Aliases for PTPRK Gene
Aliases for PTPRK Gene
- Protein Tyrosine Phosphatase, Receptor Type K 2 3 5
- Protein-Tyrosine Phosphatase Kappa 3 4
- R-PTP-Kappa 3 4
- DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
- Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
- Receptor-Type Tyrosine-Protein Phosphatase Kappa 3
- EC 3.1.3.48 4
- PTPK 4
External Ids for PTPRK Gene
- HGNC: 9674
- Entrez Gene: 5796
- Ensembl: ENSG00000152894
- OMIM: 602545
- UniProtKB: Q15262
Previous GeneCards Identifiers for PTPRK Gene
- GC06M128137
- GC06M128270
- GC06M128331
- GC06M125866
- GC06M128289
Summaries for PTPRK Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRK Gene
PTPRK (Protein Tyrosine Phosphatase, Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Eye Lymphoma. Among its related pathways are RET signaling and Listeria monocytogenes entry into host cells. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRM.
UniProtKB/Swiss-Prot for PTPRK Gene
-
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Additional gene information for PTPRK Gene
- Monarch Initiative
- Search for PTPRK at DataMed
- Search for PTPRK at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRK Gene
Genomics for PTPRK Gene
GeneHancer (GH) Regulatory Elements for PTPRK Gene
Promoters and enhancers for PTPRK Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J128515 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 653.2 | +2.2 | 2203 | 6.4 | PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 FOS | PTPRK ENSG00000224733 | |
| GH06J128397 | Promoter | 0.5 | EPDnew | 650.1 | +123.3 | 123295 | 0.1 | PTPRK GC06M128431 GC06P128257 | ||
| GH06J128490 | Promoter/Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 11 | +29.1 | 29109 | 2.9 | SOX13 EBF1 YY1 ZNF335 GATA3 POLR2A ZNF366 SCRT2 FOSL2 FOS | PTPRK ENSG00000224733 GC06M128448 | |
| GH06J128493 | Enhancer | 0.8 | dbSUPER | 11.2 | +25.6 | 25605 | 3.8 | PKNOX1 FOXA2 ARID4B MZF1 FEZF1 YY1 ZNF335 ZNF213 MIXL1 ZBTB25 | PTPRK ENSG00000224733 GC06M128448 | |
| GH06J129186 | Enhancer | 0.7 | ENCODE | 4.6 | -666.2 | -666243 | 1.1 | JUN INSM2 ZEB1 ZNF366 FOS KLF8 KLF13 ZNF639 ZNF362 ZNF189 | PTPRK BMPR1APS1 GC06P129295 LAMA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPRK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTPRK gene promoter:
-
- E2F-2
- E2F
- E2F-1
- AREB6
- E2F-3a
- E2F-4
Regulatory Element Products
Genomic Locations for PTPRK Gene
Genomic Locations for PTPRK Gene
- chr6:127,968,779-128,520,847
- (GRCh38/hg38)
- Size:
- 552,069 bases
- Orientation:
- Minus strand
- chr6:128,289,924-128,841,870
- (GRCh37/hg19)
- Size:
- 551,947 bases
- Orientation:
- Minus strand
Genomic View for PTPRK Gene
Genes around PTPRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by Entrez Gene
- 6q22.33 by HGNC
- 6q22.33 by Ensembl
PTPRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPRK Gene
Proteins for PTPRK Gene
-
Protein details for PTPRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15262-PTPRK_HUMAN
- Recommended name:
- Receptor-type tyrosine-protein phosphatase kappa
- Protein Accession:
- Q15262
- B2RTQ8
- B7ZMG0
- Q14763
- Q5TG10
- Q5TG11
Protein attributes for PTPRK Gene
- Size:
- 1439 amino acids
- Molecular mass:
- 162102 Da
- Quaternary structure:
- No Data Available
Protein Expression for PTPRK Gene
Post-translational modifications for PTPRK Gene
- This protein undergoes proteolytic processing.
- Glycosylation at posLast=690690, Asn607, Asn590, posLast=586586, Asn552, Asn462, posLast=436436, Asn424, posLast=416416, posLast=211211, Asn140, and posLast=101101
- Modification sites at PhosphoSitePlus
Other Protein References for PTPRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PTPRK
-
Abcam antibodies for PTPRK
- Invitrogen Antibodies for PTPRK
- GeneTex PTPRK Antibody for PTPRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
Protein Products
-
OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
- Search GeneTex for Proteins for PTPRK
Assay Products
No data available for DME Specific Peptides for PTPRK Gene
Domains & Families for PTPRK Gene
Gene Families for PTPRK Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for PTPRK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPRK Gene
- GenScript: Design optimal peptide antigens:
-
- Receptor-type tyrosine-protein phosphatase kappa (PTPRK_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRN8_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRZ3_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT32_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT33_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15262UniProtKB/Swiss-Prot:
PTPRK_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Function for PTPRK Gene
Molecular function for PTPRK Gene
- UniProtKB/Swiss-Prot Function:
- Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- GENATLAS Biochemistry:
- protein tyrosine phosphatase receptor type,kappa polypeptide,expressed in spleen,prostate,ovary,keratinocytes,epidermal cell lines
Enzyme Numbers (IUBMB) for PTPRK Gene
Phenotypes From GWAS Catalog for PTPRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA,IEA | 8663237 |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | NAS | 9047348 |
| GO:0005515 | protein binding | IEA,IPI | 15899872 |
| GO:0008013 | beta-catenin binding | IPI | 8663237 |
Phenotypes for PTPRK Gene
- GenomeRNAi human phenotypes for PTPRK:
-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Apoptosis resistance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Upregulation of NF-kappaB pathway after LMP1 stimulation
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTPRK
-
CRISPR Products
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
- genomics-online: gRNA clones - Search results for 113 available PTPRK gene related products
- Overview of 113 available PTPRK gene related products
- Applied Biological Materials CRISPR for PTPRK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
- GenScript: Design CRISPR guide RNA sequences for PTPRK
miRNA for PTPRK Gene
- miRTarBase miRNAs that target PTPRK
-
- hsa-mir-30a-5p (MIRT005161)
- hsa-mir-133b (MIRT007126)
- hsa-mir-9-5p (MIRT021457)
- hsa-mir-935 (MIRT036651)
- hsa-mir-877-3p (MIRT037091)
- hsa-mir-615-3p (MIRT039631)
- hsa-mir-423-3p (MIRT042465)
- hsa-mir-149-5p (MIRT045592)
- hsa-mir-218-5p (MIRT439860)
- hsa-mir-1283 (MIRT546895)
- hsa-mir-7849-3p (MIRT546896)
- hsa-mir-548c-3p (MIRT546897)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
- genomics-online: shRNA clones - Search results for 113 available PTPRK gene related products
- Overview of 113 available PTPRK gene related products
Clone Products
-
OriGene ORF clones in human for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPRK
- VectorBuilder custom plasmid, inducible vectors for PTPRK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTPRK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
- Applied Biological Materials Clones for PTPRK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRK Gene
Localization for PTPRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPRK Gene
- Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001750 | photoreceptor outer segment | IEA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9047348 |
| GO:0005911 | cell-cell junction | IDA | 8663237 |
| GO:0005912 | adherens junction | IEA | -- |
Pathways & Interactions for PTPRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PAK Pathway | ||
| 2 | Listeria monocytogenes entry into host cells | ||
| 3 | Signaling by GPCR | ||
| 4 | RET signaling | ||
| 5 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||
Pathways by source for PTPRK Gene
1 BioSystems pathway for PTPRK Gene
3 Reactome pathways for PTPRK Gene
1 Qiagen pathway for PTPRK Gene
Interacting Proteins for PTPRK Gene
Selected Interacting proteins:
Q15262-PTPRK_HUMAN
ENSP00000357196
for PTPRK Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PTPRK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,IDA | 16263724 |
| GO:0007155 | cell adhesion | IMP | 15899872 |
| GO:0007165 | signal transduction | IDA | 16849327 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15899872 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 15899872 |
No data available for SIGNOR curated interactions for PTPRK Gene
Drugs & Compounds for PTPRK Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Drug Products
Transcripts for PTPRK Gene
mRNA/cDNA for PTPRK Gene
- (20) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (196) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000368226 6087 bps (uc003qbj.4)
- ENST00000532331 5757 bps (uc011ebu.3)
- ENST00000368213 5816 bps (uc010kfc.4)
- ENST00000368210 5025 bps (uc010kfd.2)
- ENST00000368215 4651 bps (uc003qbk.4)
Unigene Clusters for PTPRK Gene
- Protein tyrosine phosphatase, receptor type, K:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
- genomics-online: gRNA clones - Search results for 113 available PTPRK gene related products
- Overview of 113 available PTPRK gene related products
- Applied Biological Materials CRISPR for PTPRK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
- GenScript: Design CRISPR guide RNA sequences for PTPRK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
- genomics-online: shRNA clones - Search results for 113 available PTPRK gene related products
- Overview of 113 available PTPRK gene related products
Clone Products
-
OriGene ORF clones in human for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPRK
- VectorBuilder custom plasmid, inducible vectors for PTPRK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTPRK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
- Applied Biological Materials Clones for PTPRK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for PTPRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Gall Bladder (Hepatobiliary System)
This gene is overexpressed in Amniocyte (16.9) and Breast (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRK Gene
NURSA nuclear receptor signaling pathways regulating expression of PTPRK Gene:
PTPRKSOURCE GeneReport for Unigene cluster for PTPRK Gene:
Hs.155919mRNA Expression by UniProt/SwissProt for PTPRK Gene:
Q15262-PTPRK_HUMAN
Tissue specificity:
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Evidence on tissue expression from TISSUES for PTPRK Gene
- Nervous system(4.7)
- Liver(4.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for PTPRK
- genomics-online: primer clones - Search results for 113 available PTPRK gene related products
- Overview of 113 available PTPRK gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRK Gene
Orthologs for PTPRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTPRK 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTPRK 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PTPRK 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PTPRK 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PTPRK 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ptprk 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptprk 33 |
|
||
| chicken (Gallus gallus) |
Aves | PTPRK 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTPRK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptprk 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptprk 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Ptp52F 35 |
|
|
|
| CG7180 35 |
|
|
|||
| Ptp69D 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | F47B3.7 35 |
|
|
|
| T22C1.8 35 |
|
|
|||
| T27A3.5 35 |
|
|
|||
| Y48G9A.9 35 |
|
|
|||
| ZK484.7 35 |
|
|
|||
| C55B7.3 35 |
|
|
|||
| F10G8.1 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1390 34 |
|
OneToMany |
- Species where no ortholog for PTPRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PTPRK Gene
- ENSEMBL:
- Gene Tree for PTPRK (if available)
- TreeFam:
- Gene Tree for PTPRK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPRK: view image
Paralogs for PTPRK Gene
Paralogs for PTPRK Gene
(31) SIMAP similar genes for PTPRK Gene using alignment to 13 proteins:
- PTPRK_HUMAN
- B7ZMG0_HUMAN
- E9PGC5_HUMAN
- E9PMV4_HUMAN
- E9PRW2_HUMAN
- F5GXI4_HUMAN
- H0Y6P5_HUMAN
- H0Y6V4_HUMAN
- H0YD44_HUMAN
- H0YDP9_HUMAN
- Q5TG12_HUMAN
- Q6P493_HUMAN
- Q86WJ2_HUMAN
Variants for PTPRK Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009045 | -- | 128,412,236(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000010379 | -- | 128,325,018(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000013842 | -- | 128,080,971(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000021043 | -- | 128,278,680(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000023139 | -- | 127,971,521(-) | A/G | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPRK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRK Gene
Disorders for PTPRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eye lymphoma |
|
|
Search PTPRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPRK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRK Gene
Publications for PTPRK Gene
- Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. (PMID: 9047348) Yang Y … Ha H (Gene 1997) 2 3 4 22 58
- Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. (PMID: 8663237) Fuchs M … Ullrich A (The Journal of biological chemistry 1996) 2 3 4 22 58
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes. (PMID: 19864455) Xu Y … Fisher GJ (Molecular biology of the cell 2010) 3 22 58
Products for PTPRK Gene
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 5 available PTPRK Antibodies ranked by validation data
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Sources for PTPRK Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
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- (78) GenomeRNAi
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- (80) miRTarBase
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