Aliases for QPCTL Gene

Aliases for QPCTL Gene

  • Glutaminyl-Peptide Cyclotransferase Like 2 3 5
  • Golgi-Resident Glutaminyl-Peptide Cyclotransferase 3 4
  • Glutaminyl-Peptide Cyclotransferase-Like Protein 3 4
  • Glutaminyl Cyclase-Like 2 3
  • EC 2.3.2.5 4 54
  • IsoQC 3 4
  • GQC 3 4
  • EC 2.3.2 54

External Ids for QPCTL Gene

Previous GeneCards Identifiers for QPCTL Gene

  • GC19P050888
  • GC19P046195
  • GC19P042624

Summaries for QPCTL Gene

GeneCards Summary for QPCTL Gene

QPCTL (Glutaminyl-Peptide Cyclotransferase Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCT.

UniProtKB/Swiss-Prot Summary for QPCTL Gene

Additional gene information for QPCTL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for QPCTL Gene

Genomics for QPCTL Gene

GeneHancer (GH) Regulatory Elements for QPCTL Gene

Promoters and enhancers for QPCTL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QPCTL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QPCTL gene promoter:
  • AML1a
  • AP-2gamma
  • AREB6
  • c-Myc
  • GATA-1
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for QPCTL Gene

Genomic Locations for QPCTL Gene
chr19:45,692,381-45,703,990
(GRCh38/hg38)
Size:
11,610 bases
Orientation:
Plus strand
chr19:46,195,741-46,207,248
(GRCh37/hg19)
Size:
11,508 bases
Orientation:
Plus strand

Genomic View for QPCTL Gene

Genes around QPCTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPCTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPCTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCTL Gene

Proteins for QPCTL Gene

  • Protein details for QPCTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXS2-QPCTL_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase-like protein
    Protein Accession:
    Q9NXS2
    Secondary Accessions:
    • Q53HE4
    • Q96F74

    Protein attributes for QPCTL Gene

    Size:
    382 amino acids
    Molecular mass:
    42924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCTL Gene

    Alternative splice isoforms for QPCTL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCTL Gene

Selected DME Specific Peptides for QPCTL Gene

Q9NXS2:
  • DSLYGSRHLA
  • GVPVLHLI
  • DDHIPFL
  • NLHPPTVHNL
  • GATDSAVPC
  • LACHYDSK
  • FLDGEEALK
  • GAPNPTF
  • GNLQVRKFLEATL

Post-translational modifications for QPCTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QPCTL Gene

Domains & Families for QPCTL Gene

Gene Families for QPCTL Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for QPCTL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QPCTL Gene

GenScript: Design optimal peptide antigens:
  • isoQC (QPCTL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXS2

UniProtKB/Swiss-Prot:

QPCTL_HUMAN :
  • Belongs to the glutaminyl-peptide cyclotransferase family.
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.
genes like me logo Genes that share domains with QPCTL: view

Function for QPCTL Gene

Molecular function for QPCTL Gene

UniProtKB/Swiss-Prot Function:
Responsible for the biosynthesis of pyroglutamyl peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736, Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722, ChEBI:CHEBI:87215; EC=2.3.2.5; Evidence={ECO:0000269 PubMed:18486145, ECO:0000269 PubMed:21288892};.

Enzyme Numbers (IUBMB) for QPCTL Gene

Phenotypes From GWAS Catalog for QPCTL Gene

Gene Ontology (GO) - Molecular Function for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA,IBA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IBA,IDA 18486145
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with QPCTL: view
genes like me logo Genes that share phenotypes with QPCTL: view

Animal Model Products

CRISPR Products

miRNA for QPCTL Gene

miRTarBase miRNAs that target QPCTL

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QPCTL Gene

Localization for QPCTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCTL Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPCTL gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA,IDA 18486145
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with QPCTL: view

Pathways & Interactions for QPCTL Gene

PathCards logo

SuperPathways for QPCTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA,IBA 18486145
genes like me logo Genes that share ontologies with QPCTL: view

No data available for Pathways by source and SIGNOR curated interactions for QPCTL Gene

Drugs & Compounds for QPCTL Gene

(1) Drugs for QPCTL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
genes like me logo Genes that share compounds with QPCTL: view

Transcripts for QPCTL Gene

mRNA/cDNA for QPCTL Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QPCTL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for QPCTL Gene

GeneLoc Exon Structure for
QPCTL
ECgene alternative splicing isoforms for
QPCTL

Expression for QPCTL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QPCTL Gene

Protein differential expression in normal tissues from HIPED for QPCTL Gene

This gene is overexpressed in Nasal epithelium (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QPCTL Gene



Protein tissue co-expression partners for QPCTL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QPCTL Gene:

QPCTL

SOURCE GeneReport for Unigene cluster for QPCTL Gene:

Hs.631556

Evidence on tissue expression from TISSUES for QPCTL Gene

  • Intestine(4.1)
  • Kidney(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with QPCTL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPCTL Gene

Orthologs for QPCTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPCTL 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QPCTL 33 32
  • 86.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia QPCTL 33 32
  • 85.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Qpctl 17 33 32
  • 81.85 (n)
rat
(Rattus norvegicus)
Mammalia Qpctl 32
  • 81.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia QPCTL 33
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QPCTL 33
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves QPCTL 33
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPCTL 33
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpctl 32
  • 54.61 (n)
zebrafish
(Danio rerio)
Actinopterygii qpctla 33
  • 48 (a)
OneToMany
qpctlb 33
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta QC 33
  • 39 (a)
ManyToMany
CG32413 33
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 33
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER189W 32
  • 50.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YFR018C 32
  • 45.12 (n)
-- 33
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04576g 32
  • 44.92 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09018 32
  • 53.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 34 (a)
OneToMany
Species where no ortholog for QPCTL was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCTL Gene

ENSEMBL:
Gene Tree for QPCTL (if available)
TreeFam:
Gene Tree for QPCTL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for QPCTL: view image

Paralogs for QPCTL Gene

Paralogs for QPCTL Gene

(1) SIMAP similar genes for QPCTL Gene using alignment to 2 proteins:

  • QPCTL_HUMAN
  • K7EQG1_HUMAN
genes like me logo Genes that share paralogs with QPCTL: view

Variants for QPCTL Gene

Sequence variations from dbSNP and Humsavar for QPCTL Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000176536 -- 45,699,279(+) C/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000251542 -- 45,691,305(+) A/G upstream_transcript_variant
rs1000395257 -- 45,702,938(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000412954 -- 45,696,368(+) G/A intron_variant
rs1000904139 -- 45,691,967(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for QPCTL Gene

Variant ID Type Subtype PubMed ID
esv3644509 CNV gain 21293372

Variation tolerance for QPCTL Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QPCTL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QPCTL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPCTL Gene

Disorders for QPCTL Gene

Additional Disease Information for QPCTL

No disorders were found for QPCTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QPCTL Gene

Publications for QPCTL Gene

  1. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PMID: 21288892) Huang KF … Wang AH (The Journal of biological chemistry 2011) 3 4 56
  2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 43 56
  3. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H … Schilling S (Journal of molecular biology 2008) 3 4 56
  4. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. (PMID: 30833751) Logtenberg MEW … Schumacher TN (Nature medicine 2019) 3 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for QPCTL Gene

Sources for QPCTL Gene