Aliases for PTTG3P Gene

Aliases for PTTG3P Gene

  • Pituitary Tumor-Transforming 3, Pseudogene 2 3 5
  • RcPTTG1 3 4
  • PTTG3 3 4
  • Putative Pituitary Tumor-Transforming Gene 3 Protein 4
  • Pituitary Tumor-Transforming 3 2
  • Securin-3 4
  • PTTG3P 5
  • HPTTG3 4

External Ids for PTTG3P Gene

Previous HGNC Symbols for PTTG3P Gene

  • PTTG3

Previous GeneCards Identifiers for PTTG3P Gene

  • GC08M067843
  • GC08M067680
  • GC08M063171

Summaries for PTTG3P Gene

GeneCards Summary for PTTG3P Gene

PTTG3P (Pituitary Tumor-Transforming 3, Pseudogene) is a Pseudogene. Among its related pathways are Cell cycle. Gene Ontology (GO) annotations related to this gene include SH3 domain binding.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTTG3P Gene

Genomics for PTTG3P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTTG3P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J066774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -7.9 -7867 3.8 ZNF600 MYC ZNF580 ZNF592 ZMYM3 POLR2A ZSCAN16 ZIC2 ZBTB10 YY1 SGK3 CSPP1 COPS5 C8orf44 PTTG3P lnc-VCPIP1-4 MCMDC2 C8orf44-SGK3 MK280607-117
GH08J066770 Enhancer 0.6 Ensembl dbSUPER 0.7 -3.6 -3566 2 CEBPA FOXA2 FOXP1 JUND SMARCC2 GATAD2A C8orf44 PTTG3P lnc-VCPIP1-4 SGK3 MCMDC2 C8orf44-SGK3 MK280607-117
GH08J066765 Enhancer 0.4 Ensembl 0.7 +2.7 2733 0.6 ZNF146 BHLHE40 ZNF24 CEBPB C8orf44 PTTG3P RF00017-6536 SGK3 C8orf44-SGK3 MCMDC2 MK280607-117
GH08J066783 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 0.4 -16.4 -16360 0.2 CEBPB SPI1 lnc-VCPIP1-4 SGK3 PTTG3P MCMDC2 C8orf44-SGK3 MK280607-117
GH08J066784 Enhancer 0.6 dbSUPER 0.4 -17.2 -17246 1.4 FOXA2 SAP130 FOXP1 SPI1 HNF4A SP1 RFX5 RAD21 GATAD2A HNF4G lnc-VCPIP1-4 PTTG3P SGK3 MCMDC2 C8orf44-SGK3 MK280607-117
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTTG3P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for PTTG3P Gene

Latest Assembly
chr8:66,767,329-66,768,034
(GRCh38/hg38)
Size:
706 bases
Orientation:
Minus strand

Previous Assembly
chr8:67,679,564-67,680,269
(GRCh37/hg19 by Entrez Gene)
Size:
706 bases
Orientation:
Minus strand

chr8:67,679,632-67,680,240
(GRCh37/hg19 by Ensembl)
Size:
609 bases
Orientation:
Minus strand

Genomic View for PTTG3P Gene

Genes around PTTG3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTTG3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTTG3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG3P Gene

Proteins for PTTG3P Gene

  • Protein details for PTTG3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH4-PTTG3_HUMAN
    Recommended name:
    Putative pituitary tumor-transforming gene 3 protein
    Protein Accession:
    Q9NZH4
    Secondary Accessions:
    • O95356

    Protein attributes for PTTG3P Gene

    Size:
    202 amino acids
    Molecular mass:
    22064 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTTG3P Gene

Post-translational modifications for PTTG3P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PTTG3P Gene

Domains & Families for PTTG3P Gene

Protein Domains for PTTG3P Gene

Suggested Antigen Peptide Sequences for PTTG3P Gene

GenScript: Design optimal peptide antigens:
  • rcPTTG1 (PTTG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZH4

UniProtKB/Swiss-Prot:

PTTG3_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG3P: view

No data available for Gene Families for PTTG3P Gene

Function for PTTG3P Gene

Gene Ontology (GO) - Molecular Function for PTTG3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with PTTG3P: view

Phenotypes for PTTG3P Gene

genes like me logo Genes that share phenotypes with PTTG3P: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PTTG3P Gene

Localization for PTTG3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG3P Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for PTTG3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTTG3P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PTTG3P Gene

Pathways & Interactions for PTTG3P Gene

PathCards logo

SuperPathways for PTTG3P Gene

SuperPathway Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with PTTG3P: view

Pathways by source for PTTG3P Gene

1 BioSystems pathway for PTTG3P Gene

Gene Ontology (GO) - Biological Process for PTTG3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045143 homologous chromosome segregation IBA 21873635
GO:0051276 chromosome organization IEA --
GO:2000816 negative regulation of mitotic sister chromatid separation IBA 21873635
genes like me logo Genes that share ontologies with PTTG3P: view

No data available for Interacting Proteins and SIGNOR curated interactions for PTTG3P Gene

Drugs & Compounds for PTTG3P Gene

No Compound Related Data Available

Transcripts for PTTG3P Gene

mRNA/cDNA for PTTG3P Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG3P Gene

No ASD Table

Relevant External Links for PTTG3P Gene

GeneLoc Exon Structure for
PTTG3P

Expression for PTTG3P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTTG3P Gene

Protein differential expression in normal tissues from HIPED for PTTG3P Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTTG3P Gene



Protein tissue co-expression partners for PTTG3P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTTG3P

SOURCE GeneReport for Unigene cluster for PTTG3P Gene:

Hs.647156

mRNA Expression by UniProt/SwissProt for PTTG3P Gene:

Q9NZH4-PTTG3_HUMAN
Tissue specificity: Expressed in ovarian tumor and tumor cell lines (SK-OV-3 and PA1).
genes like me logo Genes that share expression patterns with PTTG3P: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTTG3P Gene

Orthologs for PTTG3P Gene

Evolution for PTTG3P Gene

ENSEMBL:
Gene Tree for PTTG3P (if available)
TreeFam:
Gene Tree for PTTG3P (if available)
Alliance of Genome Resources:
Additional Orthologs for PTTG3P

No data available for Orthologs for PTTG3P Gene

Paralogs for PTTG3P Gene

(3) SIMAP similar genes for PTTG3P Gene using alignment to 1 proteins:

  • PTTG3_HUMAN
genes like me logo Genes that share paralogs with PTTG3P: view

No data available for Paralogs for PTTG3P Gene

Variants for PTTG3P Gene

Structural Variations from Database of Genomic Variants (DGV) for PTTG3P Gene

Variant ID Type Subtype PubMed ID
nsv1026746 CNV gain 25217958
nsv971317 CNV duplication 23825009

Additional Variant Information for PTTG3P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTTG3P
Leiden Open Variation Database (LOVD)
PTTG3P

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for PTTG3P Gene

Disorders for PTTG3P Gene

Additional Disease Information for PTTG3P

No disorders were found for PTTG3P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTTG3P Gene

Publications for PTTG3P Gene

  1. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. (PMID: 10806349) Chen L … Kakar SS (Gene 2000) 2 3 4
  2. The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma. (PMID: 29803224) Huang JL … Wang Q (Molecular cancer 2018) 2 3
  3. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques AC … Kaessmann H (PLoS biology 2005) 3 4
  4. Long non-coding RNA PTTG3P functions as an oncogene by sponging miR-383 and up-regulating CCND1 and PARP2 in hepatocellular carcinoma. (PMID: 31340767) Zhou Q … Liu S (BMC cancer 2019) 3
  5. PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis. (PMID: 28631396) Weng W … Du X (Journal of cellular and molecular medicine 2017) 3

Products for PTTG3P Gene

Sources for PTTG3P Gene