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Aliases for PXMP4 Gene

Aliases for PXMP4 Gene

  • Peroxisomal Membrane Protein 4 2 3 5
  • 24 KDa Peroxisomal Intrinsic Membrane Protein 2 3 4
  • Peroxisomal Membrane Protein 4, 24kDa 2 3
  • PMP24 3 4
  • Peroxisomal Membrane Protein 4 (24kD) 2

External Ids for PXMP4 Gene

Previous GeneCards Identifiers for PXMP4 Gene

  • GC20M032053
  • GC20M032962
  • GC20M033010
  • GC20M031758
  • GC20M032290
  • GC20M029076

Summaries for PXMP4 Gene

GeneCards Summary for PXMP4 Gene

PXMP4 (Peroxisomal Membrane Protein 4) is a Protein Coding gene. Among its related pathways are Peroxisome.

Gene Wiki entry for PXMP4 Gene

Additional gene information for PXMP4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXMP4 Gene

Genomics for PXMP4 Gene

GeneHancer (GH) Regulatory Elements for PXMP4 Gene

Promoters and enhancers for PXMP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I033719 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 170 1.6 HDGF PKNOX1 SIN3A YY1 ZNF207 ZNF143 FOS SP3 CEBPZ NFYC PXMP4 ZNF341-AS1 EIF2S2 ACTL10 PIGU CBFA2T2 GC20M033707
GH20I033672 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.1 +46.0 45973 4.5 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF213 KLF13 SP3 MXD4 ENSG00000271803 NECAB3 CBFA2T2 PXMP4 ZNF341 ENSG00000229188 E2F1 ZNF341-AS1 ASIP ACTL10
GH20I033368 Enhancer 1 ENCODE 19.5 +348.3 348303 6.1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 PXMP4 SNTA1 ENSG00000229188 ZNF341 BPIFA1 CBFA2T2 AHCY GC20P033389 BPIFB9P CDK5RAP1
GH20I033561 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.2 +158.0 157980 1.2 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 YY1 TCF12 SLC30A9 ATF7 CBFA2T2 GC20P033562 C20orf144 ACTL10 NECAB3 PXMP4 ENSG00000229188 ZNF341 GC20P033491 GC20P033492
GH20I033553 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +165.4 165386 3.1 HDGF PKNOX1 FOXA2 MLX ZNF48 YY1 ATF7 RXRA NFYC MIER2 CBFA2T2 C20orf144 ACTL10 NECAB3 PXMP4 ENSG00000229188 ZNF341 CDK5RAP1 CHMP4B BPIFB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PXMP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PXMP4 gene promoter:

Genomic Locations for PXMP4 Gene

Genomic Locations for PXMP4 Gene
chr20:33,702,744-33,720,330
(GRCh38/hg38)
Size:
17,587 bases
Orientation:
Minus strand
chr20:32,290,550-32,308,136
(GRCh37/hg19)

Genomic View for PXMP4 Gene

Genes around PXMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXMP4 Gene

Proteins for PXMP4 Gene

  • Protein details for PXMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I8-PXMP4_HUMAN
    Recommended name:
    Peroxisomal membrane protein 4
    Protein Accession:
    Q9Y6I8
    Secondary Accessions:
    • A2A2I7
    • Q9H0T4

    Protein attributes for PXMP4 Gene

    Size:
    212 amino acids
    Molecular mass:
    24264 Da
    Quaternary structure:
    • Interacts with PEX19.
    Miscellaneous:
    • Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

    Alternative splice isoforms for PXMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXMP4 Gene

Post-translational modifications for PXMP4 Gene

  • Glycosylation at Asn57 and Asn206
  • Modification sites at PhosphoSitePlus

Other Protein References for PXMP4 Gene

No data available for DME Specific Peptides for PXMP4 Gene

Domains & Families for PXMP4 Gene

Gene Families for PXMP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for PXMP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6I8

UniProtKB/Swiss-Prot:

PXMP4_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with PXMP4: view

Function for PXMP4 Gene

Phenotypes From GWAS Catalog for PXMP4 Gene

Gene Ontology (GO) - Molecular Function for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14709540
genes like me logo Genes that share ontologies with PXMP4: view
genes like me logo Genes that share phenotypes with PXMP4: view

miRNA for PXMP4 Gene

miRTarBase miRNAs that target PXMP4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PXMP4 Gene

Localization for PXMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXMP4 Gene

Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PXMP4 gene
Compartment Confidence
peroxisome 5
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Peroxisomes (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA --
GO:0005778 peroxisomal membrane ISS 10366717
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PXMP4: view

Pathways & Interactions for PXMP4 Gene

SuperPathways for PXMP4 Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with PXMP4: view

Pathways by source for PXMP4 Gene

1 KEGG pathway for PXMP4 Gene

Interacting Proteins for PXMP4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386385%0d%0a9606.ENSP00000357051%0d%0a9606.ENSP00000359233%0d%0a
Selected Interacting proteins: ENSP00000386385 Q9Y6I8-PXMP4_HUMAN for PXMP4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PXMP4: view

No data available for SIGNOR curated interactions for PXMP4 Gene

Drugs & Compounds for PXMP4 Gene

No Compound Related Data Available

Transcripts for PXMP4 Gene

Unigene Clusters for PXMP4 Gene

Peroxisomal membrane protein 4, 24kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXMP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for PXMP4 Gene

GeneLoc Exon Structure for
PXMP4
ECgene alternative splicing isoforms for
PXMP4

Expression for PXMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PXMP4 Gene

Protein differential expression in normal tissues from HIPED for PXMP4 Gene

This gene is overexpressed in Bone (28.1), Fetal ovary (13.8), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PXMP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of PXMP4 Gene:

PXMP4

SOURCE GeneReport for Unigene cluster for PXMP4 Gene:

Hs.654857

mRNA Expression by UniProt/SwissProt for PXMP4 Gene:

Q9Y6I8-PXMP4_HUMAN
Tissue specificity: Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.

Evidence on tissue expression from TISSUES for PXMP4 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PXMP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXMP4 Gene

Orthologs for PXMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PXMP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PXMP4 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia PXMP4 33 34
  • 86.01 (n)
dog
(Canis familiaris)
Mammalia PXMP4 33 34
  • 85.38 (n)
rat
(Rattus norvegicus)
Mammalia Pxmp4 33
  • 83.96 (n)
mouse
(Mus musculus)
Mammalia Pxmp4 33 16 34
  • 83.49 (n)
oppossum
(Monodelphis domestica)
Mammalia PXMP4 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXMP4 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PXMP4 33 34
  • 72.73 (n)
lizard
(Anolis carolinensis)
Reptilia PXMP4 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pxmp4 33
  • 69.03 (n)
Str.14175 33
zebrafish
(Danio rerio)
Actinopterygii PXMP4 34
  • 73 (a)
OneToOne
wu:fe02h09 33
  • 69.7 (n)
Dr.27801 33
worm
(Caenorhabditis elegans)
Secernentea F18F11.1 35 33 34
  • 53.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00828 33
  • 51.58 (n)
Species where no ortholog for PXMP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXMP4 Gene

ENSEMBL:
Gene Tree for PXMP4 (if available)
TreeFam:
Gene Tree for PXMP4 (if available)

Paralogs for PXMP4 Gene

No data available for Paralogs for PXMP4 Gene

Variants for PXMP4 Gene

Sequence variations from dbSNP and Humsavar for PXMP4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000097820 -- 33,706,079(-) C/T 3_prime_UTR_variant
rs1000188738 -- 33,703,129(-) G/T 3_prime_UTR_variant
rs1000293581 -- 33,707,807(-) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000341684 -- 33,722,269(-) G/A upstream_transcript_variant
rs1000370602 -- 33,709,464(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PXMP4 Gene

Variant ID Type Subtype PubMed ID
esv995879 CNV deletion 20482838
nsv1065189 CNV loss 25217958
nsv1143984 CNV deletion 24896259
nsv3353 CNV deletion 18451855
nsv828714 CNV loss 20364138
nsv833961 CNV loss 17160897

Variation tolerance for PXMP4 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PXMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PXMP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXMP4 Gene

Disorders for PXMP4 Gene

Additional Disease Information for PXMP4

No disorders were found for PXMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PXMP4 Gene

Publications for PXMP4 Gene

  1. Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. (PMID: 10366717) Reguenga C … Azevedo JE (Biochimica et biophysica acta 1999) 2 3 4 58
  2. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. (PMID: 20054818) Zhang X … Ho SM (The Prostate 2010) 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. (PMID: 14709540) Jones JM … Gould SJ (The Journal of cell biology 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PXMP4 Gene

Sources for PXMP4 Gene

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