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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and ... See more...
Aliases for PTPRK Gene
Aliases for PTPRK Gene
- Protein Tyrosine Phosphatase Receptor Type K 2 3 5
- R-PTP-Kappa 2 3 4
- Receptor-Type Tyrosine-Protein Phosphatase Kappa 3 4
- Protein-Tyrosine Phosphatase Kappa 3 4
- EC 3.1.3.48 4 50
- DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
- Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
- PTPRK 5
- PTPK 4
External Ids for PTPRK Gene
- HGNC: 9674
- NCBI Entrez Gene: 5796
- Ensembl: ENSG00000152894
- OMIM®: 602545
- UniProtKB/Swiss-Prot: Q15262
Previous GeneCards Identifiers for PTPRK Gene
- GC06M128137
- GC06M128270
- GC06M128331
- GC06M125866
- GC06M128289
Summaries for PTPRK Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRK Gene
PTPRK (Protein Tyrosine Phosphatase Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Extragonadal Germ Cell Cancer and Eye Lymphoma. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRM.
UniProtKB/Swiss-Prot Summary for PTPRK Gene
-
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Additional gene information for PTPRK Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRK Gene
Genomics for PTPRK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTPRK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPRK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRK
- Top Transcription factor binding sites by QIAGEN in the PTPRK gene promoter:
-
- AREB6
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
Genomic Locations for PTPRK Gene
Latest Assembly
- chr6:127,968,785-128,520,616
- (GRCh38/hg38)
- Size:
- 551,832 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:128,289,930-128,841,744
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 551,815 bases
- Orientation:
- Minus strand
Alternative Locations (GRCh38/hg38)
- chr6(ALT_REF_LOCI_1):313,983-869,933 (-)
Genomic View for PTPRK Gene
Genes around PTPRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by HGNC
- 6q22.33 by Entrez Gene
- 6q22.33 by Ensembl
PTPRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPRK Gene
Proteins for PTPRK Gene
-
Protein details for PTPRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15262-PTPRK_HUMAN
- Recommended name:
- Receptor-type tyrosine-protein phosphatase kappa
- Protein Accession:
- Q15262
- B2RTQ8
- B7ZMG0
- Q14763
- Q5TG10
- Q5TG11
Protein attributes for PTPRK Gene
- Size:
- 1439 amino acids
- Molecular mass:
- 162102 Da
- Quaternary structure:
- No Data Available
Protein Expression for PTPRK Gene
Selected DME Specific Peptides for PTPRK Gene
- Q15262:
-
- NYINAAL
- TITVLLRPAQ
- PFTVGDN
- PIAPPQL
- EGVVDIYNCV
- LVEVGRVKC
- VQTEEQY
- YIATQGP
- ELAVSTFWPNEYQ
- ITQYEISY
- NSIIGDGPI
- IAYDHSRV
- VVHCSAG
- EYESFFEG
- GRTGCYIV
- NPEGRKE
- YKLWHLDPD
- DYINANY
- WPDHGVP
- HGVPYHATGLL
- RVADLLQHI
- QTEEQYIFIHDA
- HCLNGGGRSG
- KENDTHCIDF
- DFWRLVYDYGCTSIVMLN
- VLLTRPGEGGTG
- LHPGTTY
- PIVVHCS
- DRCLPFLI
Post-translational modifications for PTPRK Gene
Other Protein References for PTPRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PTPRK Antibody
- BioLegend CD148 Antibody (328708) and CD148 Antibody (328702)
- Novus Biologicals Antibodies for PTPRK
-
Abcam antibodies for PTPRK
- Invitrogen Antibodies for PTPRK (AFLGC-PTPRK)
-
Biorbyt antibodies for PTPRK
-
Boster Bio Antibodies for PTPRK
-
Custom Antibody ServicesProSci Antibodies for PTPRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
Protein products for research
-
OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
Assay products for research
Domains & Families for PTPRK Gene
Gene Families for PTPRK Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for PTPRK Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- Fibronectin type III repeat signature
- Protein tyrosine phosphatase signature
- MAM domain signature
Suggested Antigen Peptide Sequences for PTPRK Gene
- GenScript: Design optimal peptide antigens:
-
- Receptor-type tyrosine-protein phosphatase kappa (PTPRK_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRN8_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRZ3_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT32_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT33_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15262UniProtKB/Swiss-Prot:
PTPRK_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Function for PTPRK Gene
Molecular function for PTPRK Gene
- UniProtKB/Swiss-Prot Function:
- Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
- GENATLAS Biochemistry:
- protein tyrosine phosphatase receptor type,kappa polypeptide,expressed in spleen,prostate,ovary,keratinocytes,epidermal cell lines
Enzyme Numbers (IUBMB) for PTPRK Gene
Phenotypes From GWAS Catalog for PTPRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,IDA | 8663237 |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | NAS | 9047348 |
| GO:0005515 | protein binding | IEA,IPI | 15899872 |
| GO:0008013 | beta-catenin binding | IPI | 8663237 |
Phenotypes for PTPRK Gene
- MGI mutant phenotypes for PTPRK:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTPRK:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPRK - Starting at $85 >
- * PTPRK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
miRNA for PTPRK Gene
- miRTarBase miRNAs that target PTPRK
-
- hsa-miR-30a-5p (MIRT005161)
- hsa-miR-133b (MIRT007126)
- hsa-miR-9-5p (MIRT021457)
- hsa-miR-935 (MIRT036651)
- hsa-miR-877-3p (MIRT037091)
- hsa-miR-615-3p (MIRT039631)
- hsa-miR-423-3p (MIRT042465)
- hsa-miR-149-5p (MIRT045592)
- hsa-miR-218-5p (MIRT439860)
- hsa-miR-1283 (MIRT546895)
- hsa-miR-7849-3p (MIRT546896)
- hsa-miR-548c-3p (MIRT546897)
- mmu-miR-297b-5p (MIRT586190)
- mmu-miR-297c-5p (MIRT586191)
- mmu-miR-297a-5p (MIRT586192)
- mmu-miR-669f-3p (MIRT586193)
- mmu-miR-467f (MIRT586194)
- mmu-miR-329-3p (MIRT586195)
- mmu-miR-362-3p (MIRT586196)
- mmu-miR-466i-3p (MIRT586197)
- mmu-miR-466f-3p (MIRT586198)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
Clone products for research
- Applied Biological Materials (abm): Clones for PTPRK - Starting at $45 >
- * PTPRK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PTPRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRK Gene
Localization for PTPRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPRK Gene
- Cell junction, adherens junction. Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9047348 |
| GO:0005911 | cell-cell junction | IDA | 8663237 |
| GO:0005912 | adherens junction | IEA | -- |
| GO:0009986 | cell surface | IDA | 18276111 |
Pathways & Interactions for PTPRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Commom Cytokine Receptor G Chain Siganaling Pathway | ||
| 2 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 3 | Listeria monocytogenes entry into host cells | ||
| 4 | Signaling by GPCR | ||
| 5 | RET signaling | ||
Pathways by source for PTPRK Gene
1 Sino Biological pathway for PTPRK Gene
1 BioSystems pathway for PTPRK Gene
3 Reactome pathways for PTPRK Gene
1 Qiagen pathway for PTPRK Gene
- Epithelial Adherens Junctions
Interacting Proteins for PTPRK Gene
Selected Interacting proteins:
Q15262-PTPRK_HUMAN
ENSP00000357196
for PTPRK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PTPRK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,IDA | 16263724 |
| GO:0007155 | cell adhesion | IEA,IMP | 15899872 |
| GO:0007165 | signal transduction | IDA | 16849327 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15899872 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 15899872 |
Transcripts for PTPRK Gene
mRNA/cDNA for PTPRK Gene
- 6 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368202 526 nts (view in UCSC)
- ENST00000368205 662 nts (view in UCSC)
- ENST00000368207 4758 nts (view in UCSC)
- ENST00000368210 5025 nts (view in UCSC)
- ENST00000368213 5816 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPRK - Starting at $85 >
- * PTPRK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
Clone products for research
- Applied Biological Materials (abm): Clones for PTPRK - Starting at $45 >
- * PTPRK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PTPRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for PTPRK Gene
- GeneLoc Exon Structure for
- PTPRK
Expression for PTPRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Gall Bladder (Hepatobiliary System)
This gene is overexpressed in Amniocyte (16.9) and Breast (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRK Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRK
SOURCE GeneReport for Unigene cluster for PTPRK Gene:
Hs.155919mRNA Expression by UniProt/SwissProt for PTPRK Gene:
Q15262-PTPRK_HUMAN
Tissue specificity:
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Evidence on tissue expression from TISSUES for PTPRK Gene
- Nervous system(4.8)
- Liver(4.4)
- Intestine(2.6)
- Skin(2.3)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for PTPRK
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRK Gene
Orthologs for PTPRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTPRK 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTPRK 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PTPRK 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PTPRK 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTPRK 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ptprk 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptprk 29 |
|
||
| Chicken (Gallus gallus) |
Aves | PTPRK 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTPRK 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptprk 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptprk 29 30 |
|
OneToOne | |
| -- 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ptp52F 31 |
|
|
|
| CG7180 31 |
|
|
|||
| Ptp69D 31 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | F47B3.7 31 |
|
|
|
| T22C1.8 31 |
|
|
|||
| Y48G9A.9 31 |
|
|
|||
| T27A3.5 31 |
|
|
|||
| C55B7.3 31 |
|
|
|||
| ZK484.7 31 |
|
|
|||
| F10G8.1 31 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1390 30 |
|
OneToMany |
- Species where no ortholog for PTPRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PTPRK Gene
- ENSEMBL:
- Gene Tree for PTPRK (if available)
- TreeFam:
- Gene Tree for PTPRK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPRK: view image
- Alliance of Genome Resources:
- Additional Orthologs for PTPRK
Paralogs for PTPRK Gene
Paralogs for PTPRK Gene
(31) SIMAP similar genes for PTPRK Gene using alignment to 13 proteins:
- PTPRK_HUMAN
- B7ZMG0_HUMAN
- E9PGC5_HUMAN
- E9PMV4_HUMAN
- E9PRW2_HUMAN
- F5GXI4_HUMAN
- H0Y6P5_HUMAN
- H0Y6V4_HUMAN
- H0YD44_HUMAN
- H0YDP9_HUMAN
- Q5TG12_HUMAN
- Q6P493_HUMAN
- Q86WJ2_HUMAN
Variants for PTPRK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRK Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 916695 | Uncertain Significance: sellar metastasis from primary bronchial carcinoid tumor | 128,078,900(-) |
T/C NM_002844.4(PTPRK):c.1796A>G (p.Tyr599Cys) |
MISSENSE | |
| rs11962559 | Benign: not provided | 128,083,730(-) |
G/A NM_002844.4(PTPRK):c.1560C>T (p.Ile520=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs35140919 | Benign: not provided | 127,981,272(-) |
G/C NM_002844.4(PTPRK):c.3555C>G (p.Thr1185=) |
SYNONYMOUS | |
| rs374096394 | Likely Benign: not provided | 128,322,032(-) |
T/C NM_002844.4(PTPRK):c.495+7A>G |
INTRON | |
| rs61757810 | Benign: not provided | 128,089,790(-) |
G/A NM_002844.4(PTPRK):c.1365C>T (p.Asn455=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPRK Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRK Gene
Disorders for PTPRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| extragonadal germ cell cancer |
|
|
| eye lymphoma |
|
|
| argyll robertson pupil |
|
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| abnormal pupillary function |
|
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| central nervous system hematologic cancer |
|
|
Search PTPRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPRK
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRK Gene
Publications for PTPRK Gene
- Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. (PMID: 9047348) Yang Y … Ha H (Gene 1997) 2 3 4 22
- Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. (PMID: 8663237) Fuchs M … Ullrich A (The Journal of biological chemistry 1996) 2 3 4 22
- A genome-wide association study for age-related hearing impairment in the Saami. (PMID: 20068591) Van Laer L … Van Camp G (European journal of human genetics : EJHG 2010) 3 40
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 40
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
ExternalLinks
Products for PTPRK Gene
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Sources for PTPRK Gene
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