Free for academic non-profit institutions. Other users need a Commercial license

Aliases for QPRT Gene

Aliases for QPRT Gene

  • Quinolinate Phosphoribosyltransferase 2 3 5
  • Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating) 2 3
  • EC 4 56
  • QPRTase 3 4
  • Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating] 3
  • Quinolinate Phosphoribosyltransferase [Decarboxylating] 4
  • Epididymis Secretory Sperm Binding Protein Li 90n 3
  • HEL-S-90n 3
  • QAPRTase 4

External Ids for QPRT Gene

Previous GeneCards Identifiers for QPRT Gene

  • GC16M028713
  • GC16P030014
  • GC16P029688
  • GC16P029728
  • GC16P029597
  • GC16P027351
  • GC16P029675
  • GC16P029690

Summaries for QPRT Gene

Entrez Gene Summary for QPRT Gene

  • This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for QPRT Gene

QPRT (Quinolinate Phosphoribosyltransferase) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring pentosyl groups. An important paralog of this gene is ENSG00000277669.

UniProtKB/Swiss-Prot for QPRT Gene

  • Involved in the catabolism of quinolinic acid (QA).

Additional gene information for QPRT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPRT Gene

Genomics for QPRT Gene

GeneHancer (GH) Regulatory Elements for QPRT Gene

Promoters and enhancers for QPRT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I029678 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 558 +10.2 10175 2.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 QPRT SMG1P2 ENSG00000260853 SMG1P5 SPNS1 NFATC2IP INO80E ENSG00000260367 NPIPB12 ENSG00000198106
GH16I029626 Enhancer 0.9 Ensembl ENCODE 13.5 -42.4 -42380 1.9 HDGF PKNOX1 ZFHX2 FOXK2 SCRT2 ATF7 IKZF2 EGR2 SMARCA5 SCRT1 PIR32473 SPN QPRT CA5AP1
GH16I029698 Enhancer 0.5 FANTOM5 5.7 +28.8 28750 0.1 PAF1 CBX5 CBFA2T3 TRIM28 C16orf54 MVP QPRT GC16P029695 GC16M029709
GH16I029700 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 +32.1 32084 3.6 ARID4B ZBTB7B ARID2 ZNF143 ATF7 RUNX3 DEK REST NFIL3 MIER3 NPIPB12 NPIPB13 C16orf54 MVP DOC2A ENSG00000198106 INO80E NPIPB11 ENSG00000260853 ENSG00000235560
GH16I029673 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.8 +4.5 4529 0.8 ZNF449 ZFP64 MAX ZMYM3 RAD21 ZNF48 TEAD3 ZNF121 ZFHX2 CTBP1 QPRT ENSG00000277669 GC16P029695
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around QPRT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QPRT gene promoter:

Genomic Locations for QPRT Gene

Genomic Locations for QPRT Gene
28,860 bases
Plus strand

Genomic View for QPRT Gene

Genes around QPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPRT Gene

Proteins for QPRT Gene

  • Protein details for QPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Protein Accession:
    Secondary Accessions:
    • Q53XW7
    • Q96G22
    • Q9BSG6

    Protein attributes for QPRT Gene

    297 amino acids
    Molecular mass:
    30846 Da
    Quaternary structure:
    • Hexamer formed by 3 homodimers.

    Three dimensional structures from OCA and Proteopedia for QPRT Gene

neXtProt entry for QPRT Gene

Selected DME Specific Peptides for QPRT Gene


Post-translational modifications for QPRT Gene

  • Ubiquitination at Lys183 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for QPRT Gene

Domains & Families for QPRT Gene

Gene Families for QPRT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for QPRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NadC/ModD family.
  • Belongs to the NadC/ModD family.
genes like me logo Genes that share domains with QPRT: view

Function for QPRT Gene

Molecular function for QPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; KM=23 uM for QA (at 0.3 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP) {ECO:0000269 PubMed:17868694};
UniProtKB/Swiss-Prot CatalyticActivity:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
UniProtKB/Swiss-Prot Function:
Involved in the catabolism of quinolinic acid (QA).

Enzyme Numbers (IUBMB) for QPRT Gene

Gene Ontology (GO) - Molecular Function for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA,TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016763 transferase activity, transferring pentosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view
genes like me logo Genes that share phenotypes with QPRT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QPRT

Clone Products

  • Addgene plasmids for QPRT

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QPRT Gene

Localization for QPRT Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPRT gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with QPRT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for QPRT Gene

Pathways & Interactions for QPRT Gene

genes like me logo Genes that share pathways with QPRT: view

UniProtKB/Swiss-Prot Q15274-NADC_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.

Gene Ontology (GO) - Biological Process for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0019674 NAD metabolic process TAS --
GO:0034213 quinolinate catabolic process IDA 3409840
GO:0051259 protein oligomerization IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view

No data available for SIGNOR curated interactions for QPRT Gene

Drugs & Compounds for QPRT Gene

(7) Drugs for QPRT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 946,946
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Phosphoric acid Approved Pharma 0
Quinolinic acid Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(5) Additional Compounds for QPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nicotinate beta-D-ribonucleotide
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate
  • 5-Phospho-a-D-ribosyl pyrophosphate
  • 5-Phospho-alpha-D-ribose 1-diphosphate
  • 5-Phospho-alpha-D-ribose-1-diphosphate
  • 5-Phospho-alpha-D-ribosyl pyrophosphate
  • Azabenzene
  • Azine
  • Piridina
  • Pirydyna
  • Pyridin
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with QPRT: view

Transcripts for QPRT Gene

Unigene Clusters for QPRT Gene

Quinolinate phosphoribosyltransferase:
Representative Sequences:

Clone Products

  • Addgene plasmids for QPRT

Alternative Splicing Database (ASD) splice patterns (SP) for QPRT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for QPRT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPRT Gene

This gene is overexpressed in Liver (x8.6), Adrenal Gland (x5.8), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for QPRT Gene

This gene is overexpressed in Liver, secretome (22.1) and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QPRT Gene

Protein tissue co-expression partners for QPRT Gene

NURSA nuclear receptor signaling pathways regulating expression of QPRT Gene:


SOURCE GeneReport for Unigene cluster for QPRT Gene:


Evidence on tissue expression from TISSUES for QPRT Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with QPRT: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPRT Gene

Orthologs for QPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QPRT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QPRT 33
  • 98.55 (n)
(Bos Taurus)
Mammalia QPRT 33 34
  • 86.51 (n)
(Canis familiaris)
Mammalia QPRT 33 34
  • 85.41 (n)
(Mus musculus)
Mammalia Qprt 33 16 34
  • 81.41 (n)
(Rattus norvegicus)
Mammalia Qprt 33
  • 81.07 (n)
(Monodelphis domestica)
Mammalia QPRT 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia QPRT 34
  • 69 (a)
(Anolis carolinensis)
Reptilia QPRT 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495332 33
  • 55.32 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8714 33
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR271W 33
  • 52.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA6 33 34
  • 51.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons QPT 33
  • 45.76 (n)
(Oryza sativa)
Liliopsida Os09g0553600 33
  • 43.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02998 33
  • 54.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1371 34
  • 38 (a)
Species where no ortholog for QPRT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QPRT Gene

Gene Tree for QPRT (if available)
Gene Tree for QPRT (if available)

Paralogs for QPRT Gene

Paralogs for QPRT Gene

genes like me logo Genes that share paralogs with QPRT: view

Variants for QPRT Gene

Sequence variations from dbSNP and Humsavar for QPRT Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000048681 -- 29,690,612(+) T/C intron_variant
rs1000067898 -- 29,676,943(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000087710 -- 29,679,003(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000095864 -- 29,671,503(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000177587 -- 29,693,038(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QPRT Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
esv23737 CNV gain 19812545
esv2758641 CNV gain 17122850
esv3638370 CNV loss 21293372
nsv1063706 CNV gain 25217958
nsv1134520 CNV deletion 24896259
nsv571816 CNV gain 21841781
nsv571817 CNV gain 21841781
nsv833183 CNV loss 17160897

Variation tolerance for QPRT Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QPRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPRT Gene

Disorders for QPRT Gene

Additional Disease Information for QPRT

No disorders were found for QPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QPRT Gene

Publications for QPRT Gene

  1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PMID: 9473669) Fukuoka SI … Shibata K (Biochimica et biophysica acta 1998) 2 3 4 22 58
  2. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PMID: 17868694) Liu H … Naismith JH (Journal of molecular biology 2007) 3 4 22 58
  3. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PMID: 19321014) Hinsch N … Hansmann ML (BMC cancer 2009) 3 22 58
  4. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PMID: 15837705) Zheng XQ … Ashihara H (Journal of experimental botany 2005) 22 25 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for QPRT Gene

  • Addgene plasmids for QPRT

Sources for QPRT Gene

Loading form....