Aliases for PTPRR Gene
External Ids for PTPRR Gene
Previous HGNC Symbols for PTPRR Gene
Previous GeneCards Identifiers for PTPRR Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
GeneCards Summary for PTPRR Gene
PTPRR (Protein Tyrosine Phosphatase Receptor Type R) is a Protein Coding gene. Diseases associated with PTPRR include Deafness, Autosomal Recessive 84A and Deafness, Autosomal Dominant 50. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN5.
UniProtKB/Swiss-Prot Summary for PTPRR Gene
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).