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Aliases for QRFPR Gene

Aliases for QRFPR Gene

  • Pyroglutamylated RFamide Peptide Receptor 2 3 3 5
  • Orexigenic Neuropeptide QRFP Receptor 3 4
  • G-Protein Coupled Receptor 103 3 4
  • Peptide P518 Receptor 2 3
  • GPR103 3 4
  • SP9155 3 4
  • AQ27 3 4
  • G Protein-Coupled Receptor 103 2
  • QRFP Receptor 3

External Ids for QRFPR Gene

Previous HGNC Symbols for QRFPR Gene

  • GPR103

Previous GeneCards Identifiers for QRFPR Gene

  • GC04M122472
  • GC04M122249
  • GC04M117976

Summaries for QRFPR Gene

GeneCards Summary for QRFPR Gene

QRFPR (Pyroglutamylated RFamide Peptide Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR2.

UniProtKB/Swiss-Prot for QRFPR Gene

  • Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Wiki entry for QRFPR Gene

Additional gene information for QRFPR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRFPR Gene

Genomics for QRFPR Gene

GeneHancer (GH) Regulatory Elements for QRFPR Gene

Promoters and enhancers for QRFPR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J121380 Promoter/Enhancer 1.3 EPDnew Ensembl 664.8 +0.2 235 0.9 MZF1 ZNF335 GLIS2 ZNF213 ZNF366 SP3 ZNF398 ZEB2 ZNF610 GLIS1 QRFPR LOC100418710
GH04J121358 Enhancer 0.5 ENCODE 28.9 +22.4 22428 1 JUND JUN CEBPB FOXP2 FOS EP300 TRIM28 QRFPR LOC100418710 ENSG00000207148
GH04J121727 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.9 -347.3 -347332 2.3 CTCF JUND ZFP3 CEBPB FOSL2 FOS ANXA5 PP12613 TMEM155 QRFPR
GH04J121449 Enhancer 0.3 FANTOM5 11.2 -68.6 -68613 0.3 TUBB4BP5 QRFPR
GH04J121554 Enhancer 0.2 ENCODE 4.9 -174.0 -173999 2 QRFPR LOC105377401 LOC105377402
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QRFPR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QRFPR gene promoter:
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • LHX3b
  • Lhx3a
  • POU6F1 (c2)
  • GR
  • GR-alpha
  • GR-beta
  • HEN1

Genomic Locations for QRFPR Gene

Genomic Locations for QRFPR Gene
53,849 bases
Minus strand
52,418 bases
Minus strand

Genomic View for QRFPR Gene

Genes around QRFPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRFPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRFPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFPR Gene

Proteins for QRFPR Gene

  • Protein details for QRFPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyroglutamylated RFamide peptide receptor
    Protein Accession:

    Protein attributes for QRFPR Gene

    431 amino acids
    Molecular mass:
    49488 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for QRFPR Gene

Post-translational modifications for QRFPR Gene

  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for QRFPR Gene

No data available for DME Specific Peptides for QRFPR Gene

Domains & Families for QRFPR Gene

Gene Families for QRFPR Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for QRFPR Gene

Suggested Antigen Peptide Sequences for QRFPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with QRFPR: view

Function for QRFPR Gene

Molecular function for QRFPR Gene

UniProtKB/Swiss-Prot Function:
Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Phenotypes From GWAS Catalog for QRFPR Gene

Gene Ontology (GO) - Molecular Function for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 12960173
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with QRFPR: view
genes like me logo Genes that share phenotypes with QRFPR: view

Animal Models for QRFPR Gene

MGI Knock Outs for QRFPR:

Animal Model Products

  • Taconic Biosciences Mouse Models for QRFPR

miRNA for QRFPR Gene

miRTarBase miRNAs that target QRFPR

Clone Products

  • Addgene plasmids for QRFPR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QRFPR Gene

Localization for QRFPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRFPR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 12960173
genes like me logo Genes that share ontologies with QRFPR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for QRFPR Gene

Pathways & Interactions for QRFPR Gene

genes like me logo Genes that share pathways with QRFPR: view

Gene Ontology (GO) - Biological Process for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:1901652 response to peptide IBA --
genes like me logo Genes that share ontologies with QRFPR: view

No data available for SIGNOR curated interactions for QRFPR Gene

Drugs & Compounds for QRFPR Gene

(4) Drugs for QRFPR Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
[<sup>125</sup>I]QRFP (human) Pharma Full agonist, Agonist 0
QRFP Pharma Full agonist, Agonist 0
QRFP26 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with QRFPR: view

Transcripts for QRFPR Gene

mRNA/cDNA for QRFPR Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for QRFPR Gene

Pyroglutamylated RFamide peptide receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for QRFPR

Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -

Relevant External Links for QRFPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QRFPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QRFPR Gene

mRNA differential expression in normal tissues according to GTEx for QRFPR Gene

This gene is overexpressed in Brain - Hypothalamus (x15.1), Heart - Left Ventricle (x7.6), and Kidney - Cortex (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of QRFPR Gene:


SOURCE GeneReport for Unigene cluster for QRFPR Gene:


mRNA Expression by UniProt/SwissProt for QRFPR Gene:

Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.

Evidence on tissue expression from TISSUES for QRFPR Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with QRFPR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRFPR Gene

Orthologs for QRFPR Gene

This gene was present in the common ancestor of animals.

Orthologs for QRFPR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QRFPR 34 33
  • 99.3 (n)
(Canis familiaris)
Mammalia QRFPR 34 33
  • 90.1 (n)
(Bos Taurus)
Mammalia QRFPR 34 33
  • 89.79 (n)
(Mus musculus)
Mammalia Qrfpr 16 34 33
  • 84.45 (n)
C130060K24Rik 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Qrfpr 33
  • 84.15 (n)
(Monodelphis domestica)
Mammalia QRFPR 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia QRFPR 34
  • 78 (a)
(Gallus gallus)
Aves GPR103 34
  • 78 (a)
  • 77.41 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
-- 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia qrfpr 33
  • 75.04 (n)
Str.17272 33
(Danio rerio)
Actinopterygii LOC100149491 33
  • 65.41 (n)
CABZ01084347.1 34
  • 63 (a)
qrfpra 34
  • 63 (a)
QRFPR (3 of 3) 34
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIFR 34
  • 13 (a)
Species where no ortholog for QRFPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QRFPR Gene

Gene Tree for QRFPR (if available)
Gene Tree for QRFPR (if available)
Evolutionary constrained regions (ECRs) for QRFPR: view image

Paralogs for QRFPR Gene

Paralogs for QRFPR Gene

(17) SIMAP similar genes for QRFPR Gene using alignment to 5 proteins:

  • A1A4W1_HUMAN
  • F2Z3L3_HUMAN
  • G4XH69_HUMAN
genes like me logo Genes that share paralogs with QRFPR: view

Variants for QRFPR Gene

Sequence variations from dbSNP and Humsavar for QRFPR Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000001113 -- 121,340,664(-) T/G intron_variant
rs1000033658 -- 121,340,855(-) C/T intron_variant
rs1000093056 -- 121,357,317(-) C/T intron_variant
rs1000111907 -- 121,374,152(-) G/A intron_variant
rs1000125285 -- 121,332,798(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QRFPR Gene

Variant ID Type Subtype PubMed ID
dgv125e203 CNV loss 21179565
dgv151n73 CNV deletion 24416366
dgv1524e212 CNV loss 25503493
dgv1525e212 CNV loss 25503493
dgv1526e212 CNV loss 25503493
dgv198n111 CNV deletion 26073780
dgv2896n106 CNV deletion 24896259
dgv5376n100 CNV loss 25217958
dgv5377n100 CNV loss 25217958
dgv5378n100 CNV loss 25217958
dgv894n67 CNV loss 20364138
dgv9251n54 CNV loss 21841781
dgv9252n54 CNV loss 21841781
dgv9253n54 CNV loss 21841781
dgv972e199 CNV deletion 23128226
esv1499673 CNV deletion 17803354
esv2385732 CNV deletion 18987734
esv2421795 CNV deletion 20811451
esv2533163 CNV loss 19546169
esv2539204 CNV deletion 19546169
esv25515 CNV loss 19812545
esv2728254 CNV deletion 23290073
esv3564541 CNV deletion 23714750
esv3569681 CNV loss 25503493
esv3602006 CNV loss 21293372
esv3602007 CNV loss 21293372
esv3894019 CNV loss 25118596
nsv10559 CNV loss 18304495
nsv10560 CNV loss 18304495
nsv1161140 CNV deletion 26073780
nsv1161141 CNV deletion 26073780
nsv292673 CNV deletion 16902084
nsv437422 CNV loss 16327808
nsv442920 CNV loss 18776908
nsv4494 CNV deletion 18451855
nsv499065 CNV loss 21111241
nsv508308 CNV deletion 20534489
nsv514249 CNV loss 21397061
nsv516414 CNV loss 19592680
nsv528104 CNV loss 19592680
nsv595335 CNV loss 21841781
nsv595343 CNV loss 21841781
nsv595350 CNV loss 21841781
nsv963992 CNV deletion 23825009
nsv966316 CNV duplication 23825009

Variation tolerance for QRFPR Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.83; 94.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRFPR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRFPR Gene

Disorders for QRFPR Gene

Additional Disease Information for QRFPR

No disorders were found for QRFPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRFPR Gene

Publications for QRFPR Gene

  1. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S … Fujino M (The Journal of biological chemistry 2003) 3 4 22 58
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 58
  3. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PMID: 12714592) Jiang Y … Zhang FL (The Journal of biological chemistry 2003) 3 4 58
  4. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103. (PMID: 26211894) Rouméas L … Bihel F (Peptides 2015) 3 58
  5. GPR103b functions in the peripheral regulation of adipogenesis. (PMID: 20534693) Mulumba M … Ong H (Molecular endocrinology (Baltimore, Md.) 2010) 3 58

Products for QRFPR Gene

Sources for QRFPR Gene

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