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Aliases for PTPRG Gene

Aliases for PTPRG Gene

  • Protein Tyrosine Phosphatase, Receptor Type G 2 3 5
  • PTPG 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Gamma Polypeptide 3
  • Receptor Type Protein Tyrosine Phosphatase Gamma 3
  • Receptor-Type Tyrosine-Protein Phosphatase Gamma 3
  • Receptor-Type Protein Phosphatase Gamma 3
  • Receptor Tyrosine Phosphatase Gamma 3
  • Protein Tyrosine Phosphatase Gamma 3
  • Protein-Tyrosine Phosphatase Gamma 4
  • H_RG317H01.1 3
  • R-PTP-Gamma 4
  • EC 4
  • HPTPG 3
  • RPTPG 3

External Ids for PTPRG Gene

Previous HGNC Symbols for PTPRG Gene

  • PTPG

Previous GeneCards Identifiers for PTPRG Gene

  • GC03P060412
  • GC03P060949
  • GC03P061402
  • GC03P061504

Summaries for PTPRG Gene

Entrez Gene Summary for PTPRG Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRG Gene

PTPRG (Protein Tyrosine Phosphatase, Receptor Type G) is a Protein Coding gene. Diseases associated with PTPRG include Infantile Myofibromatosis and Corneal Dystrophy, Fleck. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRZ1.

UniProtKB/Swiss-Prot for PTPRG Gene

  • Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPRG Gene

Additional gene information for PTPRG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRG Gene

Genomics for PTPRG Gene

GeneHancer (GH) Regulatory Elements for PTPRG Gene

Promoters and enhancers for PTPRG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J061558 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 664.9 +0.6 553 6.3 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ZNF143 ZNF548 PTPRG GC03P061682
GH03J061894 Enhancer 1.2 Ensembl ENCODE 11.6 +333.9 333891 2.4 PKNOX1 SMAD1 YBX1 FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 ZNF143 PTPRG GC03P061757 GC03P062066
GH03J061649 Enhancer 0.9 ENCODE 11.7 +88.7 88702 1.4 PKNOX1 INSM2 NFXL1 FEZF1 ZNF335 ZNF213 ZNF366 ZSCAN5C ZNF362 OVOL3 PTPRG RPL10AP6 GC03P061682
GH03J061847 Enhancer 0.9 Ensembl ENCODE 11.6 +286.9 286941 2.9 DDX20 MAX PAX8 NFXL1 COPS2 RAD21 ZKSCAN1 YY1 POLR2A IKZF5 PTPRG GC03P061757 GC03P062066
GH03J061725 Enhancer 0.8 ENCODE 11.7 +164.5 164515 1.5 ELF3 PKNOX1 FOXA2 ZNF133 FEZF1 ZBTB40 ZNF121 CREM SMARCA5 ZNF398 PTPRG ENSG00000252420 GC03P061682
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRG gene promoter:
  • E2F
  • Spz1
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • C/EBPalpha
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for PTPRG Gene

Genomic Locations for PTPRG Gene
736,045 bases
Plus strand
736,046 bases
Plus strand

Genomic View for PTPRG Gene

Genes around PTPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRG Gene

Proteins for PTPRG Gene

  • Protein details for PTPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma
    Protein Accession:
    Secondary Accessions:
    • B2RU12
    • B7ZLX5
    • Q15623
    • Q59EE0
    • Q68DU5

    Protein attributes for PTPRG Gene

    1445 amino acids
    Molecular mass:
    162003 Da
    Quaternary structure:
    • Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.
    • Sequence=BAD93108.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRG Gene

    Alternative splice isoforms for PTPRG Gene


neXtProt entry for PTPRG Gene

Post-translational modifications for PTPRG Gene

  • Glycosylation at posLast=722722, posLast=715715, posLast=640640, Asn631, Asn619, Asn444, Asn359, posLast=156156, Asn113, and posLast=109109
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRG Gene

No data available for DME Specific Peptides for PTPRG Gene

Domains & Families for PTPRG Gene

Gene Families for PTPRG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRG: view

Function for PTPRG Gene

Molecular function for PTPRG Gene

UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,gamma polypeptide,deleted in benign proliferative breast disease,associated with familial breast cancer

Enzyme Numbers (IUBMB) for PTPRG Gene

Phenotypes From GWAS Catalog for PTPRG Gene

Gene Ontology (GO) - Molecular Function for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 19167335
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8382771
GO:0005515 protein binding IPI 19167335
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPRG: view
genes like me logo Genes that share phenotypes with PTPRG: view

Animal Models for PTPRG Gene

MGI Knock Outs for PTPRG:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRG

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRG Gene

Localization for PTPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRG gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8382771
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PTPRG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRG Gene

Pathways & Interactions for PTPRG Gene

SuperPathways for PTPRG Gene

SuperPathway Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRG: view

Pathways by source for PTPRG Gene

1 Qiagen pathway for PTPRG Gene

Gene Ontology (GO) - Biological Process for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8382771
GO:0007420 brain development IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0010977 negative regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with PTPRG: view

No data available for SIGNOR curated interactions for PTPRG Gene

Drugs & Compounds for PTPRG Gene

(4) Drugs for PTPRG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with PTPRG: view

Transcripts for PTPRG Gene

Unigene Clusters for PTPRG Gene

Protein tyrosine phosphatase, receptor type, G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRG Gene

No ASD Table

Relevant External Links for PTPRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRG Gene

Protein differential expression in normal tissues from HIPED for PTPRG Gene

This gene is overexpressed in Serum (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRG Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPRG Gene:


SOURCE GeneReport for Unigene cluster for PTPRG Gene:


mRNA Expression by UniProt/SwissProt for PTPRG Gene:

Tissue specificity: Found in a variety of tissues.

Evidence on tissue expression from TISSUES for PTPRG Gene

  • Nervous system(4.7)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with PTPRG: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRG Gene

Orthologs for PTPRG Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRG 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia PTPRG 34 33
  • 92.56 (n)
(Monodelphis domestica)
Mammalia PTPRG 34
  • 91 (a)
(Bos Taurus)
Mammalia PTPRG 34 33
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Ptprg 33
  • 89.89 (n)
(Mus musculus)
Mammalia Ptprg 16 34 33
  • 89.41 (n)
(Ornithorhynchus anatinus)
Mammalia PTPRG 34
  • 80 (a)
(Gallus gallus)
Aves PTPRG 34 33
  • 81.59 (n)
(Anolis carolinensis)
Reptilia PTPRG 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprg 33
  • 75.13 (n)
(Danio rerio)
Actinopterygii ptprga 34 33
  • 69.87 (n)
ca16b 34
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6906 35
  • 35 (a)
Ptp69D 35
  • 32 (a)
Ptp99A 34 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea ZK616.7 35
  • 37 (a)
M04G7.2 35
  • 36 (a)
C17H12.3 35
  • 34 (a)
F47B3.7 35
  • 33 (a)
K07F5.8 35
  • 32 (a)
ZK484.7 35
  • 32 (a)
K04D7.4 35
  • 32 (a)
T27A3.5 35
  • 31 (a)
C55B7.3 35
  • 31 (a)
F47B3.1 35
  • 30 (a)
F47B3.6 35
  • 30 (a)
F10G8.1 35
  • 28 (a)
Species where no ortholog for PTPRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRG Gene

Gene Tree for PTPRG (if available)
Gene Tree for PTPRG (if available)
Evolutionary constrained regions (ECRs) for PTPRG: view image

Paralogs for PTPRG Gene

Paralogs for PTPRG Gene

(26) SIMAP similar genes for PTPRG Gene using alignment to 6 proteins:

  • L8E7E6_HUMAN
  • O60420_HUMAN
  • Q49A02_HUMAN
  • Q86TJ8_HUMAN
genes like me logo Genes that share paralogs with PTPRG: view

Variants for PTPRG Gene

Sequence variations from dbSNP and Humsavar for PTPRG Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000002833 -- 61,908,431(+) A/G intron_variant
rs1000004826 -- 61,996,559(+) G/A intron_variant
rs1000014246 -- 61,793,381(+) G/T intron_variant
rs1000016007 -- 61,942,157(+) A/G/T intron_variant
rs1000020457 -- 62,223,272(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRG Gene

Variant ID Type Subtype PubMed ID
dgv1381e212 CNV loss 25503493
dgv1382e212 CNV loss 25503493
dgv4755n100 CNV gain 25217958
dgv895e214 CNV gain 21293372
dgv896e214 CNV gain 21293372
dgv897e214 CNV loss 21293372
esv1001407 CNV deletion 20482838
esv1005605 CNV deletion 20482838
esv1217921 CNV deletion 17803354
esv1631216 CNV deletion 17803354
esv2223333 CNV deletion 18987734
esv22782 CNV loss 19812545
esv23804 CNV loss 19812545
esv2386760 CNV deletion 18987734
esv2548031 CNV insertion 19546169
esv2554644 CNV deletion 19546169
esv2599998 CNV deletion 19546169
esv2658385 CNV deletion 23128226
esv2667638 CNV deletion 23128226
esv2672277 CNV deletion 23128226
esv2673237 CNV deletion 23128226
esv2725334 CNV deletion 23290073
esv2725335 CNV deletion 23290073
esv2725336 CNV deletion 23290073
esv2725337 CNV deletion 23290073
esv2725338 CNV deletion 23290073
esv2759153 CNV gain 17122850
esv3302772 CNV tandem duplication 20981092
esv3384448 CNV insertion 20981092
esv3407063 CNV insertion 20981092
esv35004 CNV gain 17911159
esv3561968 CNV deletion 23714750
esv3561976 CNV deletion 23714750
esv3568804 CNV loss 25503493
esv3568808 CNV loss 25503493
esv3568810 CNV loss 25503493
esv3568811 CNV loss 25503493
esv3568812 CNV loss 25503493
esv3596347 CNV loss 21293372
esv3596349 CNV loss 21293372
esv3596352 CNV loss 21293372
esv3596354 CNV gain 21293372
esv3596357 CNV loss 21293372
esv3596358 CNV loss 21293372
esv3596361 CNV loss 21293372
esv3596362 CNV gain 21293372
esv3596363 CNV loss 21293372
esv3596365 CNV loss 21293372
esv3596368 CNV loss 21293372
esv3596369 CNV loss 21293372
esv3893713 CNV loss 25118596
nsv1000965 CNV gain 25217958
nsv1008615 CNV gain 25217958
nsv1009361 CNV loss 25217958
nsv1012600 CNV gain 25217958
nsv1013884 CNV loss 25217958
nsv1072694 CNV deletion 25765185
nsv1072695 CNV deletion 25765185
nsv1114384 CNV deletion 24896259
nsv1123658 CNV deletion 24896259
nsv1127964 CNV deletion 24896259
nsv1131705 CNV deletion 24896259
nsv1133321 CNV tandem duplication 24896259
nsv1148938 CNV deletion 26484159
nsv236686 CNV deletion 16902084
nsv437862 CNV loss 16468122
nsv460575 CNV gain 19166990
nsv471782 CNV loss 16327809
nsv471908 CNV novel sequence insertion 20440878
nsv478900 CNV novel sequence insertion 20440878
nsv516255 CNV loss 19592680
nsv517920 CNV loss 19592680
nsv522606 CNV loss 19592680
nsv523876 CNV loss 19592680
nsv590438 CNV loss 21841781
nsv590439 CNV loss 21841781
nsv590440 CNV gain 21841781
nsv590441 CNV loss 21841781
nsv822105 CNV gain 20364138
nsv822106 CNV gain 20364138
nsv834711 CNV loss 17160897
nsv834712 CNV gain 17160897
nsv979838 CNV duplication 23825009

Variation tolerance for PTPRG Gene

Residual Variation Intolerance Score: 5.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRG Gene

Disorders for PTPRG Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTPRG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PTPRG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPRG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTPRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRG Gene

Publications for PTPRG Gene

  1. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. (PMID: 8833149) Kastury K … Huebner K (Genomics 1996) 3 4 22 58
  2. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. (PMID: 1711217) LaForgia S … Weston A (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 22 58
  3. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J … Levinson DF (Molecular psychiatry 2011) 3 44 58
  4. Genome-wide association study identifies five new schizophrenia loci. (PMID: 21926974) Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (Nature genetics 2011) 3 44 58
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58

Products for PTPRG Gene

Sources for PTPRG Gene

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