This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008] See more...

Aliases for QPCT Gene

Aliases for QPCT Gene

  • Glutaminyl-Peptide Cyclotransferase 2 3 4 5
  • Glutaminyl Cyclase 2 3 4
  • QC 2 3 4
  • Glutaminyl-TRNA Cyclotransferase 3 4
  • Glutamyl Cyclase 3 4

External Ids for QPCT Gene

Previous GeneCards Identifiers for QPCT Gene

  • GC02P037536
  • GC02P037718
  • GC02P037546
  • GC02P037483
  • GC02P037425
  • GC02P037571
  • GC02P037313

Summaries for QPCT Gene

Entrez Gene Summary for QPCT Gene

  • This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

GeneCards Summary for QPCT Gene

QPCT (Glutaminyl-Peptide Cyclotransferase) is a Protein Coding gene. Diseases associated with QPCT include Trichuriasis and Cerebral Amyloid Angiopathy, Itm2b-Related, 1. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.

UniProtKB/Swiss-Prot Summary for QPCT Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Gene Wiki entry for QPCT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for QPCT Gene

Genomics for QPCT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for QPCT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around QPCT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for QPCT

Top Transcription factor binding sites by QIAGEN in the QPCT gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • IRF-1
  • ITF-2
  • NF-1
  • NF-1/L
  • POU2F1
  • POU2F1a
  • Tal-1beta

Genomic Locations for QPCT Gene

Latest Assembly
chr2:37,342,827-37,373,322
(GRCh38/hg38)
Size:
30,496 bases
Orientation:
Plus strand

Previous Assembly
chr2:37,571,773-37,600,465
(GRCh37/hg19 by Entrez Gene)
Size:
28,693 bases
Orientation:
Plus strand

chr2:37,571,717-37,600,465
(GRCh37/hg19 by Ensembl)
Size:
28,749 bases
Orientation:
Plus strand

Genomic View for QPCT Gene

Genes around QPCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCT Gene

Proteins for QPCT Gene

  • Protein details for QPCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16769-QPCT_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase
    Protein Accession:
    Q16769
    Secondary Accessions:
    • Q16770
    • Q3KRG6
    • Q53TR4

    Protein attributes for QPCT Gene

    Size:
    361 amino acids
    Molecular mass:
    40877 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCT Gene

    Alternative splice isoforms for QPCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCT Gene

Selected DME Specific Peptides for QPCT Gene

Q16769:
  • DSLYGSRHLA
  • GVPVLHLI
  • DDHIPFL
  • IFFDGEEAF
  • GATDSAVPC
  • LACHYDSK
  • GAPNPTF

Post-translational modifications for QPCT Gene

  • Glycosylation at Asn49 and Asn296
  • Modification sites at PhosphoSitePlus

Other Protein References for QPCT Gene

Domains & Families for QPCT Gene

Gene Families for QPCT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for QPCT Gene

Suggested Antigen Peptide Sequences for QPCT Gene

GenScript: Design optimal peptide antigens:
  • Glutamyl cyclase (QPCT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16769

UniProtKB/Swiss-Prot:

QPCT_HUMAN :
  • Belongs to the glutaminyl-peptide cyclotransferase family.
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.
genes like me logo Genes that share domains with QPCT: view

Function for QPCT Gene

Molecular function for QPCT Gene

UniProtKB/Swiss-Prot Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736, Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722, ChEBI:CHEBI:87215; EC=2.3.2.5; Evidence={ECO:0000269|PubMed:16135565, ECO:0000269|PubMed:18072935, ECO:0000269|PubMed:18486145, ECO:0000269|PubMed:21288892};.

Enzyme Numbers (IUBMB) for QPCT Gene

Phenotypes From GWAS Catalog for QPCT Gene

Gene Ontology (GO) - Molecular Function for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008270 zinc ion binding IBA,IDA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IEA,IDA 21288892
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with QPCT: view
genes like me logo Genes that share phenotypes with QPCT: view

Animal Models for QPCT Gene

MGI Knock Outs for QPCT:
  • Qpct Qpct<tm1.2Tbay>

Animal Models for research

  • Taconic Biosciences Mouse Models for QPCT

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QPCT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QPCT Gene

Localization for QPCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPCT gene
Compartment Confidence
extracellular 5
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
GO:1904724 tertiary granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with QPCT: view

Pathways & Interactions for QPCT Gene

PathCards logo

SuperPathways for QPCT Gene

genes like me logo Genes that share pathways with QPCT: view

Pathways by source for QPCT Gene

3 Reactome pathways for QPCT Gene

Gene Ontology (GO) - Biological Process for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7999256
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IBA,IDA 21288892
GO:0018215 protein phosphopantetheinylation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with QPCT: view

No data available for SIGNOR curated interactions for QPCT Gene

Drugs & Compounds for QPCT Gene

(11) Drugs for QPCT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Pidolic acid Approved, Investigational Pharma 0
Cysteine Approved Nutra 278
N-acetylhistamine Experimental Pharma Target 0
1-benzylimidazole Experimental Pharma Target 0

(2) Additional Compounds for QPCT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with QPCT: view

Transcripts for QPCT Gene

mRNA/cDNA for QPCT Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for QPCT

Alternative Splicing Database (ASD) splice patterns (SP) for QPCT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for QPCT Gene

GeneLoc Exon Structure for
QPCT

Expression for QPCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for QPCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPCT Gene

This gene is overexpressed in Whole Blood (x19.6) and Adrenal Gland (x11.4).

Protein differential expression in normal tissues from HIPED for QPCT Gene

This gene is overexpressed in Urine (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for QPCT Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for QPCT

SOURCE GeneReport for Unigene cluster for QPCT Gene:

Hs.79033

Evidence on tissue expression from TISSUES for QPCT Gene

  • Nervous system(4.6)
  • Pancreas(4.4)
  • Heart(4.3)
  • Lung(4.1)
  • Skin(3)
  • Blood(2.6)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with QPCT: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPCT Gene

Orthologs for QPCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia QPCT 29 30
  • 99.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia QPCT 29 30
  • 89.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia QPCT 29 30
  • 88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1562284 29
  • 83.16 (n)
Mouse
(Mus musculus)
Mammalia Qpct 29 16 30
  • 82.83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia QPCT 30
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia QPCT 30
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves QPCT 29 30
  • 70.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia QPCT 30
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia qpct 29
  • 65.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii qpctlb 29
  • 55.45 (n)
qpct 30
  • 51 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8710 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009673 29
  • 54.01 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta isoQC 29 30
  • 53.75 (n)
ManyToMany
CG5976 31
  • 47 (a)
QC 30
  • 39 (a)
ManyToMany
CG6168 30
  • 35 (a)
ManyToMany
CG32413 30
  • 32 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea H27A22.1 30
  • 35 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 30
  • 29 (a)
OneToMany
-- 32
Bread mold
(Neurospora crassa)
Ascomycetes NCU11249 29
  • 44.79 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToMany
Species where no ortholog for QPCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for QPCT Gene

ENSEMBL:
Gene Tree for QPCT (if available)
TreeFam:
Gene Tree for QPCT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for QPCT: view image
Alliance of Genome Resources:
Additional Orthologs for QPCT

Paralogs for QPCT Gene

Paralogs for QPCT Gene

(1) SIMAP similar genes for QPCT Gene using alignment to 3 proteins:

  • QPCT_HUMAN
  • B5MCZ9_HUMAN
  • C9JS14_HUMAN
genes like me logo Genes that share paralogs with QPCT: view

Variants for QPCT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for QPCT Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs116754028 Benign: not provided 37,372,799(+) T/C
NM_012413.4(QPCT):c.1058T>C (p.Val353Ala)
MISSENSE
rs2255991 -- p.Arg54Trp
rs4670696 -- p.His360Pro
rs895245310 -- p.Gln71Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for QPCT Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for QPCT Gene

Variant ID Type Subtype PubMed ID
nsv2685 CNV deletion 18451855
nsv2686 CNV insertion 18451855

Variation tolerance for QPCT Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QPCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QPCT
Leiden Open Variation Database (LOVD)
QPCT

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPCT Gene

Disorders for QPCT Gene

MalaCards: The human disease database

(2) MalaCards diseases for QPCT Gene - From: COP and GCD

Disorder Aliases PubMed IDs
trichuriasis
  • infection by trichuris trichura
cerebral amyloid angiopathy, itm2b-related, 1
  • dementia, familial british; fbd
- elite association - COSMIC cancer census association via MalaCards
Search QPCT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for QPCT

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with QPCT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for QPCT Gene

Publications for QPCT Gene

  1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PMID: 7999256) Song I … Bateman RC (Journal of molecular endocrinology 1994) 2 3 4 22
  2. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H … Schilling S (Journal of molecular biology 2008) 3 4 22
  3. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PMID: 18072935) Huang KF … Wang AH (The Biochemical journal 2008) 3 4 22
  4. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PMID: 16135565) Huang KF … Wang AH (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22
  5. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PMID: 15231017) Ezura Y … Emi M (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004) 3 22 40

Products for QPCT Gene

  • Boster Bio Antibodies for QPCT
  • Boster Bio ELISA Kits for QPCT

Sources for QPCT Gene