Aliases for QPCT Gene
External Ids for QPCT Gene
Previous GeneCards Identifiers for QPCT Gene
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
GeneCards Summary for QPCT Gene
QPCT (Glutaminyl-Peptide Cyclotransferase) is a Protein Coding gene. Diseases associated with QPCT include Trichuriasis and Cerebral Amyloid Angiopathy, Itm2b-Related, 1. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.
UniProtKB/Swiss-Prot Summary for QPCT Gene
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.