Aliases for PYY2 Gene

Aliases for PYY2 Gene

  • Peptide YY 2 (Pseudogene) 2 3 5
  • Peptide YY, 2 (Seminalplasmin) 2 3
  • Seminalplasmin 2 3
  • Putative Peptide YY-2 4
  • Putative Peptide YY2 4

External Ids for PYY2 Gene

Previous GeneCards Identifiers for PYY2 Gene

  • GC17P026408
  • GC17P028453
  • GC17P026699
  • GC17P023577
  • GC17P026553
  • GC17P022761

Summaries for PYY2 Gene

GeneCards Summary for PYY2 Gene

PYY2 (Peptide YY 2 (Pseudogene)) is a Pseudogene.

Additional gene information for PYY2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PYY2 Gene

Genomics for PYY2 Gene

GeneHancer (GH) Regulatory Elements for PYY2 Gene

Promoters and enhancers for PYY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028226 Promoter/Enhancer 1.2 Ensembl ENCODE 750.6 +1.1 1139 2.8 CTCF CTBP1 RAD21 POLR2A ZNF652 SP1 SP7 ZSCAN21 ZNF548 KLF14 LOC105371930 PYY2 lnc-IFT20-10 lnc-IFT20-12 lnc-NLK-5 piR-48491 ENSG00000264029 SUPT6H ENSG00000265041 NOS2P1
GH17J028225 Enhancer 0.8 FANTOM5 Ensembl ENCODE 750.6 -0.9 -920 1.3 MAFK PKNOX1 ZNF316 ZKSCAN1 EMSY PYY2 lnc-IFT20-10 lnc-NLK-5 piR-49732-238 piR-48301-163 piR-48491 LOC105371930 lnc-IFT20-12
GH17J028233 Promoter/Enhancer 1 Ensembl ENCODE 8.9 +8.0 7967 3.1 CTCF RAD21 MNT NFIB ZNF652 CREB1 TRIM22 CTBP1 RFX1 DPF2 ERVE-1 PYY2 LOC105371930
GH17J027967 Enhancer 1.2 Ensembl ENCODE dbSUPER 7 -257.9 -257889 1.5 SMARCE1 RUNX1 CC2D1A ELF1 L3MBTL2 DACH1 TEAD4 ZKSCAN8 ZFX BACH1 NOS2 PYY2 piR-43105-268 LINC01992
GH17J028239 Enhancer 0.5 Ensembl 14.4 +12.7 12738 0.6 CTCF RAD21 CBFA2T2 NCOR1 TCF12 TAL1 CBFA2T3 PYY2 SLC46A1 ERVE-1 PPY2P lnc-NLK-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PYY2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PYY2 gene promoter:
  • AREB6
  • Arnt
  • HNF-1A
  • MyoD
  • NF-1
  • NF-1/L
  • Sox5
  • Sox9
  • USF-1
  • USF1

Genomic Locations for PYY2 Gene

Genomic Locations for PYY2 Gene
chr17:28,226,563-28,228,065
(GRCh38/hg38)
Size:
1,503 bases
Orientation:
Plus strand
chr17:26,553,589-26,555,091
(GRCh37/hg19)
Size:
1,503 bases
Orientation:
Plus strand

Genomic View for PYY2 Gene

Genes around PYY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYY2 Gene

Proteins for PYY2 Gene

  • Protein details for PYY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRI6-PYY2_HUMAN
    Recommended name:
    Putative peptide YY-2
    Protein Accession:
    Q9NRI6

    Protein attributes for PYY2 Gene

    Size:
    33 amino acids
    Molecular mass:
    3432 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PYY2 Gene

Post-translational modifications for PYY2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PYY2 Gene

Domains & Families for PYY2 Gene

Protein Domains for PYY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PYY2 Gene

GenScript: Design optimal peptide antigens:
  • Putative peptide YY-2 (PYY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRI6

UniProtKB/Swiss-Prot:

PYY2_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY2: view

No data available for Gene Families for PYY2 Gene

Function for PYY2 Gene

Molecular function for PYY2 Gene

GENATLAS Biochemistry:
peptide YY2,seminalplasmin,located in a region duplicated from 17q21 and encoding PPY and PYY

Gene Ontology (GO) - Molecular Function for PYY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with PYY2: view
genes like me logo Genes that share phenotypes with PYY2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PYY2 Gene

Localization for PYY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PYY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PYY2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PYY2 Gene

Pathways & Interactions for PYY2 Gene

PathCards logo

SuperPathways for PYY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PYY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with PYY2: view

No data available for Pathways by source and SIGNOR curated interactions for PYY2 Gene

Drugs & Compounds for PYY2 Gene

No Compound Related Data Available

Transcripts for PYY2 Gene

mRNA/cDNA for PYY2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYY2 Gene

No ASD Table

Relevant External Links for PYY2 Gene

GeneLoc Exon Structure for
PYY2
ECgene alternative splicing isoforms for
PYY2

Expression for PYY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PYY2 Gene

mRNA differential expression in normal tissues according to GTEx for PYY2 Gene

This gene is overexpressed in Adrenal Gland (x21.1).

NURSA nuclear receptor signaling pathways regulating expression of PYY2 Gene:

PYY2

SOURCE GeneReport for Unigene cluster for PYY2 Gene:

Hs.157195

mRNA Expression by UniProt/SwissProt for PYY2 Gene:

Q9NRI6-PYY2_HUMAN
Tissue specificity: Expressed mainly in the testis and prostate.
genes like me logo Genes that share expression patterns with PYY2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYY2 Gene

Orthologs for PYY2 Gene

Evolution for PYY2 Gene

ENSEMBL:
Gene Tree for PYY2 (if available)
TreeFam:
Gene Tree for PYY2 (if available)

No data available for Orthologs for PYY2 Gene

Paralogs for PYY2 Gene

(2) SIMAP similar genes for PYY2 Gene using alignment to 1 proteins:

  • PYY2_HUMAN
genes like me logo Genes that share paralogs with PYY2: view

No data available for Paralogs for PYY2 Gene

Variants for PYY2 Gene

Sequence variations from dbSNP and Humsavar for PYY2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000159969 -- 28,225,275(+) T/A upstream_transcript_variant
rs1001096584 -- 28,227,279(+) A/G intron_variant
rs1002296958 -- 28,227,996(+) C/G non_coding_transcript_variant
rs1002318129 -- 28,227,491(+) G/A non_coding_transcript_variant
rs1002346216 -- 28,228,244(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PYY2 Gene

Variant ID Type Subtype PubMed ID
nsv574653 CNV gain 21841781

Additional Variant Information for PYY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYY2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PYY2 Gene

Disorders for PYY2 Gene

Additional Disease Information for PYY2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PYY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYY2 Gene

Publications for PYY2 Gene

  1. Peptide YY-2 (PYY2) and pancreatic polypeptide-2 (PPY2): species-specific evolution of novel members of the neuropeptide Y gene family. (PMID: 10756099) Couzens M … Herzog H (Genomics 2000) 3 4 23 56
  2. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (PMID: 15855352) Ma L … Baier LJ (Diabetes 2005) 3 43 56
  3. The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP). (PMID: 11825642) Conlon JM (Peptides 2002) 3 23 56
  4. Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family. (PMID: 7831336) Herzog H … Shine J (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 56

Products for PYY2 Gene

Sources for PYY2 Gene