PTPRC Gene (Protein Coding)

Protein Tyrosine Phosphatase Receptor Type C

GC01P198607
GIFtS:
51
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic dom... See more...

Aliases for PTPRC Gene

Aliases for PTPRC Gene

  • Protein Tyrosine Phosphatase Receptor Type C 2 3 5
  • T200 2 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase C 3 4
  • CD45 Antigen 3 4
  • GP180 2 3
  • CD45 3 4
  • L-CA 3 4
  • LCA 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide 3
  • T200 Leukocyte Common Antigen 3
  • Leukocyte Common Antigen 4
  • T200 Glycoprotein 3
  • EC 3.1.3.48 4
  • CD45R 3
  • PTPRC 5
  • B220 3
  • LY5 3

External Ids for PTPRC Gene

Previous HGNC Symbols for PTPRC Gene

  • CD45

Previous GeneCards Identifiers for PTPRC Gene

  • GC01P196335
  • GC01P194066
  • GC01P195074
  • GC01P195896
  • GC01P195339
  • GC01P196874
  • GC01P169775

Summaries for PTPRC Gene

Entrez Gene Summary for PTPRC Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

GeneCards Summary for PTPRC Gene

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus. Among its related pathways are B cell receptor signaling pathway (KEGG) and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot Summary for PTPRC Gene

  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

Gene Wiki entry for PTPRC Gene

Additional gene information for PTPRC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRC Gene

Genomics for PTPRC Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PTPRC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J198636 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 634.5 +9.7 9731 23.6 CREB1 ZNF629 ZNF512 RFX1 POLR2A BACH1 JUND FOXA1 RELA PKNOX1 PTPRC ATP6V1G3 ENSG00000225172 NONHSAG003874.2 ENSG00000261573
GH01J198617 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30.5 -16.6 -16577 8 SP1 POLR2A LARP7 STAT3 SMAD5 TCF12 IKZF2 RCOR1 RELA TRIM22 PTPRC NEK7 ENSG00000223881 ATP6V1G3
GH01J198660 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.8 +37.9 37885 32.1 SP1 CREB1 CTCF HNRNPL TEAD4 PRDM10 RFX1 LEF1 POLR2A ZNF7 lnc-NEK7-4 PTPRC ATP6V1G3 ENSG00000225172 PEBP1P3 lnc-ATP6V1G3-5 lnc-ATP6V1G3-6 piR-38319 ENSG00000261573 NONHSAG003874.2
GH01J198633 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -4.5 -4535 1.4 LEF1 IKZF1 JUND DDX20 RELA PKNOX1 IKZF2 BRD9 ZNF24 DPF2 ATP6V1G3 PTPRC ENSG00000225172 ENSG00000223881
GH01J198556 Enhancer 1.1 FANTOM5 ENCODE 8.3 -81.2 -81233 2 CEBPG REST LEF1 IKZF1 ZNF143 MTA2 ZNF24 IKZF2 BRD9 TRIM22 PTPRC ATP6V1G3 piR-49423-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRC

Top Transcription factor binding sites by QIAGEN in the PTPRC gene promoter:
  • AP-1
  • ATF-2
  • Nkx2-5

Genomic Locations for PTPRC Gene

Genomic Locations for PTPRC Gene
chr1:198,638,457-198,757,476
(GRCh38/hg38)
Size:
119,020 bases
Orientation:
Plus strand
chr1:198,607,801-198,726,545
(GRCh37/hg19)
Size:
118,745 bases
Orientation:
Plus strand

Genomic View for PTPRC Gene

Genes around PTPRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTPRC Gene

Proteins for PTPRC Gene

Products:

  1. Antibody
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  • Protein details for PTPRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08575-PTPRC_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C
    Protein Accession:
    P08575
    Secondary Accessions:
    • A0A0A0MT22
    • A8K7W6
    • Q16614
    • Q9H0Y6
    • X6R433

    Protein attributes for PTPRC Gene

    Size:
    1306 amino acids
    Molecular mass:
    147486 Da
    Quaternary structure:
    • Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1 (PubMed:11909961). Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL11; the interaction is required for binding of UL11 to T-cells.
    SequenceCaution:
    • Sequence=BAF84820.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA68269.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA68669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRC Gene

    Alternative splice isoforms for PTPRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRC Gene

Protein Expression for PTPRC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PTPRC Gene

  • Heavily N- and O-glycosylated.
  • Glycosylation at Asn199, Asn186, Asn234, Asn192, Asn80, Asn92, Asn97, Asn262, Asn272, Asn278, Asn286, Asn337, Asn380, Asn421, Asn470, Asn490, and Asn531
  • Ubiquitination at Lys666, Lys717, and Lys934
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTPRC_HUMAN (339)

Other Protein References for PTPRC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTPRC Gene

Domains & Families for PTPRC Gene

Gene Families for PTPRC Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PTPRC Gene

InterPro:
Blocks:
  • Protein tyrosine phosphatase signature
ProtoNet:

Suggested Antigen Peptide Sequences for PTPRC Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase, receptor type, C (B1ALS1_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C, isoform CRA_d (B1ALS2_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (B1ALS3_HUMAN)
  • T200 (PTPRC_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (Q5T9L9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08575

UniProtKB/Swiss-Prot:

PTPRC_HUMAN :
  • The first PTPase domain interacts with SKAP1.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Domain:
  • The first PTPase domain interacts with SKAP1.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
genes like me logo Genes that share domains with PTPRC: view

Function for PTPRC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PTPRC Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type I,C polypeptide

Enzyme Numbers (IUBMB) for PTPRC Gene

Phenotypes From GWAS Catalog for PTPRC Gene

Gene Ontology (GO) - Molecular Function for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS 15095367
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 15557316
GO:0005102 signaling receptor binding IEA,ISS --
GO:0005515 protein binding IEA,IPI 1970422
genes like me logo Genes that share ontologies with PTPRC: view
genes like me logo Genes that share phenotypes with PTPRC: view

Human Phenotype Ontology for PTPRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRC Gene

MGI Knock Outs for PTPRC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRC

Clone Products

  • Addgene plasmids for PTPRC

No data available for Transcription Factor Targets and HOMER Transcription for PTPRC Gene

Localization for PTPRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRC Gene

Cell membrane. Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:12676959}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRC gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
cytosol 3
lysosome 3
peroxisome 2
endosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0005925 focal adhesion IEA,ISS --
GO:0009897 external side of plasma membrane IEA,IDA 17213291
genes like me logo Genes that share ontologies with PTPRC: view

Pathways & Interactions for PTPRC Gene

genes like me logo Genes that share pathways with PTPRC: view

Pathways by source for PTPRC Gene

3 GeneGo (Thomson Reuters) pathways for PTPRC Gene
  • Chemotaxis CXCR4 signaling pathway
  • Immune response BCR pathway
  • Immune response T cell receptor signaling pathway
10 Qiagen pathways for PTPRC Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Apoptotic Pathways Triggered By HIV1
  • cAMP Pathway
  • CD28 Signaling in T-Helper Cell
1 Cell Signaling Technology pathway for PTPRC Gene

SIGNOR curated interactions for PTPRC Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001779 natural killer cell differentiation IEA,ISS --
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA,ISS --
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0001960 negative regulation of cytokine-mediated signaling pathway IEA,ISS --
genes like me logo Genes that share ontologies with PTPRC: view

Drugs & Compounds for PTPRC Gene

Products:

  1. Drug

(35) Drugs for PTPRC Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 602
Etanercept Approved, Investigational Pharma 454
Infliximab Approved Pharma 469
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(37) Additional Compounds for PTPRC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
 14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPRC: view

Transcripts for PTPRC Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PTPRC Gene

4 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRC

Clone Products

  • Addgene plasmids for PTPRC

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRC Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PTPRC Gene

GeneLoc Exon Structure for
PTPRC

Expression for PTPRC Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRC Gene

mRNA expression in normal human tissues for PTPRC Gene
mRNA expression by GTEx for PTPRC GenemRNA expression by BioGPS for PTPRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRC Gene

This gene is overexpressed in Whole Blood (x30.3) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for PTPRC Gene

This gene is overexpressed in Tlymphocyte (17.0), Lymph node (12.3), CD8 Tcells (6.9), and Monocytes (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRC Gene



Protein tissue co-expression partners for PTPRC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRC

SOURCE GeneReport for Unigene cluster for PTPRC Gene:

Hs.654514

mRNA Expression by UniProt/SwissProt for PTPRC Gene:

P08575-PTPRC_HUMAN
Tissue specificity: Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.

Evidence on tissue expression from TISSUES for PTPRC Gene

  • Blood(5)
  • Liver(4.7)
  • Spleen(4.4)
  • Bone marrow(4.3)
  • Lymph node(4.3)
  • Intestine(3.9)
  • Lung(3.8)
  • Heart(3.7)
  • Nervous system(3.5)
  • Muscle(3.4)
  • Skin(3.4)
  • Bone(3.4)
  • Kidney(3.3)
  • Pancreas(3.2)
  • Stomach(3.1)
  • Eye(2.8)
  • Thyroid gland(2.7)
  • Gall bladder(2.6)
  • Adrenal gland(2.4)
  • Urine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
Regions:
Head and neck:
  • ear
  • head
  • middle ear
Abdomen:
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
General:
  • blood
  • bone marrow
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with PTPRC: view

Orthologs for PTPRC Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PTPRC 30 31
  • 99.03 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PTPRC 30 31
  • 79.77 (n)
 OneToOne