PTPRC Gene (Protein Coding)

Protein Tyrosine Phosphatase Receptor Type C

GC01P198607
GIFtS:
52
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic dom... See more...

Aliases for PTPRC Gene

Aliases for PTPRC Gene

  • Protein Tyrosine Phosphatase Receptor Type C 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase C 3 4
  • CD45 Antigen 3 4
  • CD45 3 4
  • L-CA 3 4
  • T200 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide 3
  • T200 Leukocyte Common Antigen 3
  • Leukocyte Common Antigen 4
  • T200 Glycoprotein 3
  • EC 3.1.3.48 4
  • CD45R 3
  • GP180 3
  • B220 3
  • LCA 3
  • LY5 3

External Ids for PTPRC Gene

Previous HGNC Symbols for PTPRC Gene

  • CD45

Previous GeneCards Identifiers for PTPRC Gene

  • GC01P196335
  • GC01P194066
  • GC01P195074
  • GC01P195896
  • GC01P195339
  • GC01P196874
  • GC01P169775

Summaries for PTPRC Gene

Entrez Gene Summary for PTPRC Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

GeneCards Summary for PTPRC Gene

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus. Among its related pathways are TCR signaling (REACTOME) and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PTPRF.

UniProtKB/Swiss-Prot Summary for PTPRC Gene

  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

Gene Wiki entry for PTPRC Gene

Additional gene information for PTPRC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRC Gene

Genomics for PTPRC Gene

GeneHancer (GH) Regulatory Elements for PTPRC Gene

Promoters and enhancers for PTPRC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J198636 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 784.5 +9.7 9731 23.6 ZNF24 ZBTB40 SMARCE1 POLR2A JUND ETV6 RELA DACH1 TEAD4 ZKSCAN8 PTPRC ATP6V1G3 ENSG00000225172 NONHSAG003874.2 ENSG00000261573
GH01J198617 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30.5 -16.6 -16577 8 SP1 MYC ETV6 MAX RELA NKRF MLLT1 ZNF687 POLR2A CREM PTPRC NEK7 ENSG00000223881
GH01J198660 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.8 +37.9 37885 32.1 SP1 ZBTB40 CTCF SMARCE1 POLR2A JUND MYC CC2D1A ETV6 RELA lnc-NEK7-4 PTPRC ATP6V1G3 ENSG00000225172 PEBP1P3 lnc-ATP6V1G3-5 lnc-ATP6V1G3-6 piR-38319 ENSG00000261573 NONHSAG003874.2
GH01J198633 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -4.5 -4535 1.4 SMARCE1 CC2D1A RELA L3MBTL2 TEAD4 ZFX CBFA2T2 SMARCA4 ZNF639 TRIM24 ATP6V1G3 PTPRC ENSG00000225172 ENSG00000223881
GH01J198556 Enhancer 1.1 FANTOM5 ENCODE 8.3 -81.2 -81233 2 ZBTB40 SMARCE1 CC2D1A ETV6 ELF1 ZNF148 SP1 MLLT1 SMARCA4 CREM PTPRC ATP6V1G3 piR-49423-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRC gene promoter:
  • AP-1
  • ATF-2
  • Nkx2-5

Genomic Locations for PTPRC Gene

Genomic Locations for PTPRC Gene
chr1:198,638,457-198,757,476
(GRCh38/hg38)
Size:
119,020 bases
Orientation:
Plus strand
chr1:198,607,801-198,726,545
(GRCh37/hg19)
Size:
118,745 bases
Orientation:
Plus strand

Genomic View for PTPRC Gene

Genes around PTPRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTPRC Gene

Proteins for PTPRC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PTPRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08575-PTPRC_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C
    Protein Accession:
    P08575
    Secondary Accessions:
    • A0A0A0MT22
    • A8K7W6
    • Q16614
    • Q9H0Y6
    • X6R433

    Protein attributes for PTPRC Gene

    Size:
    1306 amino acids
    Molecular mass:
    147486 Da
    Quaternary structure:
    • Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1 (PubMed:11909961). Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL11; the interaction is required for binding of UL11 to T-cells.
    SequenceCaution:
    • Sequence=BAF84820.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68669.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRC Gene

    Alternative splice isoforms for PTPRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRC Gene

Protein Expression for PTPRC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PTPRC Gene

  • Heavily N- and O-glycosylated.
  • Glycosylation at Asn199, Asn186, Asn234, Asn192, Asn80, Asn92, Asn97, Asn262, Asn272, Asn278, Asn286, Asn337, Asn380, Asn421, Asn470, Asn490, and Asn531
  • Ubiquitination at Lys666, Lys717, and Lys934
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTPRC_HUMAN (339)

Other Protein References for PTPRC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTPRC Gene

Domains & Families for PTPRC Gene

Gene Families for PTPRC Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PTPRC Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTPRC Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase, receptor type, C (B1ALS1_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C, isoform CRA_d (B1ALS2_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (B1ALS3_HUMAN)
  • T200 (PTPRC_HUMAN)
  • Protein tyrosine phosphatase, receptor type, C (Q5T9L9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08575

UniProtKB/Swiss-Prot:

PTPRC_HUMAN :
  • The first PTPase domain interacts with SKAP1.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Domain:
  • The first PTPase domain interacts with SKAP1.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
genes like me logo Genes that share domains with PTPRC: view

Function for PTPRC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PTPRC Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type I,C polypeptide

Enzyme Numbers (IUBMB) for PTPRC Gene

Phenotypes From GWAS Catalog for PTPRC Gene

Gene Ontology (GO) - Molecular Function for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS,IEA 15095367
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 15557316
GO:0005102 signaling receptor binding ISS,IEA --
GO:0005515 protein binding IPI,IEA 1970422
genes like me logo Genes that share ontologies with PTPRC: view
genes like me logo Genes that share phenotypes with PTPRC: view

Human Phenotype Ontology for PTPRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRC Gene

MGI Knock Outs for PTPRC:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PTPRC

No data available for Transcription Factor Targets and HOMER Transcription for PTPRC Gene

Localization for PTPRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRC Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:12676959}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRC gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0005925 focal adhesion IEA,ISS --
GO:0009897 external side of plasma membrane IEA,IDA 17213291
GO:0009898 cytoplasmic side of plasma membrane NAS 15661907
genes like me logo Genes that share ontologies with PTPRC: view

No data available for