This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PM... See more...

Aliases for PXN Gene

Aliases for PXN Gene

  • Paxillin 2 3 4 5
  • Testicular Tissue Protein Li 134 3
  • PXN 5

External Ids for PXN Gene

Previous GeneCards Identifiers for PXN Gene

  • GC12M119521
  • GC12M120174
  • GC12M120431
  • GC12M119060
  • GC12M119110
  • GC12M120648
  • GC12M117656

Summaries for PXN Gene

Entrez Gene Summary for PXN Gene

  • This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

GeneCards Summary for PXN Gene

PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include Neurofibromatosis, Type Ii and Breast Adenocarcinoma. Among its related pathways are Integrin Pathway and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is TGFB1I1.

UniProtKB/Swiss-Prot Summary for PXN Gene

  • Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Gene Wiki entry for PXN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PXN Gene

Genomics for PXN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PXN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120261 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 258.8 +1.8 1842 5.2 SP1 ZNF654 MYC ZNF580 BRCA1 POLR2A CEBPB CTCF REST SMAD5 PXN lnc-RPLP0-4 SIRT4 RPLP0 MSI1 RAB35 piR-38580-071 RF00017-1186
GH12J120244 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 257.8 +14.1 14054 14.1 IKZF1 ZNF600 JUND ZNF10 ZIC2 BCL11A CTCF CEBPB BHLHE40 KLF7 PXN piR-38580-070 SIRT4 RNU4-1 RNU4-2 RNU6-1088P PLA2G1B BICDL1 RNF10 RAB35
GH12J120266 Enhancer 0.3 ENCODE dbSUPER 250.7 -1.0 -966 0 PXN lnc-RPLP0-4 RF00017-1188 SIRT4 RF00017-1186
GH12J120223 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20 +34.3 34265 15.9 BCLAF1 MYC NCOR1 ZNF654 IKZF1 ZNF600 SSRP1 JUND ZNF592 ZMYM3 PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12J120290 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -26.4 -26387 3.5 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC IKZF1 ZNF600 SIX5 SSRP1 SIRT4 RNU4-1 RNU4-2 GCN1 RPL31P52 RAB35 SRSF9 PXN PXN-AS1 RPLP0
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PXN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PXN

Top Transcription factor binding sites by QIAGEN in the PXN gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • STAT3

Genomic Locations for PXN Gene

Latest Assembly
chr12:120,210,439-120,265,771
(GRCh38/hg38)
Size:
55,333 bases
Orientation:
Minus strand

Previous Assembly
chr12:120,648,250-120,703,533
(GRCh37/hg19 by Entrez Gene)
Size:
55,284 bases
Orientation:
Minus strand

chr12:120,648,250-120,703,574
(GRCh37/hg19 by Ensembl)
Size:
55,325 bases
Orientation:
Minus strand

Genomic View for PXN Gene

Genes around PXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXN Gene

Proteins for PXN Gene

  • Protein details for PXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49023-PAXI_HUMAN
    Recommended name:
    Paxillin
    Protein Accession:
    P49023
    Secondary Accessions:
    • B2RAI3
    • B7ZMB4
    • O14970
    • O14971
    • O60360
    • Q5HYA4

    Protein attributes for PXN Gene

    Size:
    591 amino acids
    Molecular mass:
    64505 Da
    Quaternary structure:
    • Interacts in vitro with VCL/vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of CRK (PubMed:7534286). Interacts with GIT1 (PubMed:10938112). Interacts with NUDT16L1/SDOS (By similarity). Interacts with PTK2/FAK1 (PubMed:14527389). Interacts with PTK2B/PYK2 (PubMed:19358827). Interacts with ASAP2 (PubMed:10749932). Interacts with unphosphorylated ITGA4 (PubMed:10604475). Interacts with RNF5 (PubMed:12861019). Interacts with PDCD10 (PubMed:20489202). Interacts with NEK3, the interaction is prolactin-dependent (PubMed:17297458). Interacts with PTK6 (PubMed:15572663). Interacts with TGFB1I1 (By similarity). Interacts with SORBS1 (PubMed:17462669). Interacts with PARVB (PubMed:22869380). Interacts (via LD motif 4) with PARVA/PARVIN (PubMed:15817463, PubMed:18508764, PubMed:18940607). Interacts (via LD motif 4) with ILK (PubMed:15817463, PubMed:18508764, PubMed:18940607). Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988). Interacts with CD36 (via C-terminus) (PubMed:20037584).
    • [Isoform Beta]: Interacts strongly with PTK2/FAK1 and weakly with VCL/vinculin.
    • [Isoform Gamma]: Interacts strongly with VCL/vinculin but only weakly with PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for PXN Gene

    Alternative splice isoforms for PXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXN Gene

Post-translational modifications for PXN Gene

  • Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

No data available for DME Specific Peptides for PXN Gene

Domains & Families for PXN Gene

Gene Families for PXN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PXN Gene

InterPro:
Blocks:
  • Zn-binding protein, LIM
  • Paxillin signature

Suggested Antigen Peptide Sequences for PXN Gene

GenScript: Design optimal peptide antigens:
  • Paxillin (PAXI_HUMAN)
  • PXN protein (Q7Z7K5_HUMAN)
  • PXN protein (Q9BTK0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49023

UniProtKB/Swiss-Prot:

PAXI_HUMAN :
  • Belongs to the paxillin family.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with PXN: view

Function for PXN Gene

Molecular function for PXN Gene

UniProtKB/Swiss-Prot Function:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
GENATLAS Biochemistry:
focal adhesion protein (68kDa),paxillin

Phenotypes From GWAS Catalog for PXN Gene

Gene Ontology (GO) - Molecular Function for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IBA 21873635
GO:0005515 protein binding IPI 7561682
GO:0008013 beta-catenin binding IPI 17513457
GO:0017166 vinculin binding IPI 9054445
GO:0019903 protein phosphatase binding IPI 28759036
genes like me logo Genes that share ontologies with PXN: view
genes like me logo Genes that share phenotypes with PXN: view

Animal Models for PXN Gene

MGI Knock Outs for PXN:
  • Pxn Pxn<tm1Smth>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXN

Clone products for research

  • Addgene plasmids for PXN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PXN Gene

Localization for PXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXN Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269 PubMed:23128389}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PXN gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 4
extracellular 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Focal adhesion sites (4)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 24036928
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005875 microtubule associated complex TAS 10840040
genes like me logo Genes that share ontologies with PXN: view

Pathways & Interactions for PXN Gene

genes like me logo Genes that share pathways with PXN: view

Pathways by source for PXN Gene

10 GeneGo (Thomson Reuters) pathways for PXN Gene
  • Cell adhesion Ephrins signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling FAK signaling
  • Cytoskeleton remodeling Integrin outside-in signaling
2 R&D Systems pathways for PXN Gene
23 Qiagen pathways for PXN Gene
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics
  • CCKBR-Gastrin Stimulated Signaling
  • CXCR4 Pathway
2 Cell Signaling Technology pathways for PXN Gene
1 GeneTex pathway for PXN Gene

SIGNOR curated interactions for PXN Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion NAS 10840040
GO:0007160 cell-matrix adhesion IEA --
GO:0007165 signal transduction TAS 7534286
genes like me logo Genes that share ontologies with PXN: view

Drugs & Compounds for PXN Gene

(45) Drugs for PXN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(37) Additional Compounds for PXN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PXN: view

Transcripts for PXN Gene

mRNA/cDNA for PXN Gene

14 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXN

Clone products for research

  • Addgene plasmids for PXN

Alternative Splicing Database (ASD) splice patterns (SP) for PXN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: -
SP8: - - -
SP9: -
SP10:

Relevant External Links for PXN Gene

GeneLoc Exon Structure for
PXN

Expression for PXN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PXN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PXN Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for PXN Gene

This gene is overexpressed in NK cells (15.2), Peripheral blood mononuclear cells (10.0), and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PXN Gene



Protein tissue co-expression partners for PXN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PXN

SOURCE GeneReport for Unigene cluster for PXN Gene:

Hs.446336

Evidence on tissue expression from TISSUES for PXN Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Skin(4.4)
  • Lung(4.2)
  • Kidney(3.7)
  • Pancreas(3.6)
  • Muscle(3.3)
  • Eye(3.3)
  • Intestine(3.2)
  • Heart(3.1)
  • Blood(2.9)
  • Bone marrow(2.8)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Stomach(2.5)
  • Thyroid gland(2.5)
  • Adrenal gland(2.4)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with PXN: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXN Gene

Orthologs for PXN Gene

This gene was present in the common ancestor of animals.

Orthologs for PXN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PXN 29 30
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PXN 29 30
  • 91.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PXN 30
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PXN 29 30
  • 89.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pxn 29 16 30
  • 88.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pxn 29
  • 88.16 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PXN 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PXN 29 30
  • 81.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PXN 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pxn 29
  • 73.19 (n)
Str.15031 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397826 29
Zebrafish
(Danio rerio)
Actinopterygii pxna 30 30
  • 91 (a)
OneToMany
LOC565130 29
  • 69.65 (n)
PXN (1 of 3) 30
  • 33 (a)
OneToMany
sbcb631 29
Fruit Fly
(Drosophila melanogaster)
Insecta Pax 30 31
  • 45 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C28H8.6 31
  • 54 (a)
pxl-1 30
  • 42 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9134 30
  • 54 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11495 29
Species where no ortholog for PXN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PXN Gene

ENSEMBL:
Gene Tree for PXN (if available)
TreeFam:
Gene Tree for PXN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PXN: view image
Alliance of Genome Resources:
Additional Orthologs for PXN

Paralogs for PXN Gene

Paralogs for PXN Gene

(11) SIMAP similar genes for PXN Gene using alignment to 11 proteins:

  • PAXI_HUMAN
  • E7EMK8_HUMAN
  • F5GZ78_HUMAN
  • F5H836_HUMAN
  • F8VZ39_HUMAN
  • F8W0G0_HUMAN
  • F8W0K8_HUMAN
  • F8W1E0_HUMAN
  • H0YIE4_HUMAN
  • Q7Z7K5_HUMAN
  • Q9BTK0_HUMAN
genes like me logo Genes that share paralogs with PXN: view

Variants for PXN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PXN Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs114085181 Benign: not provided 120,215,095(-) C/T
NM_001080855.3(PXN):c.1104+8G>A
INTRON
rs141848390 Benign: not provided 120,224,274(-) T/C
NM_001080855.3(PXN):c.117A>G (p.Thr39=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs186612390 Benign: not provided 120,215,008(-) A/C
NM_001080855.3(PXN):c.1105-10T>G
INTRON
rs188297788 Likely Benign: not provided 120,222,754(-) G/C
NM_001080855.3(PXN):c.494-4C>G
INTRON
rs25662 Benign: not provided 120,214,855(-) G/A
NM_001080855.3(PXN):c.1248C>T (p.Arg416=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PXN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PXN Gene

Variant ID Type Subtype PubMed ID
esv3448120 CNV duplication 20981092
nsv472614 CNV novel sequence insertion 20440878
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv560435 CNV loss 21841781
nsv560436 CNV loss 21841781
nsv7238 OTHER inversion 18451855
nsv832530 CNV loss 17160897
nsv905 CNV insertion 18451855
nsv976654 CNV duplication 23825009

Variation tolerance for PXN Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PXN Gene

Human Gene Mutation Database (HGMD)
PXN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PXN
Leiden Open Variation Database (LOVD)
PXN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXN Gene

Disorders for PXN Gene

MalaCards: The human disease database

(12) MalaCards diseases for PXN Gene - From: COP and GCD

Disorder Aliases PubMed IDs
neurofibromatosis, type ii
  • nf2
breast adenocarcinoma
  • adenocarcinoma of breast
papilloma
  • papillomatosis
colorectal cancer
  • crc
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search PXN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PXN

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXN Gene

Publications for PXN Gene

  1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PMID: 7534286) Salgia R … Ernst T (The Journal of biological chemistry 1995) 2 3 4 22
  2. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (PMID: 19358827) Lulo J … Schlessinger J (Biochemical and biophysical research communications 2009) 3 4 22
  3. No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. (PMID: 19353596) Pallier K … Blons H (Molecular carcinogenesis 2009) 3 22 40
  4. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PMID: 18508764) Wang X … Qin J (The Journal of biological chemistry 2008) 3 4 22
  5. Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. (PMID: 18940607) Lorenz S … Hoellerer MK (Structure (London, England : 1993) 2008) 3 4 22

Products for PXN Gene