Aliases for QARS1 Gene
External Ids for QARS1 Gene
Previous HGNC Symbols for QARS1 Gene
Previous GeneCards Identifiers for QARS1 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for QARS1 Gene
QARS1 (Glutaminyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with QARS1 include Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy and Cortical Blindness. Among its related pathways are Viral mRNA Translation and tRNA Aminoacylation. An important paralog of this gene is EPRS1.
UniProtKB/Swiss-Prot Summary for QARS1 Gene
Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866).