Aliases for PTPRT Gene
External Ids for PTPRT Gene
Previous GeneCards Identifiers for PTPRT Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRT Gene
PTPRT (Protein Tyrosine Phosphatase Receptor Type T) is a Protein Coding gene. Diseases associated with PTPRT include Autism and Schizophrenia. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and beta-catenin binding. An important paralog of this gene is PTPRM.
UniProtKB/Swiss-Prot Summary for PTPRT Gene
May be involved in both signal transduction and cellular adhesion in the CNS.