Aliases for PURG Gene
Aliases for PURG Gene
External Ids for PURG Gene
- HGNC: 17930
- Entrez Gene: 29942
- Ensembl: ENSG00000172733
- UniProtKB: Q9UJV8
Previous GeneCards Identifiers for PURG Gene
- GC08M030758
- GC08M031340
- GC08M030946
- GC08M030911
- GC08M030972
- GC08M029398
- GC08M030853
Summaries for PURG Gene
-
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
GeneCards Summary for PURG Gene
PURG (Purine Rich Element Binding Protein G) is a Protein Coding gene. An important paralog of this gene is PURA.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PURG Gene
Genomics for PURG Gene
GeneHancer (GH) Regulatory Elements for PURG Gene
Promoters and enhancers for PURG Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J031032 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 655.3 | -0.6 | -569 | 3 | HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 | WRN PURG GTF2E2 RPS15AP24 KCTD9P6 UBXN8 SUMO2P16 | |
| GH08J030403 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 5 | +627.7 | 627662 | 6.1 | CTCF NANOG HLF RAD21 NR2F2 MITF ZFHX2 JUND POLR2A CEBPA | RBPMS-AS1 PURG GSR RBPMS PIR31328 | |
| GH08J031049 | Enhancer | 0.4 | FANTOM5 | 1.6 | -15.9 | -15921 | 0.3 | ZBTB33 ATF2 | TEX15 PURG WRN SUMO2P16 | |
| GH08J031076 | Enhancer | 0.6 | ENCODE | 0.3 | -41.9 | -41918 | 0.7 | TEAD1 CEBPB DPF2 CEBPG ZNF384 TEAD3 ZFHX2 GATA3 CEBPA TCF7L2 | PPP2CB PURG WRN SUMO2P16 | |
| GH08J031106 | Enhancer | 0.8 | Ensembl ENCODE | 0.2 | -73.5 | -73452 | 1.9 | CTCF ZNF654 JUN TRIM22 REST RAD21 ZKSCAN1 RELA ZNF143 SMC3 | WRN SUMO2P16 PURG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PURG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PURG gene promoter:
-
- p300
- AP-2alpha
- AP-2alphaA
- SRY
Regulatory Element Products
Genomic Locations for PURG Gene
Genomic Locations for PURG Gene
- chr8:30,995,802-31,033,715
- (GRCh38/hg38)
- Size:
- 37,914 bases
- Orientation:
- Minus strand
- chr8:30,853,321-30,891,231
- (GRCh37/hg19)
- Size:
- 37,911 bases
- Orientation:
- Minus strand
Genomic View for PURG Gene
Genes around PURG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p12 by Entrez Gene
- 8p12 by HGNC
- 8p12 by Ensembl
PURG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PURG Gene
Proteins for PURG Gene
-
Protein details for PURG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJV8-PURG_HUMAN
- Recommended name:
- Purine-rich element-binding protein gamma
- Protein Accession:
- Q9UJV8
- Q8TE64
Protein attributes for PURG Gene
- Size:
- 347 amino acids
- Molecular mass:
- 39556 Da
- Quaternary structure:
- No Data Available
Protein Expression for PURG Gene
Post-translational modifications for PURG Gene
Other Protein References for PURG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PURG
- Novus Biologicals Antibodies for PURG
-
Abcam antibodies for PURG
- Invitrogen Antibodies for PURG (AFLGC-PURG)
- antibodies-online: Search results for available PURG related products ranked by validation data
- Search GeneTex for Antibodies for PURG
-
Boster Bio Antibodies for PURG
Protein Products
-
OriGene Purified Proteins for PURG
- Search Origene for MassSpec and Protein Over-expression Lysates for PURG
- Origene Custom Protein Services for PURG
- antibodies-online: Search results for available PURG related products ranked by validation data
- Search GeneTex for Proteins for PURG
-
Abcam proteins for PURG
Assay Products
- antibodies-online: Search results for available PURG related products ranked by validation data
No data available for DME Specific Peptides for PURG Gene
Domains & Families for PURG Gene
Gene Families for PURG Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for PURG Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PURG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UJV8- Family:
-
- Belongs to the PUR DNA-binding protein family.
Function for PURG Gene
Phenotypes From GWAS Catalog for PURG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | IBA | -- |
Phenotypes for PURG Gene
- GenomeRNAi human phenotypes for PURG:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PURG
-
CRISPR Products
-
OriGene CRISPR knockouts for PURG
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- Overview of 90 available PURG gene related products
- Applied Biological Materials CRISPR for PURG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PURG
- GenScript: Design CRISPR guide RNA sequences for PURG
miRNA for PURG Gene
- miRTarBase miRNAs that target PURG
-
- hsa-mir-29c-3p (MIRT020365)
- hsa-mir-448 (MIRT505998)
- hsa-mir-5579-3p (MIRT505999)
- hsa-mir-5700 (MIRT506000)
- hsa-mir-1279 (MIRT506001)
- hsa-mir-6507-5p (MIRT506002)
- hsa-mir-92b-3p (MIRT506003)
- hsa-mir-367-3p (MIRT506004)
- hsa-mir-363-3p (MIRT506005)
- hsa-mir-32-5p (MIRT506006)
- hsa-mir-25-3p (MIRT506007)
- hsa-mir-92a-3p (MIRT506008)
- hsa-mir-21-5p (MIRT506009)
- hsa-mir-590-5p (MIRT506010)
- hsa-mir-190a-3p (MIRT510898)
- hsa-mir-5011-5p (MIRT510899)
- hsa-mir-1277-5p (MIRT510900)
- hsa-mir-186-5p (MIRT510901)
- hsa-mir-466 (MIRT521553)
- hsa-mir-4643 (MIRT521554)
- hsa-mir-4789-3p (MIRT521555)
- hsa-mir-942-3p (MIRT521556)
- hsa-mir-4802-3p (MIRT521557)
- hsa-mir-3591-5p (MIRT555073)
- hsa-mir-4473 (MIRT555074)
- hsa-mir-4671-3p (MIRT555075)
- hsa-mir-581 (MIRT555076)
- hsa-mir-100-3p (MIRT555077)
- hsa-mir-454-3p (MIRT555078)
- hsa-mir-4295 (MIRT555079)
- hsa-mir-3666 (MIRT555080)
- hsa-mir-301b-3p (MIRT555081)
- hsa-mir-130b-3p (MIRT555082)
- hsa-mir-130a-3p (MIRT555083)
- hsa-mir-301a-3p (MIRT555084)
- hsa-mir-19b-3p (MIRT555085)
- hsa-mir-19a-3p (MIRT555086)
- hsa-mir-4662a-3p (MIRT555087)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PURG
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- Overview of 90 available PURG gene related products
Clone Products
- Sino Biological Human cDNA Clone for PURG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PURG
- Applied Biological Materials Clones for PURG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PURG
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PURG Gene
Localization for PURG Gene
Subcellular locations from UniProtKB/Swiss-Prot for PURG Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
- Nucleoli (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for PURG Gene
No Data Available
Interacting Proteins for PURG Gene
GPS-Prot Interaction Network for PURG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PURG Gene
Transcripts for PURG Gene
mRNA/cDNA for PURG Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (19) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000339382 2693 bps (uc003xim.2)
- ENST00000475541 2875 bps (uc003xin.4)
- ENST00000523392 614 bps (uc064lty.1)
Unigene Clusters for PURG Gene
- Purine-rich element binding protein G:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PURG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PURG
- genomics-online: gRNA clones - Search results for 90 available PURG gene related products
- Overview of 90 available PURG gene related products
- Applied Biological Materials CRISPR for PURG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PURG
- GenScript: Design CRISPR guide RNA sequences for PURG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PURG
- Browse OriGene Inhibitory RNA Products For PURG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PURG
- genomics-online: shRNA clones - Search results for 90 available PURG gene related products
- Overview of 90 available PURG gene related products
Clone Products
- Sino Biological Human cDNA Clone for PURG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PURG
- Applied Biological Materials Clones for PURG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PURG Gene
mRNA differential expression in normal tissues according to GTEx for PURG Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.7).
This gene is overexpressed in Plasma (57.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PURG Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PURG Gene:
PURGSOURCE GeneReport for Unigene cluster for PURG Gene:
Hs.373778mRNA Expression by UniProt/SwissProt for PURG Gene:
Q9UJV8-PURG_HUMAN
Tissue specificity:
Isoform 1 is expressed in testis and glioblastoma. Isoform 2 is expressed in fetal lung.
Evidence on tissue expression from TISSUES for PURG Gene
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for PURG
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PURG Gene
Orthologs for PURG Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PURG 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PURG 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Purg 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Purg 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PURG 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PURG 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PURG 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PURG 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PURG 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | purg 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | purg 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Pur-alpha 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | plp-1 34 |
|
ManyToMany | |
| plp-2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PURG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PURG Gene
- ENSEMBL:
- Gene Tree for PURG (if available)
- TreeFam:
- Gene Tree for PURG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PURG: view image
Paralogs for PURG Gene
Variants for PURG Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1024719707 | uncertain-significance, Werner syndrome | 31,033,816(-) | T/A/G | upstream_transcript_variant | |
| rs11574155 | uncertain-significance, Werner syndrome | 31,033,445(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs11574156 | likely-benign, Werner syndrome | 31,033,642(-) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs11574157 | likely-benign, Werner syndrome | 31,033,772(-) | G/C | upstream_transcript_variant | |
| rs11574158 | likely-benign, Werner syndrome | 31,033,837(-) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22033 | CNV | loss | 19812545 |
| nsv1133688 | CNV | deletion | 24896259 |
| nsv1145194 | CNV | deletion | 24896259 |
| nsv527651 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.80;
47.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PURG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PURG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PURG Gene
Disorders for PURG Gene
Additional Disease Information for PURG
No disorders were found for PURG Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PURG Gene
Publications for PURG Gene
- Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. (PMID: 12034829) Liu H … Johnson EM (Nucleic acids research 2002) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim DY … Gross JD (Molecular cell 2013) 3 58
- The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz AG … Landthaler M (Molecular cell 2012) 3 58
- A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3 58
Products for PURG Gene
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- Custom Antibody ServicesOriGene Antibodies for PURG
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals
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- Invitrogen Antibodies for PURG (AFLGC-PURG)
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- antibodies-online: Search results for available PURG related products ranked by validation data
- antibodies-online: Search results for available PURG related products ranked by validation data
- antibodies-online: Search results for available PURG related products ranked by validation data
- Search GeneTex for Antibodies for PURG
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- Horizon Cell Lines for PURG
- genomics-online: cdna clones - Search results for 90 available PURG gene related products
- Overview of 90 available PURG gene related products
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- Overview of 90 available PURG gene related products
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- Overview of 90 available PURG gene related products
- genomics-online: shRNA clones - Search results for 90 available PURG gene related products
- Overview of 90 available PURG gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PURG
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- Boster Bio Antibodies for PURG
- Browse Boster Bio ELISA Kits
Sources for PURG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
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