The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The... See more...

Aliases for PTTG1 Gene

Aliases for PTTG1 Gene

  • PTTG1 Regulator Of Sister Chromatid Separation, Securin 2 3 5
  • Tumor-Transforming Protein 1 2 3 4
  • Securin 2 3 4
  • HPTTG 2 3 4
  • EAP1 2 3 4
  • PTTG 2 3 4
  • Pituitary Tumor-Transforming Gene 1 Protein 3 4
  • Pituitary Tumor-Transforming 1 2 3
  • ESP1-Associated Protein 1 2 3
  • TUTR1 3 4
  • Esp1-Associated Protein 4
  • PTTG1 5

External Ids for PTTG1 Gene

Previous HGNC Symbols for PTTG1 Gene

  • TUTR1

Previous GeneCards Identifiers for PTTG1 Gene

  • GC05P159967
  • GC05P160358
  • GC05P159784
  • GC05P159829
  • GC05P159781
  • GC05P154942
  • GC05P159850

Summaries for PTTG1 Gene

Entrez Gene Summary for PTTG1 Gene

  • The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

CIViC Summary for PTTG1 Gene

GeneCards Summary for PTTG1 Gene

PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) is a Protein Coding gene. Diseases associated with PTTG1 include Pituitary Tumors and Premature Centromere Division. Among its related pathways are Cell Cycle, Mitotic and Mitotic Metaphase and Anaphase. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is PTTG2.

UniProtKB/Swiss-Prot Summary for PTTG1 Gene

  • Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene Wiki entry for PTTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTTG1 Gene

Genomics for PTTG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTTG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J160417 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 267 -1.0 -954 7 BCLAF1 SP1 ZNF600 MYC IKZF1 ZNF580 KLF9 POLR2A CEBPA ZNF10 PTTG1 SLU7 HSALNG0046247 HSALNG0046246 lnc-PTTG1-6 ZBED8
GH05J160398 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -22.3 -22254 2.8 NCOR1 IKZF1 ZNF600 ZNF580 POLR2A YY1 SMAD5 MBD2 TBP MNT ZBED8 HSALNG0046244 lnc-PTTG1-6 PTTG1 PWWP2A C1QTNF2
GH05J160433 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 13.5 +12.1 12146 2 BCLAF1 SP1 ZNF600 FEZF1 KLF9 SMAD4 SAP130 TEAD3 CBFB BHLHE40 PTTG1 MIR146A SLU7 FABP6 PWWP2A lnc-PTTG1-4 HSALNG0046247 ATP10B
GH05J160259 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.4 -160.3 -160259 4.3 MYC NCOR1 IKZF1 ZNF592 NFIC NONO REST HES1 BHLHE40 MBD2 LOC105377691 PTTG1 PWWP2A CCNJL ENSG00000254373 HSALNG0046233 FABP6
GH05J160197 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 10.3 -223.2 -223207 3.1 IKZF1 NCOR1 ZNF223 NFIC ZIC2 ZBTB10 NONO CTCF REST ZNF592 FABP6 PTTG1 RNF145 RF00017-4584 FABP6-AS1 CCNJL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTTG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTTG1

Top Transcription factor binding sites by QIAGEN in the PTTG1 gene promoter:
  • Elk-1
  • LCR-F1
  • Lmo2
  • Nkx3-1 v4
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1

Genomic Locations for PTTG1 Gene

Latest Assembly
chr5:160,421,855-160,428,744
(GRCh38/hg38)
Size:
6,890 bases
Orientation:
Plus strand

Previous Assembly
chr5:159,848,862-159,855,751
(GRCh37/hg19 by Entrez Gene)
Size:
6,890 bases
Orientation:
Plus strand

chr5:159,848,829-159,855,748
(GRCh37/hg19 by Ensembl)
Size:
6,920 bases
Orientation:
Plus strand

Genomic View for PTTG1 Gene

Genes around PTTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG1 Gene

Proteins for PTTG1 Gene

  • Protein details for PTTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95997-PTTG1_HUMAN
    Recommended name:
    Securin
    Protein Accession:
    O95997

    Protein attributes for PTTG1 Gene

    Size:
    202 amino acids
    Molecular mass:
    22024 Da
    Quaternary structure:
    • Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP.

neXtProt entry for PTTG1 Gene

Post-translational modifications for PTTG1 Gene

  • Phosphorylated at Ser-165 by CDK1 during mitosis.
  • Phosphorylated in vitro by ds-DNA kinase.
  • Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG1 Gene

No data available for DME Specific Peptides for PTTG1 Gene

Domains & Families for PTTG1 Gene

Gene Families for PTTG1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PTTG1 Gene

Suggested Antigen Peptide Sequences for PTTG1 Gene

GenScript: Design optimal peptide antigens:
  • Pituitary tumor-transforming protein 1 (C4TNW4_HUMAN)
  • Pituitary tumor transforming gene protein (O95211_HUMAN)
  • Pituitary tumor-transforming gene 1 protein (PTTG1_HUMAN)
  • PTTG1 protein (Q2VPE7_HUMAN)
  • cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA (Q6IAL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95997

UniProtKB/Swiss-Prot:

PTTG1_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG1: view

Function for PTTG1 Gene

Molecular function for PTTG1 Gene

UniProtKB/Swiss-Prot Function:
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
GENATLAS Biochemistry:
rat pituitary tumor transforming 1,overexpressed in Jurkat cells and in several hematopoietic malignancies,mainly located in cytosol but partly in nucleus,expressed in normal adult testis,thymus,colon,brain,lung and fetal liver

Phenotypes From GWAS Catalog for PTTG1 Gene

Gene Ontology (GO) - Molecular Function for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity NAS 12194817
GO:0005515 protein binding IPI 12194817
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with PTTG1: view
genes like me logo Genes that share phenotypes with PTTG1: view

Animal Models for PTTG1 Gene

MGI Knock Outs for PTTG1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTTG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTTG1 Gene

Localization for PTTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTTG1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9811450
GO:0005737 cytoplasm TAS 9811450
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with PTTG1: view

Pathways & Interactions for PTTG1 Gene

genes like me logo Genes that share pathways with PTTG1: view

Pathways by source for PTTG1 Gene

2 GeneGo (Thomson Reuters) pathways for PTTG1 Gene
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
1 Qiagen pathway for PTTG1 Gene
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for PTTG1 Gene

SIGNOR curated interactions for PTTG1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with PTTG1: view

Drugs & Compounds for PTTG1 Gene

(7) Drugs for PTTG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PTTG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTTG1: view

Transcripts for PTTG1 Gene

mRNA/cDNA for PTTG1 Gene

3 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTTG1

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1 Gene

No ASD Table

Relevant External Links for PTTG1 Gene

GeneLoc Exon Structure for
PTTG1

Expression for PTTG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTTG1 Gene

This gene is overexpressed in Testis (x9.7).

Protein differential expression in normal tissues from HIPED for PTTG1 Gene

This gene is overexpressed in Testis (40.9) and Fetal Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTTG1 Gene



Protein tissue co-expression partners for PTTG1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTTG1

SOURCE GeneReport for Unigene cluster for PTTG1 Gene:

Hs.350966

mRNA Expression by UniProt/SwissProt for PTTG1 Gene:

O95997-PTTG1_HUMAN
Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.

Evidence on tissue expression from TISSUES for PTTG1 Gene

  • Nervous system(2.8)
  • Thyroid gland(2.8)
  • Lymph node(2.6)
  • Intestine(2.6)
  • Skin(2.6)
  • Bone marrow(2.4)
  • Blood(2)
genes like me logo Genes that share expression patterns with PTTG1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTTG1 Gene

Orthologs for PTTG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTTG1 29 30
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTTG1 29
  • 88.23 (n)
-- 30
  • 80 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC100848911 29
  • 88.23 (n)
-- 30
  • 86 (a)
ManyToMany
PTTG1 30
  • 86 (a)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Pttg1 29
  • 79.73 (n)
Mouse
(Mus musculus)
Mammalia Pttg1 29 16 30
  • 79.4 (n)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
ManyToMany
-- 30
  • 57 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 56 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PTTG1 29 30
  • 60.25 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 39 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100498440 29
  • 48.15 (n)
Species where no ortholog for PTTG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PTTG1 Gene

ENSEMBL:
Gene Tree for PTTG1 (if available)
TreeFam:
Gene Tree for PTTG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTTG1: view image
Alliance of Genome Resources:
Additional Orthologs for PTTG1

Paralogs for PTTG1 Gene

Paralogs for PTTG1 Gene

(3) SIMAP similar genes for PTTG1 Gene using alignment to 5 proteins:

  • PTTG1_HUMAN
  • C4TNW4_HUMAN
  • E5RJR4_HUMAN
  • Q2VPE7_HUMAN
  • Q6IAL9_HUMAN

Pseudogenes.org Pseudogenes for PTTG1 Gene

genes like me logo Genes that share paralogs with PTTG1: view

Variants for PTTG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTTG1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs7335 Benign: not provided 160,428,637(+) C/T
NM_004219.4(PTTG1):c.565C>T (p.Leu189=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTTG1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTTG1 Gene

Variant ID Type Subtype PubMed ID
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958

Variation tolerance for PTTG1 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTTG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTTG1
Leiden Open Variation Database (LOVD)
PTTG1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTTG1 Gene

Disorders for PTTG1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for PTTG1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pituitary tumors
  • pituitary tumor
premature centromere division
  • pcd
pituitary adenoma
  • adenoma of the pituitary gland
pituitary adenoma, prolactin-secreting
  • prolactinoma, familial
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PTTG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTTG1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTTG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTTG1 Gene

Publications for PTTG1 Gene

  1. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). (PMID: 9892021) Zhang X … Melmed S (Molecular endocrinology (Baltimore, Md.) 1999) 2 3 4 22
  2. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PMID: 19008095) Brendle A … Försti A (European journal of cancer (Oxford, England : 1990) 2009) 3 22 40
  3. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PMID: 17210994) Lo YL … Shen CY (Carcinogenesis 2007) 3 22 40
  4. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. (PMID: 12355087) Bernal JA … Pintor-Toro JA (Nature genetics 2002) 3 4 22
  5. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. (PMID: 11238996) Romero F … Tortolero M (Nucleic acids research 2001) 3 4 22

Products for PTTG1 Gene

Sources for PTTG1 Gene