Aliases for PXMP4 Gene

Aliases for PXMP4 Gene

  • Peroxisomal Membrane Protein 4 2 3 4 5
  • 24 KDa Peroxisomal Intrinsic Membrane Protein 2 3 4
  • PMP24 2 3 4
  • Peroxisomal Membrane Protein 4, 24kDa 2 3
  • Peroxisomal Membrane Protein 4 (24kD) 2
  • PXMP4 5

External Ids for PXMP4 Gene

Previous GeneCards Identifiers for PXMP4 Gene

  • GC20M032053
  • GC20M032962
  • GC20M033010
  • GC20M031758
  • GC20M032290
  • GC20M029076
  • GC20M033706
  • GC20M033707
  • GC20M033712

Summaries for PXMP4 Gene

GeneCards Summary for PXMP4 Gene

PXMP4 (Peroxisomal Membrane Protein 4) is a Protein Coding gene. Diseases associated with PXMP4 include Alpha-Methylacyl-Coa Racemase Deficiency. Among its related pathways are Peroxisome.

Gene Wiki entry for PXMP4 Gene

Additional gene information for PXMP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PXMP4 Gene

Genomics for PXMP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PXMP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PXMP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PXMP4

Top Transcription factor binding sites by QIAGEN in the PXMP4 gene promoter:
  • AREB6
  • ARP-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • MyoD
  • Nkx5-1
  • Sox9
  • STAT5A
  • TGIF

Genomic Locations for PXMP4 Gene

Genomic Locations for PXMP4 Gene
17,562 bases
Minus strand
17,587 bases
Minus strand

Genomic View for PXMP4 Gene

Genes around PXMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXMP4 Gene

Proteins for PXMP4 Gene

  • Protein details for PXMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisomal membrane protein 4
    Protein Accession:
    Secondary Accessions:
    • A2A2I7
    • Q9H0T4

    Protein attributes for PXMP4 Gene

    212 amino acids
    Molecular mass:
    24264 Da
    Quaternary structure:
    • Interacts with PEX19.
    • Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

    Alternative splice isoforms for PXMP4 Gene


neXtProt entry for PXMP4 Gene

Post-translational modifications for PXMP4 Gene

  • Glycosylation at Asn57 and Asn206
  • Modification sites at PhosphoSitePlus

Other Protein References for PXMP4 Gene

No data available for DME Specific Peptides for PXMP4 Gene

Domains & Families for PXMP4 Gene

Gene Families for PXMP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for PXMP4 Gene


Suggested Antigen Peptide Sequences for PXMP4 Gene

GenScript: Design optimal peptide antigens:
  • Peroxisomal membrane protein 4, 24kDa (A2A2I7_HUMAN)
  • cDNA FLJ53748, moderately similar to Peroxisomal membrane protein 4 (B4DWH1_HUMAN)
  • 24 kDa peroxisomal intrinsic membrane protein (PXMP4_HUMAN)
  • cDNA, FLJ95592, highly similar to Homo sapiens peroxisomal membrane protein 4, 24kDa (PXMP4), mRNA (Q6FIF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with PXMP4: view

Function for PXMP4 Gene

Phenotypes From GWAS Catalog for PXMP4 Gene

Gene Ontology (GO) - Molecular Function for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14709540
genes like me logo Genes that share ontologies with PXMP4: view
genes like me logo Genes that share phenotypes with PXMP4: view

Animal Model Products

CRISPR Products

miRNA for PXMP4 Gene

miRTarBase miRNAs that target PXMP4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXMP4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PXMP4 Gene

Localization for PXMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXMP4 Gene

Peroxisome membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PXMP4 gene
Compartment Confidence
peroxisome 5
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
extracellular 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Peroxisomes (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA --
GO:0005778 peroxisomal membrane IBA,ISS 10366717
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PXMP4: view

Pathways & Interactions for PXMP4 Gene

PathCards logo

SuperPathways for PXMP4 Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with PXMP4: view

Pathways by source for PXMP4 Gene

1 KEGG pathway for PXMP4 Gene

Interacting Proteins for PXMP4 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000386385 Q9Y6I8-PXMP4_HUMAN for PXMP4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PXMP4: view

No data available for SIGNOR curated interactions for PXMP4 Gene

Drugs & Compounds for PXMP4 Gene

No Compound Related Data Available

Transcripts for PXMP4 Gene

mRNA/cDNA for PXMP4 Gene

12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PXMP4

Alternative Splicing Database (ASD) splice patterns (SP) for PXMP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -

Relevant External Links for PXMP4 Gene

GeneLoc Exon Structure for

Expression for PXMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PXMP4 Gene

Protein differential expression in normal tissues from HIPED for PXMP4 Gene

This gene is overexpressed in Bone (28.1), Fetal ovary (13.8), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PXMP4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PXMP4

SOURCE GeneReport for Unigene cluster for PXMP4 Gene:


mRNA Expression by UniProt/SwissProt for PXMP4 Gene:

Tissue specificity: Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.

Evidence on tissue expression from TISSUES for PXMP4 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PXMP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXMP4 Gene

Orthologs for PXMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PXMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PXMP4 30 31
  • 99.84 (n)
(Bos Taurus)
Mammalia PXMP4 30 31
  • 86.01 (n)
(Canis familiaris)
Mammalia PXMP4 30 31
  • 85.38 (n)
(Rattus norvegicus)
Mammalia Pxmp4 30
  • 83.96 (n)
(Mus musculus)
Mammalia Pxmp4 30 17 31
  • 83.49 (n)
(Monodelphis domestica)
Mammalia PXMP4 31
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PXMP4 31
  • 58 (a)
(Gallus gallus)
Aves PXMP4 30 31
  • 72.73 (n)
(Anolis carolinensis)
Reptilia PXMP4 31
  • 79 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pxmp4 30
  • 69.03 (n)
Str.14175 30
(Danio rerio)
Actinopterygii PXMP4 31
  • 73 (a)
wu:fe02h09 30
  • 69.7 (n)
Dr.27801 30
(Caenorhabditis elegans)
Secernentea F18F11.1 30 31 32
  • 53.2 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00828 30
  • 51.58 (n)
Species where no ortholog for PXMP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PXMP4 Gene

Gene Tree for PXMP4 (if available)
Gene Tree for PXMP4 (if available)
Evolutionary constrained regions (ECRs) for PXMP4: view image

Paralogs for PXMP4 Gene

No data available for Paralogs for PXMP4 Gene

Variants for PXMP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PXMP4 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs910397 - p.Val204Ile

Additional dbSNP identifiers (rs#s) for PXMP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PXMP4 Gene

Variant ID Type Subtype PubMed ID
esv995879 CNV deletion 20482838
nsv1065189 CNV loss 25217958
nsv1143984 CNV deletion 24896259
nsv3353 CNV deletion 18451855
nsv828714 CNV loss 20364138
nsv833961 CNV loss 17160897

Variation tolerance for PXMP4 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PXMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXMP4 Gene

Disorders for PXMP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PXMP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alpha-methylacyl-coa racemase deficiency
  • amacrd
- elite association - COSMIC cancer census association via MalaCards
Search PXMP4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PXMP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXMP4 Gene

Publications for PXMP4 Gene

  1. Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. (PMID: 10366717) Reguenga C … Azevedo JE (Biochimica et biophysica acta 1999) 2 3 4
  2. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. (PMID: 20054818) Zhang X … Ho SM (The Prostate 2010) 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. (PMID: 14709540) Jones JM … Gould SJ (The Journal of cell biology 2004) 3 4

Products for PXMP4 Gene

  • Signalway ELISA kits for PXMP4

Sources for PXMP4 Gene