Aliases for PTPRD Gene
External Ids for PTPRD Gene
Previous GeneCards Identifiers for PTPRD Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
GeneCards Summary for PTPRD Gene
PTPRD (Protein Tyrosine Phosphatase Receptor Type D) is a Protein Coding gene. Diseases associated with PTPRD include Melanoma-Astrocytoma Syndrome and Nodal Marginal Zone Lymphoma. Among its related pathways are SALM protein interactions at the synapses and Jak Stat Signaling Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRS.
UniProtKB/Swiss-Prot Summary for PTPRD Gene
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.