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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and ... See more...
Aliases for PTPRK Gene
Aliases for PTPRK Gene
- Protein Tyrosine Phosphatase Receptor Type K 2 3 5
- Receptor-Type Tyrosine-Protein Phosphatase Kappa 3 4
- Protein-Tyrosine Phosphatase Kappa 3 4
- R-PTP-Kappa 3 4
- EC 3.1.3.48 4 52
- DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
- Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
- PTPK 4
External Ids for PTPRK Gene
- HGNC: 9674
- Entrez Gene: 5796
- Ensembl: ENSG00000152894
- OMIM: 602545
- UniProtKB: Q15262
Previous GeneCards Identifiers for PTPRK Gene
- GC06M128137
- GC06M128270
- GC06M128331
- GC06M125866
- GC06M128289
Summaries for PTPRK Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRK Gene
PTPRK (Protein Tyrosine Phosphatase Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Extragonadal Germ Cell Cancer and Eye Lymphoma. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRM.
UniProtKB/Swiss-Prot Summary for PTPRK Gene
-
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Additional gene information for PTPRK Gene
- Monarch Initiative
- Search for PTPRK at DataMed
- Search for PTPRK at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRK Gene
Genomics for PTPRK Gene
GeneHancer (GH) Regulatory Elements for PTPRK Gene
Promoters and enhancers for PTPRK Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J128515 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 503.1 | +2.2 | 2203 | 6.4 | EP300 ZNF217 CTCF MYC POLR2G NCOR1 JUND TEAD4 FOS ZFX | PTPRK lnc-THEMIS-7 lnc-LAMA2-5 lnc-LAMA2-2 | |
| GH06J128397 | Promoter | 0.3 | EPDnew | 500.1 | +123.3 | 123295 | 0.1 | PTPRK lnc-THEMIS-1 piR-45035-161 | ||
| GH06J128490 | Promoter/Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 11 | +29.1 | 29109 | 2.9 | TCF12 RFX1 ATF2 OSR2 ZBTB17 FOSL2 RBM22 SPI1 FOXA1 ZNF335 | PTPRK ENSG00000224733 lnc-THEMIS-2 | |
| GH06J128493 | Enhancer | 1 | Ensembl dbSUPER | 11.2 | +25.8 | 25846 | 2.4 | ZSCAN5C ZIC2 ZBTB25 TEAD1 ZBTB26 OSR2 WT1 FOXA2 TCF7L2 KAT7 | PTPRK ENSG00000224733 lnc-THEMIS-2 | |
| GH06J129183 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 4.7 | -663.6 | -663554 | 2.8 | ZSCAN5C FOS ZNF639 ZNF10 TRIM28 KLF7 ATF2 ZEB1 OSR2 BCL11A | HSALNG0053421 PTPRK piR-51671-072 LAMA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPRK on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRK
- Top Transcription factor binding sites by QIAGEN in the PTPRK gene promoter:
-
- AREB6
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
Genomic Locations for PTPRK Gene
Genomic Locations for PTPRK Gene
- chr6:127,968,779-128,520,847
- (GRCh38/hg38)
- Size:
- 552,069 bases
- Orientation:
- Minus strand
- chr6:128,289,924-128,841,870
- (GRCh37/hg19)
- Size:
- 551,947 bases
- Orientation:
- Minus strand
Genomic View for PTPRK Gene
Genes around PTPRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by HGNC
- 6q22.33 by Entrez Gene
- 6q22.33 by Ensembl
PTPRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPRK Gene
Proteins for PTPRK Gene
-
Protein details for PTPRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15262-PTPRK_HUMAN
- Recommended name:
- Receptor-type tyrosine-protein phosphatase kappa
- Protein Accession:
- Q15262
- B2RTQ8
- B7ZMG0
- Q14763
- Q5TG10
- Q5TG11
Protein attributes for PTPRK Gene
- Size:
- 1439 amino acids
- Molecular mass:
- 162102 Da
- Quaternary structure:
- No Data Available
Protein Expression for PTPRK Gene
Selected DME Specific Peptides for PTPRK Gene
- Q15262:
-
- NYINAAL
- TITVLLRPAQ
- PFTVGDN
- PIAPPQL
- EGVVDIYNCV
- LVEVGRVKC
- VQTEEQY
- YIATQGP
- ELAVSTFWPNEYQ
- ITQYEISY
- NSIIGDGPI
- IAYDHSRV
- VVHCSAG
- EYESFFEG
- GRTGCYIV
- NPEGRKE
- YKLWHLDPD
- DYINANY
- WPDHGVP
- HGVPYHATGLL
- RVADLLQHI
- QTEEQYIFIHDA
- HCLNGGGRSG
- KENDTHCIDF
- DFWRLVYDYGCTSIVMLN
- VLLTRPGEGGTG
- LHPGTTY
- PIVVHCS
- DRCLPFLI
Post-translational modifications for PTPRK Gene
Other Protein References for PTPRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PTPRK Antibody
- Creative Diagnostics Anti-PTPRK (aa 794-852) polyclonal antibody
- Creative Biolabs Chicken Anti-PTPRK Polyclonal IgY
- BioLegend CD148 Antibody (328708) and CD148 Antibody (328702)
- Novus Biologicals Antibodies for PTPRK
-
Abcam antibodies for PTPRK
- Invitrogen Antibodies for PTPRK (AFLGC-PTPRK)
-
Biorbyt antibodies for PTPRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
Protein Products
-
OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
-
Signalway Proteins for PTPRK
Assay Products
Domains & Families for PTPRK Gene
Gene Families for PTPRK Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for PTPRK Gene
- Blocks:
-
- Immunoglobulin subtype
- Fibronectin type III repeat signature
- MAM domain signature
- Protein tyrosine phosphatase signature
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPRK Gene
- GenScript: Design optimal peptide antigens:
-
- Receptor-type tyrosine-protein phosphatase kappa (PTPRK_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRN8_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRZ3_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT32_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT33_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15262UniProtKB/Swiss-Prot:
PTPRK_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Function for PTPRK Gene
Molecular function for PTPRK Gene
- UniProtKB/Swiss-Prot Function:
- Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
- GENATLAS Biochemistry:
- protein tyrosine phosphatase receptor type,kappa polypeptide,expressed in spleen,prostate,ovary,keratinocytes,epidermal cell lines
Enzyme Numbers (IUBMB) for PTPRK Gene
Phenotypes From GWAS Catalog for PTPRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA,IEA | 8663237 |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | NAS | 9047348 |
| GO:0005515 | protein binding | IPI,IEA | 15899872 |
| GO:0008013 | beta-catenin binding | IPI | 8663237 |
Phenotypes for PTPRK Gene
- MGI mutant phenotypes for PTPRK:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTPRK:
-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Apoptosis resistance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Upregulation of NF-kappaB pathway after LMP1 stimulation
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTPRK - Select products 50% OFF >
- * PTPRK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
- genomics-online: gRNA clones - Search for available PTPRK gRNA products
- Overview of 121 available PTPRK gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
miRNA for PTPRK Gene
- miRTarBase miRNAs that target PTPRK
-
- hsa-mir-30a-5p (MIRT005161)
- hsa-mir-133b (MIRT007126)
- hsa-mir-9-5p (MIRT021457)
- hsa-mir-935 (MIRT036651)
- hsa-mir-877-3p (MIRT037091)
- hsa-mir-615-3p (MIRT039631)
- hsa-mir-423-3p (MIRT042465)
- hsa-mir-149-5p (MIRT045592)
- hsa-mir-218-5p (MIRT439860)
- hsa-mir-1283 (MIRT546895)
- hsa-mir-7849-3p (MIRT546896)
- hsa-mir-548c-3p (MIRT546897)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
- genomics-online: shRNA clones - Search for available PTPRK shRNA products
- Overview of 121 available PTPRK gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PTPRK - Select products 50% OFF >
- * PTPRK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTPRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
- genomics-online: cdna clones - Search for available PTPRK CDNA products
- Overview of 121 available PTPRK gene related products
- orf clones - Search for available PTPRK ORF products
- Overview of 121 available PTPRK gene related products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRK Gene
Localization for PTPRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPRK Gene
- Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001750 | photoreceptor outer segment | IEA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9047348 |
| GO:0005911 | cell-cell junction | IDA | 8663237 |
| GO:0005912 | adherens junction | IEA | -- |
Pathways & Interactions for PTPRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 2 | Listeria monocytogenes entry into host cells | ||
| 3 | Signaling by GPCR | ||
| 4 | RET signaling | ||
| 5 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||
Pathways by source for PTPRK Gene
1 BioSystems pathway for PTPRK Gene
3 Reactome pathways for PTPRK Gene
1 Qiagen pathway for PTPRK Gene
- Epithelial Adherens Junctions
Interacting Proteins for PTPRK Gene
Selected Interacting proteins:
Q15262-PTPRK_HUMAN
ENSP00000357196
for PTPRK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PTPRK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IDA,IEA | 16263724 |
| GO:0007155 | cell adhesion | IMP | 15899872 |
| GO:0007165 | signal transduction | IDA | 16849327 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15899872 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 15899872 |
Drugs & Compounds for PTPRK Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for PTPRK Gene
mRNA/cDNA for PTPRK Gene
- 6 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368202 526 bps (ENST00000368202.4)
- ENST00000368205 662 bps (ENST00000368205.7)
- ENST00000368207 4758 bps (ENST00000368207.7)
- ENST00000368210 5025 bps (ENST00000368210.7)
- ENST00000368213 5816 bps (ENST00000368213.9)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTPRK - Select products 50% OFF >
- * PTPRK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PTPRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
- genomics-online: gRNA clones - Search for available PTPRK gRNA products
- Overview of 121 available PTPRK gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
- genomics-online: shRNA clones - Search for available PTPRK shRNA products
- Overview of 121 available PTPRK gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PTPRK - Select products 50% OFF >
- * PTPRK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTPRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
- genomics-online: cdna clones - Search for available PTPRK CDNA products
- Overview of 121 available PTPRK gene related products
- orf clones - Search for available PTPRK ORF products
- Overview of 121 available PTPRK gene related products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for PTPRK Gene
- GeneLoc Exon Structure for
- PTPRK
Expression for PTPRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Gall Bladder (Hepatobiliary System)
This gene is overexpressed in Amniocyte (16.9) and Breast (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRK Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRK
SOURCE GeneReport for Unigene cluster for PTPRK Gene:
Hs.155919mRNA Expression by UniProt/SwissProt for PTPRK Gene:
Q15262-PTPRK_HUMAN
Tissue specificity:
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Evidence on tissue expression from TISSUES for PTPRK Gene
- Nervous system(4.7)
- Liver(4.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for PTPRK
- genomics-online: primer clones - Search for available PTPRK Primer products
- Overview of 121 available PTPRK gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRK Gene
Orthologs for PTPRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTPRK 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PTPRK 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTPRK 31 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PTPRK 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PTPRK 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ptprk 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptprk 30 |
|
||
| chicken (Gallus gallus) |
Aves | PTPRK 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTPRK 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptprk 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptprk 31 30 |
|
OneToOne | |
| -- 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Ptp52F 32 |
|
|
|
| CG7180 32 |
|
|
|||
| Ptp69D 32 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | F47B3.7 32 |
|
|
|
| Y48G9A.9 32 |
|
|
|||
| T27A3.5 32 |
|
|
|||
| T22C1.8 32 |
|
|
|||
| ZK484.7 32 |
|
|
|||
| C55B7.3 32 |
|
|
|||
| F10G8.1 32 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1390 31 |
|
OneToMany |
- Species where no ortholog for PTPRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PTPRK Gene
- ENSEMBL:
- Gene Tree for PTPRK (if available)
- TreeFam:
- Gene Tree for PTPRK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPRK: view image
Paralogs for PTPRK Gene
Paralogs for PTPRK Gene
(31) SIMAP similar genes for PTPRK Gene using alignment to 13 proteins:
- PTPRK_HUMAN
- B7ZMG0_HUMAN
- E9PGC5_HUMAN
- E9PMV4_HUMAN
- E9PRW2_HUMAN
- F5GXI4_HUMAN
- H0Y6P5_HUMAN
- H0Y6V4_HUMAN
- H0YD44_HUMAN
- H0YDP9_HUMAN
- Q5TG12_HUMAN
- Q6P493_HUMAN
- Q86WJ2_HUMAN
Variants for PTPRK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRK Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 740486 | Likely Benign: not provided | 128,322,032(-) | T/C | INTRON_VARIANT | |
| 769321 | Benign: not provided | 128,089,790(-) | G/A | SYNONYMOUS_VARIANT | |
| 776153 | Benign: not provided | 128,083,730(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 791450 | Benign: not provided | 128,322,049(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
| 792053 | Benign: not provided | 127,981,272(-) | G/C | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPRK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRK Gene
Disorders for PTPRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| extragonadal germ cell cancer |
|
|
| eye lymphoma |
|
|
| central nervous system hematologic cancer |
|
|
Search PTPRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPRK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRK Gene
Publications for PTPRK Gene
- Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. (PMID: 9047348) Yang Y … Ha H (Gene 1997) 2 3 4 23 54
- Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. (PMID: 8663237) Fuchs M … Ullrich A (The Journal of biological chemistry 1996) 2 3 4 23 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 41 54
- The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V. (PMID: 19911372) Wang C … Zha X (Journal of cellular biochemistry 2010) 3 23 54
ExternalLinks
Products for PTPRK Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- OriGene qPCR primer pairs for PTPRK
- OriGene CRISPR knockouts for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPRK
- Sino Biological Human cDNA Clone for PTPRK
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for PTPRK
- Novus Biologicals proteins and lysates for PTPRK
- Browse Antibodies
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- Abcam antibodies for PTPRK
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- Invitrogen Antibodies for PTPRK (AFLGC-PTPRK)
- VectorBuilder Custom and pre-made DNA vectors for PTPRK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTPRK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PTPRK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PTPRK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTPRK
- antibodies-online: Show 14 available PTPRK Antibodies ranked by validation data
- Compare Top PTPRK Antibodies
- antibodies-online: Show 25 available PTPRK Elisa Kits ranked by validation data
- Compare Top PTPRK Elisa Kits
- antibodies-online: Show 8 available PTPRK Proteins ranked by validation data
- Compare Top PTPRK Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
- Search Santa Cruz Biotechnology (SCBT) for PTPRK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
- Horizon Cell Lines for PTPRK
- genomics-online: cdna clones - Search for available PTPRK CDNA products
- Overview of 121 available PTPRK gene related products
- orf clones - Search for available PTPRK ORF products
- Overview of 121 available PTPRK gene related products
- genomics-online: gRNA clones - Search for available PTPRK gRNA products
- Overview of 121 available PTPRK gene related products
- genomics-online: primer clones - Search for available PTPRK Primer products
- Overview of 121 available PTPRK gene related products
- genomics-online: shRNA clones - Search for available PTPRK shRNA products
- Overview of 121 available PTPRK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPRK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTPRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRK
- Biorbyt antibodies for PTPRK
- Search for PTPRK ELISA kits at Signalway
- Signalway Proteins for PTPRK
Sources for PTPRK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (36) Pseudogene
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- (40) HGMD
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- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
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- (56) TGDB
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- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
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- (78) ESI-BIO
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- (90) antibodies-online
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- (95) GeneReviews
- (96) GeneTex
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- (98) GTEx
- (99) ProteomicsDB
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- (105) diseasecard
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- (139) Monarch Initiative
- (140) DataMed
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- (142) genomics-online
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