The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the... See more...

Aliases for PURG Gene

Aliases for PURG Gene

  • Purine Rich Element Binding Protein G 2 3 5
  • Purine-Rich Element-Binding Protein Gamma 3 4
  • PURG-A 2 3
  • PURG-B 2 3
  • Purine-Rich Element-Binding Protein G 4
  • Pur-Gamma 3
  • PURGA 3
  • PURGB 3
  • PURG 5

External Ids for PURG Gene

Previous GeneCards Identifiers for PURG Gene

  • GC08M030758
  • GC08M031340
  • GC08M030946
  • GC08M030911
  • GC08M030972
  • GC08M029398
  • GC08M030853

Summaries for PURG Gene

Entrez Gene Summary for PURG Gene

  • The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]

GeneCards Summary for PURG Gene

PURG (Purine Rich Element Binding Protein G) is a Protein Coding gene. Diseases associated with PURG include Werner Syndrome. An important paralog of this gene is PURA.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PURG Gene

Genomics for PURG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PURG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PURG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PURG

Top Transcription factor binding sites by QIAGEN in the PURG gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • p300
  • SRY

Genomic Locations for PURG Gene

Latest Assembly
chr8:30,995,802-31,033,715
(GRCh38/hg38)
Size:
37,914 bases
Orientation:
Minus strand

Previous Assembly
chr8:30,853,318-30,890,872
(GRCh37/hg19 by Entrez Gene)
Size:
37,555 bases
Orientation:
Minus strand

chr8:30,853,321-30,891,231
(GRCh37/hg19 by Ensembl)
Size:
37,911 bases
Orientation:
Minus strand

Genomic View for PURG Gene

Genes around PURG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PURG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PURG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PURG Gene

Proteins for PURG Gene

  • Protein details for PURG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV8-PURG_HUMAN
    Recommended name:
    Purine-rich element-binding protein gamma
    Protein Accession:
    Q9UJV8
    Secondary Accessions:
    • Q8TE64

    Protein attributes for PURG Gene

    Size:
    347 amino acids
    Molecular mass:
    39556 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PURG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PURG Gene

Post-translational modifications for PURG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PURG Gene

No data available for DME Specific Peptides for PURG Gene

Domains & Families for PURG Gene

Gene Families for PURG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PURG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PURG Gene

GenScript: Design optimal peptide antigens:
  • Purine-rich element-binding protein gamma (PURG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJV8

UniProtKB/Swiss-Prot:

PURG_HUMAN :
  • Belongs to the PUR DNA-binding protein family.
Family:
  • Belongs to the PUR DNA-binding protein family.
genes like me logo Genes that share domains with PURG: view

Function for PURG Gene

Phenotypes From GWAS Catalog for PURG Gene

Gene Ontology (GO) - Molecular Function for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0032422 purine-rich negative regulatory element binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with PURG: view
genes like me logo Genes that share phenotypes with PURG: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PURG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PURG Gene

Localization for PURG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PURG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PURG gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with PURG: view

Pathways & Interactions for PURG Gene

PathCards logo

SuperPathways for PURG Gene

No Data Available

Gene Ontology (GO) - Biological Process for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with PURG: view

No data available for Pathways by source and SIGNOR curated interactions for PURG Gene

Drugs & Compounds for PURG Gene

No Compound Related Data Available

Transcripts for PURG Gene

mRNA/cDNA for PURG Gene

4 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PURG

Alternative Splicing Database (ASD) splice patterns (SP) for PURG Gene

No ASD Table

Relevant External Links for PURG Gene

GeneLoc Exon Structure for
PURG

Expression for PURG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PURG Gene

mRNA differential expression in normal tissues according to GTEx for PURG Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.7).

Protein differential expression in normal tissues from HIPED for PURG Gene

This gene is overexpressed in Plasma (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PURG Gene



Protein tissue co-expression partners for PURG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PURG

SOURCE GeneReport for Unigene cluster for PURG Gene:

Hs.373778

mRNA Expression by UniProt/SwissProt for PURG Gene:

Q9UJV8-PURG_HUMAN
Tissue specificity: Isoform 1 is expressed in testis and glioblastoma. Isoform 2 is expressed in fetal lung.

Evidence on tissue expression from TISSUES for PURG Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with PURG: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PURG Gene

Orthologs for PURG Gene

This gene was present in the common ancestor of animals.

Orthologs for PURG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PURG 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PURG 30 31
  • 95.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Purg 30
  • 94.95 (n)
Mouse
(Mus musculus)
Mammalia Purg 30 17 31
  • 93.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PURG 30 31
  • 93.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PURG 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PURG 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PURG 30 31
  • 81.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PURG 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia purg 30
  • 74 (n)
Zebrafish
(Danio rerio)
Actinopterygii purg 30 31
  • 68.17 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pur-alpha 31 32
  • 41 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea plp-1 31
  • 34 (a)
ManyToMany
plp-2 31
  • 25 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToMany
Species where no ortholog for PURG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PURG Gene

ENSEMBL:
Gene Tree for PURG (if available)
TreeFam:
Gene Tree for PURG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PURG: view image

Paralogs for PURG Gene

Paralogs for PURG Gene

(2) SIMAP similar genes for PURG Gene using alignment to 3 proteins:

  • PURG_HUMAN
  • K7ENC1_HUMAN
  • L8E8I6_HUMAN
genes like me logo Genes that share paralogs with PURG: view

Variants for PURG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PURG Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs578121063 Uncertain Significance: Werner syndrome 31,033,351(-) G/C
NM_001323311.2(PURG):c.-280C>G
FIVE_PRIME_UTR
VAR_036317 A breast cancer sample p.Lys316Thr
rs11574151 - p.Glu241Ala
rs11574153 - p.Ser26Gly
rs7464560 - p.Glu143Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PURG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PURG Gene

Variant ID Type Subtype PubMed ID
esv22033 CNV loss 19812545
nsv1133688 CNV deletion 24896259
nsv1145194 CNV deletion 24896259
nsv527651 CNV loss 19592680

Variation tolerance for PURG Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PURG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PURG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PURG Gene

Disorders for PURG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PURG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
werner syndrome
  • wrn
- elite association - COSMIC cancer census association via MalaCards
Search PURG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PURG

genes like me logo Genes that share disorders with PURG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PURG Gene

Publications for PURG Gene

  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. (PMID: 12034829) Liu H … Johnson EM (Nucleic acids research 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim DY … Gross JD (Molecular cell 2013) 3
  4. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz AG … Landthaler M (Molecular cell 2012) 3

Products for PURG Gene

Sources for PURG Gene