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Aliases for QRICH2 Gene

Aliases for QRICH2 Gene

  • Glutamine Rich 2 2 3 5
  • Glutamine-Rich Protein 2 3

External Ids for QRICH2 Gene

Previous GeneCards Identifiers for QRICH2 Gene

  • GC17M071782
  • GC17M074262
  • GC17M069698

Summaries for QRICH2 Gene

GeneCards Summary for QRICH2 Gene

QRICH2 (Glutamine Rich 2) is a Protein Coding gene. An important paralog of this gene is C16orf96.

Additional gene information for QRICH2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRICH2 Gene

Genomics for QRICH2 Gene

GeneHancer (GH) Regulatory Elements for QRICH2 Gene

Promoters and enhancers for QRICH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076258 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.1 +40.7 40715 19.6 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A UBALD2 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 METTL23 MFSD11 EXOC7
GH17J076352 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 -45.3 -45342 2.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PRPSAP1 UNK SRSF2 METTL23 ENSG00000266980 SEPT9 MFSD11 ENSG00000267342 EXOC7 SAP30BP
GH17J076238 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 +68.0 68016 3.6 ATF1 ARNT SIN3A ZNF2 ZNF48 YY1 POLR2B GLIS2 FOS ATF7 RNF157 UBALD2 FOXJ1 QRICH2 AANAT UBE2O LOC105371896
GH17J076245 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.9 +61.8 61762 2.6 HDGF PKNOX1 FOXA2 MLX ARNT IRF4 ZNF766 ZNF213 ZNF143 JUNB RNF157 QRICH2 LOC105371896
GH17J076465 Enhancer 1.1 Ensembl ENCODE 11.1 -157.5 -157492 0.8 RB1 ARID4B SIN3A DMAP1 ZSCAN9 RAD21 RARA SLC30A9 ZNF614 ARID2 PRCD CYGB QRICH2 GC17P076469 GC17M076452 AANAT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QRICH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QRICH2 gene promoter:
  • YY1
  • PPAR-gamma2
  • PPAR-gamma1
  • Arnt
  • AhR
  • STAT5A
  • CUTL1
  • GATA-3

Genomic Locations for QRICH2 Gene

Genomic Locations for QRICH2 Gene
34,642 bases
Minus strand
33,632 bases
Minus strand

Genomic View for QRICH2 Gene

Genes around QRICH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRICH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRICH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRICH2 Gene

Proteins for QRICH2 Gene

  • Protein details for QRICH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamine-rich protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RRE1
    • Q96LM3

    Protein attributes for QRICH2 Gene

    1663 amino acids
    Molecular mass:
    180827 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71667.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for QRICH2 Gene


neXtProt entry for QRICH2 Gene

Post-translational modifications for QRICH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for QRICH2 Gene

Domains & Families for QRICH2 Gene

Gene Families for QRICH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for QRICH2 Gene


Suggested Antigen Peptide Sequences for QRICH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with QRICH2: view

No data available for UniProtKB/Swiss-Prot for QRICH2 Gene

Function for QRICH2 Gene

Phenotypes From GWAS Catalog for QRICH2 Gene

genes like me logo Genes that share phenotypes with QRICH2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for QRICH2 Gene

Localization for QRICH2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRICH2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for QRICH2 Gene

Pathways & Interactions for QRICH2 Gene

SuperPathways for QRICH2 Gene

No Data Available

Interacting Proteins for QRICH2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262765 Q9H0J4-QRIC2_HUMAN for QRICH2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for QRICH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for QRICH2 Gene

Drugs & Compounds for QRICH2 Gene

No Compound Related Data Available

Transcripts for QRICH2 Gene

mRNA/cDNA for QRICH2 Gene

Unigene Clusters for QRICH2 Gene

Glutamine rich 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH2

Alternative Splicing Database (ASD) splice patterns (SP) for QRICH2 Gene

No ASD Table

Relevant External Links for QRICH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QRICH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QRICH2 Gene

mRNA differential expression in normal tissues according to GTEx for QRICH2 Gene

This gene is overexpressed in Testis (x8.2).

Protein differential expression in normal tissues from HIPED for QRICH2 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for QRICH2 Gene

Protein tissue co-expression partners for QRICH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of QRICH2 Gene:


SOURCE GeneReport for Unigene cluster for QRICH2 Gene:

genes like me logo Genes that share expression patterns with QRICH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRICH2 Gene

Orthologs for QRICH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for QRICH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QRICH2 34 33
  • 98.44 (n)
(Mus musculus)
Mammalia Qrich2 16 34 33
  • 82.63 (n)
(Canis familiaris)
Mammalia QRICH2 34 33
  • 81.37 (n)
(Bos Taurus)
Mammalia QRICH2 34 33
  • 73.92 (n)
(Rattus norvegicus)
Mammalia Qrich2 33
  • 67.46 (n)
(Ornithorhynchus anatinus)
Mammalia QRICH2 34
  • 57 (a)
(Monodelphis domestica)
Mammalia QRICH2 34
  • 24 (a)
(Anolis carolinensis)
Reptilia QRICH2 34
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for QRICH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QRICH2 Gene

Gene Tree for QRICH2 (if available)
Gene Tree for QRICH2 (if available)
Evolutionary constrained regions (ECRs) for QRICH2: view image

Paralogs for QRICH2 Gene

Paralogs for QRICH2 Gene

(40) SIMAP similar genes for QRICH2 Gene using alignment to 4 proteins:

  • H7C0E3_HUMAN
genes like me logo Genes that share paralogs with QRICH2: view

Variants for QRICH2 Gene

Sequence variations from dbSNP and Humsavar for QRICH2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000058997 -- 76,306,931(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000272203 -- 76,310,421(-) C/T upstream_transcript_variant
rs1000295439 -- 76,273,222(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000334016 -- 76,277,859(-) TCTCTC/TC intron_variant
rs1000401798 -- 76,282,925(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QRICH2 Gene

Variant ID Type Subtype PubMed ID
esv21573 CNV loss 19812545
esv2430837 CNV deletion 19546169
esv2656914 CNV deletion 23128226
esv2670769 CNV deletion 23128226
esv2671805 CNV deletion 23128226
esv2673666 CNV deletion 23128226
esv2716250 CNV deletion 23290073
esv2716253 CNV deletion 23290073
esv3554793 CNV deletion 23714750
esv3554794 CNV deletion 23714750
esv3641280 CNV loss 21293372
esv3641281 CNV loss 21293372
esv3641282 CNV loss 21293372
esv3641283 CNV loss 21293372
nsv1139680 CNV duplication 24896259
nsv512502 CNV loss 21212237
nsv833547 CNV loss 17160897

Variation tolerance for QRICH2 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.46; 99.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRICH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRICH2 Gene

Disorders for QRICH2 Gene

Additional Disease Information for QRICH2

No disorders were found for QRICH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRICH2 Gene

Publications for QRICH2 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  2. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) Köttgen A … Gieger C (Nature genetics 2013) 3 58
  3. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PMID: 19367720) Carrascal M … Abian J (Journal of proteome research 2008) 4 58
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing RM … Figeys D (Molecular systems biology 2007) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for QRICH2 Gene

Sources for QRICH2 Gene

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