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This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PM... See more...
Aliases for PXN Gene
External Ids for PXN Gene
- HGNC: 9718
- Entrez Gene: 5829
- Ensembl: ENSG00000089159
- OMIM: 602505
- UniProtKB: P49023
Previous GeneCards Identifiers for PXN Gene
- GC12M119521
- GC12M120174
- GC12M120431
- GC12M119060
- GC12M119110
- GC12M120648
- GC12M117656
Summaries for PXN Gene
-
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
GeneCards Summary for PXN Gene
PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include Neurofibromatosis, Type Ii and Papilloma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is TGFB1I1.
UniProtKB/Swiss-Prot Summary for PXN Gene
-
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Additional gene information for PXN Gene
- HGNC(9718)
- Entrez Gene(5829)
- Ensembl(ENSG00000089159)
- OMIM(602505)
- UniProtKB(P49023)
- Open Targets Platform(ENSG00000089159)
- Monarch Initiative
- Search for PXN at DataMed
- Search for PXN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PXN Gene
Genomics for PXN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PXN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PXN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PXN
- Top Transcription factor binding sites by QIAGEN in the PXN gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- E2F
- E2F-1
- E2F-2
- STAT3
Genomic Locations for PXN Gene
Genomic Locations for PXN Gene
- chr12:120,210,439-120,265,771
- (GRCh38/hg38)
- Size:
- 55,333 bases
- Orientation:
- Minus strand
- chr12:120,648,250-120,703,574
- (GRCh37/hg19)
- Size:
- 55,325 bases
- Orientation:
- Minus strand
Genomic View for PXN Gene
Genes around PXN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.23 by HGNC
- 12q24.23 by Entrez Gene
- 12q24.23 by Ensembl
PXN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PXN Gene
Proteins for PXN Gene
-
Protein details for PXN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49023-PAXI_HUMAN
- Recommended name:
- Paxillin
- Protein Accession:
- P49023
- B2RAI3
- B7ZMB4
- O14970
- O14971
- O60360
- Q5HYA4
Protein attributes for PXN Gene
- Size:
- 591 amino acids
- Molecular mass:
- 64505 Da
- Quaternary structure:
-
- Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB. Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988).
Three dimensional structures from OCA and Proteopedia for PXN Gene
Protein Expression for PXN Gene
Post-translational modifications for PXN Gene
- Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PXN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005253974.1
- XP_006719595.1
- XP_006719597.1
- XP_006719598.1
- XP_006719599.1
- XP_011536924.1
- XP_011536925.1
- XP_016875215.1
- XP_016875218.1
- XP_016875219.1
- XP_016875221.1
- XP_016875222.1
- XP_016875223.1
- XP_016875224.1
- XP_016875225.1
- XP_016875226.1
- XP_016875227.1
- XP_016875228.1
- XP_016875229.1
- XP_016875231.1
- XP_016875232.1
- XP_024304875.1
- XP_024304876.1
- XP_024304877.1
- XP_024304878.1
- NP_001074324.1
- NP_001230685.1
- NP_002850.2
- NP_079433.3
Antibody Products
- LifeSpan BioSciences PXN / Paxillin Antibody and PXN / Paxillin Monoclonal Antibody
- NSJ Bioreagents Paxillin Antibody
-
Custom Antibody ServicesOriGene Antibodies for PXN
- AM20658PU-N
- AP00184PU-N
- AP01665PU-N
- AP02387PU-N
- AP02387PU-S
- AP02469PU-N
- AP02469PU-S
- AP02638PU-N
- AP02638PU-S
- AP02711PU-N
- AP02711PU-S
- AP06280PU-N
- AP09486PU-N
- AP09486PU-S
- AP09512PU-N
- AP09512PU-S
- AP20690PU-N
- AP20813PU-N
- AP23197PU-N
- AP55781PU-N
- AP55781PU-S
- AP55792PU-N
- AP55792PU-S
- CF811256
- CF811258
- CF811259
- CF811264
- CF811265
- TA302184
- TA310006
- TA321540
- TA321541
- TA323769
- TA323770
- TA326062
- TA326090
- TA326183
- TA327809
- TA327810
- TA327869
- TA327870
- TA333025
- TA333282
- TA348434
- TA354690
- TA811256
- TA811256S
- TA811258
- TA811258S
- TA811259
- TA811259S
- TA811264
- TA811264S
- TA811265
- TA811265S
- Novus Biologicals Antibodies for PXN
-
Abcam antibodies for PXN
- Invitrogen Antibodies for PXN (AFLGC-PXN)
- antibodies-online: Show 133 available Paxillin Antibodies ranked by validation data
- Compare Top Paxillin Antibodies
-
Recommended
- 334 WB Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 7 IF Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 159 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 149 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Boster Bio Antibodies for PXN
-
Santa Cruz Biotechnology (SCBT) Antibodies for PXN
- Sino Biological Antibodies for PXN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PXN
- Origene Custom Protein Services for PXN
-
Signalway Proteins for PXN
-
Abcam proteins for PXN
Assay Products
- G Biosciences Immunotag™ Paxillin ELISA Kit
- RayBiotech Custom Human Paxillin ELISA
-
Signalway ELISA kits for PXN
No data available for DME Specific Peptides for PXN Gene
Domains & Families for PXN Gene
Gene Families for PXN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PXN Gene
- InterPro:
- Blocks:
-
- Zn-binding protein, LIM
- Paxillin signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PXN Gene
- GenScript: Design optimal peptide antigens:
-
- Paxillin (PAXI_HUMAN)
- PXN protein (Q7Z7K5_HUMAN)
- PXN protein (Q9BTK0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49023- Family:
-
- Belongs to the paxillin family.
Function for PXN Gene
Molecular function for PXN Gene
- UniProtKB/Swiss-Prot Function:
- Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
- GENATLAS Biochemistry:
- focal adhesion protein (68kDa),paxillin
Phenotypes From GWAS Catalog for PXN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription coregulator activity | IBA | 21873635 |
| GO:0005178 | integrin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 7561682 |
| GO:0008013 | beta-catenin binding | IPI | 17513457 |
| GO:0017166 | vinculin binding | IPI | 9054445 |
Phenotypes for PXN Gene
- MGI mutant phenotypes for PXN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PXN:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability ratio
- Decreased viability
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased cell migration
- Decreased POU5F1-GFP protein expression
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
Animal Models for PXN Gene
- MGI Knock Outs for PXN:
-
- Pxn Pxn<tm1Smth>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PXN - Select products 50% OFF >
- * PXN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PXN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PXN
-
Santa Cruz Biotechnology (SCBT) CRISPR for PXN
miRNA for PXN Gene
- miRTarBase miRNAs that target PXN
-
- hsa-miR-137 (MIRT007346)
- hsa-miR-335-5p (MIRT018650)
- hsa-miR-124-3p (MIRT023030)
- hsa-miR-221-3p (MIRT046850)
- hsa-miR-92a-3p (MIRT049136)
- hsa-miR-212-3p (MIRT732117)
- hsa-miR-27b-5p (MIRT732799)
- hsa-miR-145-5p (MIRT734440)
- hsa-miR-1255a (MIRT736576)
- hsa-miR-1255b-5p (MIRT736599)
- hsa-miR-139-3p (MIRT737549)
- hsa-miR-3123 (MIRT739989)
- hsa-miR-3165 (MIRT740562)
- hsa-miR-3621 (MIRT741756)
- hsa-miR-3656 (MIRT741931)
- hsa-miR-3691-5p (MIRT742525)
- hsa-miR-3913-3p (MIRT742856)
- hsa-miR-3915 (MIRT742885)
- hsa-miR-3928-3p (MIRT743049)
- hsa-miR-4734 (MIRT747979)
- hsa-miR-4753-5p (MIRT748350)
- hsa-miR-4796-3p (MIRT748974)
- hsa-miR-5693 (MIRT751237)
- hsa-miR-6077 (MIRT751717)
- hsa-miR-6744-5p (MIRT754443)
- hsa-miR-6759-3p (MIRT754897)
- hsa-miR-6782-3p (MIRT755694)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PXN
- Browse OriGene Inhibitory RNA Products For PXN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXN
Clone Products
- Applied Biological Materials (abm): Clones for PXN - Select products 50% OFF >
- * PXN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227457
- MG227462
- MR227457
- MR227457L3
- MR227457L4
- MR227462
- RC213811
- RC213811L1
- RC213811L2
- RC213811L3
- RC213811L4
- RC225692
- RC225692L3
- RC225692L4
- RC225997
- RC225997L3
- RC225997L4
- RC234550
- RG213811
- RG225692
- RG225997
- RG234550
- RR214314
- RR214314L1
- RR214314L2
- RR214314L3
- RR214314L4
- MR227457L3V
- MR227457L4V
- RC213811L1V
- RC213811L2V
- RC213811L3V
- RC213811L4V
- RC225692L3V
- RC225692L4V
- RC225997L3V
- RC225997L4V
- RR214314L1V
- RR214314L2V
- RR214314L3V
- RR214314L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PXN
- Addgene plasmids for PXN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PXN
Cell Line Products
-
Horizon Cell Lines for PXN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PXN Gene
Localization for PXN Gene
Subcellular locations from UniProtKB/Swiss-Prot for PXN Gene
- Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269 PubMed:23128389}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (4)
- Focal adhesion sites (4)
- Centrosome (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IDA | 24036928 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005875 | microtubule associated complex | TAS | 10840040 |
Pathways & Interactions for PXN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell junction organization | ||
| 2 | Focal Adhesion |
.61
.61
|
HGF Pathway
.33
|
| 3 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
|
Transendothelial Migration of Leukocytes
.38
|
| 4 | RET signaling | ||
| 5 | Human cytomegalovirus infection | ||
Pathways by source for PXN Gene
5 Sino Biological pathways for PXN Gene
23 BioSystems pathways for PXN Gene
14 Reactome pathways for PXN Gene
13 KEGG pathways for PXN Gene
10 GeneGo (Thomson Reuters) pathways for PXN Gene
- Cell adhesion Ephrins signaling
- Cell adhesion Integrin-mediated cell adhesion and migration
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling FAK signaling
- Cytoskeleton remodeling Integrin outside-in signaling
2 R&D Systems pathways for PXN Gene
23 Qiagen pathways for PXN Gene
- Agrin Interactions at Neuromuscular Junction
- Akt Signaling
- Calpain Protease Regulates Cellular Mechanics
- CCKBR-Gastrin Stimulated Signaling
- CXCR4 Pathway
2 Cell Signaling Technology pathways for PXN Gene
1 GeneTex pathway for PXN Gene
Interacting Proteins for PXN Gene
Selected Interacting proteins:
P49023-PAXI_HUMAN
ENSP00000267257
for PXN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PXN
SIGNOR curated interactions for PXN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006936 | muscle contraction | TAS | -- |
| GO:0007155 | cell adhesion | NAS | 10840040 |
| GO:0007165 | signal transduction | TAS | 7534286 |
| GO:0007172 | signal complex assembly | TAS | 9054445 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IBA,IDA | 24036928 |
Transcripts for PXN Gene
mRNA/cDNA for PXN Gene
- 4 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000228307 3785 nts (view in UCSC)
- ENST00000267257 3835 nts (view in UCSC)
- ENST00000323871 5457 nts (view in UCSC)
- ENST00000424649 3683 nts (view in UCSC)
- ENST00000440827 516 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PXN - Select products 50% OFF >
- * PXN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PXN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PXN
-
Santa Cruz Biotechnology (SCBT) CRISPR for PXN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PXN
- Browse OriGene Inhibitory RNA Products For PXN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXN
Clone Products
- Applied Biological Materials (abm): Clones for PXN - Select products 50% OFF >
- * PXN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227457
- MG227462
- MR227457
- MR227457L3
- MR227457L4
- MR227462
- RC213811
- RC213811L1
- RC213811L2
- RC213811L3
- RC213811L4
- RC225692
- RC225692L3
- RC225692L4
- RC225997
- RC225997L3
- RC225997L4
- RC234550
- RG213811
- RG225692
- RG225997
- RG234550
- RR214314
- RR214314L1
- RR214314L2
- RR214314L3
- RR214314L4
- MR227457L3V
- MR227457L4V
- RC213811L1V
- RC213811L2V
- RC213811L3V
- RC213811L4V
- RC225692L3V
- RC225692L4V
- RC225997L3V
- RC225997L4V
- RR214314L1V
- RR214314L2V
- RR214314L3V
- RR214314L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PXN
- Addgene plasmids for PXN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PXN
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for PXN Gene
- GeneLoc Exon Structure for
- PXN
Expression for PXN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
mRNA differential expression in normal tissues according to GTEx for PXN Gene
This gene is overexpressed in Whole Blood (x7.5).
This gene is overexpressed in NK cells (15.2), Peripheral blood mononuclear cells (10.0), and Bone marrow stromal cell (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PXN Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PXN
SOURCE GeneReport for Unigene cluster for PXN Gene:
Hs.446336Evidence on tissue expression from TISSUES for PXN Gene
- Nervous system(5)
- Liver(4.5)
- Skin(4.4)
- Lung(4.3)
- Kidney(3.9)
- Pancreas(3.7)
- Muscle(3.5)
- Eye(3.4)
- Intestine(3.3)
- Heart(3.3)
- Blood(3.1)
- Bone marrow(2.9)
- Lymph node(2.8)
- Spleen(2.8)
- Stomach(2.6)
- Thyroid gland(2.6)
- Bone(2.5)
- Adrenal gland(2.5)
Primer Products
-
OriGene qPCR primer pairs for PXN
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXN Gene
Orthologs for PXN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PXN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PXN 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PXN 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PXN 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pxn 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pxn 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PXN 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PXN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PXN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pxn 30 |
|
||
| Str.15031 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397826 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pxna 31 31 |
|
OneToMany | |
| LOC565130 30 |
|
||||
| PXN (1 of 3) 31 |
|
OneToMany | |||
| sbcb631 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pax 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C28H8.6 32 |
|
|
|
| pxl-1 31 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9134 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11495 30 |
|
- Species where no ortholog for PXN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PXN Gene
- ENSEMBL:
- Gene Tree for PXN (if available)
- TreeFam:
- Gene Tree for PXN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PXN: view image
Paralogs for PXN Gene
(11) SIMAP similar genes for PXN Gene using alignment to 11 proteins:
- PAXI_HUMAN
- E7EMK8_HUMAN
- F5GZ78_HUMAN
- F5H836_HUMAN
- F8VZ39_HUMAN
- F8W0G0_HUMAN
- F8W0K8_HUMAN
- F8W1E0_HUMAN
- H0YIE4_HUMAN
- Q7Z7K5_HUMAN
- Q9BTK0_HUMAN
Variants for PXN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PXN Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710179 | Benign: not provided | 120,215,008(-) | A/C | INTRON_VARIANT | |
| 715656 | Benign: not provided | 120,212,569(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 753878 | Likely Benign: not provided | 120,222,921(-) | G/A | SYNONYMOUS_VARIANT | |
| 773267 | Likely Benign: not provided | 120,222,754(-) | G/C | INTRON_VARIANT | |
| 776757 | Benign: not provided | 120,214,855(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3448120 | CNV | duplication | 20981092 |
| nsv472614 | CNV | novel sequence insertion | 20440878 |
| nsv519657 | CNV | loss | 19592680 |
| nsv560433 | CNV | loss | 21841781 |
| nsv560435 | CNV | loss | 21841781 |
| nsv560436 | CNV | loss | 21841781 |
| nsv7238 | OTHER | inversion | 18451855 |
| nsv832530 | CNV | loss | 17160897 |
| nsv905 | CNV | insertion | 18451855 |
| nsv976654 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.85;
34.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PXN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXN Gene
Disorders for PXN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neurofibromatosis, type ii |
|
|
| papilloma |
|
|
| breast adenocarcinoma |
|
|
| colorectal cancer |
|
|
| prostate cancer |
|
Search PXN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PXN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PXN Gene
Publications for PXN Gene
- Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PMID: 7534286) Salgia R … Ernst T (The Journal of biological chemistry 1995) 2 3 4 23
- Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (PMID: 19358827) Lulo J … Schlessinger J (Biochemical and biophysical research communications 2009) 3 4 23
- No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. (PMID: 19353596) Pallier K … Blons H (Molecular carcinogenesis 2009) 3 23 41
- The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PMID: 18508764) Wang X … Qin J (The Journal of biological chemistry 2008) 3 4 23
- Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. (PMID: 18940607) Lorenz S … Hoellerer MK (Structure (London, England : 1993) 2008) 3 4 23
ExternalLinks
Products for PXN Gene
- Custom Antibody ServicesOriGene Antibodies for PXN
- AM20658PU-N
- AP00184PU-N
- AP01665PU-N
- AP02387PU-N
- AP02387PU-S
- AP02469PU-N
- AP02469PU-S
- AP02638PU-N
- AP02638PU-S
- AP02711PU-N
- AP02711PU-S
- AP06280PU-N
- AP09486PU-N
- AP09486PU-S
- AP09512PU-N
- AP09512PU-S
- AP20690PU-N
- AP20813PU-N
- AP23197PU-N
- AP55781PU-N
- AP55781PU-S
- AP55792PU-N
- AP55792PU-S
- CF811256
- CF811258
- CF811259
- CF811264
- CF811265
- TA302184
- TA310006
- TA321540
- TA321541
- TA323769
- TA323770
- TA326062
- TA326090
- TA326183
- TA327809
- TA327810
- TA327869
- TA327870
- TA333025
- TA333282
- TA348434
- TA354690
- TA811256
- TA811256S
- TA811258
- TA811258S
- TA811259
- TA811259S
- TA811264
- TA811264S
- TA811265
- TA811265S
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PXN
- Origene Custom Protein Services for PXN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PXN
- Browse OriGene Inhibitory RNA Products For PXN
- OriGene qPCR primer pairs for PXN