The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic... See more...

Aliases for PTPRT Gene

Aliases for PTPRT Gene

  • Protein Tyrosine Phosphatase Receptor Type T 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Rho 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase T 3 4
  • EC 4 50
  • RPTP-Rho 3 4
  • KIAA0283 2 4
  • R-PTP-T 3 4
  • RPTPrho 2 3
  • Receptor Protein Tyrosine Phosphatase 3
  • EC 3.1.3 50
  • PTPRT 5

External Ids for PTPRT Gene

Previous GeneCards Identifiers for PTPRT Gene

  • GC20M040429
  • GC20M041339
  • GC20M041386
  • GC20M040134
  • GC20M040701
  • GC20M037438

Summaries for PTPRT Gene

Entrez Gene Summary for PTPRT Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

CIViC Summary for PTPRT Gene

GeneCards Summary for PTPRT Gene

PTPRT (Protein Tyrosine Phosphatase Receptor Type T) is a Protein Coding gene. Diseases associated with PTPRT include Autism and Schizophrenia. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and beta-catenin binding. An important paralog of this gene is PTPRM.

UniProtKB/Swiss-Prot Summary for PTPRT Gene

  • May be involved in both signal transduction and cellular adhesion in the CNS.

Gene Wiki entry for PTPRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRT Gene

Genomics for PTPRT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPRT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J043187 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 250.7 +1.5 1469 3.4 ZNF654 ZNF600 CTCF REST KLF11 TRIM22 SIN3A THAP11 RAD21 SMC3 ENSG00000233508 PTPRT SRSF6 lnc-GTSF1L-7
GH20J043192 Promoter 0.3 Ensembl 250.7 -0.5 -531 0.2 ENSG00000233508 PTPRT lnc-SRSF6-8 SRSF6
GH20J042936 Enhancer 0.5 Ensembl 11.2 +253.4 253369 1.2 ATF2 JUND JUN CREB1 HLF ATF3 ATF7 PTPRT RF00017-3237 LOC105372623 lnc-GTSF1L-8
GH20J043964 Enhancer 0.6 dbSUPER 5.1 -773.4 -773406 0.7 RXRA HNF4A HBP1 ATF2 SP1 ATF1 MLX HNF4G CREB1 ZHX2 TOX2 PTPRT piR-43105-380 lnc-GDAP1L1-3 JPH2
GH20J042991 Enhancer 0.2 Ensembl 12.1 +198.9 198869 0.6 PTPRT-AS1 PTPRT lnc-GTSF1L-8 piR-51221-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRT

Top Transcription factor binding sites by QIAGEN in the PTPRT gene promoter:
  • aMEF-2
  • Chx10
  • E47
  • FOXD1
  • FOXO3b
  • MEF-2A
  • Nkx2-5
  • Tal-1beta

Genomic Locations for PTPRT Gene

Latest Assembly
1,160,012 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,117,151 bases
Minus strand

(GRCh37/hg19 by Ensembl)
1,117,219 bases
Minus strand

Genomic View for PTPRT Gene

Genes around PTPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRT Gene

Proteins for PTPRT Gene

  • Protein details for PTPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase T
    Protein Accession:
    Secondary Accessions:
    • A8E4R6
    • O43655
    • O75664
    • Q5W0X9
    • Q5W0Y1
    • Q9BR24
    • Q9BR28
    • Q9H0Y8
    • Q9NTL1
    • Q9NU72
    • Q9UBD2
    • Q9UJL7

    Protein attributes for PTPRT Gene

    1441 amino acids
    Molecular mass:
    162134 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA22952.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRT Gene

    Alternative splice isoforms for PTPRT Gene


neXtProt entry for PTPRT Gene

Selected DME Specific Peptides for PTPRT Gene


Post-translational modifications for PTPRT Gene

  • Glycosylation at Asn78, Asn98, Asn137, Asn208, Asn421, Asn510, Asn547, Asn601, Asn654, and Asn684
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for PTPRT
  • Boster Bio Antibodies for PTPRT
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTPRT

Domains & Families for PTPRT Gene

Gene Families for PTPRT Gene

Protein Domains for PTPRT Gene

  • Fibronectin type III repeat signature
  • Protein tyrosine phosphatase signature
  • MAM domain signature

Suggested Antigen Peptide Sequences for PTPRT Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase, receptor type, T (B1AJR7_HUMAN)
  • Receptor-type tyrosine-protein phosphatase rho (PTPRT_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRT: view

Function for PTPRT Gene

Molecular function for PTPRT Gene

UniProtKB/Swiss-Prot Function:
May be involved in both signal transduction and cellular adhesion in the CNS.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor type,T,expressed in the brain and delineating with FGF1,a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex

Enzyme Numbers (IUBMB) for PTPRT Gene

Phenotypes From GWAS Catalog for PTPRT Gene

Gene Ontology (GO) - Molecular Function for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IMP 16973135
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity IDA 24846175
GO:0005515 protein binding IEA,IPI 16273344
GO:0008013 beta-catenin binding IPI 16973135
genes like me logo Genes that share ontologies with PTPRT: view
genes like me logo Genes that share phenotypes with PTPRT: view

Animal Models for PTPRT Gene

MGI Knock Outs for PTPRT:

Animal Models for research

  • Taconic Biosciences Mouse Models for PTPRT

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRT Gene

Localization for PTPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRT Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRT gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18644975
GO:0005887 integral component of plasma membrane IDA 24846175
GO:0009986 cell surface IDA 18644975
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 9602027
genes like me logo Genes that share ontologies with PTPRT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRT Gene

Pathways & Interactions for PTPRT Gene

PathCards logo

SuperPathways for PTPRT Gene

SuperPathway Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRT: view

Pathways by source for PTPRT Gene

1 Qiagen pathway for PTPRT Gene
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTPRT Gene


Gene Ontology (GO) - Biological Process for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IDA 16973135
GO:0007155 cell adhesion NAS 16973135
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 18644975
GO:0007165 signal transduction NAS 16973135
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP 16973135
genes like me logo Genes that share ontologies with PTPRT: view

Drugs & Compounds for PTPRT Gene

(3) Drugs for PTPRT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(1) Additional Compounds for PTPRT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTPRT: view

Transcripts for PTPRT Gene

mRNA/cDNA for PTPRT Gene

6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRT

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRT Gene

No ASD Table

Relevant External Links for PTPRT Gene

GeneLoc Exon Structure for

Expression for PTPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRT Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.7), Brain - Cortex (x9.4), and Brain - Anterior cingulate cortex (BA24) (x8.4).

Protein differential expression in normal tissues from HIPED for PTPRT Gene

This gene is overexpressed in Stomach (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTPRT Gene

Protein tissue co-expression partners for PTPRT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRT

SOURCE GeneReport for Unigene cluster for PTPRT Gene:


mRNA Expression by UniProt/SwissProt for PTPRT Gene:

Tissue specificity: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for PTPRT Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PTPRT: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRT Gene

Orthologs for PTPRT Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRT 29 30
  • 99.54 (n)
(Monodelphis domestica)
Mammalia PTPRT 30
  • 94 (a)
(Canis familiaris)
Mammalia PTPRT 29 30
  • 92.82 (n)
(Bos Taurus)
Mammalia PTPRT 29 30
  • 92.14 (n)
(Mus musculus)
Mammalia Ptprt 29 16 30
  • 90.66 (n)
(Ornithorhynchus anatinus)
Mammalia PTPRT 30
  • 88 (a)
(Gallus gallus)
Aves PTPRT 29 30
  • 81.69 (n)
(Anolis carolinensis)
Reptilia PTPRT 30
  • 90 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptprt 29
  • 77.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia ptprt-A-prov 29
(Danio rerio)
Actinopterygii PTPRT (2 of 2) 30
  • 86 (a)
ptprt 30
  • 81 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7180 31
  • 33 (a)
Ptp69D 31
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C17H12.3 31
  • 38 (a)
F36H1.3 31
  • 37 (a)
Y48G9A.9 31
  • 37 (a)
F47B3.7 31
  • 35 (a)
ZK616.7 31
  • 35 (a)
C55B7.3 31
  • 33 (a)
ZK484.7 31
  • 33 (a)
F10G8.1 31
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1390 30
  • 38 (a)
Species where no ortholog for PTPRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTPRT Gene

Gene Tree for PTPRT (if available)
Gene Tree for PTPRT (if available)
Evolutionary constrained regions (ECRs) for PTPRT: view image
Alliance of Genome Resources:
Additional Orthologs for PTPRT

Paralogs for PTPRT Gene

(20) SIMAP similar genes for PTPRT Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PTPRT: view

Variants for PTPRT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRT Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
996595 Association: Autism spectrum disorder 42,780,238(-) C/T
NM_007050.6(PTPRT):c.548G>A (p.Arg183Gln)
rs1060499749 Likely Pathogenic: Abnormality of brain morphology 42,352,288(-) G/A
rs111792993 Benign: not provided 42,110,428(-) G/A
NM_007050.6(PTPRT):c.3159C>T (p.His1053=)
rs115115747 Benign: not provided 42,756,571(-) G/A
NM_007050.6(PTPRT):c.750C>T (p.Ala250=)
rs121732742 A colorectal cancer p.Thr605Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPRT Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPRT Gene

Variant ID Type Subtype PubMed ID
dgv1243e212 CNV loss 25503493
dgv1244e212 CNV loss 25503493
dgv1245e212 CNV loss 25503493
dgv2251n106 CNV deletion 24896259
dgv247n21 CNV loss 19592680
dgv4310n100 CNV loss 25217958
dgv4311n100 CNV loss 25217958
dgv4312n100 CNV loss 25217958
dgv4313n100 CNV loss 25217958
dgv4314n100 CNV loss 25217958
dgv4315n100 CNV loss 25217958
dgv4316n100 CNV loss 25217958
dgv4317n100 CNV gain 25217958
dgv4318n100 CNV gain 25217958
dgv7575n54 CNV loss 21841781
dgv7576n54 CNV loss 21841781
dgv7577n54 CNV loss 21841781
dgv7578n54 CNV loss 21841781
dgv7579n54 CNV loss 21841781
dgv7580n54 CNV loss 21841781
dgv782e214 CNV loss 21293372
dgv788e199 CNV deletion 23128226
esv1402978 CNV insertion 17803354
esv1651732 CNV insertion 17803354
esv1713499 CNV insertion 17803354
esv1938054 CNV deletion 18987734
esv2232474 CNV deletion 18987734
esv2256655 CNV deletion 18987734
esv2436042 CNV insertion 19546169
esv2477377 CNV insertion 19546169
esv2488032 CNV deletion 19546169
esv2617939 CNV insertion 19546169
esv2657780 CNV deletion 23128226
esv2658478 CNV deletion 23128226
esv2658951 CNV deletion 23128226
esv2661822 CNV deletion 23128226
esv2664344 CNV deletion 23128226
esv2664766 CNV deletion 23128226
esv2668973 CNV deletion 23128226
esv2669794 CNV deletion 23128226
esv2670325 CNV deletion 23128226
esv2674976 CNV deletion 23128226
esv2722424 CNV deletion 23290073
esv2722425 CNV deletion 23290073
esv2722426 CNV deletion 23290073
esv2722427 CNV deletion 23290073
esv2722429 CNV deletion 23290073
esv2722430 CNV deletion 23290073
esv2722431 CNV deletion 23290073
esv2722432 CNV deletion 23290073
esv2722433 CNV deletion 23290073
esv2722434 CNV deletion 23290073
esv2722435 CNV deletion 23290073
esv2722436 CNV deletion 23290073
esv2751913 CNV gain 17911159
esv2751914 CNV gain 17911159
esv2758795 CNV loss 17122850
esv2760672 CNV loss 21179565
esv2762074 CNV loss 21179565
esv2762075 CNV loss 21179565
esv2762078 CNV loss 21179565
esv3324213 CNV insertion 20981092
esv33863 CNV loss 17666407
esv3557084 CNV deletion 23714750
esv3557085 CNV deletion 23714750
esv3557087 CNV deletion 23714750
esv3557090 CNV deletion 23714750
esv3557093 CNV deletion 23714750
esv3557094 CNV deletion 23714750
esv3567969 CNV loss 25503493
esv3567970 CNV loss 25503493
esv3567971 CNV loss 25503493
esv3567972 CNV loss 25503493
esv3567977 CNV loss 25503493
esv3575373 CNV gain 25503493
esv3645841 CNV gain 21293372
esv3645854 CNV gain 21293372
esv3645856 CNV gain 21293372
esv3645857 CNV loss 21293372
esv3645858 CNV loss 21293372
esv3645859 CNV loss 21293372
esv3645861 CNV loss 21293372
esv3645863 CNV loss 21293372
esv3645864 CNV loss 21293372
esv3645865 CNV loss 21293372
esv3645866 CNV loss 21293372
esv3645867 CNV loss 21293372
esv3645868 CNV loss 21293372
esv3645872 CNV loss 21293372
esv3645873 CNV loss 21293372
esv3645875 CNV loss 21293372
esv3645876 CNV loss 21293372
esv3645877 CNV loss 21293372
esv3893334 CNV loss 25118596
esv3893335 CNV loss 25118596
esv3893336 CNV loss 25118596
esv3893338 CNV loss 25118596
esv3893339 CNV loss 25118596
esv7918 CNV loss 19470904
esv989547 CNV deletion 20482838
esv995175 CNV deletion 20482838
nsv1055546 CNV loss 25217958
nsv1057847 CNV loss 25217958
nsv1060878 CNV loss 25217958
nsv1061219 CNV loss 25217958
nsv1061449 CNV loss 25217958
nsv1063422 CNV loss 25217958
nsv1063770 CNV loss 25217958
nsv1064246 CNV loss 25217958
nsv1064358 CNV loss 25217958
nsv1065268 CNV loss 25217958
nsv1072114 CNV deletion 25765185
nsv1073059 CNV deletion 25765185
nsv1123488 CNV deletion 24896259
nsv1125727 CNV tandem duplication 24896259
nsv1126596 CNV deletion 24896259
nsv1136541 CNV deletion 24896259
nsv1136543 CNV deletion 24896259
nsv1136544 CNV deletion 24896259
nsv179776 CNV deletion 16902084
nsv180358 CNV insertion 16902084
nsv3381 CNV deletion 18451855
nsv3383 CNV insertion 18451855
nsv458978 CNV loss 19166990
nsv458979 CNV loss 19166990
nsv458981 CNV loss 19166990
nsv458982 CNV loss 19166990
nsv470552 CNV loss 18288195
nsv474634 CNV novel sequence insertion 20440878
nsv478938 CNV novel sequence insertion 20440878
nsv516291 CNV gain+loss 19592680
nsv517647 CNV loss 19592680
nsv519654 CNV loss 19592680
nsv522445 CNV loss 19592680
nsv523080 CNV gain 19592680
nsv523956 CNV loss 19592680
nsv525353 CNV loss 19592680
nsv586007 CNV loss 21841781
nsv586008 CNV loss 21841781
nsv586010 CNV loss 21841781
nsv586025 CNV loss 21841781
nsv586028 CNV loss 21841781
nsv817896 CNV loss 17921354
nsv828726 CNV loss 20364138
nsv833987 CNV loss 17160897
nsv833988 CNV loss 17160897
nsv954042 CNV deletion 24416366
nsv954263 CNV deletion 24416366

Variation tolerance for PTPRT Gene

Residual Variation Intolerance Score: 3.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRT Gene

Disorders for PTPRT Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTPRT Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
  • autistic disorder
  • sczd
autism spectrum disorder
  • asd
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search PTPRT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPRT

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTPRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRT Gene

Publications for PTPRT Gene

  1. Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. (PMID: 9602027) McAndrew PE … Burghes AH (Brain research. Molecular brain research 1998) 2 3 4 22
  2. Mutational analysis of PTPRT phosphatase domains in common human cancers. (PMID: 17223850) Lee JW … Lee SH (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007) 3 22 40
  3. Genomic organization and alternative splicing of the human and mouse RPTPrho genes. (PMID: 11423001) Besco JA … Rotter A (BMC genomics 2001) 3 4 22
  4. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. (PMID: 20133777) Zhao Y … Wang Z (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 40

Products for PTPRT Gene

Sources for PTPRT Gene