOX13 JUN FEZF1 FOSL1 CTBP1 GATA3 FOSL2 FOS EZH2 SOX5 | QRSL1 RTN4IP1 PRDM1 GC06P106588 GC06P106541 | |
| GH06J106636 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 21.3 | +8.2 | 8181 | 2.6 | MEIS2 PKNOX1 BMI1 BATF IRF4 IKZF2 RUNX3 CREM SRF L3MBTL2 | QRSL1 RNU6-527P LINC02532 MIR587 RPL21P65 RTN4IP1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around QRSL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the QRSL1 gene promoter:
-
- Nkx2-5
- deltaCREB
- CREB
- COUP
- COUP-TF
- COUP-TF1
- HNF-4alpha1
- HNF-4alpha2
- GATA-3
Regulatory Element Products
Genomic Locations for QRSL1 Gene
Genomic Locations for QRSL1 Gene
- chr6:106,629,566-106,668,417
- (GRCh38/hg38)
- Size:
- 38,852 bases
- Orientation:
- Plus strand
- chr6:107,077,441-107,116,292
- (GRCh37/hg19)
- Size:
- 38,852 bases
- Orientation:
- Plus strand
Genomic View for QRSL1 Gene
Genes around QRSL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Entrez Gene
- 6q21 by HGNC
- 6q21 by Ensembl
QRSL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for QRSL1 Gene
Proteins for QRSL1 Gene
-
Protein details for QRSL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0R6-GATA_HUMAN
- Recommended name:
- Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
- Protein Accession:
- Q9H0R6
- Q5VWJ4
- Q9HA60
- Q9NV19
Protein attributes for QRSL1 Gene
- Size:
- 528 amino acids
- Molecular mass:
- 57460 Da
- Quaternary structure:
-
- Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
- SequenceCaution:
-
- Sequence=CAH72094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for QRSL1 Gene
Post-translational modifications for QRSL1 Gene
Other Protein References for QRSL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for QRSL1
-
Abcam antibodies for QRSL1
- Invitrogen Antibodies for QRSL1 (AFLGC-QRSL1)
- GeneTex QRSL1 Antibody for QRSL1
-
Boster Bio Antibodies for QRSL1
Protein Products
-
OriGene Purified Proteins for QRSL1
- Search Origene for MassSpec and Protein Over-expression Lysates for QRSL1
- Origene Custom Protein Services for QRSL1
- Search GeneTex for Proteins for QRSL1
-
Abcam proteins for QRSL1
Assay Products
No data available for DME Specific Peptides for QRSL1 Gene
Domains & Families for QRSL1 Gene
Gene Families for QRSL1 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for QRSL1 Gene
Suggested Antigen Peptide Sequences for QRSL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H0R6- Family:
-
- Belongs to the amidase family. GatA subfamily.
Function for QRSL1 Gene
Molecular function for QRSL1 Gene
- UniProtKB/Swiss-Prot Function:
- Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
Enzyme Numbers (IUBMB) for QRSL1 Gene
Phenotypes From GWAS Catalog for QRSL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004040 | amidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 19805282 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
| GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | IDA | 19805282 |
Phenotypes for QRSL1 Gene
- GenomeRNAi human phenotypes for QRSL1:
-
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
Animal Model Products
-
Taconic Biosciences Mouse Models for QRSL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for QRSL1
-
CRISPR Products
-
OriGene CRISPR knockouts for QRSL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for QRSL1
- genomics-online: gRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
- Applied Biological Materials CRISPR for QRSL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for QRSL1
- GenScript: Design CRISPR guide RNA sequences for QRSL1
miRNA for QRSL1 Gene
- miRTarBase miRNAs that target QRSL1
-
- hsa-let-7b-5p (MIRT032250)
- hsa-mir-769-5p (MIRT039213)
- hsa-mir-200b-3p (MIRT053342)
- hsa-mir-3127-5p (MIRT483518)
- hsa-mir-6754-5p (MIRT483519)
- hsa-mir-4270 (MIRT483520)
- hsa-mir-4441 (MIRT483521)
- hsa-mir-211-3p (MIRT483522)
- hsa-mir-759 (MIRT483523)
- hsa-mir-4698 (MIRT483524)
- hsa-mir-8063 (MIRT483525)
- hsa-mir-892c-5p (MIRT483526)
- hsa-mir-4753-3p (MIRT619262)
- hsa-mir-6873-3p (MIRT619263)
- hsa-mir-8085 (MIRT619264)
- hsa-mir-6731-5p (MIRT619265)
- hsa-mir-130b-5p (MIRT619266)
- hsa-mir-6817-3p (MIRT619267)
- hsa-mir-7110-3p (MIRT619268)
- hsa-mir-6760-5p (MIRT619269)
- hsa-mir-10a-3p (MIRT629513)
- hsa-mir-4284 (MIRT674755)
- hsa-mir-4772-3p (MIRT674756)
- hsa-mir-4638-5p (MIRT674757)
- hsa-mir-1307-3p (MIRT674758)
- hsa-mir-1304-3p (MIRT674759)
- hsa-mir-6741-3p (MIRT674760)
- hsa-mir-6837-5p (MIRT674761)
- hsa-mir-4685-5p (MIRT674762)
- hsa-mir-7113-5p (MIRT674763)
- hsa-mir-6823-5p (MIRT674764)
- hsa-mir-6890-3p (MIRT674765)
- hsa-mir-1306-5p (MIRT674766)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for QRSL1
- Browse OriGene Inhibitory RNA Products For QRSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRSL1
- genomics-online: shRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for QRSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for QRSL1
- genomics-online: cdna clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
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- Overview of 94 available QRSL1 gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QRSL1 Gene
Localization for QRSL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for QRSL1 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 1 |
- Centrosome (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA,IDA | 19805282 |
| GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex | IDA | 19805282 |
Pathways & Interactions for QRSL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA Aminoacylation | ||
| 2 | Metabolism | ||
Pathways by source for QRSL1 Gene
2 KEGG pathways for QRSL1 Gene
Interacting Proteins for QRSL1 Gene
Selected Interacting proteins:
Q9H0R6-GATA_HUMAN
ENSP00000358042
for QRSL1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for QRSL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0031647 | regulation of protein stability | IEA | -- |
| GO:0032543 | mitochondrial translation | IMP,IEA | 19805282 |
| GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation | IDA | 19805282 |
No data available for SIGNOR curated interactions for QRSL1 Gene
Drugs & Compounds for QRSL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist | 251 | ||
| L-Glutamine | Approved, Investigational | Nutra | Full agonist, Agonist | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for QRSL1 Gene
mRNA/cDNA for QRSL1 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (174) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369046 4106 bps (uc003prm.4)
- ENST00000467262 413 bps (uc063qjg.1)
- ENST00000369044 2158 bps (uc003prl.3)
Unigene Clusters for QRSL1 Gene
- Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for QRSL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for QRSL1
- genomics-online: gRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
- Applied Biological Materials CRISPR for QRSL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for QRSL1
- GenScript: Design CRISPR guide RNA sequences for QRSL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for QRSL1
- Browse OriGene Inhibitory RNA Products For QRSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRSL1
- genomics-online: shRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for QRSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for QRSL1
- genomics-online: cdna clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
- orf clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
- Applied Biological Materials Clones for QRSL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - |
Expression for QRSL1 Gene
This gene is overexpressed in Heart (39.9), Plasma (13.3), and Lung (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QRSL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of QRSL1 Gene:
QRSL1SOURCE GeneReport for Unigene cluster for QRSL1 Gene:
Hs.406917Evidence on tissue expression from TISSUES for QRSL1 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for QRSL1
-
OriGene qPCR primer pairs and template standards for QRSL1
- genomics-online: primer clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRSL1 Gene
Orthologs for QRSL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | QRSL1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | QRSL1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | QRSL1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Qrsl1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Qrsl1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | QRSL1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | QRSL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | QRSL1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | QRSL1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | qrsl1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | qrsl1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | qrsl1 34 33 |
|
OneToOne | |
| Dr.12246 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004057 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gatA 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | Y41D4A.6 34 33 |
|
OneToOne | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A09845g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HER2 36 34 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABR140C 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G25660 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC646.03 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00660 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.13009 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13009 33 |
|
- Species where no ortholog for QRSL1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for QRSL1 Gene
- ENSEMBL:
- Gene Tree for QRSL1 (if available)
- TreeFam:
- Gene Tree for QRSL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for QRSL1: view image
Paralogs for QRSL1 Gene
Pseudogenes.org Pseudogenes for QRSL1 Gene
No data available for Paralogs for QRSL1 Gene
Variants for QRSL1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000110281 | -- | 106,645,234(+) | C/G | intron_variant | |
| rs1000327489 | -- | 106,632,391(+) | T/A | intron_variant | |
| rs1000415521 | -- | 106,637,416(+) | A/G | intron_variant | |
| rs1000474045 | -- | 106,657,460(+) | C/G/T | intron_variant | |
| rs1000527613 | -- | 106,657,129(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3610281 | CNV | loss | 21293372 |
| nsv1114860 | CNV | deletion | 24896259 |
| nsv1124109 | CNV | deletion | 24896259 |
| nsv1142470 | CNV | tandem duplication | 24896259 |
| nsv516902 | CNV | loss | 19592680 |
| nsv970157 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.66;
72.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for QRSL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRSL1 Gene
Disorders for QRSL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphogranuloma venereum |
|
|
| intestinal volvulus |
|
|
| mitochondrial disorders |
|
|
Search QRSL1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GATA_HUMAN- Note=Defects in QRSL1 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies. {ECO:0000269 PubMed:26741492}.
Additional Disease Information for QRSL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for QRSL1 Gene
Publications for QRSL1 Gene
- Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A … Suzuki T (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for QRSL1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
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- OriGene Purified Proteins for QRSL1
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- OriGene qPCR primer pairs for QRSL1
- OriGene qPCR primer pairs and template standards for QRSL1
- OriGene CRISPR knockouts for QRSL1
- OriGene ORF clones in human for QRSL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For QRSL1
- GenScript: Next-day shipping of latest version cDNA ORF clones for QRSL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for QRSL1
- GenScript Custom Assay Services for QRSL1
- GenScript Custom overexpressing Cell Line Services for QRSL1
- GenScript: Design CRISPR guide RNA sequences for QRSL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for QRSL1
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for QRSL1
- Novus Biologicals proteins and lysates for QRSL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Taconic Biosciences Mouse Models for QRSL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for QRSL1 (AFLGC-QRSL1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for QRSL1
- antibodies-online: Search results for 36 available QRSL1 Antibodies ranked by validation data
- Compare Top QRSL1 Antibodies
- antibodies-online: Search results for 5 available QRSL1 Elisa Kits ranked by validation data
- Compare Top QRSL1 Elisa Kits
- antibodies-online: Search results for 9 available QRSL1 Proteins ranked by validation data
- Compare Top QRSL1 Proteins
- GeneTex QRSL1 Antibody for QRSL1
- Search GeneTex for Proteins for QRSL1
- genomics-online: cdna clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
- Recommended
- orf clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
- Recommended
- genomics-online: primer clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 94 available QRSL1 gene related products
- Overview of 94 available QRSL1 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for QRSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for QRSL1
- GeneCopoeia miRNA 3'UTR Target clone products for QRSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRSL1
- Boster Bio Antibodies for QRSL1
- Browse Boster Bio ELISA Kits
Sources for QRSL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt