External Ids for PXN Gene
Previous GeneCards Identifiers for PXN Gene
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
GeneCards Summary for PXN Gene
PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include Neurofibromatosis, Type Ii and Breast Adenocarcinoma. Among its related pathways are Integrin Pathway and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is TGFB1I1.
UniProtKB/Swiss-Prot Summary for PXN Gene
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).