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Aliases for PTTG2 Gene

Aliases for PTTG2 Gene

  • Pituitary Tumor-Transforming 2 2 3 5
  • Pituitary Tumor-Transforming Gene 2 Protein 3 4
  • Securin-2 3

External Ids for PTTG2 Gene

Previous GeneCards Identifiers for PTTG2 Gene

  • GC04P038126
  • GC04P037796
  • GC04P037859
  • GC04P037784
  • GC04P037639
  • GC04P037286

Summaries for PTTG2 Gene

GeneCards Summary for PTTG2 Gene

PTTG2 (Pituitary Tumor-Transforming 2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Cell cycle. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is PTTG1.

Additional gene information for PTTG2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTTG2 Gene

Genomics for PTTG2 Gene

GeneHancer (GH) Regulatory Elements for PTTG2 Gene

Promoters and enhancers for PTTG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I037960 Promoter 0.5 EPDnew 550.8 -0.1 -56 0.1 PTTG2 LOC105374407 TBC1D1
GH04I037975 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 0.4 +17.6 17580 4.3 ATF1 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 E2F8 ZNF207 ZNF143 TBC1D1 PTTG2 GC04P037993
GH04I037970 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +10.4 10375 0.8 CTCF JUND JUN ZSCAN5C ATF7 ATF2 RAD21 TBC1D1 PGM2 PTTG2 GC04P037993
GH04I037987 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 +29.6 29623 4.7 SMARCE1 NFIB MAX DPF2 REST SP1 CTBP1 ZNF316 GATA3 NFE2 TBC1D1 PGM2 GC04P037993 PTTG2
GH04I037952 Enhancer 0.6 Ensembl 0.4 -8.5 -8534 0.2 SOX5 FOXA2 HMG20A SSRP1 ZGPAT RERE TCF7 NR2F6 CREM RXRB TBC1D1 PTTG2 LOC105374407
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTTG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTTG2 gene promoter:

Genomic Locations for PTTG2 Gene

Genomic Locations for PTTG2 Gene
chr4:37,960,435-37,961,125
(GRCh38/hg38)
Size:
691 bases
Orientation:
Plus strand
chr4:37,962,056-37,962,746
(GRCh37/hg19)

Genomic View for PTTG2 Gene

Genes around PTTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG2 Gene

Proteins for PTTG2 Gene

  • Protein details for PTTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH5-PTTG2_HUMAN
    Recommended name:
    Securin-2
    Protein Accession:
    Q9NZH5
    Secondary Accessions:
    • O95355
    • Q6NTC9
    • Q9UNJ6

    Protein attributes for PTTG2 Gene

    Size:
    202 amino acids
    Molecular mass:
    22302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTTG2 Gene

Post-translational modifications for PTTG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PTTG2

No data available for DME Specific Peptides for PTTG2 Gene

Domains & Families for PTTG2 Gene

Gene Families for PTTG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTTG2 Gene

Suggested Antigen Peptide Sequences for PTTG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH5

UniProtKB/Swiss-Prot:

PTTG2_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG2: view

Function for PTTG2 Gene

Molecular function for PTTG2 Gene

GENATLAS Biochemistry:
pituitary tumor transforming gene 2,intronless expressed in normal and pituitary gland and tumors

Gene Ontology (GO) - Molecular Function for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0017124 SH3 domain binding IEA --
GO:0030414 peptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PTTG2: view
genes like me logo Genes that share phenotypes with PTTG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PTTG2 Gene

Localization for PTTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTTG2 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTTG2: view

Pathways & Interactions for PTTG2 Gene

genes like me logo Genes that share pathways with PTTG2: view

Pathways by source for PTTG2 Gene

1 BioSystems pathway for PTTG2 Gene
3 KEGG pathways for PTTG2 Gene

Gene Ontology (GO) - Biological Process for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0045143 homologous chromosome segregation IBA --
GO:0051276 chromosome organization IEA --
GO:2000816 negative regulation of mitotic sister chromatid separation IBA --
genes like me logo Genes that share ontologies with PTTG2: view

No data available for SIGNOR curated interactions for PTTG2 Gene

Drugs & Compounds for PTTG2 Gene

No Compound Related Data Available

Transcripts for PTTG2 Gene

mRNA/cDNA for PTTG2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTTG2 Gene

Pituitary tumor-transforming 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG2 Gene

No ASD Table

Relevant External Links for PTTG2 Gene

GeneLoc Exon Structure for
PTTG2
ECgene alternative splicing isoforms for
PTTG2

Expression for PTTG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTTG2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTTG2 Gene



Protein tissue co-expression partners for PTTG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTTG2 Gene:

PTTG2

SOURCE GeneReport for Unigene cluster for PTTG2 Gene:

Hs.668806

mRNA Expression by UniProt/SwissProt for PTTG2 Gene:

Q9NZH5-PTTG2_HUMAN
Tissue specificity: Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.
genes like me logo Genes that share expression patterns with PTTG2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTTG2 Gene

Orthologs for PTTG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTTG2 33
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 71 (a)
ManyToMany
PTTG1 34
  • 70 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pttg1 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PTTG1 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
Species where no ortholog for PTTG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTTG2 Gene

ENSEMBL:
Gene Tree for PTTG2 (if available)
TreeFam:
Gene Tree for PTTG2 (if available)

Paralogs for PTTG2 Gene

Paralogs for PTTG2 Gene

(3) SIMAP similar genes for PTTG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTTG2: view

Variants for PTTG2 Gene

Sequence variations from dbSNP and Humsavar for PTTG2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000335488 -- 37,961,241(+) A/G downstream_transcript_variant
rs1000443497 -- 37,960,981(+) T/C coding_sequence_variant, missense_variant
rs1000831916 -- 37,959,269(+) C/T upstream_transcript_variant
rs1001444729 -- 37,959,557(+) A/G upstream_transcript_variant
rs1001655471 -- 37,960,419(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTTG2 Gene

Variant ID Type Subtype PubMed ID
nsv593989 CNV loss 21841781
nsv967737 CNV duplication 23825009

Variation tolerance for PTTG2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTTG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTTG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTTG2 Gene

Disorders for PTTG2 Gene

Additional Disease Information for PTTG2

No disorders were found for PTTG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTTG2 Gene

Publications for PTTG2 Gene

  1. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. (PMID: 10806349) Chen L … Kakar SS (Gene 2000) 2 3 4 58
  2. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. (PMID: 10084610) Prezant TR … Melmed S (The Journal of clinical endocrinology and metabolism 1999) 2 3 4 58
  3. Pituitary tumor transforming gene PTTG2 induces psoriasis by regulating vimentin and E-cadherin expression. (PMID: 26617803) Liu XB … Yang F (International journal of clinical and experimental pathology 2015) 3 58
  4. PTTG2 silencing results in induction of epithelial-to-mesenchymal transition and apoptosis. (PMID: 23470537) Méndez-Vidal C … Pintor-Toro JA (Cell death & disease 2013) 3 58
  5. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K … Offenbacher S (Journal of dental research 2012) 3 58

Products for PTTG2 Gene

Sources for PTTG2 Gene

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