The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane ... See more...

Aliases for PTPRJ Gene

Aliases for PTPRJ Gene

  • Protein Tyrosine Phosphatase Receptor Type J 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Eta 3 4
  • Protein-Tyrosine Phosphatase Eta 3 4
  • Density-Enhanced Phosphatase 1 3 4
  • CD148 Antigen 3 4
  • EC 3.1.3.48 4 52
  • HPTP Eta 3 4
  • R-PTP-J 3 4
  • DEP-1 3 4
  • DEP1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide 3
  • Susceptibility To Colon Cancer 1, Mouse, Homolog Of 3
  • Protein-Tyrosine Phosphatase Receptor Type J 4
  • Human Density Enhanced Phosphatase-1 3
  • R-PTP-ETA 3
  • R-PTP-Eta 4
  • HPTPeta 3
  • CD148 3
  • SCC1 3

External Ids for PTPRJ Gene

Previous GeneCards Identifiers for PTPRJ Gene

  • GC11P049914
  • GC11P048896
  • GC11P048033
  • GC11P047966
  • GC11P047958
  • GC11P047712

Summaries for PTPRJ Gene

Entrez Gene Summary for PTPRJ Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRJ Gene

PTPRJ (Protein Tyrosine Phosphatase Receptor Type J) is a Protein Coding gene. Diseases associated with PTPRJ include Colorectal Cancer and Precursor B Lymphoblastic Lymphoma/Leukemia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRB.

UniProtKB/Swiss-Prot Summary for PTPRJ Gene

  • Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Gene Wiki entry for PTPRJ Gene

Additional gene information for PTPRJ Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRJ Gene

Genomics for PTPRJ Gene

GeneHancer (GH) Regulatory Elements for PTPRJ Gene

Promoters and enhancers for PTPRJ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J047979 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509 +1.5 1463 5.6 ZSCAN5C ZFX ZIC2 ZBTB10 ZBTB11 ZNF423 ZBTB26 UBTF CHD1 EZH2 PTPRJ CELF1 PTPRJ-AS1 ACP2 C1QTNF4 FNBP4
GH11J047996 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 35.6 +28.3 28325 24.6 RXRA POLR2G SP1 NCOR1 RBAK JUND EP300 ZIC2 SAP30 RFX1 PTPRJ ENSG00000200090 FNBP4 NUP160 MADD ENSG00000270060 DDB2 MYBPC3 CELF1 ACP2
GH11J047945 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 23.2 -33.5 -33523 2.9 ZNF217 TCF12 JUND PHB2 FOS ZIC2 REST AFF1 KLF4 TOE1 lnc-PTPRJ-1 PTPRJ PTPRJ-AS1 CELF1 ACP2 PACSIN3 C1QTNF4 MADD FNBP4 piR-60105
GH11J048054 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18 +75.6 75561 3.8 ZNF217 RBM25 BCL11A FOXA2 ZNF316 GABPA POLR2A CEBPG SAP130 MAX PTPRJ PTPRJ-AS1 ACP2 FNBP4 RF00017-918 piR-39281
GH11J047912 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 16.5 -61.7 -61726 13.2 ZSCAN5C TCF12 USF1 JUND FOS ZBTB5 TCF7 FOXA1 AFF1 REST RF00017-917 PTPRJ C1QTNF4 MADD NUP160 PTPRJ-AS1 ARFGAP2 MYBPC3 KBTBD4 ACP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRJ on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRJ

Top Transcription factor binding sites by QIAGEN in the PTPRJ gene promoter:
  • AP-2alphaA
  • c-Rel
  • CP2
  • HOXA5
  • Nkx5-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RSRFC4
  • Spz1
  • TBP

Genomic Locations for PTPRJ Gene

Genomic Locations for PTPRJ Gene
chr11:47,980,558-48,170,842
(GRCh38/hg38)
Size:
190,285 bases
Orientation:
Plus strand
chr11:48,002,110-48,192,394
(GRCh37/hg19)
Size:
190,285 bases
Orientation:
Plus strand

Genomic View for PTPRJ Gene

Genes around PTPRJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRJ Gene

Proteins for PTPRJ Gene

  • Protein details for PTPRJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12913-PTPRJ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase eta
    Protein Accession:
    Q12913
    Secondary Accessions:
    • Q15255
    • Q6P4H4
    • Q8NHM2
    • Q9UDA9

    Protein attributes for PTPRJ Gene

    Size:
    1337 amino acids
    Molecular mass:
    145941 Da
    Quaternary structure:
    • Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2.

    Three dimensional structures from OCA and Proteopedia for PTPRJ Gene

    Alternative splice isoforms for PTPRJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRJ Gene

Selected DME Specific Peptides for PTPRJ Gene

Q12913:
  • QFHFTSWP
  • MVQTEDQY
  • VHCSAGVGRTG
  • DYINANY
  • WPDHGVP
  • DFWRMVW

Post-translational modifications for PTPRJ Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn72, Asn82, Asn93, Asn104, Asn142, Asn172, Asn192, Asn231, Asn258, Asn278, Asn342, Asn351, Asn376, Asn391, Asn396, Asn413, Asn431, Asn501, Asn525, Asn536, Asn582, Asn603, Asn618, Asn628, Asn637, Asn666, Asn669, Asn761, Asn772, Asn784, Asn790, Asn824, Asn910, and Asn937
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTPRJ_HUMAN (1707)

Domains & Families for PTPRJ Gene

Gene Families for PTPRJ Gene

Protein Domains for PTPRJ Gene

Suggested Antigen Peptide Sequences for PTPRJ Gene

GenScript: Design optimal peptide antigens:
  • Protein-tyrosine phosphatase receptor type J (PTPRJ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12913

UniProtKB/Swiss-Prot:

PTPRJ_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRJ: view

Function for PTPRJ Gene

Molecular function for PTPRJ Gene

UniProtKB/Swiss-Prot Function:
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine kinase,receptor type,J polypeptide

Enzyme Numbers (IUBMB) for PTPRJ Gene

Phenotypes From GWAS Catalog for PTPRJ Gene

Gene Ontology (GO) - Molecular Function for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0005161 platelet-derived growth factor receptor binding IPI 10821867
GO:0005515 protein binding IPI,IEA 10821867
GO:0008013 beta-catenin binding IPI 12370829
genes like me logo Genes that share ontologies with PTPRJ: view
genes like me logo Genes that share phenotypes with PTPRJ: view

Animal Models for PTPRJ Gene

MGI Knock Outs for PTPRJ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRJ

miRNA for PTPRJ Gene

miRTarBase miRNAs that target PTPRJ

Clone Products

  • Addgene plasmids for PTPRJ

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRJ Gene

Localization for PTPRJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRJ Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRJ gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12913111
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7937872
GO:0005911 cell-cell junction IDA 12370829
GO:0009986 cell surface IDA 12913111
genes like me logo Genes that share ontologies with PTPRJ: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRJ Gene

Pathways & Interactions for PTPRJ Gene

genes like me logo Genes that share pathways with PTPRJ: view

Pathways by source for PTPRJ Gene

1 GeneGo (Thomson Reuters) pathway for PTPRJ Gene
  • Cell adhesion_Cadherin-mediated cell adhesion
1 Qiagen pathway for PTPRJ Gene
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTPRJ Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA,IEA 21873635
GO:0008285 negative regulation of cell proliferation IDA 14709717
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA 14709717
GO:0016311 dephosphorylation IEA --
GO:0030155 regulation of cell adhesion IMP 12370829
genes like me logo Genes that share ontologies with PTPRJ: view

Drugs & Compounds for PTPRJ Gene

(6) Drugs for PTPRJ Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for PTPRJ Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPRJ: view

Transcripts for PTPRJ Gene

mRNA/cDNA for PTPRJ Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for PTPRJ

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRJ Gene

No ASD Table

Relevant External Links for PTPRJ Gene

GeneLoc Exon Structure for
PTPRJ

Expression for PTPRJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRJ Gene

This gene is overexpressed in Whole Blood (x9.3).

Protein differential expression in normal tissues from HIPED for PTPRJ Gene

This gene is overexpressed in Serum (15.2), Peripheral blood mononuclear cells (14.1), Neutrophil (11.5), and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRJ Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRJ

SOURCE GeneReport for Unigene cluster for PTPRJ Gene:

Hs.318547

mRNA Expression by UniProt/SwissProt for PTPRJ Gene:

Q12913-PTPRJ_HUMAN
Tissue specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.

Evidence on tissue expression from TISSUES for PTPRJ Gene

  • Bone marrow(4.3)
  • Intestine(4.2)
  • Liver(4.2)
  • Pancreas(4.1)
  • Blood(2.8)
  • Thyroid gland(2.2)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRJ Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • reproductive
  • urinary
Regions:
Abdomen:
  • intestine
  • kidney
  • large intestine
  • stomach
Pelvis:
  • anus
  • rectum
  • ureter
  • urethra
  • urinary bladder
  • uterus
genes like me logo Genes that share expression patterns with PTPRJ: view

No data available for Protein tissue co-expression partners for PTPRJ Gene

Orthologs for PTPRJ Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRJ 31 30
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRJ 31 30
  • 79.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRJ 31 30
  • 78.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprj 17 31 30
  • 77.71 (n)
rat
(Rattus norvegicus)
Mammalia Ptprj 30
  • 77.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRJ 31
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRJ 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRJ 31 30
  • 56.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRJ 31
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptprjb 31
  • 62 (a)
OneToMany
ptprja 31 30
  • 49.65 (n)
OneToMany
PTPRJ (2 of 3) 31
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 31 32
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F36H1.3 32
  • 36 (a)
F47B3.1 32
  • 35 (a)
F47B3.6 32
  • 35 (a)
Y48G9A.9 32
  • 33 (a)
T22C1.8 32
  • 32 (a)
ZK354.8 32
  • 32 (a)
Y71G12B.31 31
  • 30 (a)
OneToMany
Y41D4A.5 32
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
ManyToMany
Cin.3156 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3156 30
Species where no ortholog for PTPRJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRJ Gene

ENSEMBL:
Gene Tree for PTPRJ (if available)
TreeFam:
Gene Tree for PTPRJ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRJ: view image

Paralogs for PTPRJ Gene

Pseudogenes.org Pseudogenes for PTPRJ Gene

genes like me logo Genes that share paralogs with PTPRJ: view

Variants for PTPRJ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRJ Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
718507 Benign: not provided 48,137,034(+) T/A MISSENSE_VARIANT
719540 Benign: not provided 48,149,984(+) A/G INTRON_VARIANT
724762 Likely Benign: not provided 48,110,061(+) C/T SYNONYMOUS_VARIANT
732980 Likely Benign: not provided 48,142,912(+) G/C INTRON_VARIANT
774475 Benign: not provided 48,167,356(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PTPRJ Gene

Structural Variations from Database of Genomic Variants (DGV) for PTPRJ Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv198e214 CNV gain 21293372
dgv635n106 CNV deletion 24896259
esv1002186 CNV deletion 20482838
esv2380235 CNV deletion 18987734
esv2458591 CNV deletion 19546169
esv2657950 CNV deletion 23128226
esv2674478 CNV deletion 23128226
esv2744445 CNV deletion 23290073
esv3256940 CNV deletion 24192839
esv3499 CNV loss 18987735
esv3547717 CNV deletion 23714750
esv3626221 CNV loss 21293372
esv3626222 CNV loss 21293372
esv3626223 CNV loss 21293372
esv3626224 CNV gain 21293372
esv3626225 CNV loss 21293372
esv3626226 CNV gain 21293372
esv3626227 CNV loss 21293372
esv3891981 CNV loss 25118596
esv3891986 CNV gain 25118596
esv7637 CNV loss 19470904
esv990562 CNV deletion 20482838
nsv1041394 CNV gain 25217958
nsv1053145 CNV gain 25217958
nsv1053528 CNV loss 25217958
nsv1069580 CNV deletion 25765185
nsv1070956 CNV deletion 25765185
nsv317 CNV deletion 18451855
nsv39746 CNV deletion 16902084
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv528641 CNV loss 19592680
nsv554211 CNV gain 21841781

Variation tolerance for PTPRJ Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRJ Gene

Human Gene Mutation Database (HGMD)
PTPRJ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRJ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRJ Gene

Disorders for PTPRJ Gene

MalaCards: The human disease database

(14) MalaCards diseases for PTPRJ Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
precursor b lymphoblastic lymphoma/leukemia
  • b lymphoblastic leukemia/lymphoma
cogan syndrome
  • cogan's syndrome
griscelli syndrome, type 3
  • gs3
interstitial keratitis
- elite association - COSMIC cancer census association via MalaCards
Search PTPRJ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPRJ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTPRJ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRJ Gene

Publications for PTPRJ Gene

  1. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. (PMID: 15378013) Iuliano R … Fusco A (Oncogene 2004) 3 4 23 41 54
  2. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. (PMID: 7994032) Honda H … Hirai H (Blood 1994) 2 3 4 23 54
  3. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. (PMID: 7937872) Ostman A … Tonks NK (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 23 54
  4. Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. (PMID: 19672627) Mita Y … Shimizu K (Journal of cancer research and clinical oncology 2010) 3 23 41 54
  5. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. (PMID: 19922411) Omerovic J … Prior IA (The Biochemical journal 2010) 3 4 23 54

Products for PTPRJ Gene

  • Addgene plasmids for PTPRJ

Sources for PTPRJ Gene