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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
PTPRK (Protein Tyrosine Phosphatase Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Extragonadal Germ Cell Cancer and Eye Lymphoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRM.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IEA,IDA | 8663237 |
GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | NAS | 9047348 |
GO:0005515 | protein binding | IEA,IPI | 15899872 |
GO:0008013 | beta-catenin binding | IPI | 8663237 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001750 | photoreceptor outer segment | IEA | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO:0005887 | integral component of plasma membrane | NAS | 9047348 |
GO:0005911 | cell-cell junction | IDA | 8663237 |
GO:0005912 | adherens junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Jak Stat Signaling Pathway | ||
2 | PAK Pathway |
Epithelial Adherens Junctions
.36
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3 | Listeria monocytogenes entry into host cells | ||
4 | Signaling by GPCR | ||
5 | RET signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA,IDA | 16263724 |
GO:0007155 | cell adhesion | IMP | 15899872 |
GO:0007165 | signal transduction | IDA | 16849327 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15899872 |
GO:0008285 | negative regulation of cell proliferation | IDA | 15899872 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
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ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PTPRK 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PTPRK 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PTPRK 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PTPRK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PTPRK 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ptprk 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ptprk 30 |
|
||
Chicken (Gallus gallus) |
Aves | PTPRK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PTPRK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptprk 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ptprk 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ptp52F 32 |
|
|
|
CG7180 32 |
|
|
|||
Ptp69D 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | F47B3.7 32 |
|
|
|
T22C1.8 32 |
|
|
|||
Y48G9A.9 32 |
|
|
|||
T27A3.5 32 |
|
|
|||
C55B7.3 32 |
|
|
|||
ZK484.7 32 |
|
|
|||
F10G8.1 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1390 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
740486 | Likely Benign: not provided | 128,322,032(-) | T/C | INTRON_VARIANT | |
769321 | Benign: not provided | 128,089,790(-) | G/A | SYNONYMOUS_VARIANT | |
776153 | Benign: not provided | 128,083,730(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
791450 | Benign: not provided | 128,322,049(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
792053 | Benign: not provided | 127,981,272(-) | G/C | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
extragonadal germ cell cancer |
|
|
eye lymphoma |
|
|
central nervous system hematologic cancer |
|
|