Aliases for PTPRF Gene
External Ids for PTPRF Gene
Previous HGNC Symbols for PTPRF Gene
Previous GeneCards Identifiers for PTPRF Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRF Gene
PTPRF (Protein Tyrosine Phosphatase Receptor Type F) is a Protein Coding gene. Diseases associated with PTPRF include Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 2 and Isolated Congenital Breast Hypoplasia/Aplasia. Among its related pathways are SALM protein interactions at the synapses and Cell adhesion_Cadherin-mediated cell adhesion. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is PTPRD.
UniProtKB/Swiss-Prot Summary for PTPRF Gene
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.