The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalyt... See more...

Aliases for PTPRA Gene

Aliases for PTPRA Gene

  • Protein Tyrosine Phosphatase Receptor Type A 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Alpha 3 4
  • Protein-Tyrosine Phosphatase Alpha 3 4
  • R-PTP-Alpha 3 4
  • EC 4 54
  • PTPRL2 3 4
  • PTPA 3 4
  • Leukocyte Common Antigen-Related Peptide (Protein Tyrosine Phosphate) 3
  • Protein Tyrosine Phosphatase, Receptor Type, Alpha Polypeptide 3
  • PTPLCA-Related Phosphatase 3
  • Tyrosine Phosphatase Alpha 3
  • PTPase-Alpha 3
  • HPTPalpha 3
  • HEPTP 3
  • HPTPA 3
  • RPTPA 3
  • HLPR 3
  • LRP 3

External Ids for PTPRA Gene

Previous HGNC Symbols for PTPRA Gene

  • PTPRL2
  • PTPA

Previous GeneCards Identifiers for PTPRA Gene

  • GC20P002809
  • GC20P002816
  • GC20P002770
  • GC20P002771
  • GC20P002772
  • GC20P002793
  • GC20P002794
  • GC20P002795
  • GC20P002796
  • GC20P002797
  • GC20P002844

Summaries for PTPRA Gene

Entrez Gene Summary for PTPRA Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRA Gene

PTPRA (Protein Tyrosine Phosphatase Receptor Type A) is a Protein Coding gene. Diseases associated with PTPRA include Estrogen-Receptor Negative Breast Cancer. Among its related pathways are RET signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRE.

Gene Wiki entry for PTPRA Gene

Additional gene information for PTPRA Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRA Gene

Genomics for PTPRA Gene

GeneHancer (GH) Regulatory Elements for PTPRA Gene

Promoters and enhancers for PTPRA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002870 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 750.4 +8.9 8940 5.8 ZNF24 ZBTB40 SP1 CTCF MLX RBPJ POLR2A HCFC1 MIXL1 ZNF362 PTPRA VPS16 NOP56 SNRPB PCED1A MAVS EBF4 ZNF343 TMEM239 C20orf141
GH20J002884 Promoter 0.7 EPDnew 761.8 +20.6 20591 0.1 MLLT1 IKZF1 IKZF2 ZNF316 ZNF140 RUNX3 JUNB NBN BATF ATF2 PTPRA VPS16 NOP56 PCED1A ZNF343 C20orf141 ENSG00000241690 TMEM239 piR-57460-389 RF00017-3496
GH20J002864 Promoter 0.3 EPDnew 750.6 +0.0 4 0.1 PTPRA piR-57460-389 VPS16
GH20J002863 Promoter 0.3 EPDnew 750.6 -0.2 -194 0.1 PTPRA piR-50237 VPS16
GH20J003795 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +940.5 940487 19.3 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 LCORL FOXA1 MLX CDC25B VPS16 SPEF1 MAVS ADAM33 UBOX5 ENSG00000229539 PCED1A PTPRA PANK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTPRA gene promoter:
  • COMP1
  • FAC1
  • Lmo2
  • Nkx2-5
  • POU2F1

Genomic Locations for PTPRA Gene

Genomic Locations for PTPRA Gene
174,893 bases
Plus strand
174,893 bases
Plus strand

Genomic View for PTPRA Gene

Genes around PTPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRA Gene

Proteins for PTPRA Gene

  • Protein details for PTPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase alpha
    Protein Accession:
    Secondary Accessions:
    • A8K2G8
    • D3DVX5
    • Q14513
    • Q7Z2I2
    • Q96TD9

    Protein attributes for PTPRA Gene

    802 amino acids
    Molecular mass:
    90719 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTPRA Gene


neXtProt entry for PTPRA Gene

Selected DME Specific Peptides for PTPRA Gene


Post-translational modifications for PTPRA Gene

  • Glycosylation at Asn21, Asn36, Asn68, Asn80, Asn86, Asn104, and Asn124
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRA Gene

Gene Families for PTPRA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PTPRA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56484, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC (B7Z2A4_HUMAN)
  • Receptor-type tyrosine-protein phosphatase alpha (PTPRA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPRA: view

Function for PTPRA Gene

Molecular function for PTPRA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type IV,alpha polypeptide

Enzyme Numbers (IUBMB) for PTPRA Gene

Phenotypes From GWAS Catalog for PTPRA Gene

Gene Ontology (GO) - Molecular Function for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS,IBA 21873635
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2169617
GO:0005515 protein binding IPI 7518772
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRA: view
genes like me logo Genes that share phenotypes with PTPRA: view

Animal Models for PTPRA Gene

MGI Knock Outs for PTPRA:

Animal Model Products

CRISPR Products

miRNA for PTPRA Gene

miRTarBase miRNAs that target PTPRA

Clone Products

  • Addgene plasmids for PTPRA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRA Gene

Localization for PTPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRA gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2169617
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with PTPRA: view

Pathways & Interactions for PTPRA Gene

PathCards logo

SuperPathways for PTPRA Gene

SuperPathway Contained pathways
1 RET signaling
2 Activation of cAMP-Dependent PKA
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with PTPRA: view

Pathways by source for PTPRA Gene

1 Sino Biological pathway for PTPRA Gene
2 BioSystems pathways for PTPRA Gene
6 Qiagen pathways for PTPRA Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Apoptotic Pathways Triggered By HIV1
  • cAMP Pathway
  • Epithelial Adherens Junctions
2 Cell Signaling Technology pathways for PTPRA Gene

SIGNOR curated interactions for PTPRA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTPRA: view

Drugs & Compounds for PTPRA Gene

(8) Drugs for PTPRA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(5) Additional Compounds for PTPRA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPRA: view

Transcripts for PTPRA Gene

mRNA/cDNA for PTPRA Gene

CRISPR Products

Clone Products

  • Addgene plasmids for PTPRA

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - - - - -
SP15: -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43a ·
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - -
SP9: - -

ExUns: 43b ^ 44 ^ 45
SP7: -

Relevant External Links for PTPRA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRA Gene

This gene is overexpressed in Breast (23.9), Peripheral blood mononuclear cells (8.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRA Gene

Protein tissue co-expression partners for PTPRA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRA Gene:


SOURCE GeneReport for Unigene cluster for PTPRA Gene:


Evidence on tissue expression from TISSUES for PTPRA Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Skin(4.4)
  • Lymph node(4.3)
  • Liver(4.2)
  • Lung(3)
  • Eye(2.4)
  • Blood(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PTPRA: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRA Gene

Orthologs for PTPRA Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRA 33 32
  • 99.58 (n)
(Canis familiaris)
Mammalia PTPRA 33 32
  • 93.77 (n)
(Bos Taurus)
Mammalia PTPRA 33 32
  • 93.01 (n)
(Rattus norvegicus)
Mammalia Ptpra 32
  • 91.05 (n)
(Mus musculus)
Mammalia Ptpra 17 33 32
  • 90.67 (n)
(Monodelphis domestica)
Mammalia PTPRA 33
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRA 33
  • 79 (a)
(Gallus gallus)
Aves PTPA 33
  • 85 (a)
  • 78.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpra 32
  • 74.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia ptpa-A-prov 32
(Danio rerio)
Actinopterygii ptpra 33 32 32
  • 71.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 34
  • 37 (a)
Ptp69D 34
  • 37 (a)
CG7180 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ZK616.7 34
  • 37 (a)
M04G7.2 34
  • 37 (a)
T22C1.8 34
  • 36 (a)
F20H11.4 34
  • 30 (a)
ptp-3 33
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4172 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4172 32
Species where no ortholog for PTPRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRA Gene

Gene Tree for PTPRA (if available)
Gene Tree for PTPRA (if available)
Evolutionary constrained regions (ECRs) for PTPRA: view image

Paralogs for PTPRA Gene

(28) SIMAP similar genes for PTPRA Gene using alignment to 6 proteins:

  • B7Z2A4_HUMAN
  • J3KP22_HUMAN
  • Q5JWG3_HUMAN Pseudogenes for PTPRA Gene

genes like me logo Genes that share paralogs with PTPRA: view

Variants for PTPRA Gene

Sequence variations from dbSNP and Humsavar for PTPRA Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000016395 -- 2,967,300(+) CTA/CTACTA intron_variant
rs1000028878 -- 3,010,436(+) G/A intron_variant
rs1000042158 -- 3,014,268(+) A/G intron_variant
rs1000064071 -- 3,010,262(+) C/T intron_variant
rs1000064680 -- 2,966,957(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRA Gene

Variant ID Type Subtype PubMed ID
dgv2205n106 CNV deletion 24896259
dgv268e215 CNV deletion 23714750
esv2207372 CNV deletion 18987734
esv2272134 CNV deletion 18987734
esv2369681 CNV deletion 18987734
esv2661520 CNV deletion 23128226
esv2664542 CNV deletion 23128226
esv2669632 CNV deletion 23128226
esv2722110 CNV deletion 23290073
esv2722111 CNV deletion 23290073
esv2722112 CNV deletion 23290073
esv2722113 CNV deletion 23290073
esv2722114 CNV deletion 23290073
esv2762056 CNV gain 21179565
esv3556735 CNV deletion 23714750
esv3645020 CNV gain 21293372
esv3645021 CNV loss 21293372
esv3645022 CNV loss 21293372
esv3645023 CNV gain 21293372
esv3645024 CNV loss 21293372
esv5581 CNV loss 19470904
esv994080 CNV gain 20482838
nsv1057187 CNV gain 25217958
nsv1057464 CNV gain 25217958
nsv1071299 CNV deletion 25765185
nsv1125837 CNV deletion 24896259
nsv1130766 CNV deletion 24896259
nsv1143131 CNV deletion 24896259
nsv1148763 CNV deletion 26484159
nsv1151978 CNV deletion 26484159
nsv179703 CNV deletion 16902084
nsv180455 CNV deletion 16902084
nsv180708 CNV deletion 16902084
nsv3262 CNV insertion 18451855
nsv3263 CNV insertion 18451855
nsv478162 CNV novel sequence insertion 20440878
nsv518708 CNV loss 19592680
nsv519680 CNV loss 19592680
nsv522009 CNV gain 19592680
nsv585276 CNV gain 21841781
nsv833895 CNV loss 17160897
nsv833896 CNV loss 17160897
nsv833897 CNV loss 17160897
nsv956217 CNV deletion 24416366

Variation tolerance for PTPRA Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRA Gene

Disorders for PTPRA Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPRA Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
estrogen-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search PTPRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPRA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTPRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRA Gene

Publications for PTPRA Gene

  1. Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase. (PMID: 2172030) Jirik FR … Harder KW (FEBS letters 1990) 2 3 4 23 56
  2. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (PMID: 2169617) Kaplan R … Schlessinger J (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4 56
  3. Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide). (PMID: 2175890) Ohagi S … Steiner DF (Nucleic acids research 1990) 3 4 23 56
  4. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. (PMID: 20208566) Krndija D … von Wichert G (Oncogene 2010) 3 23 56
  5. Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling. (PMID: 19497848) Wang Q … McCulloch CA (The Journal of biological chemistry 2009) 3 23 56

Products for PTPRA Gene