Aliases for PTTG2 Gene

Aliases for PTTG2 Gene

  • Pituitary Tumor-Transforming 2 2 3 5
  • Pituitary Tumor-Transforming Gene 2 Protein 3 4
  • Securin-2 3 4
  • PTTG2 5

External Ids for PTTG2 Gene

Previous GeneCards Identifiers for PTTG2 Gene

  • GC04P038126
  • GC04P037796
  • GC04P037859
  • GC04P037784
  • GC04P037639
  • GC04P037286

Summaries for PTTG2 Gene

GeneCards Summary for PTTG2 Gene

PTTG2 (Pituitary Tumor-Transforming 2) is a Protein Coding gene. Among its related pathways are Human T-cell leukemia virus 1 infection and Cell cycle. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is PTTG1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTTG2 Gene

Genomics for PTTG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTTG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J037933 Enhancer 0.6 Ensembl 11.9 -24.8 -24797 3.6 ATF3 RXRA HNF4A FOXA1 RAD21 ZNF133 MAX HLF SMC3 SP1 PTTG2 TBC1D1 PGM2 MK280073-494 piR-32285-070 LOC105374407
GH04J037975 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +17.6 17617 4.3 BCLAF1 ZNF207 MYC ZMYM3 POLR2A YY1 CTCF ZNF592 TRIM22 MAX TBC1D1 HSALNG0033853 HSALNG0033854 PTTG2 KLF3
GH04J037889 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.2 -68.7 -68683 4.2 BCLAF1 POLR2A YY1 BCL11A CTCF TRIM22 ZNF513 RXRA IRF4 GABPB1 TBC1D1 HSALNG0033850 RELL1 LOC105374407 PTTG2
GH04J037970 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +10.4 10402 1.6 ZNF10 CTCF JUND ZNF146 RAD21 ATF2 ATF7 TRIM22 ZSCAN5C TBC1D1 PGM2 HSALNG0033853 RF00017-3863 PTTG2 KLF3
GH04J037987 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 0.3 +29.3 29251 3.9 POLR2A CTBP1 ZNF316 NFE2 SPI1 SMARCE1 MAX MAFK TAF1 REST TBC1D1 PGM2 HSALNG0033854 lnc-PTTG2-2 PTTG2 KLF3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTTG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTTG2

Top Transcription factor binding sites by QIAGEN in the PTTG2 gene promoter:
  • aMEF-2
  • AML1a
  • E47
  • FOXI1
  • Hand1
  • HFH-1
  • HFH-3
  • MEF-2A
  • Zic3

Genomic Locations for PTTG2 Gene

Latest Assembly
chr4:37,960,398-37,961,128
(GRCh38/hg38)
Size:
731 bases
Orientation:
Plus strand

Previous Assembly
chr4:37,962,019-37,962,749
(GRCh37/hg19 by Entrez Gene)
Size:
731 bases
Orientation:
Plus strand

chr4:37,962,056-37,962,746
(GRCh37/hg19 by Ensembl)
Size:
691 bases
Orientation:
Plus strand

Genomic View for PTTG2 Gene

Genes around PTTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG2 Gene

Proteins for PTTG2 Gene

  • Protein details for PTTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH5-PTTG2_HUMAN
    Recommended name:
    Securin-2
    Protein Accession:
    Q9NZH5
    Secondary Accessions:
    • O95355
    • Q6NTC9
    • Q9UNJ6

    Protein attributes for PTTG2 Gene

    Size:
    202 amino acids
    Molecular mass:
    22302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTTG2 Gene

Post-translational modifications for PTTG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTTG2 Gene

Domains & Families for PTTG2 Gene

Gene Families for PTTG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTTG2 Gene

Suggested Antigen Peptide Sequences for PTTG2 Gene

GenScript: Design optimal peptide antigens:
  • Pituitary tumor-transforming gene 2 protein (PTTG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZH5

UniProtKB/Swiss-Prot:

PTTG2_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG2: view

Function for PTTG2 Gene

Molecular function for PTTG2 Gene

GENATLAS Biochemistry:
pituitary tumor transforming gene 2,intronless expressed in normal and pituitary gland and tumors

Phenotypes From GWAS Catalog for PTTG2 Gene

Gene Ontology (GO) - Molecular Function for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with PTTG2: view
genes like me logo Genes that share phenotypes with PTTG2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTTG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PTTG2 Gene

Localization for PTTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTTG2 gene
Compartment Confidence
nucleus 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTTG2: view

Pathways & Interactions for PTTG2 Gene

genes like me logo Genes that share pathways with PTTG2: view

Pathways by source for PTTG2 Gene

1 BioSystems pathway for PTTG2 Gene

SIGNOR curated interactions for PTTG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045143 homologous chromosome segregation IBA 21873635
GO:0051276 chromosome organization IEA --
GO:2000816 negative regulation of mitotic sister chromatid separation IBA 21873635
genes like me logo Genes that share ontologies with PTTG2: view

Drugs & Compounds for PTTG2 Gene

No Compound Related Data Available

Transcripts for PTTG2 Gene

mRNA/cDNA for PTTG2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTTG2

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG2 Gene

No ASD Table

Relevant External Links for PTTG2 Gene

GeneLoc Exon Structure for
PTTG2

Expression for PTTG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTTG2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTTG2 Gene



Protein tissue co-expression partners for PTTG2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTTG2

SOURCE GeneReport for Unigene cluster for PTTG2 Gene:

Hs.668806

mRNA Expression by UniProt/SwissProt for PTTG2 Gene:

Q9NZH5-PTTG2_HUMAN
Tissue specificity: Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.
genes like me logo Genes that share expression patterns with PTTG2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTTG2 Gene

Orthologs for PTTG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTTG2 29
  • 98.6 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 71 (a)
ManyToMany
PTTG1 30
  • 70 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 68 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Pttg1 30
  • 60 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 48 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 48 (a)
ManyToMany
-- 30
  • 48 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves PTTG1 30
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 33 (a)
OneToMany
Species where no ortholog for PTTG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PTTG2 Gene

ENSEMBL:
Gene Tree for PTTG2 (if available)
TreeFam:
Gene Tree for PTTG2 (if available)
Alliance of Genome Resources:
Additional Orthologs for PTTG2

Paralogs for PTTG2 Gene

Paralogs for PTTG2 Gene

(3) SIMAP similar genes for PTTG2 Gene using alignment to 1 proteins:

  • PTTG2_HUMAN
genes like me logo Genes that share paralogs with PTTG2: view

Variants for PTTG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTTG2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs6811863 -- p.Arg44Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTTG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTTG2 Gene

Variant ID Type Subtype PubMed ID
nsv593989 CNV loss 21841781
nsv967737 CNV duplication 23825009

Variation tolerance for PTTG2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTTG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTTG2
Leiden Open Variation Database (LOVD)
PTTG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTTG2 Gene

Disorders for PTTG2 Gene

Additional Disease Information for PTTG2

No disorders were found for PTTG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTTG2 Gene

Publications for PTTG2 Gene

  1. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. (PMID: 10806349) Chen L … Kakar SS (Gene 2000) 2 3 4
  2. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. (PMID: 10084610) Prezant TR … Melmed S (The Journal of clinical endocrinology and metabolism 1999) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Pituitary tumor transforming gene PTTG2 induces psoriasis by regulating vimentin and E-cadherin expression. (PMID: 26617803) Liu XB … Yang F (International journal of clinical and experimental pathology 2015) 3
  5. PTTG2 silencing results in induction of epithelial-to-mesenchymal transition and apoptosis. (PMID: 23470537) Méndez-Vidal C … Pintor-Toro JA (Cell death & disease 2013) 3

Products for PTTG2 Gene

Sources for PTTG2 Gene