Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTPRZ1 Gene

Aliases for PTPRZ1 Gene

  • Protein Tyrosine Phosphatase, Receptor Type Z1 2 3 5
  • Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 2 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 2 3 4
  • R-PTP-Zeta-2 3 4
  • PTPRZ 3 4
  • PTPZ 3 4
  • Protein Tyrosine Phosphatase, Receptor-Type, Zeta Polypeptide 1 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 1 4
  • Receptor-Type Tyrosine-Protein Phosphatase Zeta 3
  • Receptor-Type Tyrosine Phosphatase Beta/Zeta 3
  • EC 3.1.3.48 4
  • Phosphacan 3
  • R-PTP-Zeta 4
  • HPTPzeta 3
  • PTP-ZETA 3
  • RPTPbeta 3
  • HTPZP2 4
  • PTPRZ2 4
  • HPTPZ 3
  • PTP18 3
  • RPTPB 3

External Ids for PTPRZ1 Gene

Previous HGNC Symbols for PTPRZ1 Gene

  • PTPZ
  • PTPRZ

Previous GeneCards Identifiers for PTPRZ1 Gene

  • GC07P119991
  • GC07P121053
  • GC07P121068
  • GC07P121069
  • GC07P121108
  • GC07P121301
  • GC07P121513
  • GC07P115876

Summaries for PTPRZ1 Gene

Entrez Gene Summary for PTPRZ1 Gene

  • This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRZ1 Gene

PTPRZ1 (Protein Tyrosine Phosphatase, Receptor Type Z1) is a Protein Coding gene. Diseases associated with PTPRZ1 include Helicobacter Pylori Infection and Hyperlysinemia, Type I. Among its related pathways are Insulin receptor recycling and Microglia Activation During Neuroinflammation: Overview. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRG.

UniProtKB/Swiss-Prot for PTPRZ1 Gene

  • Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

Gene Wiki entry for PTPRZ1 Gene

Additional gene information for PTPRZ1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRZ1 Gene

Genomics for PTPRZ1 Gene

GeneHancer (GH) Regulatory Elements for PTPRZ1 Gene

Promoters and enhancers for PTPRZ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J121872 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 663.3 +0.6 557 2.7 ZSCAN4 KLF17 ZNF2 ZNF48 ZEB1 ZNF335 GLIS2 EGR2 ZNF280D YY2 PTPRZ1 ING3 RNU7-154P
GH07J121794 Enhancer 0.6 FANTOM5 ENCODE 11.9 -75.6 -75555 5.1 POLR2A PTPRZ1 PNPT1P2 RN7SKP277
GH07J121925 Enhancer 0.6 ENCODE dbSUPER 10.5 +51.4 51373 0.2 NANOG POU5F1 PTPRZ1 RNU7-154P
GH07J121936 Enhancer 0.8 ENCODE dbSUPER 4.9 +65.8 65825 4.9 FOXA2 NANOG HLF ETS1 SP1 POLR2A CTBP2 POU5F1 PTPRZ1 RNU7-154P
GH07J121904 Enhancer 0.2 FANTOM5 14.4 +32.0 32009 0.2 PTPRZ1 RNU7-154P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTPRZ1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRZ1 gene promoter:

Genomic Locations for PTPRZ1 Gene

Genomic Locations for PTPRZ1 Gene
chr7:121,873,089-122,062,036
(GRCh38/hg38)
Size:
188,948 bases
Orientation:
Plus strand
chr7:121,513,143-121,702,090
(GRCh37/hg19)

Genomic View for PTPRZ1 Gene

Genes around PTPRZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRZ1 Gene

Proteins for PTPRZ1 Gene

  • Protein details for PTPRZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23471-PTPRZ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase zeta
    Protein Accession:
    P23471
    Secondary Accessions:
    • A4D0W5
    • C9JFM0
    • O76043
    • Q9UDR6

    Protein attributes for PTPRZ1 Gene

    Size:
    2315 amino acids
    Molecular mass:
    254587 Da
    Quaternary structure:
    • The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity).
    SequenceCaution:
    • Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRZ1 Gene

    Alternative splice isoforms for PTPRZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRZ1 Gene

Post-translational modifications for PTPRZ1 Gene

  • Glycosylation at posLast=16181618, posLast=15621562, Ser1551, posLast=15491549, posLast=14571457, Thr1338, Asn1122, Asn1082, Asn1050, posLast=10171017, Ser997, posLast=724724, Thr721, posLast=690690, posLast=677677, posLast=637637, Asn629, Ser604, Asn602, Ser587, posLast=552552, posLast=501501, Asn497, Thr484, posLast=482482, Thr479, Asn381, Asn324, Asn232, Asn223, Asn134, and posLast=105105
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRZ1 Gene

No data available for DME Specific Peptides for PTPRZ1 Gene

Domains & Families for PTPRZ1 Gene

Gene Families for PTPRZ1 Gene

Suggested Antigen Peptide Sequences for PTPRZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23471

UniProtKB/Swiss-Prot:

PTPRZ_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRZ1: view

Function for PTPRZ1 Gene

Molecular function for PTPRZ1 Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,zeta polypeptide

Enzyme Numbers (IUBMB) for PTPRZ1 Gene

Gene Ontology (GO) - Molecular Function for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity ISS --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 1323835
GO:0005515 protein binding IPI 17681947
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRZ1: view
genes like me logo Genes that share phenotypes with PTPRZ1: view

Animal Models for PTPRZ1 Gene

MGI Knock Outs for PTPRZ1:

Animal Model Products

CRISPR Products

miRNA for PTPRZ1 Gene

miRTarBase miRNAs that target PTPRZ1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRZ1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRZ1 Gene

Localization for PTPRZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRZ1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRZ1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8387522
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRZ1: view

Pathways & Interactions for PTPRZ1 Gene

genes like me logo Genes that share pathways with PTPRZ1: view

Pathways by source for PTPRZ1 Gene

SIGNOR curated interactions for PTPRZ1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006470 protein dephosphorylation TAS 1323835
GO:0007409 axonogenesis IEA --
GO:0007417 central nervous system development TAS 8387522
GO:0007611 learning or memory ISS --
genes like me logo Genes that share ontologies with PTPRZ1: view

Drugs & Compounds for PTPRZ1 Gene

(3) Drugs for PTPRZ1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRZ1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with PTPRZ1: view

Transcripts for PTPRZ1 Gene

Unigene Clusters for PTPRZ1 Gene

Protein tyrosine phosphatase, receptor-type, Z polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRZ1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRZ1 Gene

No ASD Table

Relevant External Links for PTPRZ1 Gene

GeneLoc Exon Structure for
PTPRZ1
ECgene alternative splicing isoforms for
PTPRZ1

Expression for PTPRZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRZ1 Gene

This gene is overexpressed in Brain - Amygdala (x6.7), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Hippocampus (x4.3), Brain - Putamen (basal ganglia) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for PTPRZ1 Gene

This gene is overexpressed in Brain (22.3), Frontal cortex (22.2), and Fetal Brain (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTPRZ1 Gene



Protein tissue co-expression partners for PTPRZ1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRZ1 Gene:

PTPRZ1

SOURCE GeneReport for Unigene cluster for PTPRZ1 Gene:

Hs.489824

mRNA Expression by UniProt/SwissProt for PTPRZ1 Gene:

P23471-PTPRZ_HUMAN
Tissue specificity: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Evidence on tissue expression from TISSUES for PTPRZ1 Gene

  • Nervous system(5)
  • Bone marrow(4)
  • Liver(4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with PTPRZ1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRZ1 Gene

Orthologs for PTPRZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRZ1 34 33
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRZ1 34 33
  • 88.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprz1 16 34 33
  • 85.48 (n)
rat
(Rattus norvegicus)
Mammalia Ptprz1 33
  • 85.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRZ1 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRZ1 34
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRZ1 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRZ1 34 33
  • 77.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRZ1 34
  • 33 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1099 33
zebrafish
(Danio rerio)
Actinopterygii ca16c 33
  • 63.74 (n)
ptprz1b 34
  • 58 (a)
OneToMany
ptprz1a 34
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 35
  • 36 (a)
Ptp99A 34 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04G7.2 35
  • 37 (a)
F36H12.10 35
  • 36 (a)
ZK616.7 35
  • 36 (a)
C02B10.6 35
  • 36 (a)
C55B7.3 35
  • 36 (a)
K07F5.8 35
  • 34 (a)
F10G8.1 35
  • 34 (a)
ZK484.7 35
  • 34 (a)
F47B3.7 35
  • 34 (a)
C17H12.3 35
  • 33 (a)
K04D7.4 35
  • 30 (a)
F47B3.1 35
  • 28 (a)
F47B3.6 35
  • 28 (a)
Species where no ortholog for PTPRZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRZ1 Gene

ENSEMBL:
Gene Tree for PTPRZ1 (if available)
TreeFam:
Gene Tree for PTPRZ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRZ1: view image

Paralogs for PTPRZ1 Gene

Paralogs for PTPRZ1 Gene

(29) SIMAP similar genes for PTPRZ1 Gene using alignment to 2 proteins:

  • PTPRZ_HUMAN
  • C9JFM0_HUMAN
genes like me logo Genes that share paralogs with PTPRZ1: view

Variants for PTPRZ1 Gene

Sequence variations from dbSNP and Humsavar for PTPRZ1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs483352722 uncertain-significance, not provided 121,983,708(+) G/T coding_sequence_variant, synonymous_variant
rs1000023669 -- 122,034,558(+) C/A intron_variant
rs1000027996 -- 121,912,575(+) C/T intron_variant
rs1000039311 -- 122,013,633(+) T/C coding_sequence_variant, intron_variant, synonymous_variant
rs1000062124 -- 121,919,412(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRZ1 Gene

Variant ID Type Subtype PubMed ID
esv2516212 CNV deletion 19546169
esv2659008 CNV deletion 23128226
esv2735088 CNV deletion 23290073
esv3542362 CNV deletion 23714750
esv3614833 CNV loss 21293372
esv3891198 CNV gain 25118596
nsv1137284 CNV deletion 24896259
nsv365800 CNV deletion 16902084
nsv608334 CNV loss 21841781
nsv966880 CNV duplication 23825009

Variation tolerance for PTPRZ1 Gene

Residual Variation Intolerance Score: 6.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.19; 98.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRZ1 Gene

Disorders for PTPRZ1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTPRZ1 Gene - From: OMIM, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
helicobacter pylori infection
  • helicobacter pylori infection, susceptibility to
hyperlysinemia, type i
  • lysine:alpha-ketoglutarate reductase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTPRZ1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTPRZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRZ1 Gene

Publications for PTPRZ1 Gene

  1. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. (PMID: 18186075) Ito Y … Ozaki N (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 44 58
  2. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. (PMID: 15998549) Marui T … Sasaki T (Neuroscience research 2005) 3 22 44 58
  3. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. (PMID: 8387522) Levy JB … Druck T (The Journal of biological chemistry 1993) 2 3 4 58
  4. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (PMID: 20133774) Bouyain S … Watkins DJ (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58

Products for PTPRZ1 Gene

Sources for PTPRZ1 Gene

Content
Loading form....