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Aliases for PTPRC Gene

Aliases for PTPRC Gene

  • Protein Tyrosine Phosphatase Receptor Type C 2 3
  • Receptor-Type Tyrosine-Protein Phosphatase C 3 4
  • CD45 Antigen 3 4
  • CD45 3 4
  • L-CA 3 4
  • T200 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide 3
  • Protein Tyrosine Phosphatase, Receptor Type C 5
  • T200 Leukocyte Common Antigen 3
  • Leukocyte Common Antigen 4
  • T200 Glycoprotein 3
  • EC 3.1.3.48 4
  • CD45R 3
  • GP180 3
  • B220 3
  • LCA 3
  • LY5 3

External Ids for PTPRC Gene

Previous HGNC Symbols for PTPRC Gene

  • CD45

Previous GeneCards Identifiers for PTPRC Gene

  • GC01P196335
  • GC01P194066
  • GC01P195074
  • GC01P195896
  • GC01P195339
  • GC01P196874
  • GC01P169775

Summaries for PTPRC Gene

Entrez Gene Summary for PTPRC Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

GeneCards Summary for PTPRC Gene

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus. Among its related pathways are Development EPO-induced Jak-STAT pathway and TCR signaling in naive CD4+ T cells. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PTPRD.

UniProtKB/Swiss-Prot for PTPRC Gene

  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

Gene Wiki entry for PTPRC Gene

Additional gene information for PTPRC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRC Gene

Genomics for PTPRC Gene

GeneHancer (GH) Regulatory Elements for PTPRC Gene

Promoters and enhancers for PTPRC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J198636 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 600.7 +2.9 2931 10 ZNF148 NKRF MLLT1 ZNF687 MAFK JUND CREM ZBED1 MTA1 IKZF1 PTPRC ATP6V1G3 ENSG00000225172 ENSG00000261573
GH01J198648 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 34.4 +15.7 15665 11.6 ZKSCAN8 CBFA2T2 ZNF384 RELA MLLT1 ZNF404 MZF1 SMARCA4 CREB1 POLR2A PTPRC ATP6V1G3 ENSG00000225172 ENSG00000261573
GH01J198617 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30.5 -16.6 -16577 8 SP1 NKRF ZNF687 CREM MLLT1 RELA ZBED1 IKZF1 POLR2A IKZF2 PTPRC NEK7 ENSG00000223881
GH01J198660 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +37.9 37885 32.1 SP1 CC2D1A CBFA2T2 MLLT1 GTF2F1 ZNF687 NFIB CTCF BACH1 MAFK PTPRC ATP6V1G3 ENSG00000225172 PIR61364 PEBP1P3 GC01P198684 ENSG00000261573
GH01J198633 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -4.5 -4481 1.3 ZFX CC2D1A CBFA2T2 TRIM24 RELA ZNF639 SMARCA4 IKZF1 DPF2 IKZF2 ATP6V1G3 PTPRC ENSG00000225172 ENSG00000223881
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRC gene promoter:
  • AP-1
  • ATF-2
  • Nkx2-5

Genomic Locations for PTPRC Gene

Genomic Locations for PTPRC Gene
chr1:198,638,457-198,757,476
(GRCh38/hg38)
Size:
119,020 bases
Orientation:
Plus strand
chr1:198,607,801-198,726,545
(GRCh37/hg19)
Size:
118,745 bases
Orientation:
Plus strand

Genomic View for PTPRC Gene

Genes around PTPRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRC Gene

Proteins for PTPRC Gene

  • Protein details for PTPRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08575-PTPRC_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C
    Protein Accession:
    P08575
    Secondary Accessions:
    • A0A0A0MT22
    • A8K7W6
    • Q16614
    • Q9H0Y6
    • X6R433

    Protein attributes for PTPRC Gene

    Size:
    1306 amino acids
    Molecular mass:
    147486 Da
    Quaternary structure:
    • Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1 (PubMed:11909961). Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL11; the interaction is required for binding of UL11 to T-cells.
    SequenceCaution:
    • Sequence=BAF84820.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68669.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRC Gene

    Alternative splice isoforms for PTPRC Gene

neXtProt entry for PTPRC Gene

Post-translational modifications for PTPRC Gene

  • Heavily N- and O-glycosylated.
  • Glycosylation at posLast=190190, posLast=270270, posLast=378378, posLast=197197, isoforms=78, isoforms=95, posLast=240240, isoforms=2497, isoforms=2260, isoforms=184, isoforms=2488, posLast=335335, isoforms=2232, posLast=468468, posLast=276276, posLast=419419, isoforms=90, isoforms=2529, and isoforms=2284
  • Ubiquitination at posLast=715715, isoforms=2664, and posLast=932932
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTPRC_HUMAN (339)

Antibody Products

No data available for DME Specific Peptides for PTPRC Gene

Domains & Families for PTPRC Gene

Gene Families for PTPRC Gene

Suggested Antigen Peptide Sequences for PTPRC Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase, receptor type, C (B1ALS1_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C, isoform CRA_d (B1ALS2_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (B1ALS3_HUMAN)
  • T200 (PTPRC_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (Q5T9L9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08575

UniProtKB/Swiss-Prot:

PTPRC_HUMAN :
  • The first PTPase domain interacts with SKAP1.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Domain:
  • The first PTPase domain interacts with SKAP1.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
genes like me logo Genes that share domains with PTPRC: view

Function for PTPRC Gene

Molecular function for PTPRC Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type I,C polypeptide

Enzyme Numbers (IUBMB) for PTPRC Gene

Phenotypes From GWAS Catalog for PTPRC Gene

Gene Ontology (GO) - Molecular Function for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS 15095367
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 15557316
GO:0005102 signaling receptor binding ISS,IEA --
GO:0005515 protein binding IEA,IPI 1970422
genes like me logo Genes that share ontologies with PTPRC: view
genes like me logo Genes that share phenotypes with PTPRC: view

Human Phenotype Ontology for PTPRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRC Gene

MGI Knock Outs for PTPRC:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PTPRC - Now 50% OFF >
  • * PTPRC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PTPRC tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for PTPRC

No data available for Transcription Factor Targets and HOMER Transcription for PTPRC Gene

Localization for PTPRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRC Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:12676959}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRC gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0005925 focal adhesion ISS,IEA --
GO:0009897 external side of plasma membrane IDA,IEA 17213291
GO:0009898 cytoplasmic side of plasma membrane NAS 15661907
genes like me logo Genes that share ontologies with PTPRC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPRC Gene

Pathways & Interactions for PTPRC Gene

genes like me logo Genes that share pathways with PTPRC: view

SIGNOR curated interactions for PTPRC Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001779 natural killer cell differentiation ISS,IEA --
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA,ISS --
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS,IEA --
genes like me logo Genes that share ontologies with PTPRC: view

Drugs & Compounds for PTPRC Gene

(35) Drugs for PTPRC Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 561
Etanercept Approved, Investigational Pharma 434
Infliximab Approved Pharma 445
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(37) Additional Compounds for PTPRC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPRC: view

Transcripts for PTPRC Gene

Unigene Clusters for PTPRC Gene

Protein tyrosine phosphatase, receptor type, C:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PTPRC - Now 50% OFF >
  • * PTPRC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PTPRC tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for PTPRC

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRC Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PTPRC Gene

GeneLoc Exon Structure for
PTPRC
ECgene alternative splicing isoforms for
PTPRC

Expression for PTPRC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery