This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded pep... See more...

Aliases for PYY Gene

Aliases for PYY Gene

  • Peptide YY 2 3 4 5
  • Peptide Tyrosine Tyrosine 3 4
  • Prepro-PYY 2 3
  • PYY-I 3 4
  • PYY1 2 3
  • PYY 5

External Ids for PYY Gene

Previous GeneCards Identifiers for PYY Gene

  • GC17M041772
  • GC17M044207
  • GC17M042040
  • GC17M042505
  • GC17M039385
  • GC17M037794

Summaries for PYY Gene

Entrez Gene Summary for PYY Gene

  • This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

GeneCards Summary for PYY Gene

PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Anorexia Nervosa and Bulimia Nervosa. Among its related pathways are Signaling by GPCR and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot Summary for PYY Gene

  • This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Gene Wiki entry for PYY Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PYY Gene

Genomics for PYY Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PYY Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J044003 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.8 -1843 5 GATAD2A CTCF PRDM10 REST TFE3 RFX1 IKZF1 LARP7 PRDM1 MTA2 NAGS PYY KIF18B G6PC3 TMEM101 piR-42857
GH17J043953 Promoter/Enhancer 0.5 EPDnew ENCODE 611.9 +50.5 50483 0.1 PYY HSALNG0116695 NAGS ENSG00000221044 PPY
GH17J043982 Promoter 0.4 EPDnew 600.4 +21.9 21872 0.1 ZNF18 PYY PPY TMEM101 MPP2 ENSG00000221044 HSALNG0116695
GH17J044094 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -92.4 -92434 4.1 HNRNPL CTCF PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZNF692 ZNF7 JUND JX899681 ASB16-AS1 ASB16 G6PC3 TMEM101 TMUB2 UBTF LSM12 RNU6-131P HROB
GH17J044101 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -103.2 -103186 12.5 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 LEF1 SOX13 IKZF1 ASB16-AS1 TMUB2 ENSG00000267681 LINC00910 DHX8 ASB16 ENSG00000267340 NAGS G6PC3 NBR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PYY on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PYY

Top Transcription factor binding sites by QIAGEN in the PYY gene promoter:
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • Sp1
  • YY1

Genomic Locations for PYY Gene

Genomic Locations for PYY Gene
chr17:43,952,733-44,004,469
(GRCh38/hg38)
Size:
51,737 bases
Orientation:
Minus strand
chr17:42,030,106-42,081,837
(GRCh37/hg19)
Size:
51,732 bases
Orientation:
Minus strand

Genomic View for PYY Gene

Genes around PYY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYY Gene

Proteins for PYY Gene

  • Protein details for PYY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10082-PYY_HUMAN
    Recommended name:
    Peptide YY
    Protein Accession:
    P10082
    Secondary Accessions:
    • Q5U5Q6
    • Q6FGH8

    Protein attributes for PYY Gene

    Size:
    97 amino acids
    Molecular mass:
    11145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PYY Gene

    Alternative splice isoforms for PYY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYY Gene

Post-translational modifications for PYY Gene

  • The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Other Protein References for PYY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PYY Gene

Domains & Families for PYY Gene

Gene Families for PYY Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PYY Gene

InterPro:
Blocks:
  • Pancreatic hormone
ProtoNet:

Suggested Antigen Peptide Sequences for PYY Gene

GenScript: Design optimal peptide antigens:
  • Peptide tyrosine tyrosine (PYY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10082

UniProtKB/Swiss-Prot:

PYY_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY: view

Function for PYY Gene

Molecular function for PYY Gene

UniProtKB/Swiss-Prot Function:
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
GENATLAS Biochemistry:
peptide YY,gut hormone,inhibiting exocrine pancreatic secretion

Phenotypes From GWAS Catalog for PYY Gene

Gene Ontology (GO) - Molecular Function for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IPI 7493937
GO:0005179 hormone activity TAS,IBA 21873635
GO:0005184 neuropeptide hormone activity IBA 21873635
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with PYY: view
genes like me logo Genes that share phenotypes with PYY: view

Animal Models for PYY Gene

MGI Knock Outs for PYY:
  • Pyy Pyy<tm1Able>
  • Pyy Pyy<tm1.1Batt>
  • Pyy Pyy<tm1Mws>

Animal Model Products

  • Taconic Biosciences Mouse Models for PYY

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYY

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PYY Gene

Localization for PYY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYY gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with PYY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PYY Gene

Pathways & Interactions for PYY Gene

genes like me logo Genes that share pathways with PYY: view

SIGNOR curated interactions for PYY Gene

Activates:

Gene Ontology (GO) - Biological Process for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA 21873635
GO:0007631 feeding behavior IBA 21873635
GO:0060575 intestinal epithelial cell differentiation TAS 10488139
genes like me logo Genes that share ontologies with PYY: view

Drugs & Compounds for PYY Gene

(74) Drugs for PYY Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tyrosine Approved, Investigational Nutra 1044
Glucagon Approved Pharma Agonist, Full agonist 566
Hydrocortisone Approved, Vet_approved Pharma Agonist 897
Hydrocortisone acetate Approved, Vet_approved Pharma 897
Insulin detemir Approved Pharma 221

(24) Additional Compounds for PYY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PYY: view

Transcripts for PYY Gene

mRNA/cDNA for PYY Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYY

Alternative Splicing Database (ASD) splice patterns (SP) for PYY Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for PYY Gene

GeneLoc Exon Structure for
PYY

Expression for PYY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PYY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYY Gene

This gene is overexpressed in Colon - Transverse (x31.7), Small Intestine - Terminal Ileum (x13.7), and Colon - Sigmoid (x4.0).

Protein differential expression in normal tissues from HIPED for PYY Gene

This gene is overexpressed in Colon (42.1) and Rectum (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PYY Gene



Protein tissue co-expression partners for PYY Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PYY

SOURCE GeneReport for Unigene cluster for PYY Gene:

Hs.169249

Evidence on tissue expression from TISSUES for PYY Gene

  • Intestine(4.8)
  • Nervous system(4.6)
  • Stomach(3.3)
  • Blood(2.9)
  • Pancreas(2.8)
  • Liver(2.3)
  • Muscle(2.3)
  • Gall bladder(2.3)
  • Skin(2.2)
  • Adrenal gland(2.1)
  • Lung(2.1)
  • Kidney(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with PYY: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYY Gene

Orthologs for PYY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYY Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PYY 30 31
  • 96.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PYY 30 31
  • 84.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PYY 30 31
  • 80.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pyy 30
  • 80.07 (n)
Mouse
(Mus musculus)
Mammalia Pyy 30 17 31
  • 77.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PYY 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PYY 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPY 31
  • 34 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia PYY 31
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pyy 30
  • 53.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii pyya 30
  • 58.42 (n)
pyyb 31
  • 41 (a)
OneToOne
Species where no ortholog for PYY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PYY Gene

ENSEMBL:
Gene Tree for PYY (if available)
TreeFam:
Gene Tree for PYY (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PYY: view image

Paralogs for PYY Gene

Paralogs for PYY Gene

(4) SIMAP similar genes for PYY Gene using alignment to 1 proteins:

  • PYY_HUMAN

Pseudogenes.org Pseudogenes for PYY Gene

genes like me logo Genes that share paralogs with PYY: view

Variants for PYY Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PYY Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
709316 Benign: not provided 43,953,334(-) G/A SYNONYMOUS_VARIANT
768889 Benign: not provided 43,953,160(-) A/G MISSENSE_VARIANT
768890 Benign: not provided 43,953,375(-) G/C NO_SEQUENCE_ALTERATION
rs267606994 Uncertain Significance: Obesity 43,953,299(-) T/G MISSENSE_VARIANT
rs1058046 - p.Thr72Arg

Additional dbSNP identifiers (rs#s) for PYY Gene

Structural Variations from Database of Genomic Variants (DGV) for PYY Gene

Variant ID Type Subtype PubMed ID
esv2675215 CNV deletion 23128226
nsv112219 CNV insertion 16902084
nsv1125242 CNV deletion 24896259
nsv1129188 CNV insertion 24896259
nsv1142218 CNV tandem duplication 24896259
nsv1146669 OTHER inversion 26484159
nsv1152253 CNV insertion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for PYY Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PYY Gene

Human Gene Mutation Database (HGMD)
PYY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYY

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene

Disorders for PYY Gene

MalaCards: The human disease database

(34) MalaCards diseases for PYY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anorexia nervosa
  • an
bulimia nervosa
  • bulimia nervosa, susceptibility to
short bowel syndrome
  • acquired short bowel syndrome
dumping syndrome
  • dumping syndrome
eating disorder
  • eating disorders
- elite association - COSMIC cancer census association via MalaCards
Search PYY in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PYY

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PYY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYY Gene

Publications for PYY Gene

  1. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell CD … Hirschhorn JN (Diabetes 2007) 3 23 41
  2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A … Froguel P (Diabetologia 2007) 3 23 41
  3. Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. (PMID: 7782089) Hort Y … Herzog H (Genomics 1995) 2 3 23
  4. Peptide YY levels across pubertal stages and associations with growth hormone. (PMID: 20375207) Lloyd B … Misra M (The Journal of clinical endocrinology and metabolism 2010) 3 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for PYY Gene

Sources for PYY Gene