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Aliases for QRICH1 Gene

Aliases for QRICH1 Gene

  • Glutamine Rich 1 2 3 5
  • Glutamine-Rich Protein 1 3
  • Glutamine-Rich 1 2

External Ids for QRICH1 Gene

Previous GeneCards Identifiers for QRICH1 Gene

  • GC03M049043
  • GC03M049044
  • GC03M049046
  • GC03M049048
  • GC03M049051
  • GC03M049067
  • GC03M049074
  • GC03M049081
  • GC03M049086
  • GC03M049091
  • GC03M049097
  • GC03M049103
  • GC03M049113
  • GC03M049122

Summaries for QRICH1 Gene

GeneCards Summary for QRICH1 Gene

QRICH1 (Glutamine Rich 1) is a Protein Coding gene. Diseases associated with QRICH1 include Ververi-Brady Syndrome. An important paralog of this gene is ZMYM4.

Gene Wiki entry for QRICH1 Gene

Additional gene information for QRICH1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRICH1 Gene

Genomics for QRICH1 Gene

GeneHancer (GH) Regulatory Elements for QRICH1 Gene

Promoters and enhancers for QRICH1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049092 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.7 652 3.3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 QRICH1 WDR6 RBM6 RN7SL182P
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 62.6 -251.7 -251687 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 RBM6 RBM5 IP6K2 ATRIP USP19 WDR6 BSN-AS1
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 45.8 +74.1 74102 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 GC03M049024 MIR191 NDUFAF3 MIR425 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
GH03J048239 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.1 +853.4 853439 2.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF589 GC03M048234 QRICH1 PTPN23 NME6 ATRIP IP6K2 CCDC71 USP19 MRPS18AP1
GH03J048186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 44.1 +906.4 906448 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 FOS CDC25A ZNF589 QRICH1 ATRIP USP19 TMEM89 CCDC71 PTPN23 NME6 MRPS18AP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QRICH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QRICH1 gene promoter:
  • Olf-1
  • MEF-2A
  • aMEF-2
  • Sp1
  • USF2
  • USF1
  • USF-1:USF-2
  • USF-1
  • Pax-5
  • Egr-1

Genomic Locations for QRICH1 Gene

Genomic Locations for QRICH1 Gene
64,657 bases
Minus strand
64,657 bases
Minus strand

Genomic View for QRICH1 Gene

Genes around QRICH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRICH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRICH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRICH1 Gene

Proteins for QRICH1 Gene

  • Protein details for QRICH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • Q4G0F7
    • Q7L621
    • Q8TEA5

    Protein attributes for QRICH1 Gene

    776 amino acids
    Molecular mass:
    86436 Da
    Quaternary structure:
    No Data Available

neXtProt entry for QRICH1 Gene

Post-translational modifications for QRICH1 Gene

  • Ubiquitination at Lys712, posLast=495495, posLast=489489, and posLast=2828
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for QRICH1 Gene

Domains & Families for QRICH1 Gene

Gene Families for QRICH1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for QRICH1 Gene


Suggested Antigen Peptide Sequences for QRICH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with QRICH1: view

No data available for UniProtKB/Swiss-Prot for QRICH1 Gene

Function for QRICH1 Gene

Phenotypes From GWAS Catalog for QRICH1 Gene

Gene Ontology (GO) - Molecular Function for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with QRICH1: view
genes like me logo Genes that share phenotypes with QRICH1: view

Animal Model Products

CRISPR Products

miRNA for QRICH1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QRICH1 Gene

Localization for QRICH1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRICH1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with QRICH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for QRICH1 Gene

Pathways & Interactions for QRICH1 Gene

SuperPathways for QRICH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007010 cytoskeleton organization IBA --
GO:0007275 multicellular organism development IBA --
GO:0008150 biological_process ND --
GO:0022604 regulation of cell morphogenesis IBA --
genes like me logo Genes that share ontologies with QRICH1: view

No data available for Pathways by source and SIGNOR curated interactions for QRICH1 Gene

Drugs & Compounds for QRICH1 Gene

No Compound Related Data Available

Transcripts for QRICH1 Gene

Unigene Clusters for QRICH1 Gene

Glutamine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QRICH1 Gene

No ASD Table

Relevant External Links for QRICH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QRICH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QRICH1 Gene

Protein differential expression in normal tissues from HIPED for QRICH1 Gene

This gene is overexpressed in Lymph node (10.3), CD8 Tcells (9.4), and CD4 Tcells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QRICH1 Gene

Protein tissue co-expression partners for QRICH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QRICH1 Gene:


SOURCE GeneReport for Unigene cluster for QRICH1 Gene:


Evidence on tissue expression from TISSUES for QRICH1 Gene

  • Nervous system(4.4)
  • Skin(4.3)
  • Liver(4.2)
  • Adrenal gland(2.1)
  • Bone marrow(2.1)
  • Kidney(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with QRICH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRICH1 Gene

Orthologs for QRICH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for QRICH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QRICH1 34 33
  • 99.79 (n)
(Canis familiaris)
Mammalia QRICH1 34 33
  • 94.54 (n)
(Bos Taurus)
Mammalia QRICH1 34 33
  • 94.07 (n)
(Ornithorhynchus anatinus)
Mammalia QRICH1 34
  • 93 (a)
(Mus musculus)
Mammalia Qrich1 16 34 33
  • 92.1 (n)
(Rattus norvegicus)
Mammalia Qrich1 33
  • 91.79 (n)
(Monodelphis domestica)
Mammalia QRICH1 34
  • 91 (a)
(Gallus gallus)
Aves QRICH1 34 33
  • 83.29 (n)
(Anolis carolinensis)
Reptilia QRICH1 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497567 33
  • 56.96 (n)
Str.6077 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68761 33
(Danio rerio)
Actinopterygii qrich1 34 33
  • 68.38 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7441 33
fruit fly
(Drosophila melanogaster)
Insecta woc 34
  • 11 (a)
Species where no ortholog for QRICH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QRICH1 Gene

Gene Tree for QRICH1 (if available)
Gene Tree for QRICH1 (if available)
Evolutionary constrained regions (ECRs) for QRICH1: view image

Paralogs for QRICH1 Gene

Paralogs for QRICH1 Gene

genes like me logo Genes that share paralogs with QRICH1: view

Variants for QRICH1 Gene

Sequence variations from dbSNP and Humsavar for QRICH1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000069161 -- 49,080,791(-) T/C intron_variant
rs1000107605 -- 49,083,732(-) C/T intron_variant
rs1000126447 -- 49,088,057(-) G/T intron_variant
rs1000213530 -- 49,069,269(-) C/T intron_variant
rs1000225119 -- 49,038,856(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QRICH1 Gene

Variant ID Type Subtype PubMed ID
esv2664917 CNV deletion 23128226
esv3400252 CNV insertion 20981092
esv3596118 CNV loss 21293372
nsv834686 CNV loss 17160897
nsv955614 CNV deletion 24416366

Variation tolerance for QRICH1 Gene

Residual Variation Intolerance Score: 5.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRICH1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRICH1 Gene

Disorders for QRICH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for QRICH1 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
ververi-brady syndrome
  • verbras
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for QRICH1

genes like me logo Genes that share disorders with QRICH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for QRICH1 Gene

Publications for QRICH1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for QRICH1 Gene

Sources for QRICH1 Gene

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