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The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer... See more...
Aliases for PYHIN1 Gene
Aliases for PYHIN1 Gene
External Ids for PYHIN1 Gene
- HGNC: 28894
- Entrez Gene: 149628
- Ensembl: ENSG00000163564
- OMIM: 612677
- UniProtKB: Q6K0P9
Previous GeneCards Identifiers for PYHIN1 Gene
- GC01P155715
- GC01P157167
- GC01P130258
Summaries for PYHIN1 Gene
-
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for PYHIN1 Gene
PYHIN1 (Pyrin And HIN Domain Family Member 1) is a Protein Coding gene. Diseases associated with PYHIN1 include Breast Cancer and Limited Scleroderma. An important paralog of this gene is IFI16.
UniProtKB/Swiss-Prot Summary for PYHIN1 Gene
-
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Additional gene information for PYHIN1 Gene
- HGNC(28894)
- Entrez Gene(149628)
- Ensembl(ENSG00000163564)
- OMIM(612677)
- UniProtKB(Q6K0P9)
- Open Targets Platform(ENSG00000163564)
- Monarch Initiative
- Search for PYHIN1 at DataMed
- Search for PYHIN1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PYHIN1 Gene
Genomics for PYHIN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PYHIN1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J158929 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 600.7 | +1.4 | 1431 | 5.2 | JUNB SPI1 BATF TCF7 | PYHIN1 ACKR1 piR-58706-001 IFI16 | |
| GH01J159004 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 1.4 | +80.3 | 80289 | 12.6 | SP1 ATF7 IKZF1 POLR2A BACH1 JUND STAT3 RELA ZNF24 MTA1 | IFI16 OR6N2 RAD1P2 CADM3-AS1 ACKR1 AIM2 PYHIN1 lnc-AIM2-3 PYDC5 | |
| GH01J158818 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 1.3 | -111.3 | -111342 | 2 | LEF1 IKZF1 JUND MTA2 PKNOX1 ZNF24 NR2C1 ZNF740 DPF2 HDAC1 | MNDA CD1D PYHIN1 IFI16 piR-32023-021 OR10AA1P OR6N1 OR6N2 | |
| GH01J158808 | Promoter/Enhancer | 0.9 | FANTOM5 Ensembl dbSUPER | 1.8 | -121.2 | -121170 | 1.3 | SPI1 CEBPB | OR10AA1P MNDA OR6N2 OR6N1 PYHIN1 IFI16 piR-32023-021 | |
| GH01J158997 | Enhancer | 0.3 | ENCODE dbSUPER | 4.4 | +66.4 | 66410 | 0.2 | PYHIN1 IFI16 lnc-AIM2-3 piR-34416 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PYHIN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PYHIN1
- Top Transcription factor binding sites by QIAGEN in the PYHIN1 gene promoter:
-
- AREB6
- E47
- Evi-1
- IRF-7A
- ITF-2
- Meis-1b
- Nkx2-2
- Pax-6
- Tal-1beta
Genomic Locations for PYHIN1 Gene
Genomic Locations for PYHIN1 Gene
- chr1:158,930,796-158,990,909
- (GRCh38/hg38)
- Size:
- 60,114 bases
- Orientation:
- Plus strand
- chr1:158,900,586-158,946,844
- (GRCh37/hg19)
- Size:
- 46,259 bases
- Orientation:
- Plus strand
Genomic View for PYHIN1 Gene
Genes around PYHIN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.1 by HGNC
- 1q23.1 by Entrez Gene
- 1q23.1 by Ensembl
PYHIN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PYHIN1 Gene
Proteins for PYHIN1 Gene
-
Protein details for PYHIN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6K0P9-IFIX_HUMAN
- Recommended name:
- Pyrin and HIN domain-containing protein 1
- Protein Accession:
- Q6K0P9
- Q5T3W6
- Q6K0P6
- Q6K0P7
- Q6K0P8
- Q8WW65
Protein attributes for PYHIN1 Gene
- Size:
- 492 amino acids
- Molecular mass:
- 55065 Da
- Quaternary structure:
-
- Interacts with MDM2.
Protein Expression for PYHIN1 Gene
Post-translational modifications for PYHIN1 Gene
Other Protein References for PYHIN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Abcam antibodies for PYHIN1
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-
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Protein Products
-
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-
Quality Products:
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Abcam proteins for PYHIN1
No data available for DME Specific Peptides for PYHIN1 Gene
Domains & Families for PYHIN1 Gene
Gene Families for PYHIN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PYHIN1 Gene
- InterPro:
- Blocks:
-
- HIN-200/IF120x domain
- ProtoNet:
Suggested Antigen Peptide Sequences for PYHIN1 Gene
- GenScript: Design optimal peptide antigens:
-
- Interferon-inducible protein X (IFIX_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6K0P9UniProtKB/Swiss-Prot:
IFIX_HUMAN :- The HIN-200 domain mediates interaction with MDM2.
- Belongs to the HIN-200 family.
- Domain:
-
- The HIN-200 domain mediates interaction with MDM2.
- Family:
-
- Belongs to the HIN-200 family.
Function for PYHIN1 Gene
Molecular function for PYHIN1 Gene
- UniProtKB/Swiss-Prot Function:
- Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
- UniProtKB/Swiss-Prot Induction:
- By IFN-alphas and IFNG/IFN-gamma in hematopoietic cancer cells.
Phenotypes From GWAS Catalog for PYHIN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 16479015 |
Phenotypes for PYHIN1 Gene
- GenomeRNAi human phenotypes for PYHIN1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability ratio
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased vaccinia virus (VACV-LREV ) gene expression
Animal Model Products
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CRISPR Products
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Horizon Cell Lines for PYHIN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PYHIN1 Gene
Localization for PYHIN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PYHIN1 Gene
- [Isoform 1]: Nucleus, nucleoplasm.
- [Isoform 3]: Nucleus, nucleoplasm.
- [Isoform 5]: Nucleus. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0005730 | nucleolus | IBA | 21873635 |
| GO:0016607 | nuclear speck | IEA | -- |
| GO:0032991 | protein-containing complex | IMP | 16479015 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PYHIN1 Gene
Pathways & Interactions for PYHIN1 Gene
Interacting Proteins for PYHIN1 Gene
GPS-Prot Interaction Network for PYHIN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002218 | activation of innate immune response | IBA | 21873635 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0031648 | protein destabilization | IMP | 16479015 |
| GO:0032731 | positive regulation of interleukin-1 beta production | IBA | 21873635 |
| GO:0035457 | cellular response to interferon-alpha | IMP | 16479015 |
No data available for Pathways by source and SIGNOR curated interactions for PYHIN1 Gene
Transcripts for PYHIN1 Gene
mRNA/cDNA for PYHIN1 Gene
- 4 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368135 1662 nts (view in UCSC)
- ENST00000368138 1723 nts (view in UCSC)
- ENST00000368140 2088 nts (view in UCSC)
- ENST00000392252 1597 nts (view in UCSC)
- ENST00000392254 1624 nts (view in UCSC)
CRISPR Products
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-
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miRNA Products
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Clone Products
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Relevant External Links for PYHIN1 Gene
- GeneLoc Exon Structure for
- PYHIN1
Expression for PYHIN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for PYHIN1 Gene
This gene is overexpressed in Whole Blood (x23.0) and Spleen (x5.9).
This gene is overexpressed in NK cells (22.6), CD8 Tcells (20.8), Peripheral blood mononuclear cells (15.2), and CD4 Tcells (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PYHIN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PYHIN1
SOURCE GeneReport for Unigene cluster for PYHIN1 Gene:
Hs.745322mRNA Expression by UniProt/SwissProt for PYHIN1 Gene:
Q6K0P9-IFIX_HUMAN
Tissue specificity:
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Evidence on tissue expression from TISSUES for PYHIN1 Gene
- Lung(4.3)
- Blood(2.3)
- Lymph node(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for PYHIN1
-
OriGene qPCR primer pairs and template standards for PYHIN1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PYHIN1 Gene
Orthologs for PYHIN1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PYHIN1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pydc4 31 |
|
ManyToMany | |
| Pyhin1 31 |
|
ManyToMany | |||
| Ifi203 31 |
|
ManyToMany | |||
| Ifi202b 31 |
|
ManyToMany | |||
| Pydc3 31 |
|
ManyToMany | |||
| Gm4955 31 |
|
ManyToMany | |||
| AI607873 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany |
- Species where no ortholog for PYHIN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PYHIN1 Gene
- ENSEMBL:
- Gene Tree for PYHIN1 (if available)
- TreeFam:
- Gene Tree for PYHIN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PYHIN1: view image
Paralogs for PYHIN1 Gene
Variants for PYHIN1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PYHIN1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920831 | Uncertain Significance: Malignant tumor of prostate | 158,941,999(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3587688 | CNV | loss | 21293372 |
| nsv1002401 | CNV | loss | 25217958 |
| nsv1007597 | CNV | loss | 25217958 |
| nsv518819 | CNV | loss | 19592680 |
| nsv525964 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.84;
58.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PYHIN1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYHIN1 Gene
Disorders for PYHIN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| limited scleroderma |
|
|
Search PYHIN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PYHIN1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PYHIN1 Gene
Publications for PYHIN1 Gene
- Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. (PMID: 15122330) Ding Y … Yan DH (Oncogene 2004) 2 3 4 23
- Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. (PMID: 16479015) Ding Y … Yan DH (Molecular and cellular biology 2006) 3 4 23
- Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. (PMID: 21804549) Torgerson DG … Nicolae DL (Nature genetics 2011) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus. (PMID: 20595294) Kimkong I … Hirankarn N (The Journal of rheumatology 2010) 3 41
ExternalLinks
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- antibodies-online: Show 12 available PYHIN1 Antibodies ranked by validation data
- Compare Top PYHIN1 Antibodies
- antibodies-online: Search results for available PYHIN1 related products ranked by validation data
- antibodies-online: Show 3 available PYHIN1 Proteins ranked by validation data
- Compare Top PYHIN1 Proteins
- Quality Products:
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for PYHIN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PYHIN1
- Horizon Cell Lines for PYHIN1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PYHIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PYHIN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PYHIN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYHIN1
- Biorbyt antibodies for PYHIN1
Sources for PYHIN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB