Aliases for PYGB Gene
External Ids for PYGB Gene
Previous GeneCards Identifiers for PYGB Gene
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PYGB Gene
PYGB (Glycogen Phosphorylase B) is a Protein Coding gene. Diseases associated with PYGB include Glycogen Storage Disease Viii and Glycogen Storage Disease Iii. Among its related pathways are Activation of cAMP-Dependent PKA and Galactose metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and glycogen phosphorylase activity. An important paralog of this gene is PYGM.
UniProtKB/Swiss-Prot Summary for PYGB Gene
Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).