Free for academic non-profit institutions. Other users need a Commercial license
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
PURG (Purine Rich Element Binding Protein G) is a Protein Coding gene. Diseases associated with PURG include Werner Syndrome. An important paralog of this gene is PURA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0032422 | purine-rich negative regulatory element binding | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PURG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PURG 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Purg 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Purg 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PURG 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PURG 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PURG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PURG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PURG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | purg 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | purg 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Pur-alpha 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | plp-1 31 |
|
ManyToMany | |
plp-2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs578121063 | Uncertain Significance: Werner syndrome | 31,033,351(-) |
G/C NM_001323311.2(PURG):c.-280C>G |
FIVE_PRIME_UTR | |
VAR_036317 | A breast cancer sample |
p.Lys316Thr |
|||
rs11574151 | - |
p.Glu241Ala |
|||
rs11574153 | - |
p.Ser26Gly |
|||
rs7464560 | - |
p.Glu143Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv22033 | CNV | loss | 19812545 |
nsv1133688 | CNV | deletion | 24896259 |
nsv1145194 | CNV | deletion | 24896259 |
nsv527651 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
werner syndrome |
|
|