Aliases for QRICH1 Gene

Aliases for QRICH1 Gene

  • Glutamine Rich 1 2 3 5
  • Glutamine-Rich Protein 1 3 4
  • VERBRAS 3
  • AB-DIP 3

External Ids for QRICH1 Gene

Previous GeneCards Identifiers for QRICH1 Gene

  • GC03M049043
  • GC03M049044
  • GC03M049046
  • GC03M049048
  • GC03M049051
  • GC03M049067
  • GC03M049074
  • GC03M049081
  • GC03M049147
  • GC03M049154
  • GC03M049086
  • GC03M049091
  • GC03M049097
  • GC03M049103
  • GC03M049113
  • GC03M049122
  • GC03M049128
  • GC03M049138

Summaries for QRICH1 Gene

GeneCards Summary for QRICH1 Gene

QRICH1 (Glutamine Rich 1) is a Protein Coding gene. Diseases associated with QRICH1 include Ververi-Brady Syndrome and Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy. An important paralog of this gene is ZMYM4.

Gene Wiki entry for QRICH1 Gene

Additional gene information for QRICH1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for QRICH1 Gene

Genomics for QRICH1 Gene

GeneHancer (GH) Regulatory Elements for QRICH1 Gene

Promoters and enhancers for QRICH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QRICH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QRICH1 gene promoter:
  • aMEF-2
  • Egr-1
  • MEF-2A
  • Olf-1
  • Pax-5
  • Sp1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for QRICH1 Gene

Genomic Locations for QRICH1 Gene
chr3:49,029,707-49,094,363
(GRCh38/hg38)
Size:
64,657 bases
Orientation:
Minus strand
chr3:49,067,140-49,131,796
(GRCh37/hg19)
Size:
64,657 bases
Orientation:
Minus strand

Genomic View for QRICH1 Gene

Genes around QRICH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRICH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRICH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRICH1 Gene

Proteins for QRICH1 Gene

  • Protein details for QRICH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAL8-QRIC1_HUMAN
    Recommended name:
    Glutamine-rich protein 1
    Protein Accession:
    Q2TAL8
    Secondary Accessions:
    • Q4G0F7
    • Q7L621
    • Q8TEA5

    Protein attributes for QRICH1 Gene

    Size:
    776 amino acids
    Molecular mass:
    86436 Da
    Quaternary structure:
    No Data Available

neXtProt entry for QRICH1 Gene

Post-translational modifications for QRICH1 Gene

  • Ubiquitination at Lys28, Lys489, Lys495, and Lys712
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for QRICH1 Gene

Domains & Families for QRICH1 Gene

Gene Families for QRICH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for QRICH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QRICH1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77780 (A1L3Z9_HUMAN)
  • Glutamine-rich protein 1 (QRIC1_HUMAN)
genes like me logo Genes that share domains with QRICH1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for QRICH1 Gene

Function for QRICH1 Gene

Phenotypes From GWAS Catalog for QRICH1 Gene

Gene Ontology (GO) - Molecular Function for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with QRICH1: view
genes like me logo Genes that share phenotypes with QRICH1: view

Human Phenotype Ontology for QRICH1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for QRICH1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for QRICH1 Gene

Localization for QRICH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRICH1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with QRICH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for QRICH1 Gene

Pathways & Interactions for QRICH1 Gene

PathCards logo

SuperPathways for QRICH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008150 biological_process ND --
GO:0022604 regulation of cell morphogenesis IBA 21873635
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with QRICH1: view

No data available for Pathways by source and SIGNOR curated interactions for QRICH1 Gene

Drugs & Compounds for QRICH1 Gene

No Compound Related Data Available

Transcripts for QRICH1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRICH1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QRICH1 Gene

No ASD Table

Relevant External Links for QRICH1 Gene

GeneLoc Exon Structure for
QRICH1
ECgene alternative splicing isoforms for
QRICH1

Expression for QRICH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QRICH1 Gene

Protein differential expression in normal tissues from HIPED for QRICH1 Gene

This gene is overexpressed in Lymph node (10.3), CD8 Tcells (9.4), and CD4 Tcells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QRICH1 Gene



Protein tissue co-expression partners for QRICH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QRICH1 Gene:

QRICH1

SOURCE GeneReport for Unigene cluster for QRICH1 Gene:

Hs.297389

Evidence on tissue expression from TISSUES for QRICH1 Gene

  • Nervous system(4.4)
  • Skin(4.3)
  • Liver(4.2)
  • Adrenal gland(2.1)
  • Bone marrow(2.1)
  • Kidney(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with QRICH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRICH1 Gene

Orthologs for QRICH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for QRICH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QRICH1 33 32
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia QRICH1 33 32
  • 94.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia QRICH1 33 32
  • 94.07 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QRICH1 33
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qrich1 17 33 32
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia Qrich1 32
  • 91.79 (n)
oppossum
(Monodelphis domestica)
Mammalia QRICH1 33
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves QRICH1 33 32
  • 83.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QRICH1 33
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497567 32
  • 56.96 (n)
Str.6077 32
African clawed frog
(Xenopus laevis)
Amphibia MGC68761 32
zebrafish
(Danio rerio)
Actinopterygii qrich1 33 32
  • 68.38 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7441 32
fruit fly
(Drosophila melanogaster)
Insecta woc 33
  • 11 (a)
OneToMany
Species where no ortholog for QRICH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QRICH1 Gene

ENSEMBL:
Gene Tree for QRICH1 (if available)
TreeFam:
Gene Tree for QRICH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for QRICH1: view image

Paralogs for QRICH1 Gene

genes like me logo Genes that share paralogs with QRICH1: view

Variants for QRICH1 Gene

Sequence variations from dbSNP and Humsavar for QRICH1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1236702036 pathogenic, VERVERI-BRADY SYNDROME 49,032,715(-) G/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs1553738605 pathogenic, VERVERI-BRADY SYNDROME 49,032,716(-) C/CC coding_sequence_variant, frameshift
rs1553747119 pathogenic, VERVERI-BRADY SYNDROME 49,076,879(-) GC/AA coding_sequence_variant, stop_gained
rs1559930732 pathogenic, VERVERI-BRADY SYNDROME 49,046,490(-) G/A coding_sequence_variant, stop_gained
rs1559931177 pathogenic, VERVERI-BRADY SYNDROME 49,047,207(-) G/A coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for QRICH1 Gene

Variant ID Type Subtype PubMed ID
esv2664917 CNV deletion 23128226
esv3400252 CNV insertion 20981092
esv3596118 CNV loss 21293372
nsv834686 CNV loss 17160897
nsv955614 CNV deletion 24416366

Variation tolerance for QRICH1 Gene

Residual Variation Intolerance Score: 5.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRICH1 Gene

Human Gene Mutation Database (HGMD)
QRICH1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QRICH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRICH1 Gene

Disorders for QRICH1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for QRICH1 Gene - From: HGMD, OMIM, ClinVar, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

QRIC1_HUMAN
  • Ververi-Brady syndrome (VERBRAS) [MIM:617982]: An autosomal dominant disorder characterized by mild developmental delay and intellectual disability, speech delay, learning difficulties, autistic features, and mild facial dysmorphism. {ECO:0000269 PubMed:28692176}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for QRICH1

genes like me logo Genes that share disorders with QRICH1: view

No data available for Genatlas for QRICH1 Gene

Publications for QRICH1 Gene

  1. Phenotypic spectrum associated with de novo mutations in QRICH1 gene. (PMID: 28692176) Ververi A … Brady AF (Clinical genetics 2018) 2 3 4 56
  2. Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. (PMID: 15923395) Lakshmana MK … Tabira T (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for QRICH1 Gene

Sources for QRICH1 Gene