Aliases for PXT1 Gene

Aliases for PXT1 Gene

  • Peroxisomal Testis Enriched Protein 1 2 3 5
  • Small Testis-Specific Peroxisomal Protein 3 4
  • Peroxisomal Testis-Specific Protein 1 3 4
  • Peroxisomal, Testis Specific 1 2 3
  • STEPP 3 4

External Ids for PXT1 Gene

Previous GeneCards Identifiers for PXT1 Gene

  • GC06M036406
  • GC06M036466
  • GC06M036077

Summaries for PXT1 Gene

GeneCards Summary for PXT1 Gene

PXT1 (Peroxisomal Testis Enriched Protein 1) is a Protein Coding gene.

Additional gene information for PXT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PXT1 Gene

Genomics for PXT1 Gene

GeneHancer (GH) Regulatory Elements for PXT1 Gene

Promoters and enhancers for PXT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PXT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PXT1 gene promoter:
  • MyoD
  • N-Myc

Genomic Locations for PXT1 Gene

Genomic Locations for PXT1 Gene
chr6:36,390,551-36,442,889
(GRCh38/hg38)
Size:
52,339 bases
Orientation:
Minus strand
chr6:36,358,328-36,410,666
(GRCh37/hg19)
Size:
52,339 bases
Orientation:
Minus strand

Genomic View for PXT1 Gene

Genes around PXT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXT1 Gene

Proteins for PXT1 Gene

  • Protein details for PXT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFP0-PXT1_HUMAN
    Recommended name:
    Peroxisomal testis-specific protein 1
    Protein Accession:
    Q8NFP0
    Secondary Accessions:
    • J3KR74

    Protein attributes for PXT1 Gene

    Size:
    134 amino acids
    Molecular mass:
    16023 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31105.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI07050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAN03789.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PXT1 Gene

Post-translational modifications for PXT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PXT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PXT1 Gene

Domains & Families for PXT1 Gene

Gene Families for PXT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PXT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PXT1 Gene

GenScript: Design optimal peptide antigens:
  • Small testis-specific peroxisomal protein (PXT1_HUMAN)
genes like me logo Genes that share domains with PXT1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PXT1 Gene

Function for PXT1 Gene

Phenotypes From GWAS Catalog for PXT1 Gene

Gene Ontology (GO) - Molecular Function for PXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PXT1: view
genes like me logo Genes that share phenotypes with PXT1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PXT1 Gene

Localization for PXT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXT1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PXT1 gene
Compartment Confidence
peroxisome 4
nucleus 3
cytosol 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005777 peroxisome ISS,IBA 18160785
genes like me logo Genes that share ontologies with PXT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PXT1 Gene

Pathways & Interactions for PXT1 Gene

PathCards logo

SuperPathways for PXT1 Gene

No Data Available

Interacting Proteins for PXT1 Gene

Selected Interacting proteins: Q8NFP0-PXT1_HUMAN for PXT1 Gene via IID

Symbol External ID(s) Details
NOMO1

Gene Ontology (GO) - Biological Process for PXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043065 positive regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with PXT1: view

No data available for Pathways by source and SIGNOR curated interactions for PXT1 Gene

Drugs & Compounds for PXT1 Gene

No Compound Related Data Available

Transcripts for PXT1 Gene

mRNA/cDNA for PXT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXT1 Gene

No ASD Table

Relevant External Links for PXT1 Gene

GeneLoc Exon Structure for
PXT1
ECgene alternative splicing isoforms for
PXT1

Expression for PXT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PXT1 Gene

mRNA differential expression in normal tissues according to GTEx for PXT1 Gene

This gene is overexpressed in Testis (x14.2) and Whole Blood (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of PXT1 Gene:

PXT1

SOURCE GeneReport for Unigene cluster for PXT1 Gene:

Hs.520097
genes like me logo Genes that share expression patterns with PXT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXT1 Gene

Orthologs for PXT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PXT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PXT1 33 32
  • 99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PXT1 32
  • 84.96 (n)
dog
(Canis familiaris)
Mammalia PXT1 33
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pxt1 33
  • 61 (a)
OneToOne
Species where no ortholog for PXT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PXT1 Gene

ENSEMBL:
Gene Tree for PXT1 (if available)
TreeFam:
Gene Tree for PXT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PXT1: view image

Paralogs for PXT1 Gene

No data available for Paralogs for PXT1 Gene

Variants for PXT1 Gene

Sequence variations from dbSNP and Humsavar for PXT1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000024494 -- 36,402,188(-) G/A intron_variant
rs1000050759 -- 36,421,977(-) C/G intron_variant
rs1000093132 -- 36,403,855(-) G/C intron_variant
rs1000111346 -- 36,408,727(-) T/A/C intron_variant
rs1000188805 -- 36,408,233(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PXT1 Gene

Variant ID Type Subtype PubMed ID
esv1649787 CNV insertion 17803354
esv2671959 CNV deletion 23128226
esv3571007 CNV loss 25503493
esv3608703 CNV loss 21293372
nsv1114796 CNV deletion 24896259

Variation tolerance for PXT1 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PXT1 Gene

Human Gene Mutation Database (HGMD)
PXT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PXT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXT1 Gene

Disorders for PXT1 Gene

Additional Disease Information for PXT1

No disorders were found for PXT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PXT1 Gene

Publications for PXT1 Gene

  1. The putative peroxisomal gene Pxt1 is exclusively expressed in the testis. (PMID: 18160785) Grzmil P … Burfeind P (Cytogenetic and genome research 2007) 3 4 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  3. Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein. (PMID: 20068295) Kaczmarek K … Grzmil P (Cytogenetic and genome research 2009) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 56

Products for PXT1 Gene

Sources for PXT1 Gene