Aliases for QRFPR Gene

Aliases for QRFPR Gene

  • Pyroglutamylated RFamide Peptide Receptor 2 3 5
  • Pyroglutamylated RF-Amide Peptide Receptor 3 4
  • Orexigenic Neuropeptide QRFP Receptor 3 4
  • G-Protein Coupled Receptor 103 3 4
  • Peptide P518 Receptor 2 3
  • GPR103 3 4
  • SP9155 3 4
  • AQ27 3 4
  • G Protein-Coupled Receptor 103 2
  • QRFP Receptor 3
  • QRFPR 5

External Ids for QRFPR Gene

Previous HGNC Symbols for QRFPR Gene

  • GPR103

Previous GeneCards Identifiers for QRFPR Gene

  • GC04M122472
  • GC04M122249
  • GC04M117976

Summaries for QRFPR Gene

GeneCards Summary for QRFPR Gene

QRFPR (Pyroglutamylated RFamide Peptide Receptor) is a Protein Coding gene. Diseases associated with QRFPR include Allergic Urticaria. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR2.

UniProtKB/Swiss-Prot Summary for QRFPR Gene

  • Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Wiki entry for QRFPR Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for QRFPR Gene

Genomics for QRFPR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for QRFPR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J121380 Promoter 1.3 EPDnew Ensembl 264.8 +0.6 558 1.8 ZNF600 ZIC2 ZBTB10 ZNF341 KLF9 ZNF610 SP2 ZBTB48 ZFP37 GLIS1 QRFPR ENSG00000213480 lnc-TNIP3-2 TNIP3
GH04J121358 Enhancer 0.6 Ensembl ENCODE 28.9 +22.4 22386 1.1 JUND CEBPB EP300 ATF3 FOS QRFPR LOC100418710 ENSG00000207148 HSALNG0036804 TNIP3
GH04J121726 Enhancer 1 Ensembl ENCODE dbSUPER 9.9 -346.7 -346718 3.6 ZNF654 JUND CEBPB REST TRIM22 CTCF RAD21 SMC3 YY1 SMARCA5 ANXA5 PP12613 SMIM43 QRFPR HSALNG0036819 piR-61514-131
GH04J121252 Enhancer 1.2 FANTOM5 Ensembl ENCODE 5.1 +125.9 125869 6 BCLAF1 ZNF654 JUND BCL11A CTCF REST CEBPB TRIM22 RAD21 RFX5 TNIP3 QRFPR piR-49423-187 HSALNG0036804
GH04J121454 Enhancer 0.4 Ensembl ENCODE 10.3 -73.8 -73842 1.4 POLR2A QRFPR TUBB4BP5 HSALNG0036806-001 lnc-EXOSC9-48 piR-39416-037 LOC107986309 ANXA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QRFPR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for QRFPR

Top Transcription factor binding sites by QIAGEN in the QRFPR gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Lhx3a
  • LHX3b
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for QRFPR Gene

Latest Assembly
chr4:121,328,642-121,381,059
(GRCh38/hg38)
Size:
52,418 bases
Orientation:
Minus strand

Previous Assembly
chr4:122,249,797-122,302,173
(GRCh37/hg19 by Entrez Gene)
Size:
52,377 bases
Orientation:
Minus strand

chr4:122,250,467-122,302,214
(GRCh37/hg19 by Ensembl)
Size:
51,748 bases
Orientation:
Minus strand

Genomic View for QRFPR Gene

Genes around QRFPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRFPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRFPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFPR Gene

Proteins for QRFPR Gene

  • Protein details for QRFPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P65-QRFPR_HUMAN
    Recommended name:
    Pyroglutamylated RF-amide peptide receptor
    Protein Accession:
    Q96P65

    Protein attributes for QRFPR Gene

    Size:
    431 amino acids
    Molecular mass:
    49488 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for QRFPR Gene

Post-translational modifications for QRFPR Gene

  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for QRFPR Gene

No data available for DME Specific Peptides for QRFPR Gene

Domains & Families for QRFPR Gene

Gene Families for QRFPR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for QRFPR Gene

InterPro:
Blocks:
  • Neuropeptide Y receptor signature

Suggested Antigen Peptide Sequences for QRFPR Gene

GenScript: Design optimal peptide antigens:
  • QRFPR protein (A1A4W1_HUMAN)
  • SP9155 (QRFPR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P65

UniProtKB/Swiss-Prot:

QRFPR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with QRFPR: view

Function for QRFPR Gene

Molecular function for QRFPR Gene

UniProtKB/Swiss-Prot Function:
Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Phenotypes From GWAS Catalog for QRFPR Gene

Gene Ontology (GO) - Molecular Function for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,IDA 12960173
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with QRFPR: view
genes like me logo Genes that share phenotypes with QRFPR: view

Animal Models for QRFPR Gene

MGI Knock Outs for QRFPR:

Animal Models for research

  • Taconic Biosciences Mouse Models for QRFPR

miRNA for QRFPR Gene

miRTarBase miRNAs that target QRFPR

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRFPR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QRFPR Gene

Localization for QRFPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFPR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRFPR gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 12960173
genes like me logo Genes that share ontologies with QRFPR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for QRFPR Gene

Pathways & Interactions for QRFPR Gene

genes like me logo Genes that share pathways with QRFPR: view

Gene Ontology (GO) - Biological Process for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with QRFPR: view

No data available for SIGNOR curated interactions for QRFPR Gene

Drugs & Compounds for QRFPR Gene

(4) Drugs for QRFPR Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]QRFP (human) Pharma Agonist, Full agonist 0
QRFP Pharma Agonist, Full agonist 0
QRFP26 Pharma Agonist, Full agonist 0
Calcium Nutra 6959
genes like me logo Genes that share compounds with QRFPR: view

Transcripts for QRFPR Gene

mRNA/cDNA for QRFPR Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QRFPR

Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for QRFPR Gene

GeneLoc Exon Structure for
QRFPR

Expression for QRFPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for QRFPR Gene

mRNA differential expression in normal tissues according to GTEx for QRFPR Gene

This gene is overexpressed in Brain - Hypothalamus (x15.1), Heart - Left Ventricle (x7.6), and Kidney - Cortex (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for QRFPR

SOURCE GeneReport for Unigene cluster for QRFPR Gene:

Hs.368977

mRNA Expression by UniProt/SwissProt for QRFPR Gene:

Q96P65-QRFPR_HUMAN
Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.

Evidence on tissue expression from TISSUES for QRFPR Gene

  • Nervous system(4.3)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with QRFPR: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for QRFPR Gene

Orthologs for QRFPR Gene

This gene was present in the common ancestor of animals.

Orthologs for QRFPR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia QRFPR 29 30
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia QRFPR 29 30
  • 90.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia QRFPR 29 30
  • 89.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Qrfpr 29 16 30
  • 84.45 (n)
OneToMany
C130060K24Rik 30
  • 81 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Qrfpr 29
  • 84.15 (n)
Oppossum
(Monodelphis domestica)
Mammalia QRFPR 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia QRFPR 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR103 30
  • 78 (a)
OneToOne
QRFPR 29
  • 77.41 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 74 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia qrfpr 29
  • 75.04 (n)
Str.17272 29
Zebrafish
(Danio rerio)
Actinopterygii LOC100149491 29
  • 65.41 (n)
CABZ01084347.1 30
  • 63 (a)
OneToMany
qrfpra 30
  • 63 (a)
OneToMany
QRFPR (3 of 3) 30
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta SIFR 30
  • 13 (a)
OneToMany
Species where no ortholog for QRFPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for QRFPR Gene

ENSEMBL:
Gene Tree for QRFPR (if available)
TreeFam:
Gene Tree for QRFPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for QRFPR: view image
Alliance of Genome Resources:
Additional Orthologs for QRFPR

Paralogs for QRFPR Gene

(17) SIMAP similar genes for QRFPR Gene using alignment to 5 proteins:

  • QRFPR_HUMAN
  • A1A4W1_HUMAN
  • F2Z3L3_HUMAN
  • G4XH69_HUMAN
  • J3KNR3_HUMAN
genes like me logo Genes that share paralogs with QRFPR: view

Variants for QRFPR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for QRFPR Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1157231980 Uncertain Significance: not provided 121,332,851(-) A/C
NM_198179.3(QRFPR):c.767T>G (p.Ile256Ser)
MISSENSE
rs545337361 Not Provided: not provided 121,329,584(-) AT/A
NM_198179.3(QRFPR):c.1025del (p.Asn342fs)
FRAMESHIFT
rs11947418 -- p.His149Gln
rs17438900 -- p.Phe61Val
rs2302310 -- p.Leu344Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for QRFPR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for QRFPR Gene

Variant ID Type Subtype PubMed ID
dgv125e203 CNV loss 21179565
dgv151n73 CNV deletion 24416366
dgv1524e212 CNV loss 25503493
dgv1525e212 CNV loss 25503493
dgv1526e212 CNV loss 25503493
dgv198n111 CNV deletion 26073780
dgv2896n106 CNV deletion 24896259
dgv5376n100 CNV loss 25217958
dgv5377n100 CNV loss 25217958
dgv5378n100 CNV loss 25217958
dgv894n67 CNV loss 20364138
dgv9251n54 CNV loss 21841781
dgv9252n54 CNV loss 21841781
dgv9253n54 CNV loss 21841781
dgv972e199 CNV deletion 23128226
esv1499673 CNV deletion 17803354
esv2385732 CNV deletion 18987734
esv2421795 CNV deletion 20811451
esv2533163 CNV loss 19546169
esv2539204 CNV deletion 19546169
esv25515 CNV loss 19812545
esv2728254 CNV deletion 23290073
esv3564541 CNV deletion 23714750
esv3569681 CNV loss 25503493
esv3602006 CNV loss 21293372
esv3602007 CNV loss 21293372
esv3894019 CNV loss 25118596
nsv10559 CNV loss 18304495
nsv10560 CNV loss 18304495
nsv1161140 CNV deletion 26073780
nsv1161141 CNV deletion 26073780
nsv292673 CNV deletion 16902084
nsv437422 CNV loss 16327808
nsv442920 CNV loss 18776908
nsv4494 CNV deletion 18451855
nsv499065 CNV loss 21111241
nsv508308 CNV deletion 20534489
nsv514249 CNV loss 21397061
nsv516414 CNV loss 19592680
nsv528104 CNV loss 19592680
nsv595335 CNV loss 21841781
nsv595343 CNV loss 21841781
nsv595350 CNV loss 21841781
nsv963992 CNV deletion 23825009
nsv966316 CNV duplication 23825009

Variation tolerance for QRFPR Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.83; 94.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QRFPR Gene

Human Gene Mutation Database (HGMD)
QRFPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QRFPR
Leiden Open Variation Database (LOVD)
QRFPR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRFPR Gene

Disorders for QRFPR Gene

MalaCards: The human disease database

(1) MalaCards diseases for QRFPR Gene - From: COP

Disorder Aliases PubMed IDs
allergic urticaria
- elite association - COSMIC cancer census association via MalaCards
Search QRFPR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for QRFPR

genes like me logo Genes that share disorders with QRFPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for QRFPR Gene

Publications for QRFPR Gene

  1. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S … Fujino M (The Journal of biological chemistry 2003) 3 4 22
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4
  3. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PMID: 12714592) Jiang Y … Zhang FL (The Journal of biological chemistry 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes. (PMID: 30633125) Melton PE … Moses EK (Journal of hypertension 2019) 3

Products for QRFPR Gene

Sources for QRFPR Gene