Aliases for PYGO2 Gene

Aliases for PYGO2 Gene

  • Pygopus Family PHD Finger 2 2 3 5
  • Pygopus Homolog 2 3 4
  • Pygopus Homolog 2 (Drosophila) 2
  • 1190004M21Rik 3
  • Pygopus 2 3
  • PYGO2 5

External Ids for PYGO2 Gene

Previous GeneCards Identifiers for PYGO2 Gene

  • GC01P148193
  • GC01M150660
  • GC01M151704
  • GC01M152146
  • GC01M151742
  • GC01M153196
  • GC01M154929
  • GC01M126291

Summaries for PYGO2 Gene

GeneCards Summary for PYGO2 Gene

PYGO2 (Pygopus Family PHD Finger 2) is a Protein Coding gene. Diseases associated with PYGO2 include Oligospermia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone acetyltransferase regulator activity. An important paralog of this gene is PYGO1.

UniProtKB/Swiss-Prot Summary for PYGO2 Gene

Gene Wiki entry for PYGO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PYGO2 Gene

Genomics for PYGO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PYGO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PYGO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PYGO2

Top Transcription factor binding sites by QIAGEN in the PYGO2 gene promoter:
  • AP-1
  • AP-4
  • c-Myb
  • c-Rel
  • E47
  • HOXA5
  • p53
  • STAT3

Genomic Locations for PYGO2 Gene

Latest Assembly
6,828 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
4,757 bases
Minus strand

(GRCh37/hg19 by Ensembl)
6,828 bases
Minus strand

Genomic View for PYGO2 Gene

Genes around PYGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO2 Gene

Proteins for PYGO2 Gene

  • Protein details for PYGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pygopus homolog 2
    Protein Accession:
    Secondary Accessions:
    • Q8WYZ4
    • Q96CY2

    Protein attributes for PYGO2 Gene

    406 amino acids
    Molecular mass:
    41244 Da
    Quaternary structure:
    • Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.
    • Sequence=AAL55782.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PYGO2 Gene

neXtProt entry for PYGO2 Gene

Post-translational modifications for PYGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PYGO2 Gene

Domains & Families for PYGO2 Gene

Gene Families for PYGO2 Gene

Protein Domains for PYGO2 Gene

  • Zn-finger-like, PHD finger

Suggested Antigen Peptide Sequences for PYGO2 Gene

GenScript: Design optimal peptide antigens:
  • Pygopus homolog 2 (PYGO2_HUMAN)
  • cDNA FLJ35070 fis, clone PLACE5000139 (Q5T170_HUMAN)
genes like me logo Genes that share domains with PYGO2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PYGO2 Gene

Function for PYGO2 Gene

Molecular function for PYGO2 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Phenotypes From GWAS Catalog for PYGO2 Gene

Gene Ontology (GO) - Molecular Function for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 17113272
GO:0035034 histone acetyltransferase regulator activity IEA --
GO:0042393 histone binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PYGO2: view
genes like me logo Genes that share phenotypes with PYGO2: view

Animal Models for PYGO2 Gene

MGI Knock Outs for PYGO2:
  • Pygo2 Pygo2<tm1.2Ssp>
  • Pygo2 Pygo2<tm1.2Xdai>
  • Pygo2 Pygo2<tm1b(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYGO2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO2 Gene

Localization for PYGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYGO2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:1990907 beta-catenin-TCF complex IDA 28296634
genes like me logo Genes that share ontologies with PYGO2: view

Pathways & Interactions for PYGO2 Gene

genes like me logo Genes that share pathways with PYGO2: view

Gene Ontology (GO) - Biological Process for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA,IBA 21873635
GO:0002088 lens development in camera-type eye IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IBA 21873635
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with PYGO2: view

No data available for SIGNOR curated interactions for PYGO2 Gene

Drugs & Compounds for PYGO2 Gene

No Compound Related Data Available

Transcripts for PYGO2 Gene

mRNA/cDNA for PYGO2 Gene

9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYGO2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for PYGO2 Gene

GeneLoc Exon Structure for

Expression for PYGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PYGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PYGO2 Gene

This gene is overexpressed in CD4 Tcells (20.3), Placenta (17.9), Peripheral blood mononuclear cells (16.1), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PYGO2 Gene

Protein tissue co-expression partners for PYGO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PYGO2

SOURCE GeneReport for Unigene cluster for PYGO2 Gene:


Evidence on tissue expression from TISSUES for PYGO2 Gene

  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PYGO2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYGO2 Gene

Orthologs for PYGO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PYGO2 29 30
  • 99.75 (n)
(Monodelphis domestica)
Mammalia PYGO2 30
  • 96 (a)
(Bos Taurus)
Mammalia PYGO2 29 30
  • 93.5 (n)
(Canis familiaris)
Mammalia PYGO2 29 30
  • 92.1 (n)
(Rattus norvegicus)
Mammalia Pygo2 29
  • 89.05 (n)
(Mus musculus)
Mammalia Pygo2 29 16 30
  • 88.59 (n)
(Gallus gallus)
Aves LOC100857999 29
  • 75.41 (n)
PYGO2 30
  • 73 (a)
(Anolis carolinensis)
Reptilia PYGO2 30
  • 70 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11797 29
(Danio rerio)
Actinopterygii pygo2 30
  • 35 (a)
wufc56f02 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3192 29
Fruit Fly
(Drosophila melanogaster)
Insecta pygo 30
  • 12 (a)
Species where no ortholog for PYGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PYGO2 Gene

Gene Tree for PYGO2 (if available)
Gene Tree for PYGO2 (if available)
Evolutionary constrained regions (ECRs) for PYGO2: view image
Alliance of Genome Resources:
Additional Orthologs for PYGO2

Paralogs for PYGO2 Gene

Paralogs for PYGO2 Gene

(1) SIMAP similar genes for PYGO2 Gene using alignment to 3 proteins:

  • Q5T170_HUMAN
  • Q5T171_HUMAN
genes like me logo Genes that share paralogs with PYGO2: view

Variants for PYGO2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PYGO2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PYGO2 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489

Variation tolerance for PYGO2 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PYGO2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PYGO2 Gene

Disorders for PYGO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PYGO2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search PYGO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PYGO2

genes like me logo Genes that share disorders with PYGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYGO2 Gene

Publications for PYGO2 Gene

  1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PMID: 11955446) Kramps T … Basler K (Cell 2002) 3 4
  4. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B … Bienz M (Nature cell biology 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PYGO2 Gene

Sources for PYGO2 Gene