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PYDC1 (Pyrin Domain Containing 1) is a Protein Coding gene. Diseases associated with PYDC1 include Autosomal Dominant Non-Syndromic Intellectual Disability 8 and Listeriosis. Among its related pathways are NOD-like receptor signaling pathway. An important paralog of this gene is PYCARD.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004197 | cysteine-type endopeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 12656673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 12656673 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | 12656673 |
GO:0008385 | IkappaB kinase complex | IDA | 12656673 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NOD-like receptor signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006469 | negative regulation of protein kinase activity | IDA | 12656673 |
GO:0006508 | proteolysis | IEA | -- |
GO:0009968 | negative regulation of signal transduction | IEA | -- |
GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | IMP | 24871464 |
GO:0032088 | NOT negative regulation of NF-kappaB transcription factor activity | IDA,IMP | 24871464 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PYDC1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | pycard 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4990n54 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant non-syndromic intellectual disability 8 |
|
|
listeriosis |
|
|
retinitis pigmentosa 23 |
|
|
noonan syndrome 8 |
|
|
retinitis pigmentosa 24 |
|
|