The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008] See more...

Aliases for PTPRCAP Gene

Aliases for PTPRCAP Gene

  • Protein Tyrosine Phosphatase Receptor Type C Associated Protein 2 3 5
  • CD45-AP 2 3 4
  • LPAP 2 3 4
  • Protein Tyrosine Phosphatase Receptor Type C-Associated Protein 3 4
  • Lymphocyte Phosphatase-Associated Phosphoprotein 3 4
  • PTPRC-Associated Protein 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide-Associated Protein 3
  • CD45 Associated Protein 3
  • CD45-Associated Protein 4
  • PTPRCAP 5

External Ids for PTPRCAP Gene

Previous GeneCards Identifiers for PTPRCAP Gene

  • GC11P069666
  • GC11M068899
  • GC11M067452
  • GC11M066978
  • GC11M066959
  • GC11M067202
  • GC11M063531
  • GC11M067436

Summaries for PTPRCAP Gene

Entrez Gene Summary for PTPRCAP Gene

  • The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRCAP Gene

PTPRCAP (Protein Tyrosine Phosphatase Receptor Type C Associated Protein) is a Protein Coding gene. Among its related pathways are TNFR1 Pathway.

Gene Wiki entry for PTPRCAP Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRCAP Gene

Genomics for PTPRCAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPRCAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRCAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRCAP

Top Transcription factor binding sites by QIAGEN in the PTPRCAP gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • Nkx2-5
  • Olf-1

Genomic Locations for PTPRCAP Gene

Latest Assembly
chr11:67,435,510-67,437,682
(GRCh38/hg38)
Size:
2,173 bases
Orientation:
Minus strand

Previous Assembly
chr11:67,202,981-67,205,153
(GRCh37/hg19 by Entrez Gene)
Size:
2,173 bases
Orientation:
Minus strand

chr11:67,202,981-67,205,538
(GRCh37/hg19 by Ensembl)
Size:
2,558 bases
Orientation:
Minus strand

Genomic View for PTPRCAP Gene

Genes around PTPRCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRCAP Gene

Proteins for PTPRCAP Gene

  • Protein details for PTPRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14761-PTCA_HUMAN
    Recommended name:
    Protein tyrosine phosphatase receptor type C-associated protein
    Protein Accession:
    Q14761
    Secondary Accessions:
    • B2R512
    • O00643
    • Q6I9S6

    Protein attributes for PTPRCAP Gene

    Size:
    206 amino acids
    Molecular mass:
    21196 Da
    Quaternary structure:
    • Interacts with CD45/PTPRC.

neXtProt entry for PTPRCAP Gene

Post-translational modifications for PTPRCAP Gene

Other Protein References for PTPRCAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTPRCAP Gene

Domains & Families for PTPRCAP Gene

Gene Families for PTPRCAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTPRCAP Gene

InterPro:

Suggested Antigen Peptide Sequences for PTPRCAP Gene

GenScript: Design optimal peptide antigens:
  • Lymphocyte phosphatase-associated phosphoprotein (PTCA_HUMAN)
genes like me logo Genes that share domains with PTPRCAP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PTPRCAP Gene

Function for PTPRCAP Gene

Molecular function for PTPRCAP Gene

GENATLAS Biochemistry:
phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa

Phenotypes From GWAS Catalog for PTPRCAP Gene

Gene Ontology (GO) - Molecular Function for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with PTPRCAP: view
genes like me logo Genes that share phenotypes with PTPRCAP: view

Animal Models for PTPRCAP Gene

MGI Knock Outs for PTPRCAP:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRCAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTPRCAP Gene

Localization for PTPRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRCAP Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRCAP gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1
golgi apparatus 1
mitochondrion 0
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11390434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRCAP Gene

Pathways & Interactions for PTPRCAP Gene

PathCards logo

SuperPathways for PTPRCAP Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
genes like me logo Genes that share pathways with PTPRCAP: view

Pathways by source for PTPRCAP Gene

1 BioSystems pathway for PTPRCAP Gene

Gene Ontology (GO) - Biological Process for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7961877
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for SIGNOR curated interactions for PTPRCAP Gene

Drugs & Compounds for PTPRCAP Gene

(1) Drugs for PTPRCAP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTPRCAP: view

Transcripts for PTPRCAP Gene

mRNA/cDNA for PTPRCAP Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRCAP

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRCAP Gene

No ASD Table

Relevant External Links for PTPRCAP Gene

GeneLoc Exon Structure for
PTPRCAP

Expression for PTPRCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRCAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRCAP Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x9.1).

Protein differential expression in normal tissues from HIPED for PTPRCAP Gene

This gene is overexpressed in NK cells (15.1), Tlymphocyte (13.6), Lymph node (10.9), Blymphocyte (9.1), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRCAP Gene



Protein tissue co-expression partners for PTPRCAP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRCAP

SOURCE GeneReport for Unigene cluster for PTPRCAP Gene:

Hs.155975

Evidence on tissue expression from TISSUES for PTPRCAP Gene

  • Blood(4.5)
  • Liver(4.1)
  • Intestine(2.5)
  • Spleen(2.3)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with PTPRCAP: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRCAP Gene

Orthologs for PTPRCAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTPRCAP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTPRCAP 29 30
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTPRCAP 29 30
  • 76.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptprcap 29
  • 74.83 (n)
Mouse
(Mus musculus)
Mammalia Ptprcap 29 16 30
  • 74.49 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PTPRCAP 30
  • 49 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTPRCAP 30
  • 33 (a)
OneToOne
Species where no ortholog for PTPRCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PTPRCAP Gene

ENSEMBL:
Gene Tree for PTPRCAP (if available)
TreeFam:
Gene Tree for PTPRCAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRCAP: view image
Alliance of Genome Resources:
Additional Orthologs for PTPRCAP

Paralogs for PTPRCAP Gene

No data available for Paralogs for PTPRCAP Gene

Variants for PTPRCAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRCAP Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs60969594 -- p.Gly128Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPRCAP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPRCAP Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680

Variation tolerance for PTPRCAP Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRCAP Gene

Human Gene Mutation Database (HGMD)
PTPRCAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRCAP
Leiden Open Variation Database (LOVD)
PTPRCAP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRCAP Gene

Disorders for PTPRCAP Gene

Additional Disease Information for PTPRCAP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PTPRCAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRCAP Gene

Publications for PTPRCAP Gene

  1. Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PMID: 8954783) Bruyns E … Schraven B (Genomics 1996) 3 4 22
  2. Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. (PMID: 8537410) Bruyns E … Schraven B (The Journal of biological chemistry 1995) 3 4 22
  3. LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. (PMID: 7961877) Schraven B … Ratnofsky S (The Journal of biological chemistry 1994) 3 4 22
  4. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. (PMID: 20019842) Ju H … Kang C (Neoplasia (New York, N.Y.) 2009) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PTPRCAP Gene

Sources for PTPRCAP Gene