Aliases for PTPRM Gene
External Ids for PTPRM Gene
Previous HGNC Symbols for PTPRM Gene
Previous GeneCards Identifiers for PTPRM Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRM Gene
PTPRM (Protein Tyrosine Phosphatase Receptor Type M) is a Protein Coding gene. Diseases associated with PTPRM include Noonan Syndrome 1. Among its related pathways are Cell adhesion_Cadherin-mediated cell adhesion and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.
UniProtKB/Swiss-Prot Summary for PTPRM Gene
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.