Aliases for PTX3 Gene
External Ids for PTX3 Gene
Previous HGNC Symbols for PTX3 Gene
Previous GeneCards Identifiers for PTX3 Gene
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
GeneCards Summary for PTX3 Gene
PTX3 (Pentraxin 3) is a Protein Coding gene. Diseases associated with PTX3 include Infectious Myocarditis and Hyper-Igd Syndrome. Among its related pathways are Innate Immune System and Lung fibrosis. Gene Ontology (GO) annotations related to this gene include virion binding and (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTXR.
UniProtKB/Swiss-Prot for PTX3 Gene
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.