The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalyt... See more...

Aliases for PTPRA Gene

Aliases for PTPRA Gene

  • Protein Tyrosine Phosphatase Receptor Type A 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Alpha 3 4
  • Protein-Tyrosine Phosphatase Alpha 3 4
  • R-PTP-Alpha 3 4
  • EC 3.1.3.48 4 51
  • PTPRL2 3 4
  • HPTPA 2 3
  • RPTPA 2 3
  • HLPR 2 3
  • PTPA 3 4
  • LRP 2 3
  • Leukocyte Common Antigen-Related Peptide (Protein Tyrosine Phosphate) 3
  • Protein Tyrosine Phosphatase, Receptor Type, Alpha Polypeptide 3
  • PTPLCA-Related Phosphatase 3
  • Tyrosine Phosphatase Alpha 3
  • PTPase-Alpha 3
  • HPTPalpha 3
  • HEPTP 3
  • PTPRA 5

External Ids for PTPRA Gene

Previous HGNC Symbols for PTPRA Gene

  • PTPRL2
  • PTPA

Previous GeneCards Identifiers for PTPRA Gene

  • GC20P002809
  • GC20P002816
  • GC20P002770
  • GC20P002771
  • GC20P002772
  • GC20P002793
  • GC20P002794
  • GC20P002795
  • GC20P002796
  • GC20P002797
  • GC20P002844

Summaries for PTPRA Gene

Entrez Gene Summary for PTPRA Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRA Gene

PTPRA (Protein Tyrosine Phosphatase Receptor Type A) is a Protein Coding gene. Diseases associated with PTPRA include Common Peroneal Nerve Lesion and Noonan Syndrome With Multiple Lentigines. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRE.

UniProtKB/Swiss-Prot Summary for PTPRA Gene

  • Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

Gene Wiki entry for PTPRA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPRA Gene

Genomics for PTPRA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPRA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002870 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +8.9 8940 5.8 TBP SP1 MXD4 NR2C1 MNT IKZF1 SMAD5 ZFP64 MBD2 POLR2A HSALNG0128222 PTPRA VPS16 NOP56 PCED1A EBF4 TMEM239 C20orf141 ENSG00000241690 CDC25B
GH20J002884 Promoter/Enhancer 1.1 EPDnew Ensembl 261.8 +24.1 24116 12.6 MNT IKZF1 FOXA2 NBN ZEB2 ZNF316 FOSL1 PRDM6 BATF FOXK2 PTPRA VPS16 PCED1A NOP56 MRPS26 ZNF343 EBF4 C20orf141 ENSG00000241690 TMEM239
GH20J002863 Promoter 0.3 EPDnew 250.7 -0.2 -194 0.1 PTPRA piR-50237 PCED1A VPS16
GH20J002864 Promoter 0.3 EPDnew 250.7 +0.0 4 0.1 PTPRA piR-57460-389 VPS16 GNRH2
GH20J003795 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +938.1 938117 14.6 CHD2 TBP ZBTB10 SP1 MXD4 BCL11A CEBPA ZNF217 MNT IKZF1 CDC25B LINC01730 PANK2-AS1 VPS16 SPEF1 PTPRA UBOX5 ADAM33 PANK2 ENSG00000274949
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPRA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPRA

Top Transcription factor binding sites by QIAGEN in the PTPRA gene promoter:
  • COMP1
  • FAC1
  • Lmo2
  • Nkx2-5
  • POU2F1

Genomic Locations for PTPRA Gene

Latest Assembly
chr20:2,864,184-3,039,076
(GRCh38/hg38)
Size:
174,893 bases
Orientation:
Plus strand

Previous Assembly
chr20:2,844,830-3,019,315
(GRCh37/hg19 by Entrez Gene)
Size:
174,486 bases
Orientation:
Plus strand

chr20:2,844,830-3,019,722
(GRCh37/hg19 by Ensembl)
Size:
174,893 bases
Orientation:
Plus strand

Genomic View for PTPRA Gene

Genes around PTPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRA Gene

Proteins for PTPRA Gene

  • Protein details for PTPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18433-PTPRA_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase alpha
    Protein Accession:
    P18433
    Secondary Accessions:
    • A8K2G8
    • D3DVX5
    • Q14513
    • Q7Z2I2
    • Q96TD9

    Protein attributes for PTPRA Gene

    Size:
    802 amino acids
    Molecular mass:
    90719 Da
    Quaternary structure:
    • Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain), and SRC (PubMed:22801373). Within the complex, interacts (when phosphorylated on Tyr-798) with BCAR3 (via SH2 domain) (PubMed:22801373). Interacts with GRB2 (PubMed:22801373).

    Three dimensional structures from OCA and Proteopedia for PTPRA Gene

    Alternative splice isoforms for PTPRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRA Gene

Selected DME Specific Peptides for PTPRA Gene

P18433:
  • EKNKFIAAQGPK
  • LRLQRPHMVQ
  • QFHFTSWP
  • IAAVQKQQQQ
  • YLYGDTEL
  • TNLKERKE
  • RQFHFHGWPE
  • VVHCSAG
  • NASFIDGYR
  • VHCSAGVGRTG
  • DYINASF
  • LDVFQTV
  • HFTSWPDFGVPFTPIGMLKFLKKVK
  • GNHPITVHCSAGAGRTGTF
  • FIYQALLE

Post-translational modifications for PTPRA Gene

  • Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
  • Glycosylation at Asn21, Asn36, Asn68, Asn80, Asn86, Asn104, and Asn124
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRA Gene

Gene Families for PTPRA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PTPRA Gene

Suggested Antigen Peptide Sequences for PTPRA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56484, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48) (B7Z2A4_HUMAN)
  • Receptor-type tyrosine-protein phosphatase alpha (PTPRA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18433

UniProtKB/Swiss-Prot:

PTPRA_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPRA: view

Function for PTPRA Gene

Molecular function for PTPRA Gene

UniProtKB/Swiss-Prot Function:
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type IV,alpha polypeptide

Enzyme Numbers (IUBMB) for PTPRA Gene

Phenotypes From GWAS Catalog for PTPRA Gene

Gene Ontology (GO) - Molecular Function for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS,ISS --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2169617
GO:0005515 protein binding IPI 7518772
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRA: view
genes like me logo Genes that share phenotypes with PTPRA: view

Animal Models for PTPRA Gene

MGI Knock Outs for PTPRA:

miRNA for PTPRA Gene

miRTarBase miRNAs that target PTPRA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRA

Clone products for research

  • Addgene plasmids for PTPRA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRA Gene

Localization for PTPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRA Gene

Cell membrane. Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250 UniProtKB:P18052}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRA gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
endoplasmic reticulum 3
cytosol 3
cytoskeleton 2
golgi apparatus 2
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2169617
GO:0005925 focal adhesion ISS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRA: view

Pathways & Interactions for PTPRA Gene

PathCards logo

SuperPathways for PTPRA Gene

SuperPathway Contained pathways
1 RET signaling
2 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with PTPRA: view

Pathways by source for PTPRA Gene

6 Qiagen pathways for PTPRA Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Apoptotic Pathways Triggered By HIV1
  • cAMP Pathway
  • Epithelial Adherens Junctions
2 Cell Signaling Technology pathways for PTPRA Gene

SIGNOR curated interactions for PTPRA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007229 integrin-mediated signaling pathway ISS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with PTPRA: view

Drugs & Compounds for PTPRA Gene

(8) Drugs for PTPRA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(4) Additional Compounds for PTPRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTPRA: view

Transcripts for PTPRA Gene

mRNA/cDNA for PTPRA Gene

25 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPRA

Clone products for research

  • Addgene plasmids for PTPRA

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43a ·
SP1:
SP2:
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 43b ^ 44 ^ 45
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PTPRA Gene

GeneLoc Exon Structure for
PTPRA

Expression for PTPRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRA Gene

This gene is overexpressed in Breast (23.9), Peripheral blood mononuclear cells (8.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRA Gene



Protein tissue co-expression partners for PTPRA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPRA

SOURCE GeneReport for Unigene cluster for PTPRA Gene:

Hs.269577

Evidence on tissue expression from TISSUES for PTPRA Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Kidney(4.5)
  • Lymph node(4.4)
  • Liver(4.4)
  • Lung(3.3)
  • Eye(2.9)
  • Intestine(2.8)
  • Blood(2.7)
  • Stomach(2.3)
  • Heart(2.1)
  • Muscle(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PTPRA: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRA Gene

Orthologs for PTPRA Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTPRA 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTPRA 30 31
  • 93.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTPRA 30 31
  • 93.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptpra 30
  • 91.05 (n)
Mouse
(Mus musculus)
Mammalia Ptpra 30 17 31
  • 90.67 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PTPRA 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTPRA 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTPA 31
  • 85 (a)
OneToOne
PTPRA 30
  • 78.26 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptpra 30
  • 74.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia ptpa-A-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ptpra 30 31
  • 71.86 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ptp52F 32
  • 37 (a)
Ptp69D 32
  • 37 (a)
CG7180 32
  • 29 (a)
Worm
(Caenorhabditis elegans)
Secernentea M04G7.2 32
  • 37 (a)
ZK616.7 32
  • 37 (a)
T22C1.8 32
  • 36 (a)
F20H11.4 32
  • 30 (a)
ptp-3 31
  • 13 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4172 30
Species where no ortholog for PTPRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTPRA Gene

ENSEMBL:
Gene Tree for PTPRA (if available)
TreeFam:
Gene Tree for PTPRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPRA: view image

Paralogs for PTPRA Gene

(28) SIMAP similar genes for PTPRA Gene using alignment to 6 proteins:

  • PTPRA_HUMAN
  • B7Z2A4_HUMAN
  • J3KP22_HUMAN
  • Q5JWG0_HUMAN
  • Q5JWG2_HUMAN
  • Q5JWG3_HUMAN

Pseudogenes.org Pseudogenes for PTPRA Gene

genes like me logo Genes that share paralogs with PTPRA: view

Variants for PTPRA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPRA Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
987481 Pathogenic: not provided 2,864,631(+) C/T
NM_022575.4(VPS16):c.1903C>T (p.Arg635Ter)
NONSENSE,FIVE_PRIME_UTR
rs78716368 Benign: not provided 2,986,784(+) G/A
NM_002836.3(PTPRA):c.462G>A (p.Ala154=)
SYNONYMOUS
rs1178027 - p.Pro109Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPRA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPRA Gene

Variant ID Type Subtype PubMed ID
dgv2205n106 CNV deletion 24896259
dgv268e215 CNV deletion 23714750
esv2207372 CNV deletion 18987734
esv2272134 CNV deletion 18987734
esv2369681 CNV deletion 18987734
esv2661520 CNV deletion 23128226
esv2664542 CNV deletion 23128226
esv2669632 CNV deletion 23128226
esv2722110 CNV deletion 23290073
esv2722111 CNV deletion 23290073
esv2722112 CNV deletion 23290073
esv2722113 CNV deletion 23290073
esv2722114 CNV deletion 23290073
esv2762056 CNV gain 21179565
esv3556735 CNV deletion 23714750
esv3645020 CNV gain 21293372
esv3645021 CNV loss 21293372
esv3645022 CNV loss 21293372
esv3645023 CNV gain 21293372
esv3645024 CNV loss 21293372
esv5581 CNV loss 19470904
esv994080 CNV gain 20482838
nsv1057187 CNV gain 25217958
nsv1057464 CNV gain 25217958
nsv1071299 CNV deletion 25765185
nsv1125837 CNV deletion 24896259
nsv1130766 CNV deletion 24896259
nsv1143131 CNV deletion 24896259
nsv1148763 CNV deletion 26484159
nsv1151978 CNV deletion 26484159
nsv179703 CNV deletion 16902084
nsv180455 CNV deletion 16902084
nsv180708 CNV deletion 16902084
nsv3262 CNV insertion 18451855
nsv3263 CNV insertion 18451855
nsv478162 CNV novel sequence insertion 20440878
nsv518708 CNV loss 19592680
nsv519680 CNV loss 19592680
nsv522009 CNV gain 19592680
nsv585276 CNV gain 21841781
nsv833895 CNV loss 17160897
nsv833896 CNV loss 17160897
nsv833897 CNV loss 17160897
nsv956217 CNV deletion 24416366

Variation tolerance for PTPRA Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPRA Gene

Human Gene Mutation Database (HGMD)
PTPRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRA Gene

Disorders for PTPRA Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTPRA Gene - From: COP

Disorder Aliases PubMed IDs
common peroneal nerve lesion
noonan syndrome with multiple lentigines
  • capute-rimoin-konigsmark-esterly-richardson syndrome
rasopathy
  • ras/mitogen-activated protein kinase syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTPRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPRA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTPRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRA Gene

Publications for PTPRA Gene

  1. Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase. (PMID: 2172030) Jirik FR … Harder KW (FEBS letters 1990) 2 3 4 23
  2. Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide). (PMID: 2175890) Ohagi S … Steiner DF (Nucleic acids research 1990) 3 4 23
  3. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (PMID: 2169617) Kaplan R … Schlessinger J (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4
  4. Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. (PMID: 22801373) Sun G … Pallen CJ (Molecular and cellular biology 2012) 3 4
  5. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. (PMID: 20208566) Krndija D … von Wichert G (Oncogene 2010) 3 23

Products for PTPRA Gene

Sources for PTPRA Gene