This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] See more...

Aliases for PTPRZ1 Gene

Aliases for PTPRZ1 Gene

  • Protein Tyrosine Phosphatase Receptor Type Z1 2 3 5
  • Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 2 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 2 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase Zeta 3 4
  • R-PTP-Zeta-2 3 4
  • EC 3.1.3.48 4 52
  • PTPRZ 3 4
  • PTPZ 3 4
  • Protein Tyrosine Phosphatase, Receptor-Type, Zeta Polypeptide 1 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 1 4
  • Receptor-Type Tyrosine Phosphatase Beta/Zeta 3
  • Phosphacan 3
  • R-PTP-Zeta 4
  • HPTPzeta 3
  • PTP-ZETA 3
  • RPTPbeta 3
  • HTPZP2 4
  • PTPRZ2 4
  • HPTPZ 3
  • PTP18 3
  • RPTPB 3

External Ids for PTPRZ1 Gene

Previous HGNC Symbols for PTPRZ1 Gene

  • PTPZ
  • PTPRZ

Previous GeneCards Identifiers for PTPRZ1 Gene

  • GC07P119991
  • GC07P121053
  • GC07P121068
  • GC07P121069
  • GC07P121108
  • GC07P121301
  • GC07P121513
  • GC07P115876

Summaries for PTPRZ1 Gene

Entrez Gene Summary for PTPRZ1 Gene

  • This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRZ1 Gene

PTPRZ1 (Protein Tyrosine Phosphatase Receptor Type Z1) is a Protein Coding gene. Diseases associated with PTPRZ1 include Oligodendroglioma and Niemann-Pick Disease, Type C1. Among its related pathways are Microglia Activation During Neuroinflammation: Overview and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRB.

UniProtKB/Swiss-Prot Summary for PTPRZ1 Gene

  • Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

Gene Wiki entry for PTPRZ1 Gene

Additional gene information for PTPRZ1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRZ1 Gene

Genomics for PTPRZ1 Gene

GeneHancer (GH) Regulatory Elements for PTPRZ1 Gene

Promoters and enhancers for PTPRZ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J121872 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 513.2 +2.2 2212 6.2 CTCF ZNF354C ZBTB26 ZEB1 EZH2 ZNF341 POLR2A SMC3 ZBTB17 ZNF263 PTPRZ1 AB372598-004 ING3 piR-56037-065
GH07J121951 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.9 +80.4 80439 4.1 TEAD4 CEBPG FOS ATF4 JUND ATF2 CEBPB ATF3 POU5F1 NANOG PTPRZ1 piR-56037-065 AB372598-004
GH07J121794 Enhancer 0.7 FANTOM5 ENCODE 11.9 -75.6 -75555 5.1 EP300 TEAD4 POLR2A HDAC2 FOS TAF1 CHD7 MYC STAT3 PTPRZ1 HSALNG0060965 RF00100-141 RN7SKP277 lnc-PTPRZ1-8
GH07J121925 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.5 +52.0 52012 5.4 HDAC2 TCF12 CHD7 POU5F1 NANOG KDM1A PTPRZ1 piR-56037-065 AB372598-004
GH07J121931 Enhancer 1 Ensembl ENCODE dbSUPER 5.5 +65.7 65712 16.8 EP300 HDAC2 POLR2A FOXA2 FOS YY1 NANOG CEBPB TCF12 ETS1 PTPRZ1 ING3 piR-56037-065 AB372598-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRZ1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRZ1

Top Transcription factor binding sites by QIAGEN in the PTPRZ1 gene promoter:
  • C/EBPalpha
  • Cart-1
  • CUTL1
  • E47
  • GR
  • GR-alpha
  • HOXA3
  • IRF-7A
  • POU6F1 (c2)
  • Tal-1beta

Genomic Locations for PTPRZ1 Gene

Genomic Locations for PTPRZ1 Gene
chr7:121,873,089-122,062,036
(GRCh38/hg38)
Size:
188,948 bases
Orientation:
Plus strand
chr7:121,513,143-121,702,090
(GRCh37/hg19)
Size:
188,948 bases
Orientation:
Plus strand

Genomic View for PTPRZ1 Gene

Genes around PTPRZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRZ1 Gene

Proteins for PTPRZ1 Gene

  • Protein details for PTPRZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23471-PTPRZ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase zeta
    Protein Accession:
    P23471
    Secondary Accessions:
    • A4D0W5
    • C9JFM0
    • O76043
    • Q9UDR6

    Protein attributes for PTPRZ1 Gene

    Size:
    2315 amino acids
    Molecular mass:
    254587 Da
    Quaternary structure:
    • The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity). Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity).
    SequenceCaution:
    • Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRZ1 Gene

    Alternative splice isoforms for PTPRZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRZ1 Gene

Selected DME Specific Peptides for PTPRZ1 Gene

P23471:
  • LPVLTFVR
  • HYTQWPD
  • VQTEEQY
  • VVHCSAG
  • VHCSAGVGRTG
  • DYINANY
  • QVAKMINLMRPGVF
  • GTDYINASYIMGYY
  • KDFWRMIWDHNAQ
  • GFLKHIR
  • KCDQYWP
  • GPVVVHCS
  • AEDEFVYWP
  • DSMLQQI
  • DFILEATQDDYVLEVRHFQCPKWPNPD

Post-translational modifications for PTPRZ1 Gene

  • Glycosylation at Asn105, Asn134, Asn223, Asn232, Asn324, Asn381, Thr479, Ser482, Thr484, Asn497, Asn501, Asn552, Ser587, Ser600, Asn602, Ser604, Asn629, Ser637, Asn677, Ser686, Thr689, Thr690, Thr721, Thr724, Asn1618, Ser997, Asn1017, Asn1050, Asn1082, Asn1122, Thr1338, Ser1339, Thr1340, Asn1457, Ser1549, Ser1551, and Asn1562
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTPRZ_HUMAN (2068)

Domains & Families for PTPRZ1 Gene

Gene Families for PTPRZ1 Gene

Protein Domains for PTPRZ1 Gene

Blocks:
  • Carbonic anhydrase, eukaryotic
  • Protein tyrosine phosphatase signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTPRZ1 Gene

GenScript: Design optimal peptide antigens:
  • R-PTP-zeta-2 (PTPRZ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23471

UniProtKB/Swiss-Prot:

PTPRZ_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRZ1: view

Function for PTPRZ1 Gene

Molecular function for PTPRZ1 Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,zeta polypeptide

Enzyme Numbers (IUBMB) for PTPRZ1 Gene

Phenotypes From GWAS Catalog for PTPRZ1 Gene

Gene Ontology (GO) - Molecular Function for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity ISS,IEA --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 1323835
GO:0005178 integrin binding IDA 19141530
GO:0005515 protein binding IEA,IPI 10706604
genes like me logo Genes that share ontologies with PTPRZ1: view
genes like me logo Genes that share phenotypes with PTPRZ1: view

Animal Models for PTPRZ1 Gene

MGI Knock Outs for PTPRZ1:

Animal Model Products

CRISPR Products

miRNA for PTPRZ1 Gene

miRTarBase miRNAs that target PTPRZ1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRZ1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRZ1 Gene

Localization for PTPRZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRZ1 Gene

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRZ1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8387522
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRZ1: view

Pathways & Interactions for PTPRZ1 Gene

genes like me logo Genes that share pathways with PTPRZ1: view

Pathways by source for PTPRZ1 Gene

1 BioSystems pathway for PTPRZ1 Gene
1 Qiagen pathway for PTPRZ1 Gene
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTPRZ1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006470 protein dephosphorylation IEA,IBA 21873635
GO:0007409 axonogenesis IEA --
GO:0007417 central nervous system development TAS 8387522
GO:0007611 learning or memory ISS --
genes like me logo Genes that share ontologies with PTPRZ1: view

Drugs & Compounds for PTPRZ1 Gene

(3) Drugs for PTPRZ1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRZ1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPRZ1: view

Transcripts for PTPRZ1 Gene

mRNA/cDNA for PTPRZ1 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRZ1

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRZ1 Gene

No ASD Table

Relevant External Links for PTPRZ1 Gene

GeneLoc Exon Structure for
PTPRZ1

Expression for PTPRZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRZ1 Gene

This gene is overexpressed in Brain - Amygdala (x6.7), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Hippocampus (x4.3), Brain - Putamen (basal ganglia) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for PTPRZ1 Gene

This gene is overexpressed in Brain (22.3), Frontal cortex (22.2), and Fetal Brain (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTPRZ1 Gene



Protein tissue co-expression partners for PTPRZ1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRZ1

SOURCE GeneReport for Unigene cluster for PTPRZ1 Gene:

Hs.489824

mRNA Expression by UniProt/SwissProt for PTPRZ1 Gene:

P23471-PTPRZ_HUMAN
Tissue specificity: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Evidence on tissue expression from TISSUES for PTPRZ1 Gene

  • Nervous system(5)
  • Bone marrow(4)
  • Liver(4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with PTPRZ1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRZ1 Gene

Orthologs for PTPRZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRZ1 31 30
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRZ1 31 30
  • 88.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprz1 17 31 30
  • 85.48 (n)
rat
(Rattus norvegicus)
Mammalia Ptprz1 30
  • 85.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRZ1 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRZ1 31
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRZ1 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRZ1 31 30
  • 77.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRZ1 31
  • 33 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1099 30
zebrafish
(Danio rerio)
Actinopterygii ca16c 30
  • 63.74 (n)
ptprz1b 31
  • 58 (a)
OneToMany
ptprz1a 31
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 32
  • 36 (a)
Ptp99A 31 32
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04G7.2 32
  • 37 (a)
F36H12.10 32
  • 36 (a)
ZK616.7 32
  • 36 (a)
C55B7.3 32
  • 36 (a)
C02B10.6 32
  • 36 (a)
F10G8.1 32
  • 34 (a)
ZK484.7 32
  • 34 (a)
F47B3.7 32
  • 34 (a)
K07F5.8 32
  • 34 (a)
C17H12.3 32
  • 33 (a)
K04D7.4 32
  • 30 (a)
F47B3.1 32
  • 28 (a)
F47B3.6 32
  • 28 (a)
Species where no ortholog for PTPRZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRZ1 Gene

ENSEMBL:
Gene Tree for PTPRZ1 (if available)
TreeFam:
Gene Tree for PTPRZ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRZ1: view image

Paralogs for PTPRZ1 Gene

Variants for PTPRZ1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRZ1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
717861 Benign: not provided 122,011,167(+) T/C SYNONYMOUS_VARIANT
726411 Likely Benign: not provided 121,976,277(+) T/C INTRON_VARIANT
729560 Likely Benign: not provided 121,996,551(+) T/C SYNONYMOUS_VARIANT
738957 Benign: not provided 122,031,470(+) G/A INTRON_VARIANT
741354 Benign: not provided 121,984,068(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PTPRZ1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTPRZ1 Gene

Variant ID Type Subtype PubMed ID
esv2516212 CNV deletion 19546169
esv2659008 CNV deletion 23128226
esv2735088 CNV deletion 23290073
esv3542362 CNV deletion 23714750
esv3614833 CNV loss 21293372
esv3891198 CNV gain 25118596
nsv1137284 CNV deletion 24896259
nsv365800 CNV deletion 16902084
nsv608334 CNV loss 21841781
nsv966880 CNV duplication 23825009

Variation tolerance for PTPRZ1 Gene

Residual Variation Intolerance Score: 6.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.19; 98.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRZ1 Gene

Disorders for PTPRZ1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTPRZ1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
niemann-pick disease, type c1
  • npc1
glioma susceptibility 1
  • glm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTPRZ1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTPRZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRZ1 Gene

Publications for PTPRZ1 Gene

  1. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. (PMID: 18186075) Ito Y … Ozaki N (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41 54
  2. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. (PMID: 15998549) Marui T … Sasaki T (Neuroscience research 2005) 3 23 41 54
  3. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. (PMID: 8387522) Levy JB … Druck T (The Journal of biological chemistry 1993) 2 3 4 54
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 41 54
  5. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (PMID: 20133774) Bouyain S … Watkins DJ (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 54

Products for PTPRZ1 Gene

Sources for PTPRZ1 Gene