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Aliases for QPCT Gene

Aliases for QPCT Gene

  • Glutaminyl-Peptide Cyclotransferase 2 3 5
  • Glutaminyl Cyclase 2 3 4
  • Glutaminyl-TRNA Cyclotransferase 3 4
  • Glutamyl Cyclase 3 4
  • EC 2.3.2.5 4 56
  • SQC 3 4
  • EC 3 4
  • QC 3 4
  • GCT 3

External Ids for QPCT Gene

Previous GeneCards Identifiers for QPCT Gene

  • GC02P037536
  • GC02P037718
  • GC02P037546
  • GC02P037483
  • GC02P037425
  • GC02P037571
  • GC02P037313

Summaries for QPCT Gene

Entrez Gene Summary for QPCT Gene

  • This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

GeneCards Summary for QPCT Gene

QPCT (Glutaminyl-Peptide Cyclotransferase) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.

UniProtKB/Swiss-Prot for QPCT Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Gene Wiki entry for QPCT Gene

Additional gene information for QPCT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPCT Gene

Genomics for QPCT Gene

GeneHancer (GH) Regulatory Elements for QPCT Gene

Promoters and enhancers for QPCT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I037342 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.5 -546 2.7 FOXA2 ZFP64 KLF17 SIN3A ZNF2 RAD21 ZNF48 ZNF335 GLIS2 EGR1 QPCT CEBPZOS CEBPZ EIF2AK2 NDUFAF7 PRKD3 GC02M037332 RNU6-939P
GH02I037388 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +45.8 45787 3 ELF3 PKNOX1 ATF1 FOXA2 SIN3A BATF IRF4 EGR1 SCRT2 ZNF143 LOC101929542 PRKD3 QPCT RNU6-939P CYP1B1 RMDN2 CDC42EP3 EIF2AK2 GC02P037427
GH02I037664 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6 +324.2 324158 9.2 ATF1 SIN3A FEZF1 IRF4 GLIS2 ZNF207 ZNF143 RUNX3 SP3 REST CDC42EP3 LOC105374464 QPCT CYP1B1 GC02P037671 GC02M037562 GC02P037427
GH02I037317 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 -26.1 -26130 1.5 PKNOX1 FEZF1 BATF IRF4 ZNF366 FOS ZNF600 L3MBTL2 ZEB2 ZNF843 CEBPZOS QPCT PRKD3 GC02M037305
GH02I037760 Enhancer 0.6 FANTOM5 Ensembl 17.3 +417.0 417027 2.8 POLR2A QPCT CDC42EP3 ENSG00000236572 GC02M037793
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around QPCT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the QPCT gene promoter:

Genomic Locations for QPCT Gene

Genomic Locations for QPCT Gene
chr2:37,344,574-37,373,322
(GRCh38/hg38)
Size:
28,749 bases
Orientation:
Plus strand
chr2:37,571,717-37,600,465
(GRCh37/hg19)

Genomic View for QPCT Gene

Genes around QPCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCT Gene

Proteins for QPCT Gene

  • Protein details for QPCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16769-QPCT_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase
    Protein Accession:
    Q16769
    Secondary Accessions:
    • Q16770
    • Q3KRG6
    • Q53TR4

    Protein attributes for QPCT Gene

    Size:
    361 amino acids
    Molecular mass:
    40877 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCT Gene

    Alternative splice isoforms for QPCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCT Gene

Selected DME Specific Peptides for QPCT Gene

Q16769:
  • DSLYGSRHLA
  • GVPVLHLI
  • DDHIPFL
  • IFFDGEEAF
  • GATDSAVPC
  • LACHYDSK
  • GAPNPTF

Post-translational modifications for QPCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QPCT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for QPCT (Glutaminyl-peptide Cyclotransferase/QPCT)
  • Abcam antibodies for QPCT
  • Santa Cruz Biotechnology (SCBT) Antibodies for QPCT

Domains & Families for QPCT Gene

Gene Families for QPCT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for QPCT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QPCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16769

UniProtKB/Swiss-Prot:

QPCT_HUMAN :
  • Belongs to the glutaminyl-peptide cyclotransferase family.
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.
genes like me logo Genes that share domains with QPCT: view

Function for QPCT Gene

Molecular function for QPCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
UniProtKB/Swiss-Prot Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Enzyme Numbers (IUBMB) for QPCT Gene

Phenotypes From GWAS Catalog for QPCT Gene

Gene Ontology (GO) - Molecular Function for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IDA,IEA 21288892
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with QPCT: view
genes like me logo Genes that share phenotypes with QPCT: view

Animal Models for QPCT Gene

MGI Knock Outs for QPCT:

Animal Model Products

  • Taconic Biosciences Mouse Models for QPCT

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QPCT Gene

Localization for QPCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPCT gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:0070062 extracellular exosome HDA,IDA 23376485
GO:1904724 tertiary granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with QPCT: view

Pathways & Interactions for QPCT Gene

genes like me logo Genes that share pathways with QPCT: view

Pathways by source for QPCT Gene

3 Reactome pathways for QPCT Gene

Gene Ontology (GO) - Biological Process for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7999256
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA 21288892
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with QPCT: view

No data available for SIGNOR curated interactions for QPCT Gene

Drugs & Compounds for QPCT Gene

(11) Drugs for QPCT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Pidolic Acid Approved, Experimental, Investigational Pharma 0
L-Cysteine Approved Nutra 0
N-Acetylhistamine Experimental Pharma Target 0
1-benzylimidazole Experimental Pharma Target 0

(2) Additional Compounds for QPCT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with QPCT: view

Transcripts for QPCT Gene

Unigene Clusters for QPCT Gene

Glutaminyl-peptide cyclotransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QPCT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for QPCT Gene

GeneLoc Exon Structure for
QPCT
ECgene alternative splicing isoforms for
QPCT

Expression for QPCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QPCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPCT Gene

This gene is overexpressed in Whole Blood (x19.6) and Adrenal Gland (x11.4).

Protein differential expression in normal tissues from HIPED for QPCT Gene

This gene is overexpressed in Urine (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for QPCT Gene



NURSA nuclear receptor signaling pathways regulating expression of QPCT Gene:

QPCT

SOURCE GeneReport for Unigene cluster for QPCT Gene:

Hs.79033

Evidence on tissue expression from TISSUES for QPCT Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Pancreas(4.3)
  • Heart(4.1)
  • Skin(2.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with QPCT: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPCT Gene

Orthologs for QPCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPCT 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia QPCT 33 34
  • 89.01 (n)
dog
(Canis familiaris)
Mammalia QPCT 33 34
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562284 33
  • 83.16 (n)
mouse
(Mus musculus)
Mammalia Qpct 33 16 34
  • 82.83 (n)
oppossum
(Monodelphis domestica)
Mammalia QPCT 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPCT 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves QPCT 33 34
  • 70.71 (n)
lizard
(Anolis carolinensis)
Reptilia QPCT 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpct 33
  • 65.54 (n)
zebrafish
(Danio rerio)
Actinopterygii qpctlb 33
  • 55.45 (n)
qpct 34
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8710 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009673 33
  • 54.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta isoQC 33 34
  • 53.75 (n)
CG5976 35
  • 47 (a)
QC 34
  • 39 (a)
ManyToMany
CG6168 34
  • 35 (a)
ManyToMany
CG32413 34
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 29 (a)
OneToMany
-- 36
bread mold
(Neurospora crassa)
Ascomycetes NCU11249 33
  • 44.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for QPCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCT Gene

ENSEMBL:
Gene Tree for QPCT (if available)
TreeFam:
Gene Tree for QPCT (if available)

Paralogs for QPCT Gene

Paralogs for QPCT Gene

(1) SIMAP similar genes for QPCT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QPCT: view

Variants for QPCT Gene

Sequence variations from dbSNP and Humsavar for QPCT Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000248057 -- 37,343,123(+) A/T upstream_transcript_variant
rs1000465135 -- 37,368,825(+) T/A intron_variant
rs1000614052 -- 37,348,326(+) C/T intron_variant
rs1000722771 -- 37,343,193(+) A/T upstream_transcript_variant
rs1001040740 -- 37,346,317(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QPCT Gene

Variant ID Type Subtype PubMed ID
nsv2685 CNV deletion 18451855
nsv2686 CNV insertion 18451855

Variation tolerance for QPCT Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QPCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QPCT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPCT Gene

Disorders for QPCT Gene

Additional Disease Information for QPCT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for QPCT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QPCT Gene

Publications for QPCT Gene

  1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PMID: 7999256) Song I … Bateman RC (Journal of molecular endocrinology 1994) 2 3 4 22 58
  2. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PMID: 18072935) Huang KF … Wang AH (The Biochemical journal 2008) 3 4 22 58
  3. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H … Schilling S (Journal of molecular biology 2008) 3 4 22 58
  4. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PMID: 16135565) Huang KF … Wang AH (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  5. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PMID: 15231017) Ezura Y … Emi M (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004) 3 22 44 58

Products for QPCT Gene

Sources for QPCT Gene

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