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Aliases for PTPRCAP Gene

Aliases for PTPRCAP Gene

  • Protein Tyrosine Phosphatase, Receptor Type C Associated Protein 2 3 5
  • Lymphocyte Phosphatase-Associated Phosphoprotein 3 4
  • PTPRC-Associated Protein 3 4
  • CD45-AP 3 4
  • LPAP 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide-Associated Protein 3
  • Protein Tyrosine Phosphatase Receptor Type C-Associated Protein 3
  • CD45 Associated Protein 3
  • CD45-Associated Protein 4

External Ids for PTPRCAP Gene

Previous GeneCards Identifiers for PTPRCAP Gene

  • GC11P069666
  • GC11M068899
  • GC11M066978
  • GC11M066959
  • GC11M067202
  • GC11M063531

Summaries for PTPRCAP Gene

Entrez Gene Summary for PTPRCAP Gene

  • The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRCAP Gene

PTPRCAP (Protein Tyrosine Phosphatase, Receptor Type C Associated Protein) is a Protein Coding gene. Among its related pathways are TNFR1 Pathway.

Gene Wiki entry for PTPRCAP Gene

Additional gene information for PTPRCAP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRCAP Gene

Genomics for PTPRCAP Gene

GeneHancer (GH) Regulatory Elements for PTPRCAP Gene

Promoters and enhancers for PTPRCAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J067433 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 707.4 -2.3 -2311 14.7 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 PTPRCAP CORO1B CARNS1 SSH3 RPS6KB2-AS1 RPS6KB2
GH11J067482 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54.4 -47.3 -47300 6.3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 AIP GC11P067486 PTPRCAP CARNS1 ALDH3B2 NUDT8
GH11J067467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 55.3 -30.5 -30455 2.7 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ZNF207 TMEM134 PTPRCAP CARNS1 GC11M067462
GH11J067427 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 55.6 +9.5 9484 2.5 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 RPS6KB2 PTPRCAP CARNS1 RPS6KB2-AS1
GH11J067579 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 24.7 -146.3 -146270 10.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A GSTP1 ENSG00000255119 NUDT8 PTPRCAP NDUFV1 C11orf72 DOC2GP RHOD LRP5 ALDH3B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRCAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRCAP gene promoter:
  • E2F-2
  • E2F
  • E2F-1
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • Nkx2-5
  • Olf-1

Genomic Locations for PTPRCAP Gene

Genomic Locations for PTPRCAP Gene
chr11:67,435,510-67,438,067
(GRCh38/hg38)
Size:
2,558 bases
Orientation:
Minus strand
chr11:67,202,981-67,205,538
(GRCh37/hg19)
Size:
2,558 bases
Orientation:
Minus strand

Genomic View for PTPRCAP Gene

Genes around PTPRCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRCAP Gene

Proteins for PTPRCAP Gene

  • Protein details for PTPRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14761-PTCA_HUMAN
    Recommended name:
    Protein tyrosine phosphatase receptor type C-associated protein
    Protein Accession:
    Q14761
    Secondary Accessions:
    • B2R512
    • O00643
    • Q6I9S6

    Protein attributes for PTPRCAP Gene

    Size:
    206 amino acids
    Molecular mass:
    21196 Da
    Quaternary structure:
    • Interacts with CD45/PTPRC.

neXtProt entry for PTPRCAP Gene

Post-translational modifications for PTPRCAP Gene

Other Protein References for PTPRCAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTPRCAP Gene

Domains & Families for PTPRCAP Gene

Gene Families for PTPRCAP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PTPRCAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTPRCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTPRCAP: view

No data available for UniProtKB/Swiss-Prot for PTPRCAP Gene

Function for PTPRCAP Gene

Molecular function for PTPRCAP Gene

GENATLAS Biochemistry:
phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa

Phenotypes From GWAS Catalog for PTPRCAP Gene

genes like me logo Genes that share phenotypes with PTPRCAP: view

Animal Models for PTPRCAP Gene

MGI Knock Outs for PTPRCAP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRCAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTPRCAP Gene

Localization for PTPRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRCAP Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRCAP gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11390434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRCAP Gene

Pathways & Interactions for PTPRCAP Gene

SuperPathways for PTPRCAP Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
genes like me logo Genes that share pathways with PTPRCAP: view

Pathways by source for PTPRCAP Gene

1 BioSystems pathway for PTPRCAP Gene

Gene Ontology (GO) - Biological Process for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7961877
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for SIGNOR curated interactions for PTPRCAP Gene

Drugs & Compounds for PTPRCAP Gene

(1) Drugs for PTPRCAP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTPRCAP: view

Transcripts for PTPRCAP Gene

mRNA/cDNA for PTPRCAP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(629) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRCAP Gene

Protein tyrosine phosphatase, receptor type, C-associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRCAP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRCAP Gene

No ASD Table

Relevant External Links for PTPRCAP Gene

GeneLoc Exon Structure for
PTPRCAP
ECgene alternative splicing isoforms for
PTPRCAP

Expression for PTPRCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRCAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRCAP Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x9.1).

Protein differential expression in normal tissues from HIPED for PTPRCAP Gene

This gene is overexpressed in NK cells (15.1), Tlymphocyte (13.6), Lymph node (10.9), Blymphocyte (9.1), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRCAP Gene



Protein tissue co-expression partners for PTPRCAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRCAP Gene:

PTPRCAP

SOURCE GeneReport for Unigene cluster for PTPRCAP Gene:

Hs.155975

Evidence on tissue expression from TISSUES for PTPRCAP Gene

  • Blood(4.4)
  • Liver(4.1)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with PTPRCAP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRCAP Gene

Orthologs for PTPRCAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTPRCAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRCAP 34 33
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRCAP 34 33
  • 76.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprcap 33
  • 74.83 (n)
mouse
(Mus musculus)
Mammalia Ptprcap 16 34 33
  • 74.49 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPRCAP 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRCAP 34
  • 33 (a)
OneToOne
Species where no ortholog for PTPRCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTPRCAP Gene

ENSEMBL:
Gene Tree for PTPRCAP (if available)
TreeFam:
Gene Tree for PTPRCAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRCAP: view image

Paralogs for PTPRCAP Gene

No data available for Paralogs for PTPRCAP Gene

Variants for PTPRCAP Gene

Sequence variations from dbSNP and Humsavar for PTPRCAP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000306398 -- 67,435,821(-) CTCAGCAGGGCCTCAGCA/CTCAGCA coding_sequence_variant, stop_gained
rs1001235173 -- 67,438,919(-) C/A/T upstream_transcript_variant
rs1001436161 -- 67,437,788(-) C/T upstream_transcript_variant
rs1001510902 -- 67,437,490(-) C/T intron_variant
rs1001846227 -- 67,436,571(-) CAGCTGCA/CA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRCAP Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680

Variation tolerance for PTPRCAP Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRCAP Gene

Human Gene Mutation Database (HGMD)
PTPRCAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRCAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRCAP Gene

Disorders for PTPRCAP Gene

Additional Disease Information for PTPRCAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PTPRCAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRCAP Gene

Publications for PTPRCAP Gene

  1. Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PMID: 8954783) Bruyns E … Schraven B (Genomics 1996) 3 4 22 58
  2. Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. (PMID: 8537410) Bruyns E … Schraven B (The Journal of biological chemistry 1995) 3 4 22 58
  3. LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. (PMID: 7961877) Schraven B … Ratnofsky S (The Journal of biological chemistry 1994) 3 4 22 58
  4. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. (PMID: 20019842) Ju H … Kang C (Neoplasia (New York, N.Y.) 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PTPRCAP Gene

Sources for PTPRCAP Gene

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